Protein: SPCS1
Signal peptidase complex subunit 1 (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit)

Gene: SPCS1
Organism: Homo sapiens
Interactions: 144
UniProt ID: Q9Y6A9

Gene Ontology (top 5):
GO:0005787 - signal peptidase complex
GO:0005789 - endoplasmic reticulum membrane
GO:0006465 - signal peptide processing
GO:0006508 - proteolysis
GO:0019068 - virion assembly

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1316119

SC11C
Signal peptidase complex catalytic subunit SEC11C

2

3

High-throughput

0.628

High

1165087

MOXD1
DBH-like monooxygenase protein 1

2

0

High-throughput

0.602

High

1354124

MGT4C
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

2

0

High-throughput

0.602

High

1377720

NALD2
N-acetylated-alpha-linked acidic dipeptidase 2

2

0

High-throughput

0.588

High

1062511

SPCS2
Signal peptidase complex subunit 2

2

0

High-throughput

0.585

High

905576

TSN5
Tetraspanin-5

2

1

High-throughput

0.558

High

1310324

TM2D3
TM2 domain-containing protein 3

2

1

High-throughput

0.558

High

931573

SC11A
Signal peptidase complex catalytic subunit SEC11A

1

3

High-throughput

0.536

High

1317665

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

1

1

High-throughput

0.536

High

1349670

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.536

High

1356434

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

1

1

High-throughput

0.536

High

149792

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.513

High

502736

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.513

High

621827

PRTN3
Myeloblastin

1

0

High-throughput

0.513

High

654945

CALX
Calnexin

1

0

High-throughput

0.513

High

894918

SPCS3
Signal peptidase complex subunit 3

1

0

High-throughput

0.513

High

966679

OTUD4
OTU domain-containing protein 4

1

0

High-throughput

0.513

High

1014781

SIAT6
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase

1

0

High-throughput

0.513

High

1039420

PKD2
Polycystin-2

1

0

High-throughput

0.513

High

1126709

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.513

High

1147950

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

1

0

High-throughput

0.513

High

1192864

TMED4
Transmembrane emp24 domain-containing protein 4

1

0

High-throughput

0.513

High

1199474

LYRIC
Protein LYRIC

1

0

High-throughput

0.513

High

1267672

SL9A6
Sodium/hydrogen exchanger 6

1

0

High-throughput

0.513

High

1282508

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.513

High

1283346

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1283754

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

1

0

High-throughput

0.513

High

1301885

CLCC1
Chloride channel CLIC-like protein 1

1

0

High-throughput

0.513

High

1334817

LMA1L
Protein ERGIC-53-like

1

0

High-throughput

0.513

High

1345259

PLCC
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

1

0

High-throughput

0.513

High

1354438

CATF
Cathepsin F

1

0

High-throughput

0.513

High

1378194

TEST
Testisin

1

0

High-throughput

0.513

High

266586

GPC4
Glypican-4

1

1

High-throughput

0.489

High

714888

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

1

High-throughput

0.489

High

821104

PRC2A
Protein PRRC2A

1

1

High-throughput

0.489

High

1049545

SAFB2
Scaffold attachment factor B2

1

1

High-throughput

0.489

High

1165680

ARSK
Arylsulfatase K

1

1

High-throughput

0.489

High

1289645

ARSG
Arylsulfatase G

1

1

High-throughput

0.489

High

1309976

BUD13
BUD13 homolog

1

2

High-throughput

0.489

High

1315097

TM2D2
TM2 domain-containing protein 2

1

1

High-throughput

0.489

High

1333084

AT133
Polyamine-transporting ATPase 13A3

1

1

High-throughput

0.489

High

1347214

SLTM
SAFB-like transcription modulator

1

1

High-throughput

0.489

High

1348572

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

1

High-throughput

0.489

High

349037

RASN
GTPase NRas

1

1

High-throughput

0.479

High

350740

RASK
GTPase KRas

1

1

High-throughput

0.479

High

436598

RHOC
Rho-related GTP-binding protein RhoC

1

3

High-throughput

0.479

High

545729

RAC2
Ras-related C3 botulinum toxin substrate 2

1

3

High-throughput

0.479

High

901102

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

951502

RHOG
Rho-related GTP-binding protein RhoG

1

3

High-throughput

0.479

High

116725

UBXN8
UBX domain-containing protein 8

1

0

High-throughput

0.460

High

1062727

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

1198722

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

0

High-throughput

0.458

High

1234012

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.458

High

1237051

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

1256096

RHBL4
Rhomboid-related protein 4

1

0

High-throughput

0.458

High

781316

AQP2
Aquaporin-2

1

2

Small-scale

0.439

High

120741

RHOD
Rho-related GTP-binding protein RhoD

1

5

High-throughput

0.437

High

1156761

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1292915

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

1335427

RHOF
Rho-related GTP-binding protein RhoF

1

5

High-throughput

0.437

High

236520

NEMF
Ribosome quality control complex subunit NEMF

1

1

High-throughput

0.407

High

310370

LYPD3
Ly6/PLAUR domain-containing protein 3

3

0

High-throughput

0.347

High

713686

GBRA3
Gamma-aminobutyric acid receptor subunit alpha-3

2

0

High-throughput

0.328

High

1262508

SSMM1
Serine-rich single-pass membrane protein 1

2

0

High-throughput

0.328

High

824989

DNSL1
Deoxyribonuclease-1-like 1

2

0

High-throughput

0.318

High

1150418

PVRIG
Transmembrane protein PVRIG

2

0

High-throughput

0.318

High

165271

PLXB2
Plexin-B2

1

0

High-throughput

0.279

Low

216627

S28A2
Sodium/nucleoside cotransporter 2

1

0

High-throughput

0.279

Low

224867

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

0

High-throughput

0.279

Low

233994

NMD3B
Glutamate receptor ionotropic, NMDA 3B

1

0

High-throughput

0.279

Low

240922

S19A2
Thiamine transporter 1

1

0

High-throughput

0.279

Low

267204

GEMI
Geminin

1

0

High-throughput

0.279

Low

315916

VNN2
Pantetheine hydrolase VNN2

1

0

High-throughput

0.279

Low

384052

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

0

High-throughput

0.279

Low

398482

PPBT
Alkaline phosphatase, tissue-nonspecific isozyme

1

0

High-throughput

0.279

Low

534160

T2FB
General transcription factor IIF subunit 2

1

0

High-throughput

0.279

Low

644729

NKG2D
NKG2-D type II integral membrane protein

1

0

High-throughput

0.279

Low

722661

T2FA
General transcription factor IIF subunit 1

1

0

High-throughput

0.279

Low

833675

NUMB
Protein numb homolog

1

0

High-throughput

0.279

Low

856505

EFNA4
Ephrin-A4

1

0

High-throughput

0.279

Low

871990

AT12A
Potassium-transporting ATPase alpha chain 2

1

0

High-throughput

0.279

Low

941841

RBM6
RNA-binding protein 6

1

0

High-throughput

0.279

Low

944718

MAP1A
Microtubule-associated protein 1A

1

0

High-throughput

0.279

Low

1022359

TSN31
Tetraspanin-31

1

0

High-throughput

0.279

Low

1052052

ELOA1
Elongin-A

1

0

High-throughput

0.279

Low

1056649

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

0

High-throughput

0.279

Low

1075346

TAF1A
TATA box-binding protein-associated factor RNA polymerase I subunit A

1

0

High-throughput

0.279

Low

1101878

HYAL4
Hyaluronidase-4

1

0

High-throughput

0.279

Low

1128565

HABP4
Intracellular hyaluronan-binding protein 4

1

0

High-throughput

0.279

Low

1129807

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

0

High-throughput

0.279

Low

1138163

PR38B
Pre-mRNA-splicing factor 38B

1

0

High-throughput

0.279

Low

1157638

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.279

Low

1183380

DDX46
Probable ATP-dependent RNA helicase DDX46

1

0

High-throughput

0.279

Low

1205009

SPAS2
Spermatogenesis-associated serine-rich protein 2

1

0

High-throughput

0.279

Low

1224755

CA2D3
Voltage-dependent calcium channel subunit alpha-2/delta-3

1

0

High-throughput

0.279

Low

1230772

FXL14
F-box/LRR-repeat protein 14

1

0

High-throughput

0.279

Low

1234284

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

0

High-throughput

0.279

Low

1239295

PR38A
Pre-mRNA-splicing factor 38A

1

0

High-throughput

0.279

Low

1243172

SRFB1
Serum response factor-binding protein 1

1

0

High-throughput

0.279

Low

1250761

RP9
Retinitis pigmentosa 9 protein

1

0

High-throughput

0.279

Low

1255076

DMXL2
DmX-like protein 2

1

0

High-throughput

0.279

Low

1261521

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.279

Low

1286131

LENG1
Leukocyte receptor cluster member 1

1

0

High-throughput

0.279

Low

1286434

CSTOS
Protein CUSTOS

1

0

High-throughput

0.279

Low

1289277

RMXL1
RNA binding motif protein, X-linked-like-1

1

0

High-throughput

0.279

Low

1290275

MITOK
Mitochondrial potassium channel

1

0

High-throughput

0.279

Low

1290351

RRP36
Ribosomal RNA processing protein 36 homolog

1

0

High-throughput

0.279

Low

1293456

CREL1
Protein disulfide isomerase CRELD1

1

0

High-throughput

0.279

Low

1302428

IWS1
Protein IWS1 homolog

1

0

High-throughput

0.279

Low

1306526

S29A1
Equilibrative nucleoside transporter 1

1

0

High-throughput

0.279

Low

1314184

RIOK2
Serine/threonine-protein kinase RIO2

1

0

High-throughput

0.279

Low

1317945

GTPB4
GTP-binding protein 4

1

0

High-throughput

0.279

Low

1318326

RTN4R
Reticulon-4 receptor

1

0

High-throughput

0.279

Low

1327336

LSG1
Large subunit GTPase 1 homolog

1

0

High-throughput

0.279

Low

1329947

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.279

Low

1331866

ESF1
ESF1 homolog

1

0

High-throughput

0.279

Low

1342527

TREM1
Triggering receptor expressed on myeloid cells 1

1

0

High-throughput

0.279

Low

1342647

NRN1
Neuritin

1

0

High-throughput

0.279

Low

1345358

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.279

Low

1346286

DCA13
DDB1- and CUL4-associated factor 13

1

0

High-throughput

0.279

Low

1350467

RBM27
RNA-binding protein 27

1

0

High-throughput

0.279

Low

1354511

ZO2
Tight junction protein ZO-2

1

0

High-throughput

0.279

Low

1377450

WBP11
WW domain-binding protein 11

1

0

High-throughput

0.279

Low

1378042

PCDG3
Protocadherin gamma-A3

1

0

High-throughput

0.279

Low

1378067

UTP18
U3 small nucleolar RNA-associated protein 18 homolog

1

0

High-throughput

0.279

Low

1378193

WNT6
Protein Wnt-6

1

0

High-throughput

0.279

Low

392967

IGF1
Insulin-like growth factor I

1

0

High-throughput

0.269

Low

173327

S22A2
Solute carrier family 22 member 2

1

0

Small-scale

0.251

Low

1283990

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.251

Low

1298741

TMM74
Transmembrane protein 74

1

0

High-throughput

0.251

Low

1314818

YIPF2
Protein YIPF2

1

0

High-throughput

0.251

Low

1327994

FXYD6
FXYD domain-containing ion transport regulator 6

1

0

High-throughput

0.251

Low

1345323

RPRM
Protein reprimo

1

0

High-throughput

0.251

Low

1377669

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.251

Low

206236

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

387820

P53
Cellular tumor antigen p53

1

0

High-throughput

0.249

Low

749998

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.249

Low

882672

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.249

Low

941636

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1087645

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.249

Low

1346097

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

1346226

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

204567

PROM1
Prominin-1

1

0

Small-scale

0.238

Low

1296581

BT2A3
Putative butyrophilin subfamily 2 member A3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024