Protein: BRE1A
E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A)

Gene: BRE1A, RNF20
Organism: Homo sapiens
Interactions: 161
UniProt ID: Q5VTR2

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0002039 - p53 binding
GO:0003682 - chromatin binding
GO:0003713 - transcription coactivator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

927757

UBE2B
Ubiquitin-conjugating enzyme E2 B

7

16

Small-scale

0.970

High

829017

UBE2A
Ubiquitin-conjugating enzyme E2 A

6

16

Small-scale

0.950

High

932532

UB2L3
Ubiquitin-conjugating enzyme E2 L3

2

16

Small-scale

0.778

High

256280

BRE1B
E3 ubiquitin-protein ligase BRE1B

15

19

Small-scale

0.762

High

851821

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

13

Small-scale

0.724

High

1138167

BRE1A
E3 ubiquitin-protein ligase BRE1A

5

17

Small-scale

0.718

High

386898

P53
Cellular tumor antigen p53

5

6

Small-scale

0.711

High

1138213

WAC
WW domain-containing adapter protein with coiled-coil

4

5

Small-scale

0.703

High

1138172

CDC73
Parafibromin

4

4

Small-scale

0.696

High

707654

H2B1B
Histone H2B type 1-B

4

20

Small-scale

0.689

High

487507

ANDR
Androgen receptor

4

20

Small-scale

0.676

High

849218

PSMD7
26S proteasome non-ATPase regulatory subunit 7

3

7

High-throughput

0.667

High

1138221

DSN1
Kinetochore-associated protein DSN1 homolog

3

2

High-throughput

0.667

High

791648

HD
Huntingtin

3

6

High-throughput

0.664

High

1087184

H2B2E
Histone H2B type 2-E

3

20

Small-scale

0.655

High

919748

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

13

High-throughput

0.647

High

1138238

AMOL2
Angiomotin-like protein 2

4

18

High-throughput

0.637

High

1138237

PA2G4
Proliferation-associated protein 2G4

2

1

Small-scale

0.634

High

1037058

MED21
Mediator of RNA polymerase II transcription subunit 21

2

1

High-throughput

0.628

High

1138198

TCP1L
T-complex protein 10A homolog 1

2

2

High-throughput

0.628

High

1138218

TX13A
Testis-expressed protein 13A

2

1

High-throughput

0.628

High

1138223

SMUF2
E3 ubiquitin-protein ligase SMURF2

2

4

Small-scale

0.624

High

1049062

TRI14
Tripartite motif-containing protein 14

1

5

High-throughput

0.621

High

227722

PRKN
E3 ubiquitin-protein ligase parkin

1

13

High-throughput

0.618

High

475893

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

12

Small-scale

0.618

High

668747

PML
Protein PML

1

11

High-throughput

0.618

High

908684

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

17

High-throughput

0.618

High

1029520

TIF1B
Transcription intermediary factor 1-beta

1

13

High-throughput

0.618

High

1138190

PAF1
RNA polymerase II-associated factor 1 homolog

2

2

Small-scale

0.611

High

1138242

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

14

Small-scale

0.611

High

320335

SNP29
Synaptosomal-associated protein 29

3

1

High-throughput

0.609

High

1138197

PKHO2
Pleckstrin homology domain-containing family O member 2

3

6

High-throughput

0.609

High

1138234

IL36A
Interleukin-36 alpha

3

1

High-throughput

0.609

High

998083

NCBP1
Nuclear cap-binding protein subunit 1

2

2

High-throughput

0.606

High

664095

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.602

High

917418

H4
Histone H4

2

13

Small-scale

0.595

High

244555

BRD4
Bromodomain-containing protein 4

2

9

High-throughput

0.584

High

347021

MYC
Myc proto-oncogene protein

2

11

High-throughput

0.584

High

1138170

VIR
Protein virilizer homolog

2

6

High-throughput

0.584

High

1138188

SIR6
NAD-dependent protein deacylase sirtuin-6

2

9

Small-scale

0.584

High

331305

CHK2
Serine/threonine-protein kinase Chk2

1

11

High-throughput

0.582

High

1138227

AIRIM
AFG2-interacting ribosome maturation factor

2

0

High-throughput

0.580

High

669396

EF1D
Elongation factor 1-delta

1

4

Small-scale

0.578

High

855665

KIF11
Kinesin-like protein KIF11

1

4

Small-scale

0.578

High

1138177

INSY2
Inhibitory synaptic factor 2A

2

1

High-throughput

0.574

High

1138208

NOE3
Noelin-3

2

2

High-throughput

0.574

High

1138225

RAB6B
Ras-related protein Rab-6B

2

9

High-throughput

0.574

High

1138239

COG6
Conserved oligomeric Golgi complex subunit 6

2

1

High-throughput

0.574

High

1138240

WASC3
WASH complex subunit 3

2

1

High-throughput

0.574

High

130936

PSDE
26S proteasome non-ATPase regulatory subunit 14

2

6

Small-scale

0.571

High

1138201

BRK1
Protein BRICK1

2

2

High-throughput

0.567

High

988084

RAD51
DNA repair protein RAD51 homolog 1

1

6

Small-scale

0.561

High

1031542

ATM
Serine-protein kinase ATM

1

10

Small-scale

0.561

High

1138245

TACC3
Transforming acidic coiled-coil-containing protein 3

2

17

High-throughput

0.553

High

1138178

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.553

High

207061

XRCC3
DNA repair protein XRCC3

1

6

High-throughput

0.541

High

314068

BAG4
BAG family molecular chaperone regulator 4

1

1

High-throughput

0.541

High

1138196

FBH1
F-box DNA helicase 1

1

0

Small-scale

0.537

High

258065

DNJB6
DnaJ homolog subfamily B member 6

1

4

High-throughput

0.536

High

638983

S100P
Protein S100-P

1

18

High-throughput

0.536

High

740176

NUP62
Nuclear pore glycoprotein p62

1

12

High-throughput

0.536

High

986923

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.536

High

1138184

RB12B
RNA-binding protein 12B

1

18

High-throughput

0.536

High

1138194

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.536

High

1138204

CSN5
COP9 signalosome complex subunit 5

1

7

Small-scale

0.536

High

1138206

SGF29
SAGA-associated factor 29

1

2

High-throughput

0.536

High

1138220

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

1

High-throughput

0.536

High

1138224

DISC1
Disrupted in schizophrenia 1 protein

1

5

High-throughput

0.536

High

1138226

RBM12
RNA-binding protein 12

1

18

High-throughput

0.536

High

1138236

PRP19
Pre-mRNA-processing factor 19

1

16

High-throughput

0.536

High

1138243

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

1

High-throughput

0.536

High

1138189

USBP1
Harmonin-binding protein USHBP1

1

17

High-throughput

0.523

High

559755

H12
Histone H1.2

1

6

High-throughput

0.515

High

517303

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.513

High

870307

OAZ1
Ornithine decarboxylase antizyme 1

1

0

High-throughput

0.513

High

1138211

TSNAX
Translin-associated protein X

1

0

High-throughput

0.513

High

1138235

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.513

High

391741

H2A1B
Histone H2A type 1-B/E

1

18

Small-scale

0.501

High

902622

SUMO2
Small ubiquitin-related modifier 2

1

3

High-throughput

0.501

High

961154

HSF1
Heat shock factor protein 1

1

4

Small-scale

0.501

High

1087019

H2A2C
Histone H2A type 2-C

1

18

Small-scale

0.501

High

1138169

MSL1
Male-specific lethal 1 homolog

1

1

Small-scale

0.501

High

1138171

H2A2A
Histone H2A type 2-A

1

18

Small-scale

0.501

High

1138175

PRP8
Pre-mRNA-processing-splicing factor 8

1

3

Small-scale

0.501

High

1138180

H32
Histone H3.2

1

12

Small-scale

0.501

High

608006

FGFR4
Fibroblast growth factor receptor 4

1

10

High-throughput

0.494

High

1138183

ZDH17
Palmitoyltransferase ZDHHC17

1

6

High-throughput

0.494

High

1138199

RBCC1
RB1-inducible coiled-coil protein 1

1

18

High-throughput

0.494

High

375752

GBA1
Lysosomal acid glucosylceramidase

1

2

High-throughput

0.489

High

574369

RL35A
Large ribosomal subunit protein eL33

1

1

High-throughput

0.489

High

648282

G0S2
G0/G1 switch protein 2

1

1

High-throughput

0.489

High

1101715

CF184
Cilia- and flagella-associated protein 184

1

1

High-throughput

0.489

High

1102578

INSY1
Inhibitory synaptic factor 1

1

1

High-throughput

0.489

High

1138174

L2GL2
LLGL scribble cell polarity complex component 2

1

8

High-throughput

0.489

High

1138185

SYCE1
Synaptonemal complex central element protein 1

1

1

High-throughput

0.489

High

1138209

CC85A
Coiled-coil domain-containing protein 85A

1

1

High-throughput

0.489

High

1138212

KXDL1
KxDL motif-containing protein 1

1

3

High-throughput

0.489

High

1138215

BBLN
Bublin coiled-coil protein

1

1

High-throughput

0.489

High

1138232

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

5

High-throughput

0.489

High

1138205

RBPMS
RNA-binding protein with multiple splicing

1

3

High-throughput

0.481

High

1138241

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

1138214

URM1
Ubiquitin-related modifier 1

1

0

Small-scale

0.479

High

123971

SPT5H
Transcription elongation factor SPT5

1

6

High-throughput

0.479

High

303293

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

326676

SNAI1
Zinc finger protein SNAI1

1

11

Small-scale

0.479

High

583497

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

616362

RS3
Small ribosomal subunit protein uS3

1

2

Small-scale

0.479

High

749584

BRCA1
Breast cancer type 1 susceptibility protein

1

11

High-throughput

0.479

High

785957

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

6

High-throughput

0.479

High

790938

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

7

Small-scale

0.479

High

826289

CDK8
Cyclin-dependent kinase 8

1

18

High-throughput

0.479

High

853921

NCBP2
Nuclear cap-binding protein subunit 2

1

11

High-throughput

0.479

High

855092

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

18

Small-scale

0.479

High

899922

ISL1
Insulin gene enhancer protein ISL-1

1

6

Small-scale

0.479

High

1014143

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

4

High-throughput

0.479

High

1021122

FOXC1
Forkhead box protein C1

1

8

High-throughput

0.479

High

1035819

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

1041769

CUL3
Cullin-3

1

13

High-throughput

0.479

High

1064396

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

7

High-throughput

0.479

High

1138176

FXL19
F-box/LRR-repeat protein 19

1

3

Small-scale

0.479

High

1138179

MOB3C
MOB kinase activator 3C

1

4

High-throughput

0.479

High

1138181

SPT6H
Transcription elongation factor SPT6

1

3

Small-scale

0.479

High

1138182

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

1138191

ZSCA4
Zinc finger and SCAN domain-containing protein 4

1

7

Small-scale

0.479

High

1138195

FA98A
Protein FAM98A

1

1

High-throughput

0.479

High

1138202

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

1

High-throughput

0.479

High

1138207

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

4

Small-scale

0.479

High

1138216

RN126
E3 ubiquitin-protein ligase RNF126

1

3

High-throughput

0.479

High

1138217

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

19

Small-scale

0.479

High

1138228

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1138233

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1138244

SP16H
FACT complex subunit SPT16

1

1

Small-scale

0.479

High

1138193

TXND5
Thioredoxin domain-containing protein 5

1

5

High-throughput

0.470

High

123620

PGRC1
Membrane-associated progesterone receptor component 1

1

0

Small-scale

0.458

High

869820

PMS1
PMS1 protein homolog 1

1

0

High-throughput

0.458

High

1138203

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.458

High

1138229

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1138210

CDC5L
Cell division cycle 5-like protein

1

4

High-throughput

0.457

High

1138187

RYBP
RING1 and YY1-binding protein

1

5

High-throughput

0.445

High

1138219

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

1138200

DI3L1
DIS3-like exonuclease 1

1

1

High-throughput

0.439

High

1138230

ITSN2
Intersectin-2

1

8

High-throughput

0.439

High

100854

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

297633

RHBT1
Rho-related BTB domain-containing protein 1

1

20

High-throughput

0.437

High

322746

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

9

High-throughput

0.437

High

329776

AGR2
Anterior gradient protein 2 homolog

1

5

High-throughput

0.437

High

384983

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.437

High

418976

TPM3
Tropomyosin alpha-3 chain

1

15

Small-scale

0.437

High

646983

1433T
14-3-3 protein theta

1

20

Small-scale

0.437

High

670067

MARCS
Myristoylated alanine-rich C-kinase substrate

1

4

Small-scale

0.437

High

932202

ACTC
Actin, alpha cardiac muscle 1

1

17

High-throughput

0.437

High

1138186

RHG24
Rho GTPase-activating protein 24

1

8

High-throughput

0.437

High

1138192

KDF1
Keratinocyte differentiation factor 1

1

1

High-throughput

0.437

High

1138222

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.437

High

1063076

ABRX2
BRISC complex subunit Abraxas 2

1

0

Small-scale

0.426

High

1091118

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

2

High-throughput

0.407

High

1130168

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

High-throughput

0.407

High

1138168

SLX4I
Protein SLX4IP

1

0

High-throughput

0.279

Low

1138173

F117B
Protein FAM117B

1

0

High-throughput

0.279

Low

1138231

SLAI2
SLAIN motif-containing protein 2

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024