Protein: LEMD2
LEM domain-containing protein 2 (hLEM2)

Gene: LEMD2
Organism: Homo sapiens
Interactions: 96
UniProt ID: Q8NC56

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0005635 - nuclear envelope
GO:0005637 - nuclear inner membrane
GO:0005737 - cytoplasm
GO:0005819 - spindle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

360171

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

4

5

Small-scale

0.676

High

985144

ACHB3
Neuronal acetylcholine receptor subunit beta-3

3

6

High-throughput

0.667

High

946047

DLK1
Protein delta homolog 1

3

0

High-throughput

0.638

High

687005

ACHA3
Neuronal acetylcholine receptor subunit alpha-3

2

6

High-throughput

0.628

High

1160149

S39A4
Zinc transporter ZIP4

3

2

High-throughput

0.609

High

1241121

ACHA9
Neuronal acetylcholine receptor subunit alpha-9

3

6

High-throughput

0.609

High

676579

CTR1
High affinity cationic amino acid transporter 1

2

0

High-throughput

0.602

High

823067

AGRE5
Adhesion G protein-coupled receptor E5

2

0

High-throughput

0.602

High

966846

AT2B2
Plasma membrane calcium-transporting ATPase 2

2

0

High-throughput

0.602

High

1117475

ANO6
Anoctamin-6

2

0

High-throughput

0.602

High

802356

5HT3A
5-hydroxytryptamine receptor 3A

2

8

High-throughput

0.574

High

1241116

S39A8
Metal cation symporter ZIP8

2

2

High-throughput

0.574

High

118975

KCNK1
Potassium channel subfamily K member 1

1

1

High-throughput

0.536

High

126034

UPK1A
Uroplakin-1a

1

3

High-throughput

0.536

High

157058

AIM2
Interferon-inducible protein AIM2

1

1

High-throughput

0.536

High

163887

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

3

High-throughput

0.536

High

439841

NEP
Neprilysin

1

1

High-throughput

0.536

High

677154

ACHB4
Neuronal acetylcholine receptor subunit beta-4

1

6

High-throughput

0.536

High

768549

ADCY8
Adenylate cyclase type 8

1

1

High-throughput

0.536

High

798533

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

5

High-throughput

0.536

High

957436

IDD
Integral membrane protein DGCR2/IDD

1

1

High-throughput

0.536

High

1241102

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

3

High-throughput

0.536

High

1241107

CREL1
Protein disulfide isomerase CRELD1

1

1

High-throughput

0.536

High

1241113

CML1
Chemerin-like receptor 1

1

1

High-throughput

0.536

High

1241117

TTYH1
Protein tweety homolog 1

1

1

High-throughput

0.536

High

1241118

TF7L2
Transcription factor 7-like 2

1

1

High-throughput

0.536

High

130262

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

1

0

High-throughput

0.513

High

133570

NOP56
Nucleolar protein 56

1

0

High-throughput

0.513

High

235961

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.513

High

536537

IRF2
Interferon regulatory factor 2

1

0

High-throughput

0.513

High

620533

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

0

High-throughput

0.513

High

649613

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

1053720

PDE3A
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

1

0

High-throughput

0.513

High

1241103

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

0

High-throughput

0.513

High

1241108

TM169
Transmembrane protein 169

1

0

High-throughput

0.513

High

1241112

SORT
Sortilin

1

0

High-throughput

0.513

High

1241122

BACE2
Beta-secretase 2

1

0

High-throughput

0.513

High

326137

TSN15
Tetraspanin-15

1

2

High-throughput

0.489

High

506336

ACHB
Acetylcholine receptor subunit beta

1

6

High-throughput

0.489

High

558757

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

3

High-throughput

0.489

High

608285

KCNA5
Potassium voltage-gated channel subfamily A member 5

1

3

High-throughput

0.489

High

977416

KCNC4
Potassium voltage-gated channel subfamily C member 4

1

2

High-throughput

0.489

High

1081671

KCA10
Potassium voltage-gated channel subfamily A member 10

1

3

High-throughput

0.489

High

1119718

S39AC
Zinc transporter ZIP12

1

2

High-throughput

0.489

High

1125062

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.489

High

1241106

ZDH12
Palmitoyltransferase ZDHHC12

1

1

High-throughput

0.489

High

1241110

TMM74
Transmembrane protein 74

1

1

High-throughput

0.489

High

175047

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

402255

JUN
Transcription factor Jun

1

1

High-throughput

0.479

High

553208

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

818256

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

917607

H4
Histone H4

1

1

High-throughput

0.479

High

941178

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

1083578

SGCA
Alpha-sarcoglycan

1

1

High-throughput

0.479

High

1085831

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

1170856

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1240682

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

1241100

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

1241120

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

210132

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

228077

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

591022

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

719548

MERL
Merlin

1

0

High-throughput

0.458

High

799124

NKX21
Homeobox protein Nkx-2.1

1

0

High-throughput

0.458

High

877803

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

931742

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.458

High

1066413

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1241104

SH3K1
SH3 domain-containing kinase-binding protein 1

1

0

High-throughput

0.458

High

882437

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.445

High

1233102

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.445

High

100964

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

205692

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

651708

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

720934

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

905532

TSN5
Tetraspanin-5

1

2

High-throughput

0.437

High

1165768

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1217052

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.437

High

1220365

SKA3
Spindle and kinetochore-associated protein 3

1

1

Small-scale

0.437

High

1231143

SYNE4
Nesprin-4

1

1

High-throughput

0.437

High

1043963

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.426

High

1241114

HAUS7
HAUS augmin-like complex subunit 7

3

0

High-throughput

0.347

High

206502

B4GA1
Beta-1,4-glucuronyltransferase 1

2

0

High-throughput

0.328

High

1016630

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

0

High-throughput

0.328

High

1241101

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

2

0

High-throughput

0.328

High

1241109

SGSM3
Small G protein signaling modulator 3

2

0

High-throughput

0.319

High

1234532

SH2D3
SH2 domain-containing protein 3C

2

0

High-throughput

0.298

High

1241111

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

0

High-throughput

0.288

High

159663

QCR10
Cytochrome b-c1 complex subunit 10

1

0

High-throughput

0.279

Low

265895

LGR5
Leucine-rich repeat-containing G-protein coupled receptor 5

1

0

High-throughput

0.279

Low

373040

VTNC
Vitronectin

1

0

High-throughput

0.279

Low

456174

IFI6
Interferon alpha-inducible protein 6

1

0

High-throughput

0.279

Low

1241105

SAAL1
Protein SAAL1

1

0

High-throughput

0.279

Low

1241115

SSBP3
Single-stranded DNA-binding protein 3

1

0

High-throughput

0.279

Low

1239694

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

1241119

ANLN
Anillin

1

0

High-throughput

0.249

Low

718024

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024