Protein: DLG5
Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG)

Gene: DLG5
Organism: Homo sapiens
Interactions: 173
UniProt ID: Q8TDM6

Gene Ontology (top 5):
GO:0001837 - epithelial to mesenchymal transition
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0005912 - adherens junction
GO:0007165 - signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

235554

VINEX
Vinexin

2

16

Small-scale

0.836

High

915856

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

557746

NCK1
SH2/SH3 adapter protein NCK1

1

18

High-throughput

0.691

High

904899

1433G
14-3-3 protein gamma

4

20

High-throughput

0.691

High

451288

TPM1
Tropomyosin alpha-1 chain

3

3

High-throughput

0.667

High

683563

1433B
14-3-3 protein beta/alpha

3

20

High-throughput

0.662

High

982311

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

717220

CTNB1
Catenin beta-1

3

9

Small-scale

0.640

High

647929

MARK3
MAP/microtubule affinity-regulating kinase 3

2

2

High-throughput

0.628

High

928408

DYL1
Dynein light chain 1, cytoplasmic

2

8

High-throughput

0.628

High

120553

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

297649

RHBT1
Rho-related BTB domain-containing protein 1

1

20

High-throughput

0.618

High

318190

DIRA3
GTP-binding protein Di-Ras3

1

8

High-throughput

0.618

High

350381

RASK
GTPase KRas

1

20

High-throughput

0.618

High

411800

LCK
Tyrosine-protein kinase Lck

1

12

High-throughput

0.618

High

433909

LYN
Tyrosine-protein kinase Lyn

1

14

High-throughput

0.618

High

436422

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

564623

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

665293

EPHA2
Ephrin type-A receptor 2

1

13

High-throughput

0.618

High

852565

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

876450

AFAD
Afadin

1

20

High-throughput

0.618

High

892500

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

894240

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

900722

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

901205

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.618

High

925457

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

951180

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

990892

ZO1
Tight junction protein ZO-1

1

18

High-throughput

0.618

High

1070317

RAB35
Ras-related protein Rab-35

1

8

High-throughput

0.618

High

1076677

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1170945

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.618

High

1183473

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1255111

PARD3
Partitioning defective 3 homolog

1

17

High-throughput

0.618

High

1255113

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.618

High

1255122

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.618

High

1255129

RHBT2
Rho-related BTB domain-containing protein 2

1

20

High-throughput

0.618

High

1255133

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1255135

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1255142

ZO2
Tight junction protein ZO-2

1

17

High-throughput

0.618

High

430276

PROF1
Profilin-1

2

3

High-throughput

0.614

High

1255119

DYL2
Dynein light chain 2, cytoplasmic

2

8

High-throughput

0.611

High

647130

1433T
14-3-3 protein theta

2

20

High-throughput

0.601

High

835896

GSK3B
Glycogen synthase kinase-3 beta

2

6

High-throughput

0.584

High

1164960

SAS6
Spindle assembly abnormal protein 6 homolog

2

6

High-throughput

0.584

High

1255146

FBW1A
F-box/WD repeat-containing protein 1A

2

6

Small-scale

0.584

High

370068

ESR1
Estrogen receptor

2

10

High-throughput

0.571

High

887907

CD81
CD81 antigen

1

2

High-throughput

0.541

High

415005

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.536

High

909845

1433E
14-3-3 protein epsilon

1

4

High-throughput

0.536

High

927332

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

929935

ACTG
Actin, cytoplasmic 2

1

2

High-throughput

0.536

High

1042114

CUL3
Cullin-3

1

4

High-throughput

0.536

High

1052264

SRC8
Src substrate cortactin

1

12

High-throughput

0.536

High

1183078

MARK2
Serine/threonine-protein kinase MARK2

1

2

High-throughput

0.536

High

1255123

LURA1
Leucine rich adaptor protein 1

1

3

High-throughput

0.536

High

1255132

SAV1
Protein salvador homolog 1

1

20

High-throughput

0.536

High

1255144

BAG5
BAG family molecular chaperone regulator 5

1

2

High-throughput

0.536

High

1145855

CP135
Centrosomal protein of 135 kDa

2

5

High-throughput

0.533

High

869691

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.518

High

1255128

BTBDA
BTB/POZ domain-containing protein 10

1

0

High-throughput

0.518

High

1255124

CEP63
Centrosomal protein of 63 kDa

2

8

High-throughput

0.513

High

1255125

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.513

High

739202

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

3

High-throughput

0.494

High

806354

RL21
Large ribosomal subunit protein eL21

1

0

High-throughput

0.493

High

942215

GTF2I
General transcription factor II-I

1

0

High-throughput

0.493

High

1062304

MELT
Ventricular zone-expressed PH domain-containing protein homolog 1

1

0

High-throughput

0.493

High

718042

BMI1
Polycomb complex protein BMI-1

1

4

High-throughput

0.489

High

129803

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

7

High-throughput

0.479

High

155410

NRP1
Neuropilin-1

1

6

High-throughput

0.479

High

178686

STX7
Syntaxin-7

1

5

High-throughput

0.479

High

212947

STX6
Syntaxin-6

1

2

High-throughput

0.479

High

230989

CE104
Centrosomal protein of 104 kDa

1

1

High-throughput

0.479

High

232942

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

11

High-throughput

0.479

High

279650

FLOT1
Flotillin-1

1

4

High-throughput

0.479

High

301939

TRI37
E3 ubiquitin-protein ligase TRIM37

1

13

High-throughput

0.479

High

338732

EGFR
Epidermal growth factor receptor

1

18

High-throughput

0.479

High

374582

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

385214

NTRK1
High affinity nerve growth factor receptor

1

18

High-throughput

0.479

High

387167

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

408878

K1C18
Keratin, type I cytoskeletal 18

1

7

High-throughput

0.479

High

409174

K2C8
Keratin, type II cytoskeletal 8

1

5

High-throughput

0.479

High

422427

NFM
Neurofilament medium polypeptide

1

9

High-throughput

0.479

High

444435

K1C19
Keratin, type I cytoskeletal 19

1

7

High-throughput

0.479

High

452459

PGFRB
Platelet-derived growth factor receptor beta

1

12

High-throughput

0.479

High

476091

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

High-throughput

0.479

High

504448

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

508118

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.479

High

518726

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

1

High-throughput

0.479

High

522083

CADH1
Cadherin-1

1

9

High-throughput

0.479

High

547149

EZRI
Ezrin

1

20

High-throughput

0.479

High

557208

PGFRA
Platelet-derived growth factor receptor alpha

1

15

High-throughput

0.479

High

567187

CXA1
Gap junction alpha-1 protein

1

17

High-throughput

0.479

High

601553

FGFR2
Fibroblast growth factor receptor 2

1

20

High-throughput

0.479

High

601954

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

17

High-throughput

0.479

High

608056

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.479

High

666625

LTK
Leukocyte tyrosine kinase receptor

1

20

High-throughput

0.479

High

716736

CTNA1
Catenin alpha-1

1

7

High-throughput

0.479

High

719751

RADI
Radixin

1

20

High-throughput

0.479

High

738562

TGFR1
TGF-beta receptor type-1

1

1

Small-scale

0.479

High

793015

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

2

High-throughput

0.479

High

818281

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

823457

PAXI
Paxillin

1

10

High-throughput

0.479

High

835465

GSK3A
Glycogen synthase kinase-3 alpha

1

6

High-throughput

0.479

High

896788

ARP3
Actin-related protein 3

1

4

High-throughput

0.479

High

925953

AP2B1
AP-2 complex subunit beta

1

3

High-throughput

0.479

High

959557

VIGLN
Vigilin

1

4

High-throughput

0.479

High

968438

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.479

High

974938

CAV1
Caveolin-1

1

4

High-throughput

0.479

High

1017723

STX4
Syntaxin-4

1

5

High-throughput

0.479

High

1021434

ANK3
Ankyrin-3

1

6

High-throughput

0.479

High

1041108

CUL1
Cullin-1

1

4

Small-scale

0.479

High

1043984

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.479

High

1074375

STIL
SCL-interrupting locus protein

1

1

High-throughput

0.479

High

1077041

MARE1
Microtubule-associated protein RP/EB family member 1

1

1

High-throughput

0.479

High

1080732

ZYX
Zyxin

1

7

High-throughput

0.479

High

1083871

NTRK2
BDNF/NT-3 growth factors receptor

1

18

High-throughput

0.479

High

1084112

OCLN
Occludin

1

6

High-throughput

0.479

High

1119004

AMOT
Angiomotin

1

20

High-throughput

0.479

High

1124568

ODFP2
Outer dense fiber protein 2

1

3

High-throughput

0.479

High

1148139

RNF43
E3 ubiquitin-protein ligase RNF43

1

4

High-throughput

0.479

High

1153713

STYK1
Tyrosine-protein kinase STYK1

1

18

High-throughput

0.479

High

1168599

SYNE3
Nesprin-3

1

7

High-throughput

0.479

High

1185490

MOB1B
MOB kinase activator 1B

1

2

High-throughput

0.479

High

1192094

DNJB7
DnaJ homolog subfamily B member 7

1

3

High-throughput

0.479

High

1202433

HOOK3
Protein Hook homolog 3

1

14

High-throughput

0.479

High

1230293

CXD3
Gap junction delta-3 protein

1

17

High-throughput

0.479

High

1255114

ESR2
Estrogen receptor beta

1

10

High-throughput

0.479

High

1255118

ENTR1
Endosome-associated-trafficking regulator 1

1

2

High-throughput

0.479

High

1255127

LZTS2
Leucine zipper putative tumor suppressor 2

1

20

High-throughput

0.479

High

1255130

GAN
Gigaxonin

1

2

High-throughput

0.479

High

1255131

DNJC5
DnaJ homolog subfamily C member 5

1

6

High-throughput

0.479

High

1255134

MOB1A
MOB kinase activator 1A

1

2

High-throughput

0.479

High

1255136

E41LA
Band 4.1-like protein 4A

1

20

High-throughput

0.479

High

1255138

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

1255145

MARE3
Microtubule-associated protein RP/EB family member 3

1

1

High-throughput

0.479

High

1255148

PHOCN
MOB-like protein phocein

1

2

High-throughput

0.479

High

929005

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.458

High

1039267

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.458

High

1068828

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.458

High

240107

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.445

High

1233119

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.445

High

132541

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

2

High-throughput

0.437

High

155055

NDC80
Kinetochore protein NDC80 homolog

1

7

High-throughput

0.437

High

279327

DNJB5
DnaJ homolog subfamily B member 5

1

2

High-throughput

0.437

High

302573

CE152
Centrosomal protein of 152 kDa

1

1

High-throughput

0.437

High

305558

ZFPL1
Zinc finger protein-like 1

1

2

High-throughput

0.437

High

325824

LATS1
Serine/threonine-protein kinase LATS1

1

13

High-throughput

0.437

High

657527

TMOD1
Tropomodulin-1

1

1

High-throughput

0.437

High

969877

KIF23
Kinesin-like protein KIF23

1

19

High-throughput

0.437

High

1063976

TNIP1
TNFAIP3-interacting protein 1

1

12

High-throughput

0.437

High

1146648

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.437

High

1159400

FBX42
F-box only protein 42

1

1

High-throughput

0.437

High

1172689

CE128
Centrosomal protein of 128 kDa

1

12

High-throughput

0.437

High

1192486

CNTRL
Centriolin

1

7

High-throughput

0.437

High

1204293

DYR2
Dihydrofolate reductase 2, mitochondrial

1

1

High-throughput

0.437

High

1242607

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

5

High-throughput

0.437

High

1255112

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

7

High-throughput

0.437

High

1255116

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

2

High-throughput

0.437

High

1255117

CK052
Uncharacterized protein C11orf52

1

5

High-throughput

0.437

High

1255121

RPGR1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

1

7

High-throughput

0.437

High

1255126

CEP89
Centrosomal protein of 89 kDa

1

9

High-throughput

0.437

High

1255139

ANLN
Anillin

1

4

High-throughput

0.437

High

1255140

SEP10
Septin-10

1

3

High-throughput

0.437

High

1255141

ANFY1
Rabankyrin-5

1

6

High-throughput

0.437

High

1255143

ANC2
Anaphase-promoting complex subunit 2

1

5

High-throughput

0.437

High

1255147

NINL
Ninein-like protein

1

6

High-throughput

0.437

High

319016

CEP43
Centrosomal protein 43

1

0

High-throughput

0.279

Low

116603

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

0

High-throughput

0.249

Low

232366

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.249

Low

583526

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.249

Low

1255115

GOGA1
Golgin subfamily A member 1

1

0

High-throughput

0.249

Low

1255120

AURKB
Aurora kinase B

1

0

High-throughput

0.249

Low

1255137

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024