Protein: WAPL
Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor)

Gene: WAPL
Organism: Homo sapiens
Interactions: 161
UniProt ID: Q7Z5K2

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0000775 - chromosome, centromeric region
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1191038

WAPL
Wings apart-like protein homolog

3

0

High-throughput

0.811

High

1191050

STAG2
Cohesin subunit SA-2

9

2

Small-scale

0.754

High

1057301

SMC1A
Structural maintenance of chromosomes protein 1A

7

2

Small-scale

0.749

High

1191094

SMC3
Structural maintenance of chromosomes protein 3

7

2

Small-scale

0.746

High

1100521

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

6

2

Small-scale

0.736

High

1191057

STAG1
Cohesin subunit SA-1

6

2

Small-scale

0.730

High

224463

RAD21
Double-strand-break repair protein rad21 homolog

10

0

Small-scale

0.725

High

1191083

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

5

3

Small-scale

0.718

High

160642

AURKA
Aurora kinase A

4

0

High-throughput

0.664

High

1191053

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

3

0

High-throughput

0.638

High

1191064

CDCA5
Sororin

3

0

Small-scale

0.632

High

262496

TULP3
Tubby-related protein 3

2

0

High-throughput

0.602

High

965245

DEF5
Defensin alpha 5

2

0

High-throughput

0.602

High

1191091

PFD2
Prefoldin subunit 2

2

0

High-throughput

0.602

High

347181

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.584

High

553064

RFA2
Replication protein A 32 kDa subunit

2

1

High-throughput

0.584

High

934925

H31
Histone H3.1

2

1

High-throughput

0.584

High

523847

XRCC6
X-ray repair cross-complementing protein 6

2

0

High-throughput

0.559

High

651567

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

0

High-throughput

0.559

High

720805

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.559

High

779665

CCNF
Cyclin-F

2

0

High-throughput

0.559

High

1191051

SIR6
NAD-dependent protein deacylase sirtuin-6

2

0

Small-scale

0.559

High

1191062

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

2

0

Small-scale

0.559

High

1191090

ZRAN1
Ubiquitin thioesterase ZRANB1

2

0

High-throughput

0.559

High

198111

MTLR
Motilin receptor

1

1

High-throughput

0.536

High

270805

FOXH1
Forkhead box protein H1

1

2

High-throughput

0.536

High

1044632

FHL3
Four and a half LIM domains protein 3

1

1

High-throughput

0.536

High

1050689

FHL2
Four and a half LIM domains protein 2

1

1

High-throughput

0.536

High

1169823

FOXI2
Forkhead box protein I2

1

1

High-throughput

0.536

High

1191071

FOXB1
Forkhead box protein B1

1

1

High-throughput

0.536

High

1191076

REN3A
Regulator of nonsense transcripts 3A

1

1

High-throughput

0.536

High

1051170

BTG3
Protein BTG3

1

0

High-throughput

0.518

High

865053

TTC3
E3 ubiquitin-protein ligase TTC3

1

0

High-throughput

0.513

High

976177

PTPS
6-pyruvoyl tetrahydrobiopterin synthase

1

0

High-throughput

0.513

High

1023191

FLII
Protein flightless-1 homolog

1

0

High-throughput

0.513

High

1024564

CAF1B
Chromatin assembly factor 1 subunit B

1

0

High-throughput

0.513

High

1038204

CROC4
Protein CROC-4

1

0

High-throughput

0.513

High

1039650

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

1085416

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.513

High

1125664

SGO1
Shugoshin 1

1

0

Small-scale

0.513

High

1167077

KSR2
Kinase suppressor of Ras 2

1

0

High-throughput

0.513

High

1191063

ATG4C
Cysteine protease ATG4C

1

0

High-throughput

0.513

High

1191065

Z512B
Zinc finger protein 512B

1

0

High-throughput

0.513

High

1191077

E41LB
Band 4.1-like protein 4B

1

0

High-throughput

0.513

High

1191080

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.513

High

1191082

PAAT
ATPase PAAT

1

0

High-throughput

0.513

High

1191084

CARF
CDKN2A-interacting protein

1

0

High-throughput

0.513

High

1191101

TEST
Testisin

1

0

High-throughput

0.513

High

1191039

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

0

Small-scale

0.493

High

1191070

CML1
Chemerin-like receptor 1

1

1

High-throughput

0.489

High

1191048

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.486

High

902651

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

268772

SF3B1
Splicing factor 3B subunit 1

1

1

High-throughput

0.479

High

322815

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

487555

ANDR
Androgen receptor

1

1

High-throughput

0.479

High

502269

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.479

High

649579

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

707671

H2B1B
Histone H2B type 1-B

1

1

High-throughput

0.479

High

803943

NSF
Vesicle-fusing ATPase

1

1

High-throughput

0.479

High

808733

YAP1
Transcriptional coactivator YAP1

1

1

High-throughput

0.479

High

861818

PLK1
Serine/threonine-protein kinase PLK1

1

1

High-throughput

0.479

High

877306

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

2

High-throughput

0.479

High

918476

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

933254

TBA1B
Tubulin alpha-1B chain

1

1

High-throughput

0.479

High

944846

RED1
Double-stranded RNA-specific editase 1

1

2

High-throughput

0.479

High

952437

H33
Histone H3.3

1

1

High-throughput

0.479

High

1026461

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

1047763

CKAP5
Cytoskeleton-associated protein 5

1

1

High-throughput

0.479

High

1191046

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

1191047

SRRM1
Serine/arginine repetitive matrix protein 1

1

1

High-throughput

0.479

High

1191059

GCN1
Stalled ribosome sensor GCN1

1

2

High-throughput

0.479

High

1191060

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1191072

TBA1C
Tubulin alpha-1C chain

1

1

High-throughput

0.479

High

1191074

WWTR1
WW domain-containing transcription regulator protein 1

1

1

High-throughput

0.479

High

1191088

CAMP3
Calmodulin-regulated spectrin-associated protein 3

1

1

High-throughput

0.479

High

1191092

STAG3
Cohesin subunit SA-3

1

2

High-throughput

0.479

High

1191067

ARAP1
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

1

0

Small-scale

0.460

High

153712

ANM5
Protein arginine N-methyltransferase 5

1

0

High-throughput

0.458

High

164412

TRI66
Tripartite motif-containing protein 66

1

0

High-throughput

0.458

High

244613

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

272187

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

0

High-throughput

0.458

High

360094

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

475978

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.458

High

504313

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

551757

DESP
Desmoplakin

1

0

High-throughput

0.458

High

598199

FLNA
Filamin-A

1

0

High-throughput

0.458

High

613502

SFPQ
Splicing factor, proline- and glutamine-rich

1

0

High-throughput

0.458

High

652901

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

682867

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

0

High-throughput

0.458

High

749627

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

785986

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

789866

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

794022

MATR3
Matrin-3

1

0

High-throughput

0.458

High

824145

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

826306

CDK8
Cyclin-dependent kinase 8

1

0

High-throughput

0.458

High

875070

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

897553

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

923089

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.458

High

928626

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.458

High

932763

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.458

High

942192

GTF2I
General transcription factor II-I

1

0

High-throughput

0.458

High

958062

RBM10
RNA-binding protein 10

1

0

High-throughput

0.458

High

966584

OTUD4
OTU domain-containing protein 4

1

0

High-throughput

0.458

High

966723

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

0

High-throughput

0.458

High

1027089

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

1035853

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1041914

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1064444

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1070003

PWP2
Periodic tryptophan protein 2 homolog

1

0

High-throughput

0.458

High

1073039

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.458

High

1088422

F263
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

1

0

High-throughput

0.458

High

1125322

FILA2
Filaggrin-2

1

0

High-throughput

0.458

High

1154044

NIPBL
Nipped-B-like protein

1

0

High-throughput

0.458

High

1170596

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1188495

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1191040

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1191043

MISP
Mitotic interactor and substrate of PLK1

1

0

High-throughput

0.458

High

1191044

MGAP
MAX gene-associated protein

1

0

High-throughput

0.458

High

1191052

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.458

High

1191054

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1191055

WDR48
WD repeat-containing protein 48

1

0

High-throughput

0.458

High

1191056

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1191058

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

0

High-throughput

0.458

High

1191061

FUBP2
Far upstream element-binding protein 2

1

0

High-throughput

0.458

High

1191066

SNX27
Sorting nexin-27

1

0

High-throughput

0.458

High

1191068

RBM15
RNA-binding protein 15

1

0

High-throughput

0.458

High

1191075

DDX47
Probable ATP-dependent RNA helicase DDX47

1

0

High-throughput

0.458

High

1191078

DEFI6
Differentially expressed in FDCP 6 homolog

1

0

High-throughput

0.458

High

1191079

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1191085

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1191087

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1191089

SLAI2
SLAIN motif-containing protein 2

1

0

High-throughput

0.458

High

1191093

BRPF3
Bromodomain and PHD finger-containing protein 3

1

0

High-throughput

0.458

High

1191095

RUVB2
RuvB-like 2

1

0

High-throughput

0.458

High

1191097

PKP3
Plakophilin-3

1

0

High-throughput

0.458

High

1191098

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

1191099

TF3C3
General transcription factor 3C polypeptide 3

1

0

High-throughput

0.458

High

1191102

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.458

High

101765

F8W7C6
Large ribosomal subunit protein uL16

1

1

High-throughput

0.445

High

851940

NDUA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

3

0

High-throughput

0.347

High

1191041

CMTD1
Catechol O-methyltransferase domain-containing protein 1

3

0

High-throughput

0.347

High

1191045

DJC10
DnaJ homolog subfamily C member 10

3

0

High-throughput

0.347

High

551408

SIAT1
Beta-galactoside alpha-2,6-sialyltransferase 1

2

0

High-throughput

0.328

High

1191100

SO1B1
Solute carrier organic anion transporter family member 1B1

2

0

High-throughput

0.328

High

1030992

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

0

High-throughput

0.279

Low

1103049

ATG2A
Autophagy-related protein 2 homolog A

1

0

High-throughput

0.279

Low

1103716

DB136
Defensin beta 136

1

0

High-throughput

0.279

Low

1129267

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

0

High-throughput

0.279

Low

1166501

BTNL9
Butyrophilin-like protein 9

1

0

High-throughput

0.279

Low

1191042

ZSWM9
Uncharacterized protein ZSWIM9

1

0

High-throughput

0.279

Low

1191069

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.279

Low

1191073

SEM4C
Semaphorin-4C

1

0

High-throughput

0.279

Low

1191081

GREM2
Gremlin-2

1

0

High-throughput

0.279

Low

1191096

CCL26
C-C motif chemokine 26

1

0

High-throughput

0.279

Low

815899

MTR1A
Melatonin receptor type 1A

1

0

High-throughput

0.265

Low

385085

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

946556

DCD
Dermcidin

1

0

High-throughput

0.249

Low

1165713

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1191049

LSME2
Leucine-rich single-pass membrane protein 2

1

0

High-throughput

0.249

Low

1191086

PSD3
PH and SEC7 domain-containing protein 3

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024