Protein: TIE2
Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b)

Gene: TIE2, TEK
Organism: Homo sapiens
Interactions: 115
UniProt ID: Q02763

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001666 - response to hypoxia
GO:0001934 - positive regulation of protein phosphorylation
GO:0001935 - endothelial cell proliferation
GO:0001938 - positive regulation of endothelial cell proliferation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

616913

PTPRB
Receptor-type tyrosine-protein phosphatase beta

2

19

Small-scale

0.778

High

666073

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.770

High

168297

ANGP2
Angiopoietin-2

7

6

Small-scale

0.754

High

972329

ANGP1
Angiopoietin-1

6

6

Small-scale

0.733

High

972319

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

High-throughput

0.698

High

972327

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

20

High-throughput

0.698

High

972347

DUS18
Dual specificity protein phosphatase 18

1

19

High-throughput

0.698

High

972350

STYX
Serine/threonine/tyrosine-interacting protein

1

19

High-throughput

0.698

High

972337

SHC4
SHC-transforming protein 4

1

20

Small-scale

0.692

High

592654

RAB6A
Ras-related protein Rab-6A

1

9

High-throughput

0.691

High

647548

MK03
Mitogen-activated protein kinase 3

1

6

High-throughput

0.691

High

441193

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

20

High-throughput

0.647

High

617103

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

17

High-throughput

0.647

High

972315

TIE2
Angiopoietin-1 receptor

1

19

Small-scale

0.647

High

972318

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

20

High-throughput

0.647

High

972322

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

20

High-throughput

0.647

High

972328

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

16

High-throughput

0.647

High

972332

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

17

High-throughput

0.647

High

452395

PGFRB
Platelet-derived growth factor receptor beta

1

20

High-throughput

0.646

High

972361

NUD12
NAD-capped RNA hydrolase NUDT12

1

20

High-throughput

0.646

High

972324

PWP1
Periodic tryptophan protein 1 homolog

1

11

High-throughput

0.618

High

972377

WDR3
WD repeat-containing protein 3

1

3

High-throughput

0.618

High

181846

SOCS1
Suppressor of cytokine signaling 1

1

20

Small-scale

0.618

High

383752

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.618

High

610359

CBL
E3 ubiquitin-protein ligase CBL

1

20

Small-scale

0.618

High

725304

TIE1
Tyrosine-protein kinase receptor Tie-1

1

19

Small-scale

0.618

High

972378

ANGP4
Angiopoietin-4

2

6

Small-scale

0.602

High

235075

DOK2
Docking protein 2

2

20

Small-scale

0.584

High

972316

CAV1
Caveolin-1

1

7

Small-scale

0.561

High

972381

NEMO
NF-kappa-B essential modulator

1

13

High-throughput

0.561

High

972348

TNIP2
TNFAIP3-interacting protein 2

1

0

Small-scale

0.549

High

116818

KIF2A
Kinesin-like protein KIF2A

1

1

High-throughput

0.536

High

207927

XPOT
Exportin-T

1

11

High-throughput

0.536

High

208563

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

5

High-throughput

0.536

High

229370

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

4

High-throughput

0.536

High

311530

SMC2
Structural maintenance of chromosomes protein 2

1

13

High-throughput

0.536

High

571707

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

10

High-throughput

0.536

High

574656

ARF4
ADP-ribosylation factor 4

1

14

High-throughput

0.536

High

588880

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

4

High-throughput

0.536

High

658653

SMCA1
Probable global transcription activator SNF2L1

1

4

High-throughput

0.536

High

783017

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

6

High-throughput

0.536

High

838779

EMD
Emerin

1

11

High-throughput

0.536

High

896419

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

6

High-throughput

0.536

High

944192

PRKDC
DNA-dependent protein kinase catalytic subunit

1

15

High-throughput

0.536

High

972321

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

1

8

High-throughput

0.536

High

972323

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

1

High-throughput

0.536

High

972325

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

6

High-throughput

0.536

High

972335

RIF1
Telomere-associated protein RIF1

1

3

High-throughput

0.536

High

972336

SKI3
Superkiller complex protein 3

1

2

High-throughput

0.536

High

972339

POGZ
Pogo transposable element with ZNF domain

1

6

High-throughput

0.536

High

972340

MYH14
Myosin-14

1

5

High-throughput

0.536

High

972349

DDX54
ATP-dependent RNA helicase DDX54

1

13

High-throughput

0.536

High

972351

DNJC9
DnaJ homolog subfamily C member 9

1

20

High-throughput

0.536

High

972353

RT27
Small ribosomal subunit protein mS27

1

1

High-throughput

0.536

High

972355

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

5

High-throughput

0.536

High

972357

DDX27
Probable ATP-dependent RNA helicase DDX27

1

13

High-throughput

0.536

High

972358

RBM14
RNA-binding protein 14

1

10

High-throughput

0.536

High

972363

GTPB4
GTP-binding protein 4

1

3

High-throughput

0.536

High

972364

NAT10
RNA cytidine acetyltransferase

1

2

High-throughput

0.536

High

972367

YTDC2
3'-5' RNA helicase YTHDC2

1

4

High-throughput

0.536

High

972370

MDN1
Midasin

1

12

High-throughput

0.536

High

972373

ABCF2
ATP-binding cassette sub-family F member 2

1

2

High-throughput

0.536

High

972375

BAZ1B
Tyrosine-protein kinase BAZ1B

1

10

High-throughput

0.536

High

972376

MRT4
mRNA turnover protein 4 homolog

1

5

High-throughput

0.536

High

972379

HYOU1
Hypoxia up-regulated protein 1

1

20

High-throughput

0.536

High

972380

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

2

High-throughput

0.536

High

549003

NQO1
NAD(P)H dehydrogenase [quinone] 1

1

0

High-throughput

0.513

High

972338

KCNT2
Potassium channel subfamily T member 2

1

0

High-throughput

0.513

High

972342

SLN11
Schlafen family member 11

1

0

High-throughput

0.513

High

394569

A4
Amyloid-beta precursor protein

1

11

High-throughput

0.501

High

215130

LANC1
Glutathione S-transferase LANCL1

1

3

High-throughput

0.500

High

260023

TBCA
Tubulin-specific chaperone A

1

1

High-throughput

0.500

High

344485

A2MG
Alpha-2-macroglobulin

1

1

High-throughput

0.500

High

363511

FETUA
Alpha-2-HS-glycoprotein

1

3

High-throughput

0.500

High

417711

G6PI
Glucose-6-phosphate isomerase

1

2

High-throughput

0.500

High

456553

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

4

High-throughput

0.500

High

509637

UBL4A
Ubiquitin-like protein 4A

1

9

High-throughput

0.500

High

637857

PSA3
Proteasome subunit alpha type-3

1

3

High-throughput

0.500

High

671645

PEBP1
Phosphatidylethanolamine-binding protein 1

1

5

High-throughput

0.500

High

803495

BAG6
Large proline-rich protein BAG6

1

8

High-throughput

0.500

High

914736

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

3

High-throughput

0.500

High

972317

LGUL
Lactoylglutathione lyase

1

2

High-throughput

0.500

High

972330

CDC37
Hsp90 co-chaperone Cdc37

1

20

High-throughput

0.500

High

972341

YTHD3
YTH domain-containing family protein 3

1

13

High-throughput

0.500

High

972359

PSB7
Proteasome subunit beta type-7

1

2

High-throughput

0.500

High

972365

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

7

High-throughput

0.494

High

130488

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

7

High-throughput

0.489

High

260851

H2AY
Core histone macro-H2A.1

1

6

High-throughput

0.489

High

315351

NSA2
Ribosome biogenesis protein NSA2 homolog

1

2

High-throughput

0.489

High

398691

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

6

High-throughput

0.489

High

809897

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

4

High-throughput

0.489

High

947039

RT25
Small ribosomal subunit protein mS25

1

2

High-throughput

0.489

High

948550

RT09
Small ribosomal subunit protein uS9m

1

3

High-throughput

0.489

High

972320

SSRP1
FACT complex subunit SSRP1

1

5

High-throughput

0.489

High

972326

RRS1
Ribosome biogenesis regulatory protein homolog

1

2

High-throughput

0.489

High

972333

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

6

High-throughput

0.489

High

972334

ZN326
DBIRD complex subunit ZNF326

1

4

High-throughput

0.489

High

972343

ZCH18
Zinc finger CCCH domain-containing protein 18

1

6

High-throughput

0.489

High

972344

PHF6
PHD finger protein 6

1

9

High-throughput

0.489

High

972345

NUP93
Nuclear pore complex protein Nup93

1

5

High-throughput

0.489

High

972346

KRI1
Protein KRI1 homolog

1

11

High-throughput

0.489

High

972352

ELYS
Protein ELYS

1

10

High-throughput

0.489

High

972354

NU205
Nuclear pore complex protein Nup205

1

8

High-throughput

0.489

High

972360

EBP2
Probable rRNA-processing protein EBP2

1

2

High-throughput

0.489

High

972362

CG050
Uncharacterized protein C7orf50

1

1

High-throughput

0.489

High

972366

CCD86
Coiled-coil domain-containing protein 86

1

2

High-throughput

0.489

High

972368

SAR1A
Small COPII coat GTPase SAR1A

1

15

High-throughput

0.489

High

972369

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

15

High-throughput

0.489

High

972371

RBM28
RNA-binding protein 28

1

8

High-throughput

0.489

High

972372

NOP53
Ribosome biogenesis protein NOP53

1

1

High-throughput

0.489

High

972374

BAZ2A
Bromodomain adjacent to zinc finger domain protein 2A

1

18

High-throughput

0.489

High

337085

HPRT
Hypoxanthine-guanine phosphoribosyltransferase

1

0

High-throughput

0.479

High

972331

CP1B1
Cytochrome P450 1B1

1

2

Small-scale

0.479

High

972356

RM24
Large ribosomal subunit protein uL24m

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024