Protein: IF4A2
Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2)

Gene: IF4A2, EIF4A2
Organism: Homo sapiens
Interactions: 169
UniProt ID: Q14240

Gene Ontology (top 5):
GO:0002183 - cytoplasmic translational initiation
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity
GO:0003743 - translation initiation factor activity
GO:0004386 - helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

979902

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

6

20

Small-scale

0.938

High

1051874

PDCD4
Programmed cell death protein 4

5

15

High-throughput

0.930

High

892800

IF4A1
Eukaryotic initiation factor 4A-I

5

17

High-throughput

0.922

High

203371

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

3

20

High-throughput

0.839

High

941985

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

3

20

Small-scale

0.839

High

1051921

TRI39
E3 ubiquitin-protein ligase TRIM39

2

3

High-throughput

0.811

High

134037

DDX3X
ATP-dependent RNA helicase DDX3X

2

14

High-throughput

0.754

High

1032088

EIF3I
Eukaryotic translation initiation factor 3 subunit I

2

14

High-throughput

0.754

High

1051862

IF4A2
Eukaryotic initiation factor 4A-II

1

15

High-throughput

0.698

High

177022

EIF3H
Eukaryotic translation initiation factor 3 subunit H

4

19

High-throughput

0.683

High

1051926

IBTK
Inhibitor of Bruton tyrosine kinase

2

8

High-throughput

0.675

High

416987

IF4E
Eukaryotic translation initiation factor 4E

3

5

High-throughput

0.667

High

802435

ATRX
Transcriptional regulator ATRX

1

20

High-throughput

0.665

High

275871

EIF3G
Eukaryotic translation initiation factor 3 subunit G

3

12

High-throughput

0.656

High

1049548

EIF3A
Eukaryotic translation initiation factor 3 subunit A

3

10

High-throughput

0.650

High

1051881

EIF3M
Eukaryotic translation initiation factor 3 subunit M

3

1

High-throughput

0.650

High

1051928

EIF3K
Eukaryotic translation initiation factor 3 subunit K

3

1

High-throughput

0.650

High

124860

EIF3F
Eukaryotic translation initiation factor 3 subunit F

3

11

High-throughput

0.640

High

1051929

IPO11
Importin-11

2

12

High-throughput

0.631

High

1051932

EIF3L
Eukaryotic translation initiation factor 3 subunit L

3

0

High-throughput

0.622

High

328843

TOP3B
DNA topoisomerase 3-beta-1

1

3

High-throughput

0.618

High

640475

DDX6
Probable ATP-dependent RNA helicase DDX6

1

16

High-throughput

0.618

High

1051871

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

7

High-throughput

0.618

High

1051894

RENT1
Regulator of nonsense transcripts 1

1

6

High-throughput

0.618

High

1051925

4ET
Eukaryotic translation initiation factor 4E transporter

1

2

High-throughput

0.618

High

176782

EIF3D
Eukaryotic translation initiation factor 3 subunit D

2

2

High-throughput

0.601

High

516515

PABP1
Polyadenylate-binding protein 1

2

13

High-throughput

0.601

High

1051916

DDX24
ATP-dependent RNA helicase DDX24

1

17

High-throughput

0.590

High

1051920

ECT2
Protein ECT2

2

4

High-throughput

0.586

High

227437

PRKN
E3 ubiquitin-protein ligase parkin

2

17

High-throughput

0.584

High

879246

EIF3B
Eukaryotic translation initiation factor 3 subunit B

2

13

High-throughput

0.584

High

888363

EIF3E
Eukaryotic translation initiation factor 3 subunit E

2

2

High-throughput

0.584

High

1051903

SMG1
Serine/threonine-protein kinase SMG1

2

4

High-throughput

0.584

High

1051905

EIF3C
Eukaryotic translation initiation factor 3 subunit C

2

3

High-throughput

0.584

High

388438

HSPB1
Heat shock protein beta-1

1

3

High-throughput

0.582

High

1051913

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

4

High-throughput

0.575

High

1051891

PIHD2
PIH1 domain-containing protein 2

2

5

High-throughput

0.573

High

1051922

TRI36
E3 ubiquitin-protein ligase TRIM36

1

20

High-throughput

0.573

High

497009

TAU
Microtubule-associated protein tau

2

10

High-throughput

0.571

High

1051878

ZN620
Zinc finger protein 620

2

1

High-throughput

0.553

High

1051879

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.553

High

1051885

ANR35
Ankyrin repeat domain-containing protein 35

1

8

Small-scale

0.553

High

1051930

HECD1
E3 ubiquitin-protein ligase HECTD1

1

16

Small-scale

0.553

High

327934

FTCD
Formimidoyltransferase-cyclodeaminase

1

1

High-throughput

0.541

High

418269

NPM
Nucleophosmin

1

3

High-throughput

0.536

High

828761

SRP09
Signal recognition particle 9 kDa protein

1

3

High-throughput

0.536

High

907909

RS16
Small ribosomal subunit protein uS9

1

6

High-throughput

0.536

High

911382

RS11
Small ribosomal subunit protein uS17

1

5

High-throughput

0.536

High

1051892

PSPC1
Paraspeckle component 1

1

20

High-throughput

0.536

High

1051904

CDC5L
Cell division cycle 5-like protein

1

7

High-throughput

0.536

High

1051910

RBM42
RNA-binding protein 42

1

19

High-throughput

0.536

High

1051933

DRG1
Developmentally-regulated GTP-binding protein 1

1

7

High-throughput

0.536

High

214267

SPOP
Speckle-type POZ protein

2

2

High-throughput

0.533

High

1051882

MOT9
Monocarboxylate transporter 9

1

1

High-throughput

0.523

High

1051909

SH3G3
Endophilin-A3

2

6

High-throughput

0.521

High

159363

PLD2
Phospholipase D2

1

0

High-throughput

0.517

High

1051886

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.517

High

214576

MYO1B
Unconventional myosin-Ib

1

5

High-throughput

0.515

High

229670

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

9

High-throughput

0.515

High

313274

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

1

High-throughput

0.515

High

418954

TPM3
Tropomyosin alpha-3 chain

1

1

High-throughput

0.515

High

423228

PDIA1
Protein disulfide-isomerase

1

1

High-throughput

0.515

High

911005

RS29
Small ribosomal subunit protein uS14

1

2

High-throughput

0.515

High

968690

AK17A
A-kinase anchor protein 17A

1

1

High-throughput

0.515

High

997369

VAC14
Protein VAC14 homolog

1

11

High-throughput

0.515

High

1031983

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

2

High-throughput

0.515

High

791558

HD
Huntingtin

1

2

High-throughput

0.515

High

868489

ATX1
Ataxin-1

1

2

High-throughput

0.515

High

851325

NEK2
Serine/threonine-protein kinase Nek2

1

11

High-throughput

0.508

High

1051868

HSPB2
Heat shock protein beta-2

1

3

High-throughput

0.508

High

902582

SUMO2
Small ubiquitin-related modifier 2

1

8

High-throughput

0.501

High

883106

DSCR6
Protein ripply3

1

1

High-throughput

0.494

High

1051900

CMBL
Carboxymethylenebutenolidase homolog

1

0

High-throughput

0.493

High

1051912

TX101
Testis-expressed protein 101

1

1

High-throughput

0.489

High

378691

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.486

High

749490

BRCA1
Breast cancer type 1 susceptibility protein

1

12

High-throughput

0.481

High

117695

MYO1C
Unconventional myosin-Ic

1

3

High-throughput

0.479

High

148803

CTRO
Citron Rho-interacting kinase

1

14

High-throughput

0.479

High

209979

PRC1
Protein regulator of cytokinesis 1

1

4

High-throughput

0.479

High

233443

NUPR1
Nuclear protein 1

1

6

High-throughput

0.479

High

282651

RNF8
E3 ubiquitin-protein ligase RNF8

1

6

High-throughput

0.479

High

301814

TRI37
E3 ubiquitin-protein ligase TRIM37

1

18

High-throughput

0.479

High

308701

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

324400

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

377321

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

398466

PPBT
Alkaline phosphatase, tissue-nonspecific isozyme

1

2

High-throughput

0.479

High

453356

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

15

High-throughput

0.479

High

504069

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

529104

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.479

High

618625

IF4B
Eukaryotic translation initiation factor 4B

1

17

High-throughput

0.479

High

623120

EF1B
Elongation factor 1-beta

1

1

High-throughput

0.479

High

779401

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

793640

DCC
Netrin receptor DCC

1

3

Small-scale

0.479

High

813461

CAPZB
F-actin-capping protein subunit beta

1

5

High-throughput

0.479

High

820918

PRC2A
Protein PRRC2A

1

20

High-throughput

0.479

High

832453

MCM2
DNA replication licensing factor MCM2

1

8

High-throughput

0.479

High

874924

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.479

High

923682

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

7

Small-scale

0.479

High

964328

RUNX1
Runt-related transcription factor 1

1

3

High-throughput

0.479

High

969690

KIF23
Kinesin-like protein KIF23

1

14

High-throughput

0.479

High

1029415

TIF1B
Transcription intermediary factor 1-beta

1

16

High-throughput

0.479

High

1031325

PABP4
Polyadenylate-binding protein 4

1

13

High-throughput

0.479

High

1038210

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

1

1

High-throughput

0.479

High

1051863

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

10

High-throughput

0.479

High

1051865

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

1051866

PCBP1
Poly(rC)-binding protein 1

1

17

Small-scale

0.479

High

1051867

SMAD2
Mothers against decapentaplegic homolog 2

1

13

High-throughput

0.479

High

1051872

CRY2
Cryptochrome-2

1

9

High-throughput

0.479

High

1051875

PRC2B
Protein PRRC2B

1

20

High-throughput

0.479

High

1051877

GGYF2
GRB10-interacting GYF protein 2

1

3

High-throughput

0.479

High

1051884

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

1

High-throughput

0.479

High

1051893

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

9

High-throughput

0.479

High

1051897

CHM4C
Charged multivesicular body protein 4c

1

9

High-throughput

0.479

High

1051898

OPTN
Optineurin

1

12

High-throughput

0.479

High

1051906

ATX2
Ataxin-2

1

12

High-throughput

0.479

High

1051908

BAG1
BAG family molecular chaperone regulator 1

1

3

High-throughput

0.479

High

1051911

SYTM
Threonine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

1051915

TRI31
E3 ubiquitin-protein ligase TRIM31

1

8

High-throughput

0.479

High

1051919

TDRD3
Tudor domain-containing protein 3

1

3

High-throughput

0.479

High

1051923

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

3

High-throughput

0.479

High

1051924

ANLN
Anillin

1

5

High-throughput

0.479

High

1051935

FBX7
F-box only protein 7

1

2

High-throughput

0.479

High

1051936

PRC2C
Protein PRRC2C

1

19

High-throughput

0.479

High

1051937

YTHD2
YTH domain-containing family protein 2

1

5

High-throughput

0.479

High

1051938

RBM8A
RNA-binding protein 8A

1

20

High-throughput

0.479

High

456409

PPBI
Intestinal-type alkaline phosphatase

1

2

High-throughput

0.470

High

1051899

DDT4L
DNA damage-inducible transcript 4-like protein

1

1

High-throughput

0.470

High

428208

TBB5
Tubulin beta chain

1

0

High-throughput

0.458

High

1051890

DYH5
Dynein axonemal heavy chain 5

1

0

High-throughput

0.458

High

1051895

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

1051901

CDCA5
Sororin

1

0

High-throughput

0.458

High

1051931

ANGE1
Protein angel homolog 1

1

0

High-throughput

0.458

High

867423

ICLN
Methylosome subunit pICln

1

1

High-throughput

0.457

High

717815

BMI1
Polycomb complex protein BMI-1

1

9

High-throughput

0.445

High

1051876

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

High-throughput

0.445

High

994866

GOGA2
Golgin subfamily A member 2

1

5

High-throughput

0.439

High

129759

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

2

High-throughput

0.437

High

303233

HEXI1
Protein HEXIM1

1

6

High-throughput

0.437

High

353293

CD4
T-cell surface glycoprotein CD4

1

2

Small-scale

0.437

High

552711

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.437

High

651186

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

720448

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

785914

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

5

High-throughput

0.437

High

824000

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

12

High-throughput

0.437

High

887847

CD81
CD81 antigen

1

5

High-throughput

0.437

High

1038241

4EBP2
Eukaryotic translation initiation factor 4E-binding protein 2

1

1

High-throughput

0.437

High

1051864

SUZ12
Polycomb protein SUZ12

1

3

High-throughput

0.437

High

1051869

CRY1
Cryptochrome-1

1

9

High-throughput

0.437

High

1051873

DUS28
Dual specificity phosphatase 28

1

1

High-throughput

0.437

High

1051883

PLD3
5'-3' exonuclease PLD3

1

2

High-throughput

0.437

High

1051887

PLD5
Inactive phospholipase D5

1

2

High-throughput

0.437

High

1051889

TIP
T-cell immunomodulatory protein

1

3

High-throughput

0.437

High

1051896

PLD4
5'-3' exonuclease PLD4

1

2

High-throughput

0.437

High

1051902

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.437

High

1051914

ACE2
Angiotensin-converting enzyme 2

1

5

Small-scale

0.437

High

1051917

SPRTN
DNA-dependent metalloprotease SPRTN

1

3

High-throughput

0.437

High

1051927

GBG12

1

1

High-throughput

0.437

High

378047

PRIO
Major prion protein

1

0

High-throughput

0.426

High

1047078

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

4

High-throughput

0.407

High

1051880

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.299

High

1051907

MDFI
MyoD family inhibitor

1

0

High-throughput

0.299

High

1051934

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.299

High

1051870

CP51A
Lanosterol 14-alpha demethylase

1

0

High-throughput

0.279

Low

245977

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.265

Low

1051888

MCPH1
Microcephalin

1

0

Small-scale

0.251

Low

100758

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

1014228

MN1
Transcriptional activator MN1

1

0

Small-scale

0.249

Low

1051918

Q9H376
PRO0720

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024