Protein: AAK1
AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1)

Gene: AAK1
Organism: Homo sapiens
Interactions: 108
UniProt ID: Q2M2I8

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005112 - Notch binding
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1101676

WNK1
Serine/threonine-protein kinase WNK1

2

19

High-throughput

0.789

High

1101670

AP2M1
AP-2 complex subunit mu

7

11

High-throughput

0.750

High

925884

AP2B1
AP-2 complex subunit beta

5

18

High-throughput

0.718

High

864078

AP2S1
AP-2 complex subunit sigma

4

9

High-throughput

0.699

High

1071095

RBP1
RalA-binding protein 1

4

13

High-throughput

0.699

High

161665

GAK
Cyclin-G-associated kinase

1

18

High-throughput

0.691

High

1083211

KCC4
Calcium/calmodulin-dependent protein kinase type IV

1

15

High-throughput

0.691

High

1101680

ANLN
Anillin

1

4

High-throughput

0.691

High

1101688

WNK2
Serine/threonine-protein kinase WNK2

1

19

High-throughput

0.691

High

1101651

RUN3A
RUN domain-containing protein 3A

3

1

High-throughput

0.667

High

1101671

REPS1
RalBP1-associated Eps domain-containing protein 1

3

14

High-throughput

0.667

High

1101649

AAK1
AP2-associated protein kinase 1

1

17

Small-scale

0.647

High

1101682

RBM12
RNA-binding protein 12

1

7

High-throughput

0.618

High

374309

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.618

High

384930

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

1101656

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

321559

AP2A1
AP-2 complex subunit alpha-1

2

19

High-throughput

0.611

High

451682

CLCB
Clathrin light chain B

2

7

High-throughput

0.611

High

502164

BIP
Endoplasmic reticulum chaperone BiP

2

10

High-throughput

0.611

High

1014021

AP1B1
AP-1 complex subunit beta-1

2

19

High-throughput

0.611

High

1068547

PLEC
Plectin

2

16

High-throughput

0.584

High

1080676

ZYX
Zyxin

2

7

High-throughput

0.584

High

1101679

AT132
Polyamine-transporting ATPase 13A2

1

8

Small-scale

0.582

High

1043837

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

20

High-throughput

0.575

High

1101655

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.575

High

1101658

TLK2
Serine/threonine-protein kinase tousled-like 2

1

19

High-throughput

0.575

High

369718

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1101654

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

2

2

High-throughput

0.558

High

323793

BAG2
BAG family molecular chaperone regulator 2

1

3

High-throughput

0.536

High

533681

GYS1
Glycogen [starch] synthase, muscle

1

2

High-throughput

0.536

High

664236

TPP2
Tripeptidyl-peptidase 2

1

3

High-throughput

0.536

High

849209

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

3

High-throughput

0.536

High

857137

CAZA1
F-actin-capping protein subunit alpha-1

1

6

High-throughput

0.536

High

862402

ACLY
ATP-citrate synthase

1

1

High-throughput

0.536

High

874108

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

4

High-throughput

0.536

High

929485

RACK1
Small ribosomal subunit protein RACK1

1

11

High-throughput

0.536

High

960821

CLH1
Clathrin heavy chain 1

1

8

High-throughput

0.536

High

1039223

DCTN2
Dynactin subunit 2

1

1

High-throughput

0.536

High

1051556

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

3

High-throughput

0.536

High

1101683

NECP2
Adaptin ear-binding coat-associated protein 2

1

1

High-throughput

0.536

High

1101684

GTSE1
G2 and S phase-expressed protein 1

1

3

High-throughput

0.536

High

1101673

EXOC2
Exocyst complex component 2

1

0

High-throughput

0.513

High

1101677

GEMI7
Gem-associated protein 7

1

0

High-throughput

0.513

High

394821

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

126250

ODPX
Pyruvate dehydrogenase protein X component, mitochondrial

1

1

High-throughput

0.489

High

1101678

PAAT
ATPase PAAT

1

2

High-throughput

0.489

High

151012

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

20

High-throughput

0.479

High

162799

XPO1
Exportin-1

1

11

High-throughput

0.479

High

302160

AP2A2
AP-2 complex subunit alpha-2

1

19

High-throughput

0.479

High

315712

SC24B
Protein transport protein Sec24B

1

5

High-throughput

0.479

High

322704

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.479

High

352120

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

2

High-throughput

0.479

High

430199

PROF1
Profilin-1

1

1

High-throughput

0.479

High

443548

VIME
Vimentin

1

10

High-throughput

0.479

High

451455

CLCA
Clathrin light chain A

1

7

High-throughput

0.479

High

497123

TAU
Microtubule-associated protein tau

1

15

High-throughput

0.479

High

518675

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

8

High-throughput

0.479

High

521971

CADH1
Cadherin-1

1

12

High-throughput

0.479

High

646938

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

668728

PML
Protein PML

1

12

High-throughput

0.479

High

683387

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

684068

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

737834

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

20

High-throughput

0.479

High

742328

SYUA
Alpha-synuclein

1

3

High-throughput

0.479

High

781907

PERI
Peripherin

1

10

High-throughput

0.479

High

833605

NUMB
Protein numb homolog

1

8

High-throughput

0.479

High

840486

VASP
Vasodilator-stimulated phosphoprotein

1

8

High-throughput

0.479

High

904628

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

905937

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

20

High-throughput

0.479

High

909618

1433E
14-3-3 protein epsilon

1

20

High-throughput

0.479

High

919738

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

3

High-throughput

0.479

High

927099

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

982063

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1101650

GRDN
Girdin

1

17

High-throughput

0.479

High

1101659

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

1101664

REPS2
RalBP1-associated Eps domain-containing protein 2

1

10

High-throughput

0.479

High

1101666

BICD2
Protein bicaudal D homolog 2

1

16

High-throughput

0.479

High

1101667

STON2
Stonin-2

1

11

High-throughput

0.479

High

1101668

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

8

High-throughput

0.479

High

1101669

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

20

High-throughput

0.479

High

1101672

BICD1
Protein bicaudal D homolog 1

1

15

High-throughput

0.479

High

1101685

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1101686

NDUAC
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

1

1

High-throughput

0.479

High

201022

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

0

High-throughput

0.458

High

1101663

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

1101665

URGCP
Up-regulator of cell proliferation

1

0

High-throughput

0.458

High

1101674

NUP88
Nuclear pore complex protein Nup88

1

0

High-throughput

0.458

High

1101681

I17RB
Interleukin-17 receptor B

1

0

Small-scale

0.458

High

378072

PRIO
Major prion protein

1

1

High-throughput

0.445

High

891170

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

2

High-throughput

0.445

High

100814

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

318633

EYA4
Eyes absent homolog 4

1

6

High-throughput

0.437

High

346928

MYC
Myc proto-oncogene protein

1

14

High-throughput

0.437

High

552855

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.437

High

651344

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.437

High

720596

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

782722

IPP2
Protein phosphatase inhibitor 2

1

2

High-throughput

0.437

High

928607

DYLT1
Dynein light chain Tctex-type 1

1

2

High-throughput

0.437

High

1101043

QSER1
Glutamine and serine-rich protein 1

1

4

High-throughput

0.437

High

1101657

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

9

High-throughput

0.437

High

1101660

LUZP1
Leucine zipper protein 1

1

18

High-throughput

0.437

High

1101661

HOOK3
Protein Hook homolog 3

1

15

High-throughput

0.437

High

1101675

ERP44
Endoplasmic reticulum resident protein 44

1

2

High-throughput

0.437

High

1101662

RYBP
RING1 and YY1-binding protein

1

3

High-throughput

0.407

High

1101652

RM02
Large ribosomal subunit protein uL2m

1

0

High-throughput

0.279

Low

1101687

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

1

0

High-throughput

0.279

Low

1101653

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024