Protein: NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (P1)

Gene: NUCKS, NUCKS1
Organism: Homo sapiens
Interactions: 159
UniProt ID: Q9H1E3

Gene Ontology (top 5):
GO:0000724 - double-strand break repair via homologous recombination
GO:0000785 - chromatin
GO:0001678 - intracellular glucose homeostasis
GO:0003682 - chromatin binding
GO:0003690 - double-stranded DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

802496

ATRX
Transcriptional regulator ATRX

2

3

Small-scale

0.639

High

331882

NSD2
Histone-lysine N-methyltransferase NSD2

2

2

Small-scale

0.611

High

559940

H12
Histone H1.2

2

1

High-throughput

0.611

High

586976

CSK22
Casein kinase II subunit alpha'

2

2

High-throughput

0.611

High

934466

CSK21
Casein kinase II subunit alpha

2

2

High-throughput

0.611

High

1174650

H32
Histone H3.2

2

1

High-throughput

0.611

High

962968

MDM2
E3 ubiquitin-protein ligase Mdm2

2

0

Small-scale

0.569

High

229491

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

2

High-throughput

0.536

High

261004

H2AY
Core histone macro-H2A.1

1

4

High-throughput

0.536

High

266060

PSIP1
PC4 and SFRS1-interacting protein

1

1

High-throughput

0.536

High

268280

EED
Polycomb protein EED

1

1

High-throughput

0.536

High

296134

MTA2
Metastasis-associated protein MTA2

1

2

High-throughput

0.536

High

299081

PHF14
PHD finger protein 14

1

1

High-throughput

0.536

High

309742

KAT7
Histone acetyltransferase KAT7

1

1

High-throughput

0.536

High

455860

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.536

High

470153

H2AZ
Histone H2A.Z

1

3

High-throughput

0.536

High

509120

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.536

High

559488

H13
Histone H1.3

1

1

High-throughput

0.536

High

658732

SMCA1
Probable global transcription activator SNF2L1

1

2

High-throughput

0.536

High

672890

CDC27
Cell division cycle protein 27 homolog

1

1

High-throughput

0.536

High

708514

MCM4
DNA replication licensing factor MCM4

1

2

High-throughput

0.536

High

709049

MCM7
DNA replication licensing factor MCM7

1

2

High-throughput

0.536

High

722290

RFC1
Replication factor C subunit 1

1

1

High-throughput

0.536

High

800522

CBX5
Chromobox protein homolog 5

1

2

High-throughput

0.536

High

847076

SMCA4
Transcription activator BRG1

1

2

High-throughput

0.536

High

876720

BRPF1
Peregrin

1

3

High-throughput

0.536

High

949881

CBX1
Chromobox protein homolog 1

1

2

High-throughput

0.536

High

973396

TOP2B
DNA topoisomerase 2-beta

1

1

High-throughput

0.536

High

975322

KMT2A
Histone-lysine N-methyltransferase 2A

1

2

High-throughput

0.536

High

997900

RBBP4
Histone-binding protein RBBP4

1

2

High-throughput

0.536

High

1027252

CBX3
Chromobox protein homolog 3

1

2

High-throughput

0.536

High

1031946

MTA1
Metastasis-associated protein MTA1

1

2

High-throughput

0.536

High

1043212

CUL4A
Cullin-4A

1

1

High-throughput

0.536

High

1043574

CUL4B
Cullin-4B

1

1

High-throughput

0.536

High

1051256

ZMYM3
Zinc finger MYM-type protein 3

1

1

High-throughput

0.536

High

1055632

MCM6
DNA replication licensing factor MCM6

1

2

High-throughput

0.536

High

1070772

RBBP5
Retinoblastoma-binding protein 5

1

2

High-throughput

0.536

High

1080327

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.536

High

1083386

RBBP7
Histone-binding protein RBBP7

1

2

High-throughput

0.536

High

1087397

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.536

High

1137565

RIF1
Telomere-associated protein RIF1

1

1

High-throughput

0.536

High

1151381

H2A2A
Histone H2A type 2-A

1

2

High-throughput

0.536

High

1170085

SRCAP
Helicase SRCAP

1

3

High-throughput

0.536

High

1185529

KDM3B
Lysine-specific demethylase 3B

1

1

High-throughput

0.536

High

1189294

POGZ
Pogo transposable element with ZNF domain

1

1

High-throughput

0.536

High

1190874

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

2

High-throughput

0.536

High

1191025

RAI1
Retinoic acid-induced protein 1

1

3

High-throughput

0.536

High

1199192

PB1
Protein polybromo-1

1

2

High-throughput

0.536

High

1216264

H2A2B
Histone H2A type 2-B

1

2

High-throughput

0.536

High

1242203

Z280C
Zinc finger protein 280C

1

1

High-throughput

0.536

High

1262815

PHIP
PH-interacting protein

1

2

High-throughput

0.536

High

1270922

KAT6A
Histone acetyltransferase KAT6A

1

2

High-throughput

0.536

High

1272937

SMRC1
SWI/SNF complex subunit SMARCC1

1

1

High-throughput

0.536

High

1274387

H2A1C
Histone H2A type 1-C

1

2

High-throughput

0.536

High

1281240

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

1

High-throughput

0.536

High

1295399

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

2

High-throughput

0.536

High

1302680

RSF1
Remodeling and spacing factor 1

1

3

High-throughput

0.536

High

1303046

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

1

High-throughput

0.536

High

1315220

CECR2
Chromatin remodeling regulator CECR2

1

7

High-throughput

0.536

High

1328683

HM20A
High mobility group protein 20A

1

1

High-throughput

0.536

High

1328684

BRD7
Bromodomain-containing protein 7

1

4

High-throughput

0.536

High

1328687

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

8

High-throughput

0.536

High

1328690

H2AW
Core histone macro-H2A.2

1

4

High-throughput

0.536

High

1328691

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

1

High-throughput

0.536

High

1328694

TCF20
Transcription factor 20

1

2

High-throughput

0.536

High

1328696

BAZ1B
Tyrosine-protein kinase BAZ1B

1

8

High-throughput

0.536

High

1328697

APC7
Anaphase-promoting complex subunit 7

1

1

High-throughput

0.536

High

1328698

RCOR1
REST corepressor 1

1

2

High-throughput

0.536

High

1328701

MTF2
Metal-response element-binding transcription factor 2

1

1

High-throughput

0.536

High

1328702

KAD5
Adenylate kinase isoenzyme 5

1

0

High-throughput

0.518

High

170472

TIF1A
Transcription intermediary factor 1-alpha

1

0

High-throughput

0.513

High

268524

BAF
Barrier-to-autointegration factor

1

0

High-throughput

0.513

High

309055

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.513

High

417840

DPOLB
DNA polymerase beta

1

0

High-throughput

0.513

High

426734

H10
Histone H1.0

1

0

High-throughput

0.513

High

439860

NEP
Neprilysin

1

0

Small-scale

0.513

High

475182

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

0

High-throughput

0.513

High

525055

XRCC5
X-ray repair cross-complementing protein 5

1

0

High-throughput

0.513

High

563509

ZNF22
Zinc finger protein 22

1

0

High-throughput

0.513

High

609696

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

1

0

High-throughput

0.513

High

616518

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.513

High

629181

ZA2G
Zinc-alpha-2-glycoprotein

1

0

High-throughput

0.513

High

637551

PSA1
Proteasome subunit alpha type-1

1

0

High-throughput

0.513

High

722513

RL22
Large ribosomal subunit protein eL22

1

0

High-throughput

0.513

High

777923

RFC5
Replication factor C subunit 5

1

0

High-throughput

0.513

High

836775

DNLI3
DNA ligase 3

1

0

High-throughput

0.513

High

837085

MRE11
Double-strand break repair protein MRE11

1

0

High-throughput

0.513

High

848124

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.513

High

903512

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.513

High

917908

H4
Histone H4

1

0

High-throughput

0.513

High

922914

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.513

High

944425

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

High-throughput

0.513

High

1017229

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.513

High

1056979

MDC1
Mediator of DNA damage checkpoint protein 1

1

0

High-throughput

0.513

High

1061240

NUMA1
Nuclear mitotic apparatus protein 1

1

0

High-throughput

0.513

High

1063618

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.513

High

1082385

DDB1
DNA damage-binding protein 1

1

0

High-throughput

0.513

High

1121623

BOREA
Borealin

1

0

High-throughput

0.513

High

1131402

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

High-throughput

0.513

High

1148056

MSL1
Male-specific lethal 1 homolog

1

0

High-throughput

0.513

High

1148333

INT3
Integrator complex subunit 3

1

0

High-throughput

0.513

High

1241774

RN169
E3 ubiquitin-protein ligase RNF169

1

0

High-throughput

0.513

High

1246273

CDC26
Anaphase-promoting complex subunit CDC26

1

0

High-throughput

0.513

High

1250930

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

0

High-throughput

0.513

High

1264480

ING5
Inhibitor of growth protein 5

1

0

High-throughput

0.513

High

1266347

H1X
Histone H1.10

1

0

High-throughput

0.513

High

1295478

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.513

High

1297781

ZN512
Zinc finger protein 512

1

0

High-throughput

0.513

High

1328685

DPOE3
DNA polymerase epsilon subunit 3

1

0

High-throughput

0.513

High

1328686

CHRC1
Chromatin accessibility complex protein 1

1

0

High-throughput

0.513

High

1328688

SOSSC
SOSS complex subunit C

1

0

High-throughput

0.513

High

1328693

KDM5B
Lysine-specific demethylase 5B

1

0

High-throughput

0.513

High

1328700

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.513

High

1139744

ZMYM4
Zinc finger MYM-type protein 4

1

1

High-throughput

0.489

High

1284862

R51A1
RAD51-associated protein 1

1

0

Small-scale

0.480

High

244925

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

596819

CD11B
Cyclin-dependent kinase 11B

1

1

High-throughput

0.479

High

918678

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

935226

H31
Histone H3.1

1

1

High-throughput

0.479

High

999081

EP300
Histone acetyltransferase p300

1

4

High-throughput

0.479

High

1243553

CSK23
Casein kinase II subunit alpha 3

1

2

High-throughput

0.479

High

1328682

Q9H4D1
Protein kinase

1

1

High-throughput

0.479

High

1328699

CD11A
Cyclin-dependent kinase 11A

1

1

High-throughput

0.479

High

232977

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

0

High-throughput

0.458

High

239401

CC14B
Dual specificity protein phosphatase CDC14B

1

0

High-throughput

0.458

High

338961

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

398947

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.458

High

504740

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

553679

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

652214

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

721409

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

724278

MSX2
Homeobox protein MSX-2

1

0

High-throughput

0.458

High

782097

WNT5A
Protein Wnt-5a

1

0

High-throughput

0.458

High

870903

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

909105

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

932372

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

967427

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

1036068

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1064136

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.458

High

1171660

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1200654

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1240982

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1245179

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1267155

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1328689

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1328692

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1328695

TBK1
Serine/threonine-protein kinase TBK1

1

0

High-throughput

0.458

High

497584

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

883641

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

1079598

NEDD8
NEDD8

1

1

High-throughput

0.445

High

378167

PRIO
Major prion protein

1

0

High-throughput

0.426

High

414371

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.426

High

831678

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

793762

GLP1R
Glucagon-like peptide 1 receptor

1

0

Small-scale

0.288

High

1317681

DOCK9
Dedicator of cytokinesis protein 9

1

0

High-throughput

0.282

High

1286355

P5CR2
Pyrroline-5-carboxylate reductase 2

1

0

High-throughput

0.279

Low

101171

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

1286694

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.249

Low

1173333

NEK10
Serine/threonine-protein kinase Nek10

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024