Protein: PDPK1
3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1)

Gene: PDPK1
Organism: Homo sapiens
Interactions: 192
UniProt ID: O15530

Gene Ontology (top 5):
GO:0003323 - type B pancreatic cell development
GO:0004674 - protein serine/threonine kinase activity
GO:0004676 - 3-phosphoinositide-dependent protein kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

182095

AKT1
RAC-alpha serine/threonine-protein kinase

11

20

Small-scale

0.972

High

182056

PDPK1
3-phosphoinositide-dependent protein kinase 1

6

20

Small-scale

0.941

High

182141

KPCZ
Protein kinase C zeta type

4

20

Small-scale

0.914

High

116945

SGK1
Serine/threonine-protein kinase Sgk1

4

19

Small-scale

0.888

High

182115

KC1D
Casein kinase I isoform delta

3

14

Small-scale

0.853

High

182107

KPCI
Protein kinase C iota type

3

19

Small-scale

0.849

High

182059

ROCK2
Rho-associated protein kinase 2

3

19

High-throughput

0.839

High

182155

SQSTM
Sequestosome-1

3

3

High-throughput

0.839

High

182203

OSBL8
Oxysterol-binding protein-related protein 8

3

2

High-throughput

0.839

High

182116

KC1E
Casein kinase I isoform epsilon

3

17

Small-scale

0.817

High

182167

CDC37
Hsp90 co-chaperone Cdc37

3

10

High-throughput

0.817

High

182166

PKN2
Serine/threonine-protein kinase N2

2

19

Small-scale

0.800

High

182071

KPCB
Protein kinase C beta type

2

19

Small-scale

0.768

High

182106

CSK
Tyrosine-protein kinase CSK

2

17

High-throughput

0.767

High

182180

ZDH17
Palmitoyltransferase ZDHHC17

1

5

High-throughput

0.752

High

182084

KS6B1
Ribosomal protein S6 kinase beta-1

2

19

Small-scale

0.743

High

182133

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

2

2

High-throughput

0.737

High

182196

SRPK1
SRSF protein kinase 1

1

19

High-throughput

0.735

High

182123

WDR5
WD repeat-containing protein 5

5

3

Small-scale

0.727

High

182149

PAK1
Serine/threonine-protein kinase PAK 1

1

19

Small-scale

0.724

High

182139

1433F
14-3-3 protein eta

5

20

Small-scale

0.714

High

182142

KPCD
Protein kinase C delta type

1

19

Small-scale

0.713

High

182165

PKN1
Serine/threonine-protein kinase N1

1

19

Small-scale

0.713

High

182171

PDPK2
Putative 3-phosphoinositide-dependent protein kinase 2

2

18

High-throughput

0.712

High

182170

EGFLA
Pikachurin

1

6

High-throughput

0.691

High

182221

NRBP
Nuclear receptor-binding protein

1

9

High-throughput

0.691

High

182076

HSP7C
Heat shock cognate 71 kDa protein

4

6

High-throughput

0.691

High

182081

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

19

Small-scale

0.680

High

182100

SDC2
Syndecan-2

3

2

High-throughput

0.675

High

182098

1433B
14-3-3 protein beta/alpha

4

20

Small-scale

0.672

High

182125

1433E
14-3-3 protein epsilon

4

13

Small-scale

0.672

High

182127

1433Z
14-3-3 protein zeta/delta

4

20

Small-scale

0.672

High

182088

1433T
14-3-3 protein theta

3

20

Small-scale

0.670

High

182064

MTMR5
Myotubularin-related protein 5

1

1

High-throughput

0.656

High

182120

ZN133
Zinc finger protein 133

1

1

High-throughput

0.656

High

182160

PEA15
Astrocytic phosphoprotein PEA-15

1

2

High-throughput

0.656

High

182228

GIT1
ARF GTPase-activating protein GIT1

1

6

High-throughput

0.656

High

182151

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.656

High

129616

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

3

6

High-throughput

0.650

High

182061

GPC4
Glypican-4

3

3

High-throughput

0.650

High

182073

FGF2
Fibroblast growth factor 2

3

2

High-throughput

0.650

High

182082

SDC1
Syndecan-1

3

2

High-throughput

0.650

High

182094

SDC4
Syndecan-4

3

2

High-throughput

0.650

High

182102

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

3

3

High-throughput

0.650

High

182122

ECHB
Trifunctional enzyme subunit beta, mitochondrial

3

1

High-throughput

0.650

High

182072

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

5

High-throughput

0.647

High

182074

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

11

High-throughput

0.647

High

182085

PTPRB
Receptor-type tyrosine-protein phosphatase beta

1

5

High-throughput

0.647

High

182086

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

5

High-throughput

0.647

High

182112

MK08
Mitogen-activated protein kinase 8

1

20

Small-scale

0.647

High

182117

GSK3B
Glycogen synthase kinase-3 beta

1

20

Small-scale

0.647

High

182147

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

6

High-throughput

0.647

High

182161

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

5

High-throughput

0.647

High

182168

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

6

High-throughput

0.647

High

182234

TBL2
Transducin beta-like protein 2

4

5

High-throughput

0.638

High

182099

1433S
14-3-3 protein sigma

3

20

High-throughput

0.633

High

182124

1433G
14-3-3 protein gamma

3

20

High-throughput

0.633

High

182190

GSLG1
Golgi apparatus protein 1

3

0

High-throughput

0.622

High

182057

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

7

Small-scale

0.618

High

182060

ULK1
Serine/threonine-protein kinase ULK1

1

19

Small-scale

0.618

High

182093

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

20

High-throughput

0.618

High

182096

AKT2
RAC-beta serine/threonine-protein kinase

1

20

Small-scale

0.618

High

182119

KS6A3
Ribosomal protein S6 kinase alpha-3

1

19

Small-scale

0.618

High

182135

KPCE
Protein kinase C epsilon type

1

19

Small-scale

0.618

High

182138

KPCT
Protein kinase C theta type

1

19

Small-scale

0.618

High

182153

ILK
Integrin-linked protein kinase

1

10

Small-scale

0.618

High

182154

SNTB2
Beta-2-syntrophin

1

4

High-throughput

0.618

High

182174

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.618

High

182178

RASF3
Ras association domain-containing protein 3

1

1

High-throughput

0.618

High

182210

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.618

High

182214

INCE
Inner centromere protein

1

9

High-throughput

0.618

High

182092

KAIN
Kallistatin

3

1

High-throughput

0.609

High

182201

CAR11
Caspase recruitment domain-containing protein 11

2

5

Small-scale

0.600

High

182065

APBB3
Amyloid-beta A4 precursor protein-binding family B member 3

2

2

High-throughput

0.594

High

182105

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

3

1

High-throughput

0.593

High

182058

SPOP
Speckle-type POZ protein

1

3

Small-scale

0.578

High

182075

BIP
Endoplasmic reticulum chaperone BiP

2

11

High-throughput

0.571

High

182078

PLAK
Junction plakoglobin

2

6

High-throughput

0.571

High

182079

CD44
CD44 antigen

2

2

High-throughput

0.571

High

182080

HSP76
Heat shock 70 kDa protein 6

2

8

High-throughput

0.571

High

182087

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

4

High-throughput

0.571

High

182101

HSP74
Heat shock 70 kDa protein 4

2

16

High-throughput

0.571

High

182104

GRP75
Stress-70 protein, mitochondrial

2

20

High-throughput

0.571

High

182114

IQGA1
Ras GTPase-activating-like protein IQGAP1

2

5

High-throughput

0.571

High

182129

RL38
Large ribosomal subunit protein eL38

2

1

High-throughput

0.571

High

182136

AKA12
A-kinase anchor protein 12

2

2

High-throughput

0.571

High

182144

DHX9
ATP-dependent RNA helicase A

2

2

High-throughput

0.571

High

182148

CAF1B
Chromatin assembly factor 1 subunit B

2

3

High-throughput

0.571

High

182152

MTA1
Metastasis-associated protein MTA1

2

1

High-throughput

0.571

High

182158

FLNC
Filamin-C

2

3

High-throughput

0.571

High

182159

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

1

High-throughput

0.571

High

182185

TBC15
TBC1 domain family member 15

2

3

High-throughput

0.571

High

182186

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

2

1

High-throughput

0.571

High

182188

HS105
Heat shock protein 105 kDa

2

17

High-throughput

0.571

High

182191

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

6

High-throughput

0.571

High

182192

LRC59
Leucine-rich repeat-containing protein 59

2

3

High-throughput

0.571

High

182195

SNX18
Sorting nexin-18

2

3

High-throughput

0.571

High

182204

DDX24
ATP-dependent RNA helicase DDX24

2

13

High-throughput

0.571

High

182219

CAMP3
Calmodulin-regulated spectrin-associated protein 3

2

1

High-throughput

0.571

High

182130

UBC9
SUMO-conjugating enzyme UBC9

1

5

Small-scale

0.561

High

182183

PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

1

2

Small-scale

0.561

High

181276

ARPC5
Actin-related protein 2/3 complex subunit 5

2

0

High-throughput

0.547

High

182110

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

2

0

High-throughput

0.547

High

182131

GTF2I
General transcription factor II-I

2

0

High-throughput

0.547

High

182145

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

0

High-throughput

0.547

High

182172

CAVN1
Caveolae-associated protein 1

2

0

High-throughput

0.547

High

182198

S29A1
Equilibrative nucleoside transporter 1

2

0

High-throughput

0.547

High

182199

TCF25
Ribosome quality control complex subunit TCF25

2

0

High-throughput

0.547

High

182132

ADA17
Disintegrin and metalloproteinase domain-containing protein 17

1

2

Small-scale

0.536

High

155208

NRP1
Neuropilin-1

1

3

High-throughput

0.536

High

182066

BAG2
BAG family molecular chaperone regulator 2

1

3

High-throughput

0.536

High

182091

TPP2
Tripeptidyl-peptidase 2

1

2

High-throughput

0.536

High

182109

CASP3
Caspase-3

1

6

High-throughput

0.536

High

182118

GPC3
Glypican-3

1

3

High-throughput

0.536

High

182137

TGBR3
Transforming growth factor beta receptor type 3

1

1

High-throughput

0.536

High

182162

RBBP5
Retinoblastoma-binding protein 5

1

4

High-throughput

0.536

High

182169

FAXC
Failed axon connections homolog

1

1

High-throughput

0.536

High

182175

SND1
Staphylococcal nuclease domain-containing protein 1

1

6

High-throughput

0.536

High

182182

TEFF1
Tomoregulin-1

1

2

High-throughput

0.536

High

182224

PA2G4
Proliferation-associated protein 2G4

1

3

High-throughput

0.536

High

182233

NRX3A
Neurexin-3

1

4

High-throughput

0.536

High

182237

GPC6
Glypican-6 [Cleaved into: Secreted glypican-6]

1

3

High-throughput

0.536

High

182083

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

2

3

High-throughput

0.521

High

182097

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

2

3

High-throughput

0.521

High

182213

GRPE1
GrpE protein homolog 1, mitochondrial

2

1

High-throughput

0.521

High

182063

PRS23
Serine protease 23

1

0

High-throughput

0.518

High

182134

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

3

Small-scale

0.515

High

182111

HD
Huntingtin

1

5

High-throughput

0.515

High

182121

ATX3
Ataxin-3

1

2

High-throughput

0.515

High

182187

JPH3
Junctophilin-3

1

1

High-throughput

0.515

High

179129

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.513

High

182163

CDSN
Corneodesmosin

1

0

High-throughput

0.513

High

182189

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

147364

SOCS3
Suppressor of cytokine signaling 3

1

20

High-throughput

0.508

High

182077

XRCC6
X-ray repair cross-complementing protein 6

1

2

High-throughput

0.508

High

182146

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

High-throughput

0.508

High

182217

DDIT4
DNA damage-inducible transcript 4 protein

1

1

High-throughput

0.508

High

182223

XPO7
Exportin-7

1

10

High-throughput

0.508

High

182070

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.501

High

182140

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

10

High-throughput

0.501

High

182156

CUL3
Cullin-3

1

6

Small-scale

0.501

High

182226

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

8

High-throughput

0.501

High

182069

FETUA
Alpha-2-HS-glycoprotein

1

1

High-throughput

0.489

High

174253

TELT
Telethonin

1

0

High-throughput

0.486

High

182157

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.486

High

182177

ZC3C1
Zinc finger C3HC-type protein 1

1

0

High-throughput

0.486

High

182184

PXL2B
Prostamide/prostaglandin F synthase

1

0

High-throughput

0.486

High

182205

KTBL1
KATNB1-like protein 1

1

0

High-throughput

0.486

High

182212

PHAX
Phosphorylated adapter RNA export protein

1

0

High-throughput

0.486

High

182216

PNO1
RNA-binding protein PNO1

1

0

High-throughput

0.486

High

182227

PDIP2
Polymerase delta-interacting protein 2

1

0

High-throughput

0.486

High

162217

XPO1
Exportin-1

1

10

High-throughput

0.479

High

182062

DFFB
DNA fragmentation factor subunit beta

1

1

High-throughput

0.479

High

182089

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

182090

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

7

Small-scale

0.479

High

182113

UTRN
Utrophin

1

2

High-throughput

0.479

High

182126

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

4

Small-scale

0.479

High

182128

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

3

High-throughput

0.479

High

182164

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

9

Small-scale

0.479

High

182193

Q96BE0
Heat shock cognate 71 kDa protein

1

7

High-throughput

0.479

High

182208

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

1

Small-scale

0.479

High

182220

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

182232

STRAP
Serine-threonine kinase receptor-associated protein

1

5

Small-scale

0.479

High

182235

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

9

Small-scale

0.479

High

182179

TCAM2
TIR domain-containing adapter molecule 2

1

0

High-throughput

0.458

High

182202

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.458

High

182206

ATG5
Autophagy protein 5

1

0

Small-scale

0.458

High

182209

SENP3
Sentrin-specific protease 3

1

0

Small-scale

0.458

High

182108

MTOR
Serine/threonine-protein kinase mTOR

1

18

Small-scale

0.457

High

182068

IGHG1
Immunoglobulin heavy constant gamma 1

1

5

High-throughput

0.445

High

182143

B2CL1
Bcl-2-like protein 1

1

3

Small-scale

0.445

High

182150

CBLB
E3 ubiquitin-protein ligase CBL-B

1

7

Small-scale

0.445

High

182181

CDAN1
Codanin-1

1

0

High-throughput

0.438

High

182207

PININ
Pinin

1

0

High-throughput

0.438

High

182215

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

182067

COX2
Cytochrome c oxidase subunit 2

1

1

Small-scale

0.437

High

182103

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

182225

PLAK2
PALM2-AKAP2 fusion protein

1

2

High-throughput

0.437

High

182231

TMED7
Transmembrane emp24 domain-containing protein 7

1

1

High-throughput

0.407

High

182222

CBPA4
Carboxypeptidase A4

3

0

High-throughput

0.347

High

182229

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

3

0

High-throughput

0.330

High

182173

F199X
Protein FAM199X

2

0

High-throughput

0.318

High

127415

RPOM
DNA-directed RNA polymerase, mitochondrial

2

0

High-throughput

0.298

High

182218

T161A
Transmembrane protein 161A

2

0

High-throughput

0.298

High

182236

TF3C5
General transcription factor 3C polypeptide 5

2

0

High-throughput

0.298

High

182176

HS2ST
Heparan sulfate 2-O-sulfotransferase 1

1

0

High-throughput

0.279

Low

182194

SCRN2
Secernin-2

1

0

High-throughput

0.279

Low

182197

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.279

Low

182200

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.279

Low

182211

WDCP
WD repeat and coiled-coil-containing protein

1

0

High-throughput

0.265

Low

182230

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.265

Low


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Last updated: 15 Jul 2024