Protein: ERAP1
Endoplasmic reticulum aminopeptidase 1 (EC 3.4.11.-) (ARTS-1) (Adipocyte-derived leucine aminopeptidase) (A-LAP) (Aminopeptidase PILS) (Puromycin-insensitive leucyl-specific aminopeptidase) (PILS-AP) (Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator)

Gene: ERAP1
Organism: Homo sapiens
Interactions: 65
UniProt ID: Q9NZ08

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0002250 - adaptive immune response
GO:0002474 - antigen processing and presentation of peptide antigen via MHC class I
GO:0004175 - endopeptidase activity
GO:0004177 - aminopeptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1072975

DHC24
Delta(24)-sterol reductase

3

0

High-throughput

0.638

High

1167704

SG1D4
Secretoglobin family 1D member 4

2

2

High-throughput

0.628

High

1240117

TM87A
Transmembrane protein 87A

2

1

High-throughput

0.628

High

1282534

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

2

2

High-throughput

0.628

High

1348803

KLK11
Kallikrein-11

2

1

High-throughput

0.611

High

584487

TNR1A
Tumor necrosis factor receptor superfamily member 1A

3

0

Small-scale

0.609

High

887069

DEF1
Neutrophil defensin 1

2

0

High-throughput

0.602

High

1309576

APOL2
Apolipoprotein L2

2

0

High-throughput

0.602

High

354585

HLAB
HLA class I histocompatibility antigen, B alpha chain

2

3

High-throughput

0.552

High

172262

GP182
G-protein coupled receptor 182

1

7

High-throughput

0.536

High

529812

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

599018

FPR1
fMet-Leu-Phe receptor

1

5

High-throughput

0.536

High

723425

APJ
Apelin receptor

1

4

High-throughput

0.536

High

749911

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.536

High

801644

S15A1
Solute carrier family 15 member 1

1

1

High-throughput

0.536

High

895749

CXCR4
C-X-C chemokine receptor type 4

1

5

High-throughput

0.536

High

1266049

AQP3
Aquaporin-3

1

1

High-throughput

0.536

High

1348805

ALK
ALK tyrosine kinase receptor

1

3

High-throughput

0.536

High

943168

KC1G2
Casein kinase I isoform gamma-2

1

3

High-throughput

0.515

High

1348806

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

2

High-throughput

0.515

High

352286

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.513

High

441039

CD14
Monocyte differentiation antigen CD14

1

0

High-throughput

0.513

High

1109422

KR196
Keratin-associated protein 19-6

1

0

High-throughput

0.513

High

1233057

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

1051264

ZMYM3
Zinc finger MYM-type protein 3

1

0

High-throughput

0.493

High

1165143

TM205
Transmembrane protein 205

1

0

High-throughput

0.493

High

849716

CCR6
C-C chemokine receptor type 6

1

3

High-throughput

0.489

High

1031099

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

6

High-throughput

0.489

High

1257294

MOT10
Monocarboxylate transporter 10

1

2

High-throughput

0.489

High

1348807

GPR45
Probable G-protein coupled receptor 45

1

3

High-throughput

0.489

High

945901

NUCB2
Nucleobindin-2

1

0

Small-scale

0.484

High

206074

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

228915

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

403554

DQB2
HLA class II histocompatibility antigen, DQ beta 2 chain

1

8

High-throughput

0.479

High

429138

ADRB2
Beta-2 adrenergic receptor

1

1

Small-scale

0.479

High

504870

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

532004

PDIA4
Protein disulfide-isomerase A4

1

3

High-throughput

0.479

High

745325

RBMX
RNA-binding motif protein, X chromosome

1

1

Small-scale

0.479

High

836036

GSK3B
Glycogen synthase kinase-3 beta

1

3

High-throughput

0.479

High

890470

SC61B
Protein transport protein Sec61 subunit beta

1

2

High-throughput

0.479

High

1043264

CUL4A
Cullin-4A

1

1

High-throughput

0.479

High

1168716

SYNE3
Nesprin-3

1

2

High-throughput

0.479

High

1172023

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

1284120

LRC59
Leucine-rich repeat-containing protein 59

1

5

High-throughput

0.479

High

1318312

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

2

Small-scale

0.479

High

1331475

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

1334820

SIAE
Sialate O-acetylesterase

1

1

High-throughput

0.479

High

1344579

FBX6
F-box only protein 6

1

6

High-throughput

0.479

High

1348802

HDAC6
Histone deacetylase 6

1

2

Small-scale

0.479

High

1348804

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

445731

IL6RA
Interleukin-6 receptor subunit alpha

1

0

Small-scale

0.458

High

575605

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

798276

KI2S2
Killer cell immunoglobulin-like receptor 2DS2

1

0

High-throughput

0.458

High

1030768

SLAF1
Signaling lymphocytic activation molecule

1

0

High-throughput

0.458

High

1286088

PLD4
5'-3' exonuclease PLD4

1

0

High-throughput

0.458

High

1348808

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

1

0

Small-scale

0.458

High

652447

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

1202751

P2RY8
P2Y purinoceptor 8

1

7

High-throughput

0.437

High

1346076

T106B
Transmembrane protein 106B

1

1

High-throughput

0.437

High

1086333

H31T
Histone H3.1t

1

0

Small-scale

0.391

High

891395

ROMO1
Reactive oxygen species modulator 1

2

0

High-throughput

0.319

High

1299264

OPALI
Opalin

1

0

High-throughput

0.279

Low

1332158

F124B
Protein FAM124B

1

0

High-throughput

0.279

Low

101235

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

1252043

DPTOR
DEP domain-containing mTOR-interacting protein

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024