Protein: MP2K1
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)

Gene: MP2K1, MAP2K1
Organism: Homo sapiens
Interactions: 238
UniProt ID: Q02750

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004708 - MAP kinase kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

374082

RAF1
RAF proto-oncogene serine/threonine-protein kinase

28

20

Small-scale

0.993

High

542865

BRAF
Serine/threonine-protein kinase B-raf

23

20

Small-scale

0.993

High

658897

MK01
Mitogen-activated protein kinase 1

15

20

Small-scale

0.984

High

647547

MK03
Mitogen-activated protein kinase 3

9

20

Small-scale

0.973

High

488687

ARAF
Serine/threonine-protein kinase A-Raf

8

20

Small-scale

0.969

High

972220

KSR1
Kinase suppressor of Ras 1

8

20

Small-scale

0.969

High

734917

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

4

19

High-throughput

0.909

High

972188

M3K1
Mitogen-activated protein kinase kinase kinase 1

4

19

Small-scale

0.886

High

972212

KSR2
Kinase suppressor of Ras 2

3

20

Small-scale

0.867

High

783317

M3K8
Mitogen-activated protein kinase kinase kinase 8

3

18

Small-scale

0.840

High

972178

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

3

18

Small-scale

0.834

High

350092

RASK
GTPase KRas

3

20

High-throughput

0.817

High

972219

VRK2
Serine/threonine-protein kinase VRK2

2

19

Small-scale

0.789

High

972254

PKHF2
Pleckstrin homology domain-containing family F member 2

2

2

High-throughput

0.783

High

227215

PRKN
E3 ubiquitin-protein ligase parkin

2

20

High-throughput

0.754

High

683280

1433B
14-3-3 protein beta/alpha

7

20

Small-scale

0.747

High

904460

1433G
14-3-3 protein gamma

7

20

High-throughput

0.746

High

972180

1433F
14-3-3 protein eta

7

20

High-throughput

0.746

High

972190

GRB10
Growth factor receptor-bound protein 10

1

20

Small-scale

0.740

High

162017

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

2

16

High-throughput

0.737

High

243371

DNJA2
DnaJ homolog subfamily A member 2

2

20

High-throughput

0.737

High

844490

RAB5C
Ras-related protein Rab-5C

2

8

High-throughput

0.737

High

925211

RAC1
Ras-related C3 botulinum toxin substrate 1

2

20

High-throughput

0.737

High

972185

TADBP
TAR DNA-binding protein 43

2

18

High-throughput

0.737

High

972189

SRSF5
Serine/arginine-rich splicing factor 5

2

8

High-throughput

0.737

High

972191

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

17

High-throughput

0.737

High

972200

STK38
Serine/threonine-protein kinase 38

2

17

High-throughput

0.737

High

972201

RCN1
Reticulocalbin-1

2

14

High-throughput

0.737

High

972205

CDC37
Hsp90 co-chaperone Cdc37

2

14

High-throughput

0.737

High

972270

RALY
RNA-binding protein Raly

2

6

High-throughput

0.737

High

646815

1433T
14-3-3 protein theta

5

20

High-throughput

0.716

High

276171

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

8

Small-scale

0.715

High

926945

1433Z
14-3-3 protein zeta/delta

5

20

High-throughput

0.712

High

160522

AURKA
Aurora kinase A

1

17

High-throughput

0.698

High

211004

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

20

High-throughput

0.698

High

383751

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.698

High

522922

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

High-throughput

0.698

High

738334

BMR1A
Bone morphogenetic protein receptor type-1A

1

15

High-throughput

0.698

High

739954

TGFR2
TGF-beta receptor type-2

1

14

High-throughput

0.698

High

972183

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

4

High-throughput

0.698

High

972203

STK11
Serine/threonine-protein kinase STK11

1

19

High-throughput

0.698

High

972252

WNK1
Serine/threonine-protein kinase WNK1

1

19

High-throughput

0.698

High

197896

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

20

High-throughput

0.691

High

257984

DNJB6
DnaJ homolog subfamily B member 6

1

20

High-throughput

0.691

High

972251

SLK
STE20-like serine/threonine-protein kinase

1

20

High-throughput

0.691

High

909461

1433E
14-3-3 protein epsilon

4

15

High-throughput

0.691

High

833413

RBM25
RNA-binding protein 25

2

13

High-throughput

0.659

High

972186

PAK1
Serine/threonine-protein kinase PAK 1

1

18

Small-scale

0.647

High

972280

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

18

Small-scale

0.647

High

972268

NUFP1
FMR1-interacting protein NUFIP1

3

0

High-throughput

0.638

High

388386

HSPB1
Heat shock protein beta-1

3

8

High-throughput

0.633

High

361853

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

3

High-throughput

0.628

High

740505

PPARG
Peroxisome proliferator-activated receptor gamma

2

18

Small-scale

0.624

High

972271

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

2

20

Small-scale

0.624

High

972195

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

17

High-throughput

0.621

High

972266

LTOR3
Ragulator complex protein LAMTOR3

2

1

Small-scale

0.620

High

120398

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

181602

CFLAR
CASP8 and FADD-like apoptosis regulator

1

11

Small-scale

0.618

High

326596

SNAI1
Zinc finger protein SNAI1

1

11

High-throughput

0.618

High

349260

RASH
GTPase HRas

1

17

Small-scale

0.618

High

427879

CAN1
Calpain-1 catalytic subunit

1

3

High-throughput

0.618

High

431753

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

435615

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.618

High

438087

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

453300

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

12

High-throughput

0.618

High

548687

VAV
Proto-oncogene vav

1

10

Small-scale

0.618

High

575384

EGR1
Early growth response protein 1

1

8

High-throughput

0.618

High

612098

LSHR
Lutropin-choriogonadotropic hormone receptor

1

4

High-throughput

0.618

High

821997

KC1A
Casein kinase I isoform alpha

1

18

High-throughput

0.618

High

844883

RAB7A
Ras-related protein Rab-7a

1

10

High-throughput

0.618

High

900394

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

915619

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

972182

RB40B
Ras-related protein Rab-40B

1

6

Small-scale

0.618

High

972239

DNJC1
DnaJ homolog subfamily C member 1

1

16

High-throughput

0.618

High

972241

TRIB3
Tribbles homolog 3

1

19

Small-scale

0.618

High

972242

TRIB1
Tribbles homolog 1

1

19

Small-scale

0.618

High

972244

SRPK1
SRSF protein kinase 1

1

19

High-throughput

0.618

High

972253

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

972255

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

808528

YAP1
Transcriptional coactivator YAP1

2

16

Small-scale

0.612

High

503929

HSP7C
Heat shock cognate 71 kDa protein

2

17

High-throughput

0.611

High

972206

DGUOK
Deoxyguanosine kinase, mitochondrial

2

3

High-throughput

0.611

High

574309

RL35A
Large ribosomal subunit protein eL33

2

0

High-throughput

0.585

High

809273

IQGA1
Ras GTPase-activating-like protein IQGAP1

2

11

High-throughput

0.584

High

874839

TERA
Transitional endoplasmic reticulum ATPase

2

8

High-throughput

0.584

High

110871

H7C560
non-specific serine/threonine protein kinase

1

20

High-throughput

0.575

High

972194

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

20

High-throughput

0.575

High

972210

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

20

High-throughput

0.575

High

972243

PEBP4
Phosphatidylethanolamine-binding protein 4

2

6

Small-scale

0.574

High

179099

MOT4
Monocarboxylate transporter 4

2

3

High-throughput

0.571

High

271311

NPM3
Nucleoplasmin-3

2

6

High-throughput

0.571

High

426623

H10
Histone H1.0

2

4

High-throughput

0.571

High

518856

TPR
Nucleoprotein TPR

2

20

High-throughput

0.571

High

564869

HMGA1
High mobility group protein HMG-I/HMG-Y

2

3

High-throughput

0.571

High

602246

CD9
CD9 antigen

2

1

High-throughput

0.571

High

603459

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

2

High-throughput

0.571

High

639884

ITA3
Integrin alpha-3

2

1

High-throughput

0.571

High

643846

SYVC
Valine--tRNA ligase

2

7

High-throughput

0.571

High

653232

PYR1
Multifunctional protein CAD

2

7

High-throughput

0.571

High

708423

MCM4
DNA replication licensing factor MCM4

2

10

High-throughput

0.571

High

814766

RL29
Large ribosomal subunit protein eL29

2

1

High-throughput

0.571

High

815356

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

2

2

High-throughput

0.571

High

949757

CBX1
Chromobox protein homolog 1

2

3

High-throughput

0.571

High

966057

LAT1
Large neutral amino acids transporter small subunit 1

2

2

High-throughput

0.571

High

972179

AKA12
A-kinase anchor protein 12

2

15

High-throughput

0.571

High

972187

CBX3
Chromobox protein homolog 3

2

3

High-throughput

0.571

High

972196

FAT1
Protocadherin Fat 1

2

4

High-throughput

0.571

High

972248

GNL3
Guanine nucleotide-binding protein-like 3

2

1

High-throughput

0.571

High

972261

ATD3A
ATPase family AAA domain-containing protein 3A

2

14

High-throughput

0.571

High

972262

DDX18
ATP-dependent RNA helicase DDX18

2

16

High-throughput

0.571

High

972275

NOP58
Nucleolar protein 58

2

1

High-throughput

0.571

High

972213

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.553

High

717723

BMI1
Polycomb complex protein BMI-1

1

9

Small-scale

0.552

High

299766

PLPHP
Pyridoxal phosphate homeostasis protein

2

0

High-throughput

0.547

High

311231

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

2

0

High-throughput

0.547

High

836449

5NTC
Cytosolic purine 5'-nucleotidase

2

0

High-throughput

0.547

High

972209

TOIP1
Torsin-1A-interacting protein 1

2

0

High-throughput

0.547

High

972246

TCF25
Ribosome quality control complex subunit TCF25

2

0

High-throughput

0.547

High

972250

NAT10
RNA cytidine acetyltransferase

2

0

High-throughput

0.547

High

972260

TOM22
Mitochondrial import receptor subunit TOM22 homolog

2

0

High-throughput

0.547

High

972264

SLAI2
SLAIN motif-containing protein 2

2

0

High-throughput

0.547

High

972269

DPP2
Dipeptidyl peptidase 2

2

0

High-throughput

0.547

High

972276

NOC2L
Nucleolar complex protein 2 homolog

2

0

High-throughput

0.547

High

237489

TLR2
Toll-like receptor 2

1

2

High-throughput

0.541

High

521874

CADH1
Cadherin-1

1

9

High-throughput

0.541

High

626102

APC
Adenomatous polyposis coli protein

1

9

High-throughput

0.541

High

716660

CTNA1
Catenin alpha-1

1

5

High-throughput

0.541

High

787211

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

7

High-throughput

0.541

High

855457

MSH6
DNA mismatch repair protein Msh6

1

5

High-throughput

0.541

High

972181

BAX
Apoptosis regulator BAX

1

8

High-throughput

0.541

High

972202

SMAD2
Mothers against decapentaplegic homolog 2

1

17

High-throughput

0.541

High

972235

FBXW7
F-box/WD repeat-containing protein 7

1

20

High-throughput

0.541

High

972267

MLH3
DNA mismatch repair protein Mlh3

1

3

High-throughput

0.541

High

346568

MYC
Myc proto-oncogene protein

1

12

High-throughput

0.536

High

960042

HXC5
Homeobox protein Hox-C5

1

7

High-throughput

0.536

High

972198

NUMA1
Nuclear mitotic apparatus protein 1

1

20

High-throughput

0.536

High

972221

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

7

High-throughput

0.536

High

972229

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.536

High

972231

CC4L
C-C motif chemokine 4-like

1

1

High-throughput

0.536

High

972237

RBM33
RNA-binding protein 33

1

7

High-throughput

0.536

High

972256

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

2

High-throughput

0.536

High

972257

DCP1A
mRNA-decapping enzyme 1A

1

1

High-throughput

0.536

High

972259

ZN277
Zinc finger protein 277

1

1

High-throughput

0.536

High

972273

NTNG1
Netrin-G1

1

3

High-throughput

0.536

High

972277

MB212
Protein mab-21-like 2

1

4

High-throughput

0.536

High

972278

WIF1
Wnt inhibitory factor 1

1

6

High-throughput

0.536

High

972272

FBW1A
F-box/WD repeat-containing protein 1A

1

20

Small-scale

0.534

High

800752

MK08
Mitogen-activated protein kinase 8

1

20

Small-scale

0.527

High

215339

U3IP2
U3 small nucleolar RNA-interacting protein 2

2

20

High-throughput

0.521

High

802066

NOP2
Probable 28S rRNA

2

1

High-throughput

0.521

High

972263

CAMP3
Calmodulin-regulated spectrin-associated protein 3

2

3

High-throughput

0.521

High

516208

DCOR
Ornithine decarboxylase

1

0

High-throughput

0.518

High

685915

ARRB2
Beta-arrestin-2

1

11

Small-scale

0.515

High

972216

BRAP
BRCA1-associated protein

1

11

Small-scale

0.515

High

429520

HEXB
Beta-hexosaminidase subunit beta

1

0

High-throughput

0.513

High

532106

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.513

High

952215

MXRA7
Matrix-remodeling-associated protein 7

1

0

High-throughput

0.513

High

972223

SKA3
Spindle and kinetochore-associated protein 3

1

0

High-throughput

0.513

High

972192

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

2

Small-scale

0.506

High

309693

KAT7
Histone acetyltransferase KAT7

1

4

Small-scale

0.501

High

362078

MBP
Myelin basic protein

1

2

Small-scale

0.501

High

671644

PEBP1
Phosphatidylethanolamine-binding protein 1

1

6

Small-scale

0.501

High

930153

UBC9
SUMO-conjugating enzyme UBC9

1

5

Small-scale

0.501

High

972238

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

16

Small-scale

0.501

High

858165

BIEA
Biliverdin reductase A

1

2

Small-scale

0.500

High

972199

PGFRL
Platelet-derived growth factor receptor-like protein

1

8

High-throughput

0.494

High

972211

BSPRY
B box and SPRY domain-containing protein

1

4

High-throughput

0.489

High

972232

THOC2
THO complex subunit 2

1

8

High-throughput

0.489

High

790753

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

20

High-throughput

0.481

High

130853

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

10

High-throughput

0.479

High

133986

DDX3X
ATP-dependent RNA helicase DDX3X

1

12

High-throughput

0.479

High

135435

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

20

High-throughput

0.479

High

318606

EYA4
Eyes absent homolog 4

1

3

Small-scale

0.479

High

354424

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

2

High-throughput

0.479

High

449685

HMGB1
High mobility group protein B1

1

15

High-throughput

0.479

High

470357

H2A1
Histone H2A type 1

1

6

High-throughput

0.479

High

489008

H14
Histone H1.4

1

11

High-throughput

0.479

High

517206

PCNA
Proliferating cell nuclear antigen

1

7

High-throughput

0.479

High

532504

TCTP
Translationally-controlled tumor protein

1

4

High-throughput

0.479

High

542287

PLAK
Junction plakoglobin

1

14

High-throughput

0.479

High

552533

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.479

High

559659

H12
Histone H1.2

1

11

High-throughput

0.479

High

569618

CEBPB
CCAAT/enhancer-binding protein beta

1

6

High-throughput

0.479

High

575021

RL7
Large ribosomal subunit protein uL30

1

3

High-throughput

0.479

High

627240

MCM3
DNA replication licensing factor MCM3

1

14

High-throughput

0.479

High

636894

ATPA
ATP synthase subunit alpha, mitochondrial

1

12

High-throughput

0.479

High

637391

PSA1
Proteasome subunit alpha type-1

1

11

High-throughput

0.479

High

649468

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.479

High

650999

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

10

High-throughput

0.479

High

656589

PSB6
Proteasome subunit beta type-6

1

7

High-throughput

0.479

High

669339

EF1D
Elongation factor 1-delta

1

2

High-throughput

0.479

High

670691

PRDX6
Peroxiredoxin-6

1

13

High-throughput

0.479

High

785867

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.479

High

807692

MAP1B
Microtubule-associated protein 1B

1

11

High-throughput

0.479

High

903894

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

15

High-throughput

0.479

High

910660

RS23
Small ribosomal subunit protein uS12

1

1

High-throughput

0.479

High

913489

RL7A
Large ribosomal subunit protein eL8

1

3

High-throughput

0.479

High

916531

RS6
Small ribosomal subunit protein eS6

1

1

High-throughput

0.479

High

923330

RL8
Large ribosomal subunit protein uL2

1

1

High-throughput

0.479

High

929406

RACK1
Small ribosomal subunit protein RACK1

1

20

High-throughput

0.479

High

960750

CLH1
Clathrin heavy chain 1

1

5

High-throughput

0.479

High

972184

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

20

High-throughput

0.479

High

972197

IMB1
Importin subunit beta-1

1

6

High-throughput

0.479

High

972204

NF2L2
Nuclear factor erythroid 2-related factor 2

1

7

Small-scale

0.479

High

972214

MOB2
MOB kinase activator 2

1

16

High-throughput

0.479

High

972215

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

10

High-throughput

0.479

High

972217

MOB3B
MOB kinase activator 3B

1

16

High-throughput

0.479

High

972218

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

10

High-throughput

0.479

High

972222

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

20

High-throughput

0.479

High

972224

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

12

Small-scale

0.479

High

972225

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

2

High-throughput

0.479

High

972230

ABCF1
ATP-binding cassette sub-family F member 1

1

4

High-throughput

0.479

High

972234

HS105
Heat shock protein 105 kDa

1

20

High-throughput

0.479

High

972236

OPTN
Optineurin

1

20

High-throughput

0.479

High

972258

BIRC6
Baculoviral IAP repeat-containing protein 6

1

12

Small-scale

0.479

High

972265

DYH1
Dynein axonemal heavy chain 1

1

3

High-throughput

0.479

High

972279

SERC
Phosphoserine aminotransferase

1

1

High-throughput

0.479

High

509227

G6PD
Glucose-6-phosphate 1-dehydrogenase

1

0

High-throughput

0.458

High

703463

LSP1
Lymphocyte-specific protein 1

1

0

Small-scale

0.458

High

898887

PSME3
Proteasome activator complex subunit 3

1

0

Small-scale

0.458

High

972207

TECT1
Tectonic-1

1

0

High-throughput

0.458

High

972228

POC5
Centrosomal protein POC5

1

0

High-throughput

0.458

High

972274

LTOR2
Ragulator complex protein LAMTOR2

1

0

Small-scale

0.458

High

473437

UCRIL
Putative cytochrome b-c1 complex subunit Rieske-like protein 1

1

2

High-throughput

0.445

High

972249

ZDHC5
Palmitoyltransferase ZDHHC5

1

5

High-throughput

0.445

High

972226

ARF
Tumor suppressor ARF

1

0

High-throughput

0.438

High

720268

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.437

High

823905

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

9

High-throughput

0.437

High

972247

WDR83
WD repeat domain-containing protein 83

1

11

Small-scale

0.437

High

972208

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

1

High-throughput

0.407

High

972240

C170L
Cep170-like protein

1

2

High-throughput

0.407

High

972227

BANP
Protein BANP

3

0

High-throughput

0.352

High

888139

RNAS9
Inactive ribonuclease-like protein 9

2

0

High-throughput

0.324

High

972233

TCP11
T-complex protein 11 homolog

2

0

High-throughput

0.316

High

542511

QCR7
Cytochrome b-c1 complex subunit 7

2

0

High-throughput

0.298

High

972193

KRR1
KRR1 small subunit processome component homolog

2

0

High-throughput

0.298

High

972245

CD006
Uncharacterized protein encoded by LINC01587

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024