Protein: PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)

Gene: PLCG1
Organism: Homo sapiens
Interactions: 242
UniProt ID: P19174

Gene Ontology (top 5):
GO:0001701 - in utero embryonic development
GO:0001726 - ruffle
GO:0002862 - negative regulation of inflammatory response to antigenic stimulus
GO:0004435 - phosphatidylinositol phospholipase C activity
GO:0004629 - phospholipase C activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

507843

FGFR1
Fibroblast growth factor receptor 1

10

20

Small-scale

0.980

High

337912

EGFR
Epidermal growth factor receptor

14

20

Small-scale

0.978

High

452348

PGFRB
Platelet-derived growth factor receptor beta

10

20

Small-scale

0.971

High

384239

NTRK1
High affinity nerve growth factor receptor

8

20

Small-scale

0.966

High

580972

GRB2
Growth factor receptor-bound protein 2

7

20

Small-scale

0.963

High

580995

LCP2
Lymphocyte cytosolic protein 2

5

5

Small-scale

0.936

High

580923

FGFR2
Fibroblast growth factor receptor 2

4

20

Small-scale

0.922

High

499230

KIT
Mast/stem cell growth factor receptor Kit

5

18

Small-scale

0.918

High

580987

SOS1
Son of sevenless homolog 1

4

7

Small-scale

0.906

High

411292

INSR
Insulin receptor

4

20

Small-scale

0.896

High

581014

NTRK2
BDNF/NT-3 growth factors receptor

4

20

Small-scale

0.891

High

557029

PGFRA
Platelet-derived growth factor receptor alpha

3

20

Small-scale

0.878

High

581001

GAB1
GRB2-associated-binding protein 1

3

7

Small-scale

0.870

High

581078

ALK
ALK tyrosine kinase receptor

3

20

Small-scale

0.857

High

580988

SOS2
Son of sevenless homolog 2

2

8

Small-scale

0.852

High

383601

ERBB2
Receptor tyrosine-protein kinase erbB-2

3

20

Small-scale

0.840

High

580956

KSYK
Tyrosine-protein kinase SYK

3

20

Small-scale

0.839

High

580955

ZAP70
Tyrosine-protein kinase ZAP-70

3

20

Small-scale

0.834

High

226483

PRKN
E3 ubiquitin-protein ligase parkin

3

2

Small-scale

0.827

High

580921

RASA1
Ras GTPase-activating protein 1

3

7

Small-scale

0.827

High

580990

ITK
Tyrosine-protein kinase ITK/TSK

2

18

Small-scale

0.812

High

235042

DOK2
Docking protein 2

2

13

High-throughput

0.811

High

580971

RB11A
Ras-related protein Rab-11A

2

4

High-throughput

0.811

High

548634

VAV
Proto-oncogene vav

2

8

Small-scale

0.806

High

434135

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

2

20

Small-scale

0.799

High

581012

NTRK3
NT-3 growth factor receptor

2

20

Small-scale

0.799

High

580926

FGFR4
Fibroblast growth factor receptor 4

2

20

High-throughput

0.789

High

580927

FGFR3
Fibroblast growth factor receptor 3

2

20

High-throughput

0.789

High

580925

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

20

High-throughput

0.778

High

581035

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

3

High-throughput

0.770

High

581076

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

2

High-throughput

0.770

High

580964

CACB3
Voltage-dependent L-type calcium channel subunit beta-3

2

0

High-throughput

0.770

High

581065

SPN90
NCK-interacting protein with SH3 domain

2

0

High-throughput

0.770

High

337341

ABL1
Tyrosine-protein kinase ABL1

2

18

Small-scale

0.768

High

500944

GHR
Growth hormone receptor

2

10

Small-scale

0.768

High

580916

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

2

7

Small-scale

0.768

High

580976

3BP2
SH3 domain-binding protein 2

3

1

Small-scale

0.763

High

580944

AKT1
RAC-alpha serine/threonine-protein kinase

1

2

Small-scale

0.761

High

207423

LAT
Linker for activation of T-cells family member 1

8

2

Small-scale

0.756

High

580949

VGFR2
Vascular endothelial growth factor receptor 2

2

19

Small-scale

0.755

High

238352

JAK2
Tyrosine-protein kinase JAK2

2

20

Small-scale

0.754

High

580940

LTK
Leukocyte tyrosine kinase receptor

2

20

Small-scale

0.754

High

580952

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

2

1

Small-scale

0.754

High

580928

CBL
E3 ubiquitin-protein ligase CBL

7

5

Small-scale

0.749

High

195785

ASAP2
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2

1

2

High-throughput

0.747

High

580953

ABL2
Tyrosine-protein kinase ABL2

1

18

High-throughput

0.747

High

580973

RAC1
Ras-related C3 botulinum toxin substrate 1

1

14

Small-scale

0.747

High

581080

SHAN2
SH3 and multiple ankyrin repeat domains protein 2

1

5

High-throughput

0.747

High

580986

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

8

1

Small-scale

0.746

High

581086

IRS2
Insulin receptor substrate 2

2

3

Small-scale

0.727

High

159329

PLD2
Phospholipase D2

1

2

Small-scale

0.724

High

580968

RHOA
Transforming protein RhoA

1

16

Small-scale

0.724

High

581008

SNX17
Sorting nexin-17

1

1

High-throughput

0.724

High

581050

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

5

High-throughput

0.724

High

581085

GIT1
ARF GTPase-activating protein GIT1

1

4

Small-scale

0.724

High

580942

UFO
Tyrosine-protein kinase receptor UFO

1

19

Small-scale

0.715

High

155832

SH21B
SH2 domain-containing protein 1B

1

20

Small-scale

0.710

High

441428

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

580967

MTPN
Myotrophin

1

3

High-throughput

0.691

High

581047

FEM1A
Protein fem-1 homolog A

1

2

High-throughput

0.691

High

572583

VGFR1
Vascular endothelial growth factor receptor 1

1

18

Small-scale

0.680

High

580954

WASP
Actin nucleation-promoting factor WAS

3

2

Small-scale

0.651

High

530146

NCAM1
Neural cell adhesion molecule 1

1

3

Small-scale

0.647

High

580992

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

1

Small-scale

0.647

High

580997

PAK1
Serine/threonine-protein kinase PAK 1

1

1

Small-scale

0.647

High

581000

TNK1
Non-receptor tyrosine-protein kinase TNK1

1

19

Small-scale

0.647

High

581010

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

581013

PKN2
Serine/threonine-protein kinase N2

1

3

Small-scale

0.647

High

581024

ABI1
Abl interactor 1

1

3

Small-scale

0.647

High

581044

DOK1
Docking protein 1

1

5

Small-scale

0.647

High

581081

GAB2
GRB2-associated-binding protein 2

1

8

Small-scale

0.647

High

581043

GA2L1
GAS2-like protein 1

3

0

High-throughput

0.638

High

581057

MB12B
Multivesicular body subunit 12B

3

0

High-throughput

0.638

High

581028

RIN3
Ras and Rab interactor 3

2

1

High-throughput

0.634

High

581046

LZTS2
Leucine zipper putative tumor suppressor 2

2

3

High-throughput

0.628

High

580917

EPOR
Erythropoietin receptor

1

10

Small-scale

0.621

High

580937

EPHB2
Ephrin type-B receptor 2

1

10

Small-scale

0.621

High

64654

RHG32
Rho GTPase-activating protein 32

1

1

Small-scale

0.618

High

151706

IRS4
Insulin receptor substrate 4

1

2

Small-scale

0.618

High

167067

ARHGB
Rho guanine nucleotide exchange factor 11

1

4

High-throughput

0.618

High

386067

P53
Cellular tumor antigen p53

1

4

High-throughput

0.618

High

412000

FYN
Tyrosine-protein kinase Fyn

1

19

Small-scale

0.618

High

488061

RRAS
Ras-related protein R-Ras

1

19

High-throughput

0.618

High

522758

SRC
Proto-oncogene tyrosine-protein kinase Src

1

19

Small-scale

0.618

High

580930

JAK1
Tyrosine-protein kinase JAK1

1

20

Small-scale

0.618

High

580936

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

5

Small-scale

0.618

High

580938

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

7

Small-scale

0.618

High

580939

SHC1
SHC-transforming protein 1

1

17

Small-scale

0.618

High

580979

KPCE
Protein kinase C epsilon type

1

2

Small-scale

0.618

High

580981

RON
Macrophage-stimulating protein receptor

1

20

Small-scale

0.618

High

580982

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

7

High-throughput

0.618

High

580983

FAK1
Focal adhesion kinase 1

1

18

Small-scale

0.618

High

580985

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

6

Small-scale

0.618

High

580993

TP4A2
Protein tyrosine phosphatase type IVA 2

1

1

High-throughput

0.618

High

581007

GRB14
Growth factor receptor-bound protein 14

1

20

Small-scale

0.618

High

581009

KPCD1
Serine/threonine-protein kinase D1

1

5

Small-scale

0.618

High

581011

SHB
SH2 domain-containing adapter protein B

1

15

Small-scale

0.618

High

581017

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.618

High

581019

RHOU
Rho-related GTP-binding protein RhoU

1

18

Small-scale

0.618

High

581031

BLNK
B-cell linker protein

1

8

Small-scale

0.618

High

581036

ARHG2
Rho guanine nucleotide exchange factor 2

1

4

Small-scale

0.618

High

581062

CISH
Cytokine-inducible SH2-containing protein

1

19

Small-scale

0.618

High

581068

IBTK
Inhibitor of Bruton tyrosine kinase

1

2

Small-scale

0.618

High

581083

SH2B3
SH2B adapter protein 3

1

20

Small-scale

0.618

High

580974

RACK1
Small ribosomal subunit protein RACK1

1

0

Small-scale

0.614

High

487118

ANDR
Androgen receptor

2

4

Small-scale

0.611

High

580975

EF1A1
Elongation factor 1-alpha 1

2

0

Small-scale

0.609

High

496268

TAU
Microtubule-associated protein tau

2

6

Small-scale

0.608

High

324221

BAG3
BAG family molecular chaperone regulator 3

2

0

Small-scale

0.603

High

580958

KCNJ5
G protein-activated inward rectifier potassium channel 4

2

0

High-throughput

0.602

High

580969

HNRPK
Heterogeneous nuclear ribonucleoprotein K

2

0

High-throughput

0.602

High

581025

THMS1
Protein THEMIS

2

1

Small-scale

0.601

High

580965

EPHA4
Ephrin type-A receptor 4

1

12

High-throughput

0.590

High

199502

EFS
Embryonal Fyn-associated substrate

1

0

High-throughput

0.586

High

581003

DGKZ
Diacylglycerol kinase zeta

1

0

Small-scale

0.586

High

581082

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

Small-scale

0.586

High

580980

CAV1
Caveolin-1

1

1

Small-scale

0.586

High

448964

VILI
Villin-1

2

4

Small-scale

0.584

High

580999

PLD1
Phospholipase D1

1

2

Small-scale

0.584

High

580989

DDR1
Epithelial discoidin domain-containing receptor 1

1

20

Small-scale

0.575

High

66642

ZN785
Zinc finger protein 785

2

1

High-throughput

0.574

High

581016

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

2

1

High-throughput

0.574

High

581027

TTC9B
Tetratricopeptide repeat protein 9B

2

1

High-throughput

0.574

High

417919

NPM
Nucleophosmin

1

1

Small-scale

0.561

High

580945

FCG2B
Low affinity immunoglobulin gamma Fc region receptor II-b

1

4

High-throughput

0.561

High

581053

DUS15
Dual specificity protein phosphatase 15

1

3

High-throughput

0.561

High

580919

CD22
B-cell receptor CD22

1

5

Small-scale

0.554

High

581079

SNX7
Sorting nexin-7

1

1

High-throughput

0.553

High

581087

SNX11
Sorting nexin-11

1

1

High-throughput

0.553

High

581051

CD244
Natural killer cell receptor 2B4

1

7

Small-scale

0.550

High

167742

FYB1
FYN-binding protein 1

1

0

Small-scale

0.546

High

580962

TUB
Tubby protein homolog

1

0

Small-scale

0.537

High

557431

PECA1
Platelet endothelial cell adhesion molecule

1

5

Small-scale

0.536

High

580929

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

2

High-throughput

0.536

High

580947

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.536

High

581061

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.536

High

581075

ERRFI
ERBB receptor feedback inhibitor 1

1

1

High-throughput

0.536

High

561357

LYAM2
E-selectin

1

1

Small-scale

0.515

High

147314

DPYL4
Dihydropyrimidinase-related protein 4

1

0

High-throughput

0.513

High

388008

MT1F
Metallothionein-1F

1

0

High-throughput

0.513

High

580978

SRSF2
Serine/arginine-rich splicing factor 2

1

0

High-throughput

0.513

High

581018

CYS1
Cystin-1

1

0

High-throughput

0.513

High

581023

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

581056

GARE1
GRB2-associated and regulator of MAPK protein 1

1

0

High-throughput

0.513

High

581069

RBX2
RING-box protein 2

1

0

High-throughput

0.513

High

235700

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

1

Small-scale

0.501

High

413824

GELS
Gelsolin

1

4

Small-scale

0.501

High

581002

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

2

Small-scale

0.501

High

581041

TRPM7
Transient receptor potential cation channel subfamily M member 7

1

4

Small-scale

0.501

High

580931

TNR6
Tumor necrosis factor receptor superfamily member 6

1

2

Small-scale

0.500

High

581015

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

1

High-throughput

0.489

High

581026

MILK1
MICAL-like protein 1

1

2

High-throughput

0.489

High

581067

NHSL3
NHS-like protein 3

1

1

High-throughput

0.489

High

581005

TRI14
Tripartite motif-containing protein 14

1

4

High-throughput

0.481

High

581030

SCRB1
Scavenger receptor class B member 1

1

0

Small-scale

0.480

High

581060

ANM8
Protein arginine N-methyltransferase 8

1

0

Small-scale

0.480

High

122345

PAR3
Proteinase-activated receptor 3

1

2

High-throughput

0.479

High

145937

DLGP1
Disks large-associated protein 1

1

3

High-throughput

0.479

High

165159

PLXB2
Plexin-B2

1

6

Small-scale

0.479

High

195967

PLXB1
Plexin-B1

1

6

Small-scale

0.479

High

208319

SPY1
Protein sprouty homolog 1

1

1

Small-scale

0.479

High

261197

FLNB
Filamin-B

1

5

High-throughput

0.479

High

300525

NFAT5
Nuclear factor of activated T-cells 5

1

1

Small-scale

0.479

High

327226

DLGP3
Disks large-associated protein 3

1

3

High-throughput

0.479

High

344104

ANT3
Antithrombin-III

1

1

High-throughput

0.479

High

345890

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

580918

CD33
Myeloid cell surface antigen CD33

1

5

Small-scale

0.479

High

580920

ICAL
Calpastatin

1

2

High-throughput

0.479

High

580922

FLNA
Filamin-A

1

5

High-throughput

0.479

High

580924

RYR1
Ryanodine receptor 1

1

4

High-throughput

0.479

High

580933

IL3RA
Interleukin-3 receptor subunit alpha

1

10

High-throughput

0.479

High

580935

MAP4
Microtubule-associated protein 4

1

6

High-throughput

0.479

High

580941

PML
Protein PML

1

2

Small-scale

0.479

High

580946

FCG2C
Low affinity immunoglobulin gamma Fc region receptor II-c

1

4

High-throughput

0.479

High

580950

SYUA
Alpha-synuclein

1

2

High-throughput

0.479

High

580959

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

2

High-throughput

0.479

High

580970

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

580977

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

5

Small-scale

0.479

High

580991

EP300
Histone acetyltransferase p300

1

3

High-throughput

0.479

High

581006

FLNC
Filamin-C

1

6

High-throughput

0.479

High

581020

CSMD2
CUB and sushi domain-containing protein 2

1

1

High-throughput

0.479

High

581033

RPGF5
Rap guanine nucleotide exchange factor 5

1

5

Small-scale

0.479

High

581038

TP4A1
Protein tyrosine phosphatase type IVA 1

1

2

High-throughput

0.479

High

581045

DUS9
Dual specificity protein phosphatase 9

1

2

High-throughput

0.479

High

581052

NTAL
Linker for activation of T-cells family member 2

1

1

Small-scale

0.479

High

581066

DLGP2
Disks large-associated protein 2

1

3

High-throughput

0.479

High

581071

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

581074

HERC5
E3 ISG15--protein ligase HERC5

1

1

Small-scale

0.479

High

176549

FANCA
Fanconi anemia group A protein

1

0

High-throughput

0.458

High

205025

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

217134

EXTL3
Exostosin-like 3

1

0

High-throughput

0.458

High

217439

AIRE
Autoimmune regulator

1

0

High-throughput

0.458

High

257130

PHAR2
Phosphatase and actin regulator 2

1

0

High-throughput

0.458

High

259657

LIPA4
Liprin-alpha-4

1

0

High-throughput

0.458

High

315645

SC24B
Protein transport protein Sec24B

1

0

High-throughput

0.458

High

322168

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

580932

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.458

High

580951

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

580957

ID4
DNA-binding protein inhibitor ID-4

1

0

High-throughput

0.458

High

580960

RGS7
Regulator of G-protein signaling 7

1

0

High-throughput

0.458

High

580984

ZP2
Zona pellucida sperm-binding protein 2

1

0

High-throughput

0.458

High

581004

CKAP5
Cytoskeleton-associated protein 5

1

0

High-throughput

0.458

High

581021

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

581032

NELFB
Negative elongation factor B

1

0

High-throughput

0.458

High

581034

NELL1
Protein kinase C-binding protein NELL1

1

0

Small-scale

0.458

High

581039

DTBP1
Dysbindin

1

0

High-throughput

0.458

High

581049

TDRD1
Tudor domain-containing protein 1

1

0

High-throughput

0.458

High

581072

S23A1
Solute carrier family 23 member 1

1

0

High-throughput

0.458

High

4616

A0A1B0GTN4
DLG associated protein 2

1

3

High-throughput

0.445

High

580943

AGTR1
Type-1 angiotensin II receptor

1

1

Small-scale

0.445

High

551424

RAG1
V(D)J recombination-activating protein 1

1

4

High-throughput

0.437

High

551914

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

580934

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

580948

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

580963

AFF2
AF4/FMR2 family member 2

1

4

High-throughput

0.437

High

580996

CAF1A
Chromatin assembly factor 1 subunit A

1

2

High-throughput

0.437

High

580998

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.437

High

581037

DLX4
Homeobox protein DLX-4

1

4

High-throughput

0.437

High

581042

MINT
Msx2-interacting protein

1

1

High-throughput

0.437

High

581054

ADNP
Activity-dependent neuroprotector homeobox protein

1

1

High-throughput

0.437

High

581064

BICRA
BRD4-interacting chromatin-remodeling complex-associated protein

1

3

High-throughput

0.437

High

58341

TESP1
Protein TESPA1

1

0

Small-scale

0.426

High

581063

DDIT4
DNA damage-inducible transcript 4 protein

1

0

Small-scale

0.426

High

581040

CC120
Coiled-coil domain-containing protein 120

2

0

High-throughput

0.328

High

170529

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

2

0

High-throughput

0.318

High

581073

TEKT2
Tektin-2

2

0

High-throughput

0.318

High

580966

RBM11
Splicing regulator RBM11

1

0

High-throughput

0.282

High

253967

MTG16
Protein CBFA2T3

1

0

High-throughput

0.279

Low

581070

CS025
UPF0449 protein C19orf25

1

0

High-throughput

0.279

Low

581077

AT7L1
Ataxin-7-like protein 1

1

0

High-throughput

0.279

Low

581029

HAVR2
Hepatitis A virus cellular receptor 2

1

0

Small-scale

0.253

Low

376365

PDGFA
Platelet-derived growth factor subunit A

1

0

Small-scale

0.249

Low

514304

PERE
Eosinophil peroxidase

1

0

High-throughput

0.249

Low

580961

DNLI3
DNA ligase 3

1

0

High-throughput

0.249

Low

580994

PDIA2
Protein disulfide-isomerase A2

1

0

High-throughput

0.249

Low

581022

MGDP1
Magnesium-dependent phosphatase 1

1

0

High-throughput

0.249

Low

581048

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

0

High-throughput

0.249

Low

581055

SUV92
Histone-lysine N-methyltransferase SUV39H2

1

0

High-throughput

0.249

Low

581058

I20L2
Interferon-stimulated 20 kDa exonuclease-like 2

1

0

High-throughput

0.249

Low

581059

MEPE
Matrix extracellular phosphoglycoprotein

1

0

High-throughput

0.249

Low

581084

PLAK2
PALM2-AKAP2 fusion protein

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024