Protein: KMT5A
N-lysine methyltransferase KMT5A (EC 2.1.1.-) (H4-K20-HMTase KMT5A) (Histone-lysine N-methyltransferase KMT5A) (EC 2.1.1.361) (Lysine N-methyltransferase 5A) (Lysine-specific methylase 5A) (PR/SET domain-containing protein 07) (PR-Set7) (PR/SET07) (SET domain-containing protein 8)

Gene: KMT5A
Organism: Homo sapiens
Interactions: 73
UniProt ID: Q9NQR1

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

917987

H4
Histone H4

9

13

Small-scale

0.974

High

1343544

DTL
Denticleless protein homolog

3

20

Small-scale

0.861

High

935270

H31
Histone H3.1

2

20

High-throughput

0.789

High

1343550

FBW1A
F-box/WD repeat-containing protein 1A

1

17

Small-scale

0.747

High

517486

PCNA
Proliferating cell nuclear antigen

6

7

Small-scale

0.737

High

470571

H2A1
Histone H2A type 1

1

16

High-throughput

0.691

High

1223728

RN168
E3 ubiquitin-protein ligase RNF168

2

1

Small-scale

0.634

High

432948

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

2

15

High-throughput

0.621

High

1230139

DAW1
Dynein assembly factor with WD repeat domains 1

1

18

High-throughput

0.618

High

952646

H33
Histone H3.3

1

20

High-throughput

0.618

High

1343548

FZR1
Fizzy-related protein homolog

1

20

Small-scale

0.618

High

1076859

TWST1
Twist-related protein 1

1

13

Small-scale

0.597

High

930407

UBC9
SUMO-conjugating enzyme UBC9

1

5

Small-scale

0.586

High

282735

RNF8
E3 ubiquitin-protein ligase RNF8

1

12

Small-scale

0.578

High

1163947

U17L2
Ubiquitin carboxyl-terminal hydrolase 17

1

7

Small-scale

0.578

High

268296

EED
Polycomb protein EED

1

20

Small-scale

0.575

High

997921

RBBP4
Histone-binding protein RBBP4

1

20

Small-scale

0.575

High

1063637

SUZ12
Polycomb protein SUZ12

1

11

Small-scale

0.575

High

1080377

EZH2
Histone-lysine N-methyltransferase EZH2

1

18

Small-scale

0.575

High

1343253

TF7L2
Transcription factor 7-like 2

1

18

Small-scale

0.561

High

1343546

LEF1
Lymphoid enhancer-binding factor 1

1

14

Small-scale

0.561

High

396808

S10A8
Protein S100-A8

1

10

High-throughput

0.536

High

398953

HMGN2
Non-histone chromosomal protein HMG-17

1

2

High-throughput

0.536

High

400672

RLA2
Large ribosomal subunit protein P2

1

1

High-throughput

0.536

High

401130

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.536

High

416519

S10A9
Protein S100-A9

1

11

High-throughput

0.536

High

426741

H10
Histone H1.0

1

2

High-throughput

0.536

High

516709

PABP1
Polyadenylate-binding protein 1

1

6

High-throughput

0.536

High

574447

RL35A
Large ribosomal subunit protein eL33

1

2

High-throughput

0.536

High

575195

RL7
Large ribosomal subunit protein uL30

1

2

High-throughput

0.536

High

610065

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

13

High-throughput

0.536

High

678510

S10A7
Protein S100-A7

1

11

High-throughput

0.536

High

790580

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.536

High

899367

RL15
Large ribosomal subunit protein eL15

1

3

High-throughput

0.536

High

899858

RL27
Large ribosomal subunit protein eL27

1

1

High-throughput

0.536

High

900279

RL37A
Large ribosomal subunit protein eL43

1

4

High-throughput

0.536

High

913781

RL7A
Large ribosomal subunit protein eL8

1

4

High-throughput

0.536

High

916394

RL23A
Large ribosomal subunit protein uL23

1

6

High-throughput

0.536

High

922410

RL31
Large ribosomal subunit protein eL31

1

6

High-throughput

0.536

High

922725

RL10A
Large ribosomal subunit protein uL1

1

4

High-throughput

0.536

High

923548

RL8
Large ribosomal subunit protein uL2

1

3

High-throughput

0.536

High

949892

CBX1
Chromobox protein homolog 1

1

20

High-throughput

0.536

High

973250

RL6
Large ribosomal subunit protein eL6

1

2

High-throughput

0.536

High

1028624

SRSF9
Serine/arginine-rich splicing factor 9

1

17

High-throughput

0.536

High

1266358

H1X
Histone H1.10

1

1

High-throughput

0.536

High

1282156

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

9

High-throughput

0.536

High

1343547

RALY
RNA-binding protein Raly

1

5

High-throughput

0.536

High

1343551

RL36
Large ribosomal subunit protein eL36

1

4

High-throughput

0.536

High

387572

P53
Cellular tumor antigen p53

1

10

Small-scale

0.501

High

281433

RL1D1
Ribosomal L1 domain-containing protein 1

1

5

High-throughput

0.489

High

1343549

RL26L
Ribosomal protein uL24-like

1

3

High-throughput

0.489

High

1051779

E2F2
Transcription factor E2F2

1

7

Small-scale

0.481

High

553802

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

822168

KC1A
Casein kinase I isoform alpha

1

3

Small-scale

0.479

High

822383

KC1D
Casein kinase I isoform delta

1

2

Small-scale

0.479

High

921438

RBX1
E3 ubiquitin-protein ligase RBX1

1

2

Small-scale

0.479

High

929072

SKP1
S-phase kinase-associated protein 1

1

2

Small-scale

0.479

High

941465

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.479

High

1041213

CUL1
Cullin-1

1

13

Small-scale

0.479

High

1043242

CUL4A
Cullin-4A

1

13

Small-scale

0.479

High

1066747

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

1082407

DDB1
DNA damage-binding protein 1

1

7

Small-scale

0.479

High

1163872

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

1335471

UBP29
Ubiquitin carboxyl-terminal hydrolase 29

1

2

Small-scale

0.479

High

1343545

HDAC6
Histone deacetylase 6

1

20

Small-scale

0.479

High

1343552

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

9

Small-scale

0.479

High

1343553

TRRAP
Transformation/transcription domain-associated protein

1

7

High-throughput

0.479

High

1224946

FAM9A
Protein FAM9A

1

1

High-throughput

0.464

High

1343327

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1168996

AEBP2
Zinc finger protein AEBP2

1

20

Small-scale

0.445

High

101206

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

742555

SYUA
Alpha-synuclein

1

0

High-throughput

0.426

High

1306819

EBP2
Probable rRNA-processing protein EBP2

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024