Protein: XRCC4
DNA repair protein XRCC4 (hXRCC4) (X-ray repair cross-complementing protein 4) [Cleaved into: Protein XRCC4, C-terminus (XRCC4/C)]

Gene: XRCC4
Organism: Homo sapiens
Interactions: 78
UniProt ID: Q13426

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005958 - DNA-dependent protein kinase-DNA ligase 4 complex
GO:0006302 - double-strand break repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

836829

DNLI4
DNA ligase 4

22

1

Small-scale

0.992

High

1033945

XRCC4
DNA repair protein XRCC4

10

0

Small-scale

0.930

High

1033975

NHEJ1
Non-homologous end-joining factor 1

9

0

Small-scale

0.925

High

1033951

IFFO2
Intermediate filament family orphan 2

3

2

High-throughput

0.770

High

1033971

PNKP
Bifunctional polynucleotide phosphatase/kinase

8

1

Small-scale

0.755

High

1033956

K1C27
Keratin, type I cytoskeletal 27

2

0

High-throughput

0.742

High

1033955

APTX
Aprataxin

6

1

Small-scale

0.735

High

1000180

IFFO1
Non-homologous end joining factor IFFO1

5

2

Small-scale

0.728

High

1033959

APLF
Aprataxin and PNK-like factor

6

0

Small-scale

0.701

High

523727

XRCC6
X-ray repair cross-complementing protein 6

4

1

Small-scale

0.698

High

1033960

FAM9B
Protein FAM9B

5

0

High-throughput

0.691

High

1033965

APBP2
Amyloid protein-binding protein 2

3

2

High-throughput

0.667

High

443493

VIME
Vimentin

1

0

High-throughput

0.663

High

587557

NFKB1
Nuclear factor NF-kappa-B p105 subunit

3

0

High-throughput

0.638

High

827788

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

3

0

High-throughput

0.638

High

822009

KC1A
Casein kinase I isoform alpha

2

1

High-throughput

0.628

High

928282

DYL1
Dynein light chain 1, cytoplasmic

2

1

High-throughput

0.628

High

944224

PRKDC
DNA-dependent protein kinase catalytic subunit

3

0

Small-scale

0.619

High

975647

LMNB2
Lamin-B2

1

2

High-throughput

0.618

High

1033968

DYL2
Dynein light chain 2, cytoplasmic

2

1

High-throughput

0.611

High

1033948

LONF2
LON peptidase N-terminal domain and RING finger protein 2

3

1

High-throughput

0.609

High

795862

MAGA6
Melanoma-associated antigen 6

2

1

High-throughput

0.606

High

1033958

RN135
E3 ubiquitin-protein ligase RNF135

2

0

High-throughput

0.602

High

1033969

UIF
UAP56-interacting factor

2

0

High-throughput

0.602

High

1033976

SHCAF
SIN3-HDAC complex-associated factor

2

0

High-throughput

0.602

High

1033977

MED4
Mediator of RNA polymerase II transcription subunit 4

2

0

High-throughput

0.602

High

1033967

FBXW7
F-box/WD repeat-containing protein 7

2

0

Small-scale

0.598

High

246220

NBN
Nibrin

1

0

Small-scale

0.589

High

455400

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.586

High

524911

XRCC5
X-ray repair cross-complementing protein 5

2

1

Small-scale

0.584

High

180982

GSC2
Homeobox protein goosecoid-2

2

0

High-throughput

0.580

High

1033979

HAUS2
HAUS augmin-like complex subunit 2

2

0

High-throughput

0.580

High

359916

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

Small-scale

0.575

High

131244

BIN1
Myc box-dependent-interacting protein 1

1

0

Small-scale

0.561

High

1033972

PAXX
Protein PAXX

2

0

Small-scale

0.559

High

638954

S100P
Protein S100-P

1

2

High-throughput

0.536

High

642940

S10A4
Protein S100-A4

1

2

High-throughput

0.536

High

796070

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.536

High

822254

KC1D
Casein kinase I isoform delta

1

1

High-throughput

0.536

High

521536

ACTN1
Alpha-actinin-1

1

0

High-throughput

0.518

High

1018463

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

High-throughput

0.518

High

934142

CSK21
Casein kinase II subunit alpha

1

0

Small-scale

0.513

High

1033947

CDKN3
Cyclin-dependent kinase inhibitor 3

1

0

High-throughput

0.513

High

1033961

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.513

High

1033962

BBS1
Bardet-Biedl syndrome 1 protein

1

0

High-throughput

0.513

High

1033966

FGF11
Fibroblast growth factor 11

1

0

High-throughput

0.513

High

1033978

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

971160

H11
Histone H1.1

1

0

High-throughput

0.493

High

661251

S10A2
Protein S100-A2

1

2

High-throughput

0.489

High

1033952

KLC3
Kinesin light chain 3

1

2

High-throughput

0.489

High

174853

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

1033984

KIF3A
Kinesin-like protein KIF3A

1

1

High-throughput

0.479

High

1033970

DCR1C
Protein artemis

1

0

Small-scale

0.464

High

244389

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

507415

ERG
Transcriptional regulator ERG

1

0

Small-scale

0.458

High

569687

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

651122

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

719478

MERL
Merlin

1

0

High-throughput

0.458

High

720384

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

799097

NKX21
Homeobox protein Nkx-2.1

1

0

High-throughput

0.458

High

867583

BLM
RecQ-like DNA helicase BLM

1

0

Small-scale

0.458

High

1033946

CUL1
Cullin-1

1

0

Small-scale

0.458

High

1033950

SETMR
Histone-lysine N-methyltransferase SETMAR

1

0

Small-scale

0.458

High

1033963

DNJC9
DnaJ homolog subfamily C member 9

1

0

High-throughput

0.458

High

1033964

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1033973

CYREN
Cell cycle regulator of non-homologous end joining

1

0

Small-scale

0.458

High

1033980

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1033981

DNPEP
Aspartyl aminopeptidase

1

0

High-throughput

0.458

High

1033983

MTMR7
Myotubularin-related protein 7

1

0

High-throughput

0.458

High

111292

J3KPF9
Kinesin-like protein

1

1

High-throughput

0.407

High

1033949

ASTE1
Protein asteroid homolog 1

1

0

High-throughput

0.299

High

1033974

CAAP1
Caspase activity and apoptosis inhibitor 1

1

0

High-throughput

0.282

High

270032

RF1M
Peptide chain release factor 1, mitochondrial

1

0

High-throughput

0.279

Low

1033957

ERIC1
Glutamate-rich protein 1

1

0

High-throughput

0.269

Low

1033953

HSDL2
Hydroxysteroid dehydrogenase-like protein 2

1

0

High-throughput

0.249

Low

1033954

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1033982

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024