Protein: ZN451
E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451)

Gene: ZN451, ZNF451
Organism: Homo sapiens
Interactions: 85
UniProt ID: Q9Y4E5

Gene Ontology (top 5):
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0016605 - PML body
GO:0016925 - protein sumoylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

930471

UBC9
SUMO-conjugating enzyme UBC9

6

1

Small-scale

0.735

High

509172

TOP2A
DNA topoisomerase 2-alpha

3

1

Small-scale

0.667

High

387800

P53
Cellular tumor antigen p53

3

5

High-throughput

0.640

High

1344291

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

2

3

High-throughput

0.628

High

476623

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

5

Small-scale

0.602

High

669102

PML
Protein PML

2

20

Small-scale

0.595

High

1303890

CDC5L
Cell division cycle 5-like protein

2

1

High-throughput

0.590

High

487870

ANDR
Androgen receptor

1

17

Small-scale

0.552

High

256370

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

1

High-throughput

0.541

High

557009

CREB1
Cyclic AMP-responsive element-binding protein 1

1

2

High-throughput

0.541

High

792124

HD
Huntingtin

1

1

High-throughput

0.541

High

844300

FXR2
RNA-binding protein FXR2

1

5

High-throughput

0.541

High

879165

SUMO3
Small ubiquitin-related modifier 3

1

2

High-throughput

0.541

High

320070

HERC2
E3 ubiquitin-protein ligase HERC2

1

3

High-throughput

0.536

High

380887

S100B
Protein S100-B

1

3

High-throughput

0.536

High

973420

TOP2B
DNA topoisomerase 2-beta

1

1

High-throughput

0.536

High

1331216

SENP3
Sentrin-specific protease 3

1

1

High-throughput

0.536

High

1267461

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

2

High-throughput

0.526

High

724030

CBS
Cystathionine beta-synthase

1

0

High-throughput

0.518

High

854156

GDS1
Rap1 GTPase-GDP dissociation stimulator 1

1

0

High-throughput

0.518

High

1025612

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.518

High

500921

CLUS
Clusterin

1

0

High-throughput

0.513

High

1069578

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

203820

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

3

High-throughput

0.508

High

1157407

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

1

High-throughput

0.508

High

1307076

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.508

High

902822

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.501

High

928236

SUMO1
Small ubiquitin-related modifier 1

1

2

Small-scale

0.501

High

1242783

SIMC1
SUMO-interacting motif-containing protein 1

1

0

High-throughput

0.501

High

1235474

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

1

High-throughput

0.494

High

232612

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.486

High

1315479

CDCA4
Cell division cycle-associated protein 4

1

0

High-throughput

0.486

High

278194

PIAS1
E3 SUMO-protein ligase PIAS1

1

1

Small-scale

0.481

High

278354

PIAS2
E3 SUMO-protein ligase PIAS2

1

1

Small-scale

0.481

High

1193071

ZN467
Zinc finger protein 467

1

12

High-throughput

0.481

High

1270846

CBP
CREB-binding protein

1

8

Small-scale

0.481

High

1377843

ZN451
E3 SUMO-protein ligase ZNF451

1

7

Small-scale

0.481

High

245130

BRD4
Bromodomain-containing protein 4

1

6

High-throughput

0.479

High

348340

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.479

High

375148

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

456035

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

636455

DNJB1
DnaJ homolog subfamily B member 1

1

4

High-throughput

0.479

High

782704

HNF4A
Hepatocyte nuclear factor 4-alpha

1

8

High-throughput

0.479

High

828432

CENPA
Histone H3-like centromeric protein A

1

13

High-throughput

0.479

High

941615

RNF4
E3 ubiquitin-protein ligase RNF4

1

14

High-throughput

0.479

High

952725

H33
Histone H3.3

1

13

High-throughput

0.479

High

970095

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

1019189

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

1027350

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.479

High

1042917

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1222658

SLX4
Structure-specific endonuclease subunit SLX4

1

3

High-throughput

0.479

High

1246210

COP1
E3 ubiquitin-protein ligase COP1

1

2

High-throughput

0.479

High

1068713

PLEC
Plectin

1

2

High-throughput

0.470

High

263884

PR40A
Pre-mRNA-processing factor 40 homolog A

1

2

High-throughput

0.464

High

1344083

ANM8
Protein arginine N-methyltransferase 8

1

2

High-throughput

0.464

High

330607

ZBED1
E3 SUMO-protein ligase ZBED1

1

0

Small-scale

0.460

High

554145

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

652703

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

708553

MCM4
DNA replication licensing factor MCM4

1

0

Small-scale

0.458

High

757813

IF4A3
Eukaryotic initiation factor 4A-III

1

0

High-throughput

0.458

High

959794

VIGLN
Vigilin

1

0

High-throughput

0.458

High

1055524

DHX8
ATP-dependent RNA helicase DHX8

1

0

High-throughput

0.458

High

1220351

SLF2
SMC5-SMC6 complex localization factor protein 2

1

0

High-throughput

0.458

High

1288407

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

0

High-throughput

0.458

High

1354419

ZMYM2
Zinc finger MYM-type protein 2

1

0

High-throughput

0.458

High

131292

BIN1
Myc box-dependent-interacting protein 1

1

1

High-throughput

0.457

High

989215

FMR1
Fragile X messenger ribonucleoprotein 1

1

5

High-throughput

0.457

High

1356057

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

10

High-throughput

0.439

High

361545

APOE
Apolipoprotein E

1

0

High-throughput

0.438

High

991925

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

0

High-throughput

0.438

High

1251096

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.438

High

101311

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

1172414

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1295623

NEUL4
Neuralized-like protein 4

2

0

High-throughput

0.313

High

900092

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.282

High

1135546

CPTP
Ceramide-1-phosphate transfer protein

1

0

High-throughput

0.282

High

396431

APOD
Apolipoprotein D

1

0

High-throughput

0.279

Low

1288545

MUCL1
Mucin-like protein 1

1

0

High-throughput

0.279

Low

1347346

F118A
Protein FAM118A

1

0

High-throughput

0.265

Low

156742

OPLA
5-oxoprolinase

1

0

High-throughput

0.251

Low

1103178

KLH40
Kelch-like protein 40

1

0

High-throughput

0.251

Low

1232519

PALS1
Protein PALS1

1

0

Small-scale

0.249

Low

1239779

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

1356662

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024