Protein: CD2AP
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)

Gene: CD2AP
Organism: Homo sapiens
Interactions: 149
UniProt ID: Q9Y5K6

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0001726 - ruffle
GO:0001771 - immunological synapse formation
GO:0001889 - liver development
GO:0002102 - podosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1285235

SH3K1
SH3 domain-containing kinase-binding protein 1

8

20

Small-scale

0.962

High

924988

GRB2
Growth factor receptor-bound protein 2

3

19

High-throughput

0.875

High

1357159

STAP1
Signal-transducing adaptor protein 1

3

2

High-throughput

0.861

High

1378080

CD2AP
CD2-associated protein

3

19

Small-scale

0.853

High

486170

GRAB
Granzyme B

2

2

Small-scale

0.818

High

1307444

SH3G2
Endophilin-A1

2

20

Small-scale

0.800

High

882664

BCAR1
Breast cancer anti-estrogen resistance protein 1

2

20

Small-scale

0.768

High

610540

CBL
E3 ubiquitin-protein ligase CBL

12

20

Small-scale

0.759

High

992505

SOS1
Son of sevenless homolog 1

2

20

Small-scale

0.754

High

412426

FYN
Tyrosine-protein kinase Fyn

2

20

High-throughput

0.743

High

1356881

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

2

20

Small-scale

0.743

High

802801

CRK
Adapter molecule crk

2

20

High-throughput

0.737

High

416922

CD2
T-cell surface antigen CD2

5

12

Small-scale

0.725

High

1052363

SRC8
Src substrate cortactin

1

20

Small-scale

0.724

High

813227

CAZA2
F-actin-capping protein subunit alpha-2

5

5

High-throughput

0.718

High

1261033

BLNK
B-cell linker protein

1

20

Small-scale

0.715

High

1262768

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

20

Small-scale

0.713

High

476640

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

13

Small-scale

0.710

High

1089312

RHG44
Rho GTPase-activating protein 44

4

19

High-throughput

0.691

High

857263

CAZA1
F-actin-capping protein subunit alpha-1

4

5

Small-scale

0.689

High

813887

CAPZB
F-actin-capping protein subunit beta

4

5

Small-scale

0.686

High

1327819

RGAP1
Rac GTPase-activating protein 1

3

19

High-throughput

0.675

High

1290591

MB12A
Multivesicular body subunit 12A

4

2

Small-scale

0.674

High

1027634

CBLB
E3 ubiquitin-protein ligase CBL-B

2

20

Small-scale

0.654

High

1260427

PDC6I
Programmed cell death 6-interacting protein

3

20

Small-scale

0.647

High

1348710

TA2R7
Taste receptor type 2 member 7

3

0

High-throughput

0.638

High

1148393

RHG17
Rho GTPase-activating protein 17

3

19

Small-scale

0.633

High

1342461

PODO
Podocin

2

3

Small-scale

0.624

High

176509

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

20

Small-scale

0.618

High

229185

PRKN
E3 ubiquitin-protein ligase parkin

1

14

High-throughput

0.618

High

233028

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

4

High-throughput

0.618

High

337608

ABL1
Tyrosine-protein kinase ABL1

1

20

High-throughput

0.618

High

339199

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.618

High

442898

HCK
Tyrosine-protein kinase HCK

1

20

Small-scale

0.618

High

682092

AKT1
RAC-alpha serine/threonine-protein kinase

1

6

Small-scale

0.618

High

724576

IRS1
Insulin receptor substrate 1

1

17

Small-scale

0.618

High

840878

DYN2
Dynamin-2

1

20

Small-scale

0.618

High

992527

SOS2
Son of sevenless homolog 2

1

20

Small-scale

0.618

High

1271571

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

20

Small-scale

0.618

High

1331743

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

1343860

ANLN
Anillin

1

8

High-throughput

0.618

High

1354510

ZO2
Tight junction protein ZO-2

1

17

High-throughput

0.618

High

1188080

SETX
Probable helicase senataxin

2

0

High-throughput

0.602

High

1191815

ANS1B
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

1

20

High-throughput

0.590

High

1318065

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

6

High-throughput

0.590

High

1147690

FTM
Protein fantom

2

12

High-throughput

0.588

High

809059

YAP1
Transcriptional coactivator YAP1

2

15

Small-scale

0.584

High

1377711

3BP1
SH3 domain-binding protein 1

2

19

High-throughput

0.584

High

1251962

RIN3
Ras and Rab interactor 3

1

20

High-throughput

0.581

High

1153477

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.575

High

856872

RM12
Large ribosomal subunit protein bL12m

2

1

High-throughput

0.574

High

1255375

TCP1L
T-complex protein 10A homolog 1

2

3

High-throughput

0.574

High

370817

ESR1
Estrogen receptor

2

13

High-throughput

0.571

High

581907

VCAM1
Vascular cell adhesion protein 1

2

12

High-throughput

0.571

High

970102

KIF23
Kinesin-like protein KIF23

2

11

High-throughput

0.558

High

1235176

S2541
Mitochondrial carrier protein SCaMC-3L

2

6

High-throughput

0.558

High

991928

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

2

14

Small-scale

0.545

High

1069580

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.541

High

451625

CLCA
Clathrin light chain A

1

9

High-throughput

0.536

High

610127

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

8

High-throughput

0.536

High

873889

IF5
Eukaryotic translation initiation factor 5

1

1

High-throughput

0.536

High

907204

PRS8
26S proteasome regulatory subunit 8

1

1

High-throughput

0.536

High

934586

CSK21
Casein kinase II subunit alpha

1

4

High-throughput

0.536

High

1159756

RHGBA
Rho GTPase-activating protein 11A

1

19

High-throughput

0.536

High

1232347

MILK1
MICAL-like protein 1

1

12

High-throughput

0.536

High

1304291

GA2L1
GAS2-like protein 1

1

14

High-throughput

0.536

High

1306621

TS101
Tumor susceptibility gene 101 protein

1

4

Small-scale

0.536

High

1268522

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

18

High-throughput

0.528

High

592083

RAB4A
Ras-related protein Rab-4A

1

7

Small-scale

0.527

High

275151

RENR
Renin receptor

1

0

High-throughput

0.513

High

611535

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

11

High-throughput

0.508

High

930474

UBC9
SUMO-conjugating enzyme UBC9

1

3

Small-scale

0.501

High

771486

PSB10
Proteasome subunit beta type-10

1

2

High-throughput

0.489

High

1174036

UBP51
Ubiquitin carboxyl-terminal hydrolase 51

1

8

High-throughput

0.489

High

1221087

BAP18
Chromatin complexes subunit BAP18

1

1

High-throughput

0.489

High

1236374

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

18

High-throughput

0.489

High

1290323

SGF29
SAGA-associated factor 29

1

1

High-throughput

0.489

High

1291834

CERS2
Ceramide synthase 2

1

1

High-throughput

0.489

High

1345430

KIF15
Kinesin-like protein KIF15

1

10

High-throughput

0.489

High

207394

FRS3
Fibroblast growth factor receptor substrate 3

1

16

Small-scale

0.479

High

235248

NPHN
Nephrin

1

13

Small-scale

0.479

High

266075

PSIP1
PC4 and SFRS1-interacting protein

1

5

High-throughput

0.479

High

323371

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.479

High

360582

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

20

High-throughput

0.479

High

391985

H2A1B
Histone H2A type 1-B/E

1

4

High-throughput

0.479

High

505017

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

522292

CADH1
Cadherin-1

1

7

High-throughput

0.479

High

530779

ITA4
Integrin alpha-4

1

3

High-throughput

0.479

High

669106

PML
Protein PML

1

7

High-throughput

0.479

High

684429

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

719668

MERL
Merlin

1

10

High-throughput

0.479

High

780395

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

809499

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

13

Small-scale

0.479

High

892142

ACTB
Actin, cytoplasmic 1

1

10

High-throughput

0.479

High

905316

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

932478

ACTC
Actin, alpha cardiac muscle 1

1

10

Small-scale

0.479

High

982667

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1016269

FOXO1
Forkhead box protein O1

1

7

High-throughput

0.479

High

1024453

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

7

High-throughput

0.479

High

1038849

HDAC1
Histone deacetylase 1

1

3

High-throughput

0.479

High

1066951

KIF14
Kinesin-like protein KIF14

1

16

High-throughput

0.479

High

1072090

PCBP1
Poly(rC)-binding protein 1

1

12

Small-scale

0.479

High

1077188

MARE1
Microtubule-associated protein RP/EB family member 1

1

6

Small-scale

0.479

High

1162149

RHDF2
Inactive rhomboid protein 2

1

1

High-throughput

0.479

High

1172445

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1221880

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

1232148

RHG18
Rho GTPase-activating protein 18

1

19

High-throughput

0.479

High

1254329

BICD2
Protein bicaudal D homolog 2

1

19

High-throughput

0.479

High

1256093

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.479

High

1266618

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

4

High-throughput

0.479

High

1267301

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

1326808

WWTR1
WW domain-containing transcription regulator protein 1

1

14

High-throughput

0.479

High

1330582

CHM4B
Charged multivesicular body protein 4b

1

4

High-throughput

0.479

High

1355012

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1357075

CBLC
E3 ubiquitin-protein ligase CBL-C

1

20

Small-scale

0.479

High

198807

HXC11
Homeobox protein Hox-C11

1

7

High-throughput

0.464

High

824589

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.464

High

1163928

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

166060

SYNJ2
Synaptojanin-2

1

20

High-throughput

0.457

High

297706

DEND
Dendrin

1

1

High-throughput

0.457

High

1051533

DCTN1
Dynactin subunit 1

1

11

High-throughput

0.457

High

1318359

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

10

High-throughput

0.457

High

1357670

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

16

High-throughput

0.457

High

1186102

MICA3
[F-actin]-monooxygenase MICAL3

1

15

Small-scale

0.445

High

1334305

VP37B
Vacuolar protein sorting-associated protein 37B

1

9

Small-scale

0.445

High

1356288

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

2

Small-scale

0.445

High

1377229

ST38L
Serine/threonine-protein kinase 38-like

1

9

High-throughput

0.445

High

101317

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

232617

KDM1A
Lysine-specific histone demethylase 1A

1

5

High-throughput

0.437

High

489363

H14
Histone H1.4

1

2

High-throughput

0.437

High

554164

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

652724

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

657694

LYOX
Protein-lysine 6-oxidase

1

1

Small-scale

0.437

High

721890

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

909402

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.437

High

1026607

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.437

High

1146219

DCA15
DDB1- and CUL4-associated factor 15

1

3

High-throughput

0.437

High

1189114

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.437

High

1331819

RNF41
E3 ubiquitin-protein ligase NRDP1

1

17

Small-scale

0.437

High

1342969

MED4
Mediator of RNA polymerase II transcription subunit 4

1

3

High-throughput

0.437

High

1347004

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

5

High-throughput

0.437

High

1356505

RCOR1
REST corepressor 1

1

2

High-throughput

0.437

High

442635

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

10

High-throughput

0.417

High

1298932

DACH2
Dachshund homolog 2

2

0

High-throughput

0.328

High

1240612

IN80E
INO80 complex subunit E

1

0

High-throughput

0.279

Low

233916

HBP1
HMG box-containing protein 1

1

0

High-throughput

0.265

Low

829090

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.249

Low

1345388

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024