Protein: P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase regulatory subunit gamma) (PI3K regulatory subunit gamma) (PtdIns-3-kinase regulatory subunit gamma) (Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma) (PI3-kinase subunit p55-gamma) (PtdIns-3-kinase regulatory subunit p55-gamma) (p55PIK)

Gene: P55G, PIK3R3
Organism: Homo sapiens
Interactions: 199
UniProt ID: Q92569

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0001934 - positive regulation of protein phosphorylation
GO:0002042 - cell migration involved in sprouting angiogenesis
GO:0005829 - cytosol
GO:0005942 - phosphatidylinositol 3-kinase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

787279

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

9

20

Small-scale

0.971

High

787386

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

5

20

Small-scale

0.919

High

338776

EGFR
Epidermal growth factor receptor

5

20

High-throughput

0.918

High

126198

PK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

4

20

High-throughput

0.902

High

129321

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

4

20

High-throughput

0.895

High

983643

FAK1
Focal adhesion kinase 1

4

20

Small-scale

0.893

High

147540

SOCS6
Suppressor of cytokine signaling 6

4

20

High-throughput

0.885

High

655431

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

3

20

High-throughput

0.871

High

992597

ACK1
Activated CDC42 kinase 1

3

20

Small-scale

0.864

High

740024

TGFR2
TGF-beta receptor type-2

3

11

High-throughput

0.861

High

924735

GRB2
Growth factor receptor-bound protein 2

3

20

High-throughput

0.858

High

601964

ERBB3
Receptor tyrosine-protein kinase erbB-3

3

20

High-throughput

0.857

High

802683

CRK
Adapter molecule crk

3

20

High-throughput

0.852

High

383906

ERBB2
Receptor tyrosine-protein kinase erbB-2

3

20

High-throughput

0.845

High

523089

SRC
Proto-oncogene tyrosine-protein kinase Src

3

20

Small-scale

0.827

High

442864

HCK
Tyrosine-protein kinase HCK

2

20

High-throughput

0.819

High

1263830

SOCS4
Suppressor of cytokine signaling 4

2

20

High-throughput

0.819

High

1267424

SPSB2
SPRY domain-containing SOCS box protein 2

2

10

High-throughput

0.819

High

1267442

SH22A
SH2 domain-containing protein 2A

2

20

High-throughput

0.819

High

435709

IGF1R
Insulin-like growth factor 1 receptor

2

20

Small-scale

0.806

High

433433

YES
Tyrosine-protein kinase Yes

2

19

High-throughput

0.783

High

846504

BLK
Tyrosine-protein kinase Blk

2

20

High-throughput

0.783

High

849903

STA5B
Signal transducer and activator of transcription 5B

2

20

High-throughput

0.783

High

557757

NCK1
SH2/SH3 adapter protein NCK1

2

20

High-throughput

0.767

High

776765

STAT3
Signal transducer and activator of transcription 3

2

20

High-throughput

0.767

High

789082

ABL2
Tyrosine-protein kinase ABL2

2

19

High-throughput

0.767

High

986388

BTK
Tyrosine-protein kinase BTK

2

20

High-throughput

0.767

High

412285

FYN
Tyrosine-protein kinase Fyn

2

20

High-throughput

0.743

High

561399

FER
Tyrosine-protein kinase Fer

2

20

High-throughput

0.743

High

1267449

FLRT1
Leucine-rich repeat transmembrane protein FLRT1

2

4

High-throughput

0.726

High

724554

IRS1
Insulin receptor substrate 1

4

20

Small-scale

0.696

High

499280

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

1267438

DOCK5
Dedicator of cytokinesis protein 5

1

14

High-throughput

0.691

High

1192751

CLNK
Cytokine-dependent hematopoietic cell linker

2

20

High-throughput

0.686

High

1267416

HSH2D
Hematopoietic SH2 domain-containing protein

2

20

High-throughput

0.686

High

1267462

IRS2
Insulin receptor substrate 2

3

20

Small-scale

0.667

High

1235092

CCD33
Coiled-coil domain-containing protein 33

2

2

High-throughput

0.665

High

1253366

FNDC8
Fibronectin type III domain-containing protein 8

2

0

High-throughput

0.655

High

1070991

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

1224626

ABI1
Abl interactor 1

1

20

Small-scale

0.647

High

385265

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.646

High

610463

CBL
E3 ubiquitin-protein ligase CBL

2

20

High-throughput

0.634

High

1151622

OTU7B
OTU domain-containing protein 7B

2

3

High-throughput

0.634

High

1267444

PAR6A
Partitioning defective 6 homolog alpha

2

12

High-throughput

0.634

High

151857

IRS4
Insulin receptor substrate 4

2

20

High-throughput

0.628

High

795556

AL3B1
Aldehyde dehydrogenase family 3 member B1

2

2

High-throughput

0.628

High

1267448

EHD2
EH domain-containing protein 2

2

7

High-throughput

0.628

High

1267457

NISCH
Nischarin

2

9

High-throughput

0.628

High

225151

MYPT2
Protein phosphatase 1 regulatory subunit 12B

2

19

High-throughput

0.628

High

1224687

WDFY3
WD repeat and FYVE domain-containing protein 3

2

6

High-throughput

0.628

High

1060227

NC2A
Dr1-associated corepressor

4

1

High-throughput

0.623

High

1267415

LMBL3
Lethal(3)malignant brain tumor-like protein 3

4

5

High-throughput

0.623

High

441546

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.619

High

433926

LYN
Tyrosine-protein kinase Lyn

1

19

Small-scale

0.618

High

557215

PGFRA
Platelet-derived growth factor receptor alpha

1

20

High-throughput

0.618

High

608065

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.618

High

665299

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

968445

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.618

High

1083875

NTRK2
BDNF/NT-3 growth factors receptor

1

20

High-throughput

0.618

High

1231619

PELI3
E3 ubiquitin-protein ligase pellino homolog 3

2

0

High-throughput

0.607

High

1267420

RET7
Retinoid-binding protein 7

2

0

High-throughput

0.607

High

679278

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

2

9

High-throughput

0.606

High

1048979

SRTD2
SERTA domain-containing protein 2

2

1

High-throughput

0.606

High

1054785

CASL
Enhancer of filamentation 1

2

20

High-throughput

0.606

High

1117678

ARI4B
AT-rich interactive domain-containing protein 4B

2

7

High-throughput

0.606

High

1139077

TASO2
Protein TASOR 2

2

7

High-throughput

0.606

High

1267445

DISC1
Disrupted in schizophrenia 1 protein

2

1

High-throughput

0.606

High

791818

HD
Huntingtin

2

6

High-throughput

0.596

High

111148

I6L996
PTK2 protein

1

20

High-throughput

0.594

High

875166

TERA
Transitional endoplasmic reticulum ATPase

2

2

High-throughput

0.594

High

974626

MECOM
Histone-lysine N-methyltransferase MECOM

2

3

High-throughput

0.594

High

1267413

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

2

17

High-throughput

0.594

High

507155

LAMP1
Lysosome-associated membrane glycoprotein 1

2

12

High-throughput

0.584

High

237748

TSN2
Tetraspanin-2

2

2

High-throughput

0.581

High

581199

TNNI1
Troponin I, slow skeletal muscle

2

0

High-throughput

0.580

High

1032256

CENPR
Centromere protein R

2

0

High-throughput

0.580

High

1241873

SMIP6
Sperm microtubule inner protein 6

2

0

High-throughput

0.580

High

1267427

RUSC1
AP-4 complex accessory subunit RUSC1

2

0

High-throughput

0.580

High

1267454

PLAT4
Phospholipase A and acyltransferase 4

2

0

High-throughput

0.580

High

207359

FRS3
Fibroblast growth factor receptor substrate 3

2

20

High-throughput

0.579

High

863875

CRBA2
Beta-crystallin A2

2

2

High-throughput

0.579

High

1047950

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

2

9

High-throughput

0.576

High

1074953

TERF2
Telomeric repeat-binding factor 2

2

2

High-throughput

0.576

High

1135821

DCAF8
DDB1- and CUL4-associated factor 8

2

3

High-throughput

0.576

High

1267446

MBIP1
MAP3K12-binding inhibitory protein 1

2

1

High-throughput

0.576

High

1117377

TM52B
Transmembrane protein 52B

2

1

High-throughput

0.574

High

1255249

HAVR2
Hepatitis A virus cellular receptor 2

2

6

High-throughput

0.574

High

1267447

NLGN3
Neuroligin-3

2

2

High-throughput

0.574

High

1251352

OLIG1
Oligodendrocyte transcription factor 1

2

4

High-throughput

0.573

High

387210

P53
Cellular tumor antigen p53

1

8

Small-scale

0.569

High

414341

RB
Retinoblastoma-associated protein

1

2

Small-scale

0.561

High

50953

FSD2
Fibronectin type III and SPRY domain-containing protein 2

1

20

High-throughput

0.555

High

67791

CMI2B
Ciliary microtubule inner protein 2B

2

1

High-throughput

0.553

High

282356

NEBL
Nebulette

2

20

High-throughput

0.553

High

1077779

NAB2
NGFI-A-binding protein 2

2

1

High-throughput

0.553

High

1167489

CRDL2
Chordin-like protein 2

2

4

High-throughput

0.553

High

1169338

ZN620
Zinc finger protein 620

2

2

High-throughput

0.553

High

1238248

CCD89
Coiled-coil domain-containing protein 89

2

6

High-throughput

0.553

High

1267423

ZBT18
Zinc finger and BTB domain-containing protein 18

2

6

High-throughput

0.553

High

1267428

SSBP4
Single-stranded DNA-binding protein 4

2

3

High-throughput

0.553

High

1267441

PKHF2
Pleckstrin homology domain-containing family F member 2

2

9

High-throughput

0.553

High

260590

TP4A3
Protein tyrosine phosphatase type IVA 3

1

13

High-throughput

0.553

High

666628

LTK
Leukocyte tyrosine kinase receptor

1

20

High-throughput

0.553

High

872468

EPHA5
Ephrin type-A receptor 5

1

20

High-throughput

0.553

High

361235

TNNC2
Troponin C, skeletal muscle

2

0

High-throughput

0.551

High

1260578

BRK1
Protein BRICK1

2

0

High-throughput

0.551

High

1267422

CRBN
Protein cereblon

2

0

High-throughput

0.551

High

265690

E2F6
Transcription factor E2F6

2

3

High-throughput

0.542

High

271158

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

8

High-throughput

0.542

High

992436

PPARA
Peroxisome proliferator-activated receptor alpha

2

19

High-throughput

0.542

High

1115646

CCD14
Coiled-coil domain-containing protein 14

2

1

High-throughput

0.542

High

1267458

ZN281
Zinc finger protein 281

2

3

High-throughput

0.542

High

1267463

PCDB5
Protocadherin beta-5

2

4

High-throughput

0.542

High

991829

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

20

High-throughput

0.541

High

487623

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

1035395

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.536

High

499976

CH60
60 kDa heat shock protein, mitochondrial

1

7

High-throughput

0.536

High

943997

X3CL1
Fractalkine

1

2

High-throughput

0.536

High

674489

UFO
Tyrosine-protein kinase receptor UFO

1

20

Small-scale

0.528

High

1125953

ZMAT1
Zinc finger matrin-type protein 1

2

2

High-throughput

0.526

High

1267421

WRIP1
ATPase WRNIP1

2

1

High-throughput

0.526

High

1267430

TRI54
Tripartite motif-containing protein 54

2

20

High-throughput

0.526

High

1267453

KLF15
Krueppel-like factor 15

2

9

High-throughput

0.526

High

1267455

KMT2B
Histone-lysine N-methyltransferase 2B

2

12

High-throughput

0.526

High

1267460

MTF2
Metal-response element-binding transcription factor 2

2

2

High-throughput

0.526

High

1267461

ZN451
E3 SUMO-protein ligase ZNF451

2

2

High-throughput

0.526

High

994664

DDR1
Epithelial discoidin domain-containing receptor 1

1

20

Small-scale

0.514

High

363412

AMBP
Protein AMBP

1

14

High-throughput

0.508

High

541397

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

3

High-throughput

0.508

High

986829

PSME1
Proteasome activator complex subunit 1

1

1

High-throughput

0.508

High

988001

RING1
E3 ubiquitin-protein ligase RING1

1

10

High-throughput

0.508

High

1065553

SYK
Lysine--tRNA ligase

1

4

High-throughput

0.508

High

1224051

TRM2A
tRNA

1

2

High-throughput

0.508

High

1255753

MICA1
[F-actin]-monooxygenase MICAL1

1

19

High-throughput

0.508

High

1267431

KLC2
Kinesin light chain 2

1

2

High-throughput

0.508

High

1267443

ABCB6
ATP-binding cassette sub-family B member 6

1

4

High-throughput

0.508

High

914255

RB11A
Ras-related protein Rab-11A

1

6

High-throughput

0.501

High

179236

COPT1
High affinity copper uptake protein 1

1

2

High-throughput

0.489

High

591234

ACM3
Muscarinic acetylcholine receptor M3

1

7

High-throughput

0.489

High

814608

V1BR
Vasopressin V1b receptor

1

11

High-throughput

0.489

High

1044931

AVR2B
Activin receptor type-2B

1

11

High-throughput

0.489

High

1086131

AMHR2
Anti-Muellerian hormone type-2 receptor

1

11

High-throughput

0.489

High

1267419

NOE3
Noelin-3

1

2

High-throughput

0.489

High

1267440

MANS1
MANSC domain-containing protein 1

1

2

High-throughput

0.489

High

1267452

I20RA
Interleukin-20 receptor subunit alpha

1

20

High-throughput

0.489

High

1267464

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

3

High-throughput

0.489

High

277801

SERF1
Small EDRK-rich factor 1

1

0

High-throughput

0.486

High

364018

VTDB
Vitamin D-binding protein

1

0

High-throughput

0.486

High

814505

SYQ
Glutamine--tRNA ligase

1

0

High-throughput

0.486

High

901716

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.486

High

1267435

DSN1
Kinetochore-associated protein DSN1 homolog

1

0

High-throughput

0.486

High

1016223

FOXO1
Forkhead box protein O1

1

1

High-throughput

0.481

High

564631

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

575515

EGR1
Early growth response protein 1

1

8

High-throughput

0.479

High

856559

EFNB2
Ephrin-B2

1

9

High-throughput

0.479

High

900751

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

1070328

RAB35
Ras-related protein Rab-35

1

9

High-throughput

0.479

High

1203496

SKAP1
Src kinase-associated phosphoprotein 1

1

20

High-throughput

0.479

High

1267434

DNJC5
DnaJ homolog subfamily C member 5

1

7

High-throughput

0.479

High

1267437

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

361893

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

1

High-throughput

0.464

High

1175970

FBN3
Fibrillin-3 [Cleaved into: Fibrillin-3 C-terminal peptide]

1

11

High-throughput

0.464

High

1232889

LNX2
Ligand of Numb protein X 2

1

17

High-throughput

0.464

High

1267459

LC7L2
Putative RNA-binding protein Luc7-like 2

1

1

High-throughput

0.464

High

898048

YPEL3
Protein yippee-like 3

1

2

High-throughput

0.439

High

68242

HECA2
HEPACAM family member 2

1

20

High-throughput

0.437

High

164444

TRI66
Tripartite motif-containing protein 66

1

20

High-throughput

0.437

High

548203

CD19
B-lymphocyte antigen CD19

1

6

Small-scale

0.437

High

1182902

BT2A1
Butyrophilin subfamily 2 member A1

1

9

High-throughput

0.437

High

1267414

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

1

High-throughput

0.437

High

1267436

Q9H4D1
Protein kinase

1

12

High-throughput

0.437

High

1267456

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

17

High-throughput

0.437

High

1040818

PWP1
Periodic tryptophan protein 1 homolog

1

4

High-throughput

0.417

High

883587

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

12

High-throughput

0.407

High

1267450

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

1

High-throughput

0.407

High

1267417

CEP19
Centrosomal protein of 19 kDa

4

0

High-throughput

0.356

High

1132070

PKHS1
Pleckstrin homology domain-containing family S member 1

2

0

High-throughput

0.333

High

1146431

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

2

0

High-throughput

0.331

High

1235932

MET27
Methyltransferase-like protein 27

2

0

High-throughput

0.331

High

660973

AMPL
Cytosol aminopeptidase

2

0

High-throughput

0.316

High

1109965

CC036
Uncharacterized protein C3orf36

2

0

High-throughput

0.316

High

1172612

K0408
Uncharacterized protein KIAA0408

2

0

High-throughput

0.316

High

1267418

SPT32
Spermatogenesis-associated protein 32

2

0

High-throughput

0.316

High

1267425

ANKMT
Adenine nucleotide translocase lysine N-methyltransferase

2

0

High-throughput

0.316

High

1267429

PBX4
Pre-B-cell leukemia transcription factor 4

2

0

High-throughput

0.316

High

1267432

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.316

High

1267433

GO45
Golgin-45

2

0

High-throughput

0.316

High

1158254

PLB1
Phospholipase B1, membrane-associated

2

0

High-throughput

0.310

High

1238823

IQUB
IQ motif and ubiquitin-like domain-containing protein

2

0

High-throughput

0.310

High

1267426

PELO
Protein pelota homolog

2

0

High-throughput

0.310

High

1232382

HROB
Homologous recombination OB-fold protein

2

0

High-throughput

0.300

High

1237076

PACRL
PACRG-like protein

2

0

High-throughput

0.300

High

1267439

AUNIP
Aurora kinase A- and ninein-interacting protein

2

0

High-throughput

0.300

High

266573

GPC4
Glypican-4

1

0

High-throughput

0.279

Low

1165193

CP054
Transmembrane protein C16orf54

1

0

High-throughput

0.279

Low

1264078

PIBF1
Progesterone-induced-blocking factor 1

1

0

High-throughput

0.279

Low

4654

A0A1B0GWI1
Coiled-coil domain containing 196

1

0

High-throughput

0.268

Low

363449

A1AG1
Alpha-1-acid glycoprotein 1

1

0

High-throughput

0.265

Low

1267451

CE126
Centrosomal protein of 126 kDa

1

0

High-throughput

0.265

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024