Protein: SYVC
Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS)

Gene: SYVC, VARS1
Organism: Homo sapiens
Interactions: 167
UniProt ID: P26640

Gene Ontology (top 5):
GO:0002161 - aminoacyl-tRNA editing activity
GO:0004832 - valine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006418 - tRNA aminoacylation for protein translation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

643809

EF1G
Elongation factor 1-gamma

6

3

Small-scale

0.945

High

345335

FOS
Protein c-Fos

4

11

High-throughput

0.699

High

643813

EF1D
Elongation factor 1-delta

4

7

Small-scale

0.691

High

643815

COR1A
Coronin-1A

3

6

High-throughput

0.667

High

643842

EF1A1
Elongation factor 1-alpha 1

3

7

Small-scale

0.662

High

322209

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

3

5

High-throughput

0.640

High

643897

ABTB1
Ankyrin repeat and BTB/POZ domain-containing protein 1

2

2

High-throughput

0.628

High

643924

SYLC
Leucine--tRNA ligase, cytoplasmic

1

6

High-throughput

0.618

High

643849

EF1A2
Elongation factor 1-alpha 2

3

7

High-throughput

0.613

High

643860

CUL3
Cullin-3

2

7

High-throughput

0.611

High

548284

FOSL2
Fos-related antigen 2

3

5

High-throughput

0.609

High

643927

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

2

2

High-throughput

0.606

High

226577

PRKN
E3 ubiquitin-protein ligase parkin

2

10

High-throughput

0.584

High

643880

RICTR
Rapamycin-insensitive companion of mTOR

2

3

High-throughput

0.584

High

643926

ZRAN1
Ubiquitin thioesterase ZRANB1

2

5

High-throughput

0.584

High

643829

AF17
Protein AF-17

2

1

High-throughput

0.574

High

643856

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

4

High-throughput

0.573

High

369020

ESR1
Estrogen receptor

2

8

High-throughput

0.571

High

411603

LCK
Tyrosine-protein kinase Lck

2

4

High-throughput

0.571

High

412027

FYN
Tyrosine-protein kinase Fyn

2

4

High-throughput

0.571

High

548862

NDKA
Nucleoside diphosphate kinase A

2

3

High-throughput

0.571

High

566291

KPCA
Protein kinase C alpha type

2

5

High-throughput

0.571

High

592108

RAB5A
Ras-related protein Rab-5A

2

1

High-throughput

0.571

High

643846

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

2

7

High-throughput

0.571

High

643848

PTN12
Tyrosine-protein phosphatase non-receptor type 12

2

2

High-throughput

0.571

High

643865

KPCD1
Serine/threonine-protein kinase D1

2

6

High-throughput

0.571

High

643870

DUS6
Dual specificity protein phosphatase 6

2

3

High-throughput

0.571

High

643889

SLX4
Structure-specific endonuclease subunit SLX4

2

1

High-throughput

0.571

High

235047

DOK2
Docking protein 2

2

0

High-throughput

0.547

High

431554

HS90A
Heat shock protein HSP 90-alpha

1

9

High-throughput

0.536

High

643852

FOXC1
Forkhead box protein C1

1

18

High-throughput

0.536

High

643866

MK11
Mitogen-activated protein kinase 11

1

7

High-throughput

0.536

High

643868

PKN2
Serine/threonine-protein kinase N2

1

9

High-throughput

0.536

High

643874

BOREA
Borealin

1

1

High-throughput

0.536

High

643885

HAKAI
E3 ubiquitin-protein ligase Hakai

1

2

Small-scale

0.536

High

643904

ATGA1
Autophagy-related protein 101

1

1

High-throughput

0.536

High

643916

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

1

9

High-throughput

0.536

High

643920

BET1L
BET1-like protein

1

2

High-throughput

0.536

High

345978

MYC
Myc proto-oncogene protein

2

4

High-throughput

0.533

High

581450

VCAM1
Vascular cell adhesion protein 1

2

4

High-throughput

0.521

High

643826

CAV2
Caveolin-2

2

2

High-throughput

0.521

High

643855

DUS4
Dual specificity protein phosphatase 4

2

3

High-throughput

0.521

High

643903

SH3G3
Endophilin-A3

2

1

High-throughput

0.521

High

505556

EPB41
Protein 4.1

1

2

High-throughput

0.515

High

585629

TFE3
Transcription factor E3

1

1

High-throughput

0.515

High

643820

CCNF
Cyclin-F

1

4

High-throughput

0.515

High

643900

OTUD5
OTU domain-containing protein 5

1

2

High-throughput

0.515

High

643930

TRAF6
TNF receptor-associated factor 6

1

10

High-throughput

0.515

High

643858

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

2

High-throughput

0.515

High

643832

CF298
Cilia- and flagella-associated protein 298

1

0

High-throughput

0.513

High

643869

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.513

High

643894

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

0

High-throughput

0.513

High

643915

PDLI7
PDZ and LIM domain protein 7

1

0

High-throughput

0.513

High

401453

JUN
Transcription factor Jun

1

11

High-throughput

0.506

High

643810

1433T
14-3-3 protein theta

1

11

High-throughput

0.501

High

643835

CDC42
Cell division control protein 42 homolog

1

6

High-throughput

0.501

High

643895

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

5

High-throughput

0.501

High

643896

KPBB
Phosphorylase b kinase regulatory subunit beta

1

0

High-throughput

0.493

High

126431

FOXE1
Forkhead box protein E1

1

14

High-throughput

0.489

High

175955

FOXN1
Forkhead box protein N1

1

18

High-throughput

0.489

High

270764

FOXH1
Forkhead box protein H1

1

19

High-throughput

0.489

High

548225

FOSL1
Fos-related antigen 1

1

7

High-throughput

0.489

High

643821

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.489

High

643827

CEBPG
CCAAT/enhancer-binding protein gamma

1

13

High-throughput

0.489

High

643830

FOXG1
Forkhead box protein G1

1

15

High-throughput

0.489

High

643831

FOXA1
Hepatocyte nuclear factor 3-alpha

1

17

High-throughput

0.489

High

643833

FOXL2
Forkhead box protein L2

1

15

High-throughput

0.489

High

643853

FOXI1
Forkhead box protein I1

1

15

High-throughput

0.489

High

643854

FOXL1
Forkhead box protein L1

1

15

High-throughput

0.489

High

643882

FOXI2
Forkhead box protein I2

1

14

High-throughput

0.489

High

643899

ERP27
Endoplasmic reticulum resident protein 27

1

1

High-throughput

0.489

High

643902

FOXB1
Forkhead box protein B1

1

20

High-throughput

0.489

High

643908

FOXQ1
Forkhead box protein Q1

1

20

High-throughput

0.489

High

116971

SGK1
Serine/threonine-protein kinase Sgk1

1

6

High-throughput

0.479

High

135372

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

3

High-throughput

0.479

High

267903

EED
Polycomb protein EED

1

13

High-throughput

0.479

High

337965

EGFR
Epidermal growth factor receptor

1

9

High-throughput

0.479

High

373710

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.479

High

384304

NTRK1
High affinity nerve growth factor receptor

1

8

High-throughput

0.479

High

503476

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

617435

CRCM
Colorectal mutant cancer protein

1

2

High-throughput

0.479

High

625128

CDK2
Cyclin-dependent kinase 2

1

4

High-throughput

0.479

High

643812

SHC1
SHC-transforming protein 1

1

7

High-throughput

0.479

High

643816

STIP1
Stress-induced-phosphoprotein 1

1

5

High-throughput

0.479

High

643819

VHL
von Hippel-Lindau disease tumor suppressor

1

1

High-throughput

0.479

High

643825

CDK9
Cyclin-dependent kinase 9

1

7

High-throughput

0.479

High

643828

ATX3
Ataxin-3

1

3

High-throughput

0.479

High

643836

UBC12
NEDD8-conjugating enzyme Ubc12

1

3

High-throughput

0.479

High

643839

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

643841

1433Z
14-3-3 protein zeta/delta

1

11

High-throughput

0.479

High

643843

RED1
Double-stranded RNA-specific editase 1

1

5

High-throughput

0.479

High

643845

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

6

High-throughput

0.479

High

643851

EP300
Histone acetyltransferase p300

1

6

High-throughput

0.479

High

643857

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

643863

TNIP1
TNFAIP3-interacting protein 1

1

15

High-throughput

0.479

High

643864

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

7

High-throughput

0.479

High

643873

LARP7
La-related protein 7

1

4

High-throughput

0.479

High

643878

VIR
Protein virilizer homolog

1

3

High-throughput

0.479

High

643890

POC5
Centrosomal protein POC5

1

1

High-throughput

0.479

High

643893

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

643898

ARMC5
Armadillo repeat-containing protein 5

1

3

High-throughput

0.479

High

643906

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

11

High-throughput

0.479

High

643910

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

643914

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

643917

FBX6
F-box only protein 6

1

2

High-throughput

0.479

High

643919

MTMR4
Myotubularin-related protein 4

1

2

High-throughput

0.479

High

643923

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

3

High-throughput

0.479

High

643931

NEMO
NF-kappa-B essential modulator

1

8

High-throughput

0.479

High

643850

DMWD
Dystrophia myotonica WD repeat-containing protein

1

10

High-throughput

0.470

High

132291

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

2

High-throughput

0.464

High

643822

MTR1A
Melatonin receptor type 1A

1

2

High-throughput

0.464

High

643814

MPIP3
M-phase inducer phosphatase 3

1

0

High-throughput

0.458

High

643891

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

643921

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

643837

SUMO2
Small ubiquitin-related modifier 2

1

5

High-throughput

0.457

High

643892

JDP2
Jun dimerization protein 2

1

5

Small-scale

0.457

High

496350

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

587429

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

6

High-throughput

0.445

High

623066

EF1B
Elongation factor 1-beta

1

6

Small-scale

0.445

High

643859

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

2

High-throughput

0.445

High

643909

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

8

High-throughput

0.445

High

643928

ITM2B
Integral membrane protein 2B

1

5

High-throughput

0.445

High

500724

CLUS
Clusterin

1

0

High-throughput

0.438

High

302932

HEXI1
Protein HEXIM1

1

2

High-throughput

0.437

High

354301

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.437

High

362841

FINC
Fibronectin

1

6

High-throughput

0.437

High

391556

H2A1B
Histone H2A type 1-B/E

1

2

High-throughput

0.437

High

530441

ITA4
Integrin alpha-4

1

2

High-throughput

0.437

High

551994

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.437

High

569222

CEBPB
CCAAT/enhancer-binding protein beta

1

9

High-throughput

0.437

High

643811

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

643817

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

643818

BRCA1
Breast cancer type 1 susceptibility protein

1

6

High-throughput

0.437

High

643823

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.437

High

643838

WDR5
WD repeat-containing protein 5

1

7

High-throughput

0.437

High

643840

H4
Histone H4

1

2

High-throughput

0.437

High

643847

CREM
cAMP-responsive element modulator

1

1

Small-scale

0.437

High

643861

RBM39
RNA-binding protein 39

1

2

High-throughput

0.437

High

643862

SART3
Squamous cell carcinoma antigen recognized by T-cells 3

1

2

Small-scale

0.437

High

643867

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

643872

ANR55
Ankyrin repeat domain-containing protein 55

1

4

High-throughput

0.437

High

643876

OTUD1
OTU domain-containing protein 1

1

2

High-throughput

0.437

High

643877

TENS2
Tensin-2

1

3

High-throughput

0.437

High

643879

PRP8
Pre-mRNA-processing-splicing factor 8

1

3

High-throughput

0.437

High

643881

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

643883

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.437

High

643884

MOB3C
MOB kinase activator 3C

1

2

High-throughput

0.437

High

643886

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

643888

ASXL1
Polycomb group protein ASXL1

1

2

High-throughput

0.437

High

643905

DERL1
Derlin-1

1

1

Small-scale

0.437

High

643907

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.437

High

643911

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.437

High

643912

WDR76
WD repeat-containing protein 76

1

13

High-throughput

0.437

High

643913

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

2

High-throughput

0.437

High

643918

PIHD1
PIH1 domain-containing protein 1

1

3

High-throughput

0.437

High

643922

DAPLE
Protein Daple

1

4

High-throughput

0.437

High

643925

TR10D
Tumor necrosis factor receptor superfamily member 10D

1

1

High-throughput

0.437

High

643929

AAR2
Protein AAR2 homolog

1

3

High-throughput

0.437

High

643824

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

High-throughput

0.373

High

551074

ITF2
Transcription factor 4

1

0

High-throughput

0.279

Low

643871

INSY1
Inhibitory synaptic factor 1

1

0

High-throughput

0.279

Low

165816

KDM6B
Lysine-specific demethylase 6B

1

0

Small-scale

0.249

Low

643844

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

643875

RC3H1
Roquin-1

1

0

High-throughput

0.249

Low

643887

HDGR2
Hepatoma-derived growth factor-related protein 2

1

0

High-throughput

0.249

Low

643834

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low

643901

ZBT18
Zinc finger and BTB domain-containing protein 18

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024