Protein: TLN1
Talin-1

Gene: TLN1
Organism: Homo sapiens
Interactions: 183
UniProt ID: Q9Y490

Gene Ontology (top 5):
GO:0001726 - ruffle
GO:0001786 - phosphatidylserine binding
GO:0005178 - integrin binding
GO:0005200 - structural constituent of cytoskeleton
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

575878

VINC
Vinculin

4

18

Small-scale

0.908

High

983700

FAK1
Focal adhesion kinase 1

3

20

Small-scale

0.857

High

434319

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

2

20

High-throughput

0.778

High

1377797

TLN2
Talin-2

2

17

High-throughput

0.754

High

396601

ITB3
Integrin beta-3

6

20

Small-scale

0.733

High

231405

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

6

9

Small-scale

0.726

High

404003

ITB1
Integrin beta-1

5

20

Small-scale

0.711

High

823521

PAXI
Paxillin

4

18

Small-scale

0.696

High

505005

HSP7C
Heat shock cognate 71 kDa protein

4

6

High-throughput

0.683

High

858210

BIEA
Biliverdin reductase A

3

1

High-throughput

0.667

High

1331837

RGCC
Regulator of cell cycle RGCC

3

1

High-throughput

0.667

High

339186

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.647

High

384045

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

1305740

DOK1
Docking protein 1

1

3

Small-scale

0.647

High

1101591

RHG31
Rho GTPase-activating protein 31

3

16

High-throughput

0.641

High

1134817

KANK4
KN motif and ankyrin repeat domain-containing protein 4

2

20

High-throughput

0.628

High

385775

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

523226

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.618

High

1052848

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.618

High

581903

VCAM1
Vascular cell adhesion protein 1

2

20

High-throughput

0.612

High

361956

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

0

High-throughput

0.602

High

664149

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.602

High

229154

PRKN
E3 ubiquitin-protein ligase parkin

2

18

High-throughput

0.584

High

323357

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

17

High-throughput

0.584

High

809049

YAP1
Transcriptional coactivator YAP1

2

20

Small-scale

0.584

High

1163919

RICTR
Rapamycin-insensitive companion of mTOR

2

5

High-throughput

0.584

High

994694

DDR1
Epithelial discoidin domain-containing receptor 1

1

20

Small-scale

0.575

High

370794

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1038844

HDAC1
Histone deacetylase 1

2

9

High-throughput

0.571

High

1234587

SH2D3
SH2 domain-containing protein 3C

2

20

High-throughput

0.571

High

1336131

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

13

Small-scale

0.561

High

1224663

ABI1
Abl interactor 1

1

20

High-throughput

0.541

High

128676

DNM1L
Dynamin-1-like protein

1

4

High-throughput

0.536

High

236148

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

7

High-throughput

0.536

High

363367

FINC
Fibronectin

1

16

High-throughput

0.536

High

387794

P53
Cellular tumor antigen p53

1

8

High-throughput

0.536

High

497870

TAU
Microtubule-associated protein tau

1

20

High-throughput

0.536

High

561755

CL3L1
C-C motif chemokine 3-like 1

1

2

High-throughput

0.536

High

574486

RL35A
Large ribosomal subunit protein eL33

1

1

High-throughput

0.536

High

611368

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

2

High-throughput

0.536

High

803822

BAG6
Large proline-rich protein BAG6

1

9

High-throughput

0.536

High

855769

KIF11
Kinesin-like protein KIF11

1

7

High-throughput

0.536

High

871840

HSP72
Heat shock-related 70 kDa protein 2

1

6

High-throughput

0.536

High

1048293

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

7

High-throughput

0.536

High

1314648

RBM4
RNA-binding protein 4

1

4

High-throughput

0.536

High

1377262

NTNG1
Netrin-G1

1

8

High-throughput

0.536

High

1377798

WIF1
Wnt inhibitory factor 1

1

5

High-throughput

0.536

High

1377799

SAR1B
Small COPII coat GTPase SAR1B

1

12

High-throughput

0.536

High

886225

H2B1D
Histone H2B type 1-D

1

12

High-throughput

0.515

High

1061300

NUMA1
Nuclear mitotic apparatus protein 1

1

20

High-throughput

0.515

High

1087505

H2B2E
Histone H2B type 2-E

1

12

High-throughput

0.515

High

324139

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

1235053

RM50
Large ribosomal subunit protein mL50

1

0

High-throughput

0.513

High

1245520

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

1

0

High-throughput

0.513

High

1304365

SORT
Sortilin

1

0

High-throughput

0.513

High

1377800

OAS3
2'-5'-oligoadenylate synthase 3

1

0

High-throughput

0.513

High

815947

MTR1A
Melatonin receptor type 1A

1

7

High-throughput

0.508

High

825767

MTR1B
Melatonin receptor type 1B

1

6

High-throughput

0.508

High

639920

ITB7
Integrin beta-7

1

20

Small-scale

0.501

High

647413

1433T
14-3-3 protein theta

1

20

High-throughput

0.501

High

879868

TPTE
Putative tyrosine-protein phosphatase TPTE

1

6

High-throughput

0.501

High

880224

ITA1
Integrin alpha-1

1

5

Small-scale

0.501

High

960353

CDK5
Cyclin-dependent kinase 5

1

6

Small-scale

0.501

High

1048526

DAG1
Dystroglycan 1

1

4

Small-scale

0.501

High

1167756

TPTE2
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

1

6

High-throughput

0.501

High

1175272

TBA1A
Tubulin alpha-1A chain

1

5

Small-scale

0.501

High

704295

DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

1

0

High-throughput

0.493

High

960066

HXC5
Homeobox protein Hox-C5

1

4

High-throughput

0.489

High

1039968

SNW1
SNW domain-containing protein 1

1

6

High-throughput

0.489

High

1164484

SAMD1
Sterile alpha motif domain-containing protein 1

1

7

High-throughput

0.489

High

1233766

MESH1
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

1

1

High-throughput

0.489

High

1235726

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

4

High-throughput

0.489

High

1290187

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

11

High-throughput

0.489

High

1291833

CERS2
Ceramide synthase 2

1

2

High-throughput

0.489

High

1303887

CDC5L
Cell division cycle 5-like protein

1

7

High-throughput

0.489

High

1348311

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

2

High-throughput

0.489

High

432393

HS90A
Heat shock protein HSP 90-alpha

1

0

Small-scale

0.480

High

119579

LEG9
Galectin-9

1

3

High-throughput

0.479

High

166021

PER2
Period circadian protein homolog 2

1

4

Small-scale

0.479

High

233025

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

14

High-throughput

0.479

High

256176

OBSL1
Obscurin-like protein 1

1

20

High-throughput

0.479

High

330038

AGR2
Anterior gradient protein 2 homolog

1

5

High-throughput

0.479

High

375145

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

16

High-throughput

0.479

High

393401

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

4

High-throughput

0.479

High

516762

PABP1
Polyadenylate-binding protein 1

1

1

High-throughput

0.479

High

522287

CADH1
Cadherin-1

1

14

High-throughput

0.479

High

529956

CFTR
Cystic fibrosis transmembrane conductance regulator

1

13

High-throughput

0.479

High

530776

ITA4
Integrin alpha-4

1

5

High-throughput

0.479

High

578370

PGAM1
Phosphoglycerate mutase 1

1

3

High-throughput

0.479

High

625653

CDK2
Cyclin-dependent kinase 2

1

6

High-throughput

0.479

High

669098

PML
Protein PML

1

8

High-throughput

0.479

High

685133

STIP1
Stress-induced-phosphoprotein 1

1

9

High-throughput

0.479

High

717462

CTNB1
Catenin beta-1

1

12

High-throughput

0.479

High

740627

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.479

High

749985

BRCA1
Breast cancer type 1 susceptibility protein

1

10

High-throughput

0.479

High

780377

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

901911

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

5

High-throughput

0.479

High

909386

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

8

High-throughput

0.479

High

927698

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

932473

ACTC
Actin, alpha cardiac muscle 1

1

14

High-throughput

0.479

High

999249

EP300
Histone acetyltransferase p300

1

9

High-throughput

0.479

High

1016268

FOXO1
Forkhead box protein O1

1

1

High-throughput

0.479

High

1036238

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

1061709

CUL7
Cullin-7

1

11

High-throughput

0.479

High

1064891

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

8

High-throughput

0.479

High

1072086

PCBP1
Poly(rC)-binding protein 1

1

2

Small-scale

0.479

High

1140870

RN123
E3 ubiquitin-protein ligase RNF123

1

8

High-throughput

0.479

High

1146997

A16L1
Autophagy-related protein 16-1

1

17

High-throughput

0.479

High

1148898

VIR
Protein virilizer homolog

1

3

High-throughput

0.479

High

1166099

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1172407

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1185510

MOB1B
MOB kinase activator 1B

1

9

High-throughput

0.479

High

1200781

NAA40
N-alpha-acetyltransferase 40

1

5

High-throughput

0.479

High

1239778

NHLC2
NHL repeat-containing protein 2

1

3

High-throughput

0.479

High

1251957

RIN3
Ras and Rab interactor 3

1

10

High-throughput

0.479

High

1254326

BICD2
Protein bicaudal D homolog 2

1

20

High-throughput

0.479

High

1261032

BLNK
B-cell linker protein

1

7

Small-scale

0.479

High

1266612

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

4

High-throughput

0.479

High

1267293

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

9

High-throughput

0.479

High

1288769

ASB9
Ankyrin repeat and SOCS box protein 9

1

20

High-throughput

0.479

High

1315556

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

20

High-throughput

0.479

High

1315922

FACD2
Fanconi anemia group D2 protein

1

9

High-throughput

0.479

High

1316846

ACE2
Angiotensin-converting enzyme 2

1

3

Small-scale

0.479

High

1326802

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

1331713

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1343404

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

3

High-throughput

0.479

High

1354981

ZRAN1
Ubiquitin thioesterase ZRANB1

1

15

High-throughput

0.479

High

1355083

TES
Testin

1

19

High-throughput

0.479

High

271809

PRDM1
PR domain zinc finger protein 1

1

2

Small-scale

0.470

High

1138346

MYOME
Myomegalin

1

20

High-throughput

0.470

High

907197

PRS8
26S proteasome regulatory subunit 8

1

0

Small-scale

0.458

High

1234008

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.458

High

902819

SUMO2
Small ubiquitin-related modifier 2

1

6

High-throughput

0.457

High

886436

NAL12
NACHT, LRR and PYD domains-containing protein 12

1

4

Small-scale

0.457

High

1155940

Q6NSK7
RIN3 protein

1

7

High-throughput

0.457

High

1344863

DISC1
Disrupted in schizophrenia 1 protein

1

4

High-throughput

0.457

High

378225

PRIO
Major prion protein

1

4

High-throughput

0.445

High

625784

CXCR2
C-X-C chemokine receptor type 2

1

5

Small-scale

0.445

High

718356

BMI1
Polycomb complex protein BMI-1

1

10

High-throughput

0.445

High

875468

TERA
Transitional endoplasmic reticulum ATPase

1

9

High-throughput

0.445

High

1130767

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

High-throughput

0.445

High

1236273

CD177
CD177 antigen

1

1

Small-scale

0.445

High

1291621

OTUB1
Ubiquitin thioesterase OTUB1

1

2

High-throughput

0.445

High

1318909

ZDHC5
Palmitoyltransferase ZDHHC5

1

5

High-throughput

0.445

High

101309

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

348333

MYC
Myc proto-oncogene protein

1

19

High-throughput

0.437

High

388918

CP1A1
Cytochrome P450 1A1

1

1

High-throughput

0.437

High

554139

RFA2
Replication protein A 32 kDa subunit

1

13

High-throughput

0.437

High

570223

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.437

High

641994

U2AF2
Splicing factor U2AF 65 kDa subunit

1

8

High-throughput

0.437

High

652698

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

10

High-throughput

0.437

High

721866

RFA3
Replication protein A 14 kDa subunit

1

10

High-throughput

0.437

High

795803

MAGA3
Melanoma-associated antigen 3

1

7

Small-scale

0.437

High

832803

MCM2
DNA replication licensing factor MCM2

1

7

High-throughput

0.437

High

903638

WDR5
WD repeat-containing protein 5

1

9

High-throughput

0.437

High

1026600

RFA4
Replication protein A 30 kDa subunit

1

13

High-throughput

0.437

High

1073754

SF3A2
Splicing factor 3A subunit 2

1

6

High-throughput

0.437

High

1075037

TERF2
Telomeric repeat-binding factor 2

1

7

High-throughput

0.437

High

1080517

EZH2
Histone-lysine N-methyltransferase EZH2

1

11

High-throughput

0.437

High

1081457

E2F4
Transcription factor E2F4

1

2

High-throughput

0.437

High

1108752

ANR55
Ankyrin repeat domain-containing protein 55

1

20

High-throughput

0.437

High

1116883

FBX43
F-box only protein 43

1

2

Small-scale

0.437

High

1146481

ATG9B
Autophagy-related protein 9B

1

2

Small-scale

0.437

High

1174344

MOB3C
MOB kinase activator 3C

1

9

High-throughput

0.437

High

1183914

KCTD9
BTB/POZ domain-containing protein KCTD9

1

6

High-throughput

0.437

High

1189094

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.437

High

1219272

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

8

High-throughput

0.437

High

1256089

RHBL4
Rhomboid-related protein 4

1

5

High-throughput

0.437

High

1270014

ESR2
Estrogen receptor beta

1

20

High-throughput

0.437

High

1303647

SEC62
Translocation protein SEC62

1

1

High-throughput

0.437

High

1317405

STK33
Serine/threonine-protein kinase 33

1

5

High-throughput

0.437

High

1342963

MED4
Mediator of RNA polymerase II transcription subunit 4

1

3

High-throughput

0.437

High

1344551

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

8

High-throughput

0.437

High

831842

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.373

High

1172955

NYAP1
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1

1

7

High-throughput

0.373

High

1261516

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.328

High

1270290

TF2H4
General transcription factor IIH subunit 4

1

0

High-throughput

0.279

Low

966379

FMO1
Flavin-containing monooxygenase 1

1

0

High-throughput

0.261

Low

1062220

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

1146215

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

1197949

GLRX5
Glutaredoxin-related protein 5, mitochondrial

1

0

High-throughput

0.249

Low

1237046

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

1313642

LRC61
Leucine-rich repeat-containing protein 61

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024