Protein: SOCS2
Suppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2)

Gene: SOCS2
Organism: Homo sapiens
Interactions: 94
UniProt ID: O14508

Gene Ontology (top 5):
GO:0001558 - regulation of cell growth
GO:0005131 - growth hormone receptor binding
GO:0005159 - insulin-like growth factor receptor binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

146642

CUL5
Cullin-5

12

20

Small-scale

0.981

High

146630

ELOC
Elongin-C

7

10

Small-scale

0.960

High

146586

GHR
Growth hormone receptor

6

20

Small-scale

0.937

High

146583

IGF1R
Insulin-like growth factor 1 receptor

2

20

Small-scale

0.815

High

146592

EPOR
Erythropoietin receptor

4

20

Small-scale

0.803

High

146582

YES
Tyrosine-protein kinase Yes

2

19

High-throughput

0.783

High

146570

SOCS1
Suppressor of cytokine signaling 1

2

20

Small-scale

0.754

High

146631

ELOB
Elongin-B

6

11

Small-scale

0.722

High

146627

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.713

High

146585

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

146607

CRK
Adapter molecule crk

1

20

High-throughput

0.665

High

146609

STA5B
Signal transducer and activator of transcription 5B

1

20

High-throughput

0.665

High

146577

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.647

High

146593

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

146629

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

146622

FAK1
Focal adhesion kinase 1

1

20

High-throughput

0.621

High

146584

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.619

High

146565

SOCS3
Suppressor of cytokine signaling 3

1

20

Small-scale

0.618

High

146579

NTRK1
High affinity nerve growth factor receptor

1

20

Small-scale

0.618

High

146580

LCK
Tyrosine-protein kinase Lck

1

19

Small-scale

0.618

High

146591

IL7RA
Interleukin-7 receptor subunit alpha

1

4

Small-scale

0.618

High

146598

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

Small-scale

0.618

High

146605

MTOR
Serine/threonine-protein kinase mTOR

1

12

Small-scale

0.618

High

146625

CUL4A
Cullin-4A

1

20

High-throughput

0.618

High

146632

NTRK2
BDNF/NT-3 growth factors receptor

1

20

Small-scale

0.618

High

146650

RBX2
RING-box protein 2

2

9

Small-scale

0.611

High

146575

STK16
Serine/threonine-protein kinase 16

2

14

High-throughput

0.606

High

146646

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

2

6

High-throughput

0.601

High

146597

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.595

High

146635

CACL1
CDK2-associated and cullin domain-containing protein 1

1

20

High-throughput

0.595

High

146603

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

20

Small-scale

0.553

High

146600

BMI1
Polycomb complex protein BMI-1

1

10

High-throughput

0.541

High

146594

JAK1
Tyrosine-protein kinase JAK1

1

20

Small-scale

0.527

High

146610

JAK3
Tyrosine-protein kinase JAK3

1

20

Small-scale

0.527

High

146578

PA21B
Phospholipase A2

1

0

High-throughput

0.518

High

117060

DX39A
ATP-dependent RNA helicase DDX39A

1

5

High-throughput

0.515

High

121890

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

2

High-throughput

0.515

High

146566

IRS4
Insulin receptor substrate 4

1

20

High-throughput

0.515

High

146568

BACH1
Transcription regulator protein BACH1

1

5

High-throughput

0.515

High

146572

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

20

High-throughput

0.515

High

146576

IPO7
Importin-7

1

3

High-throughput

0.515

High

146589

EZRI
Ezrin

1

20

High-throughput

0.515

High

146596

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

5

High-throughput

0.515

High

146599

CTNB1
Catenin beta-1

1

11

High-throughput

0.515

High

146611

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

1

High-throughput

0.515

High

146615

CSN2
COP9 signalosome complex subunit 2

1

2

High-throughput

0.515

High

146617

RS11
Small ribosomal subunit protein uS17

1

1

High-throughput

0.515

High

146618

RAB1A
Ras-related protein Rab-1A

1

7

High-throughput

0.515

High

146619

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

2

High-throughput

0.515

High

146623

EF1A2
Elongation factor 1-alpha 2

1

3

High-throughput

0.515

High

146626

TTL12
Tubulin--tyrosine ligase-like protein 12

1

1

High-throughput

0.515

High

146638

WDTC1
WD and tetratricopeptide repeats protein 1

1

12

High-throughput

0.515

High

146641

RBP56
TATA-binding protein-associated factor 2N

1

5

High-throughput

0.515

High

146644

DCNL5
DCN1-like protein 5

1

3

High-throughput

0.515

High

146645

NADAP
Kanadaptin

1

3

High-throughput

0.515

High

146653

CSN3
COP9 signalosome complex subunit 3

1

2

High-throughput

0.515

High

146655

RRP44
Exosome complex exonuclease RRP44

1

1

High-throughput

0.515

High

146604

VHL
von Hippel-Lindau disease tumor suppressor

1

2

High-throughput

0.515

High

146634

HIKES
Protein Hikeshi

1

0

High-throughput

0.513

High

146569

PPM1G
Protein phosphatase 1G

1

0

High-throughput

0.493

High

146571

OGA
Protein O-GlcNAcase

1

0

High-throughput

0.493

High

146581

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.493

High

146588

GLNA
Glutamine synthetase

1

0

High-throughput

0.493

High

146601

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

0

High-throughput

0.493

High

146602

VATE1
V-type proton ATPase subunit E 1

1

0

High-throughput

0.493

High

146608

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

0

High-throughput

0.493

High

146640

KNL1
Kinetochore scaffold 1

1

0

High-throughput

0.493

High

146612

ARFP2
Arfaptin-2

1

2

High-throughput

0.481

High

146613

TPD52
Tumor protein D52

1

1

High-throughput

0.481

High

146637

RYBP
RING1 and YY1-binding protein

1

1

Small-scale

0.481

High

146590

PRLR
Prolactin receptor

1

20

Small-scale

0.479

High

146624

SQSTM
Sequestosome-1

1

4

Small-scale

0.479

High

146628

STK38
Serine/threonine-protein kinase 38

1

20

Small-scale

0.479

High

146636

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

20

Small-scale

0.479

High

146647

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

4

Small-scale

0.479

High

146567

SCAM3
Secretory carrier-associated membrane protein 3

1

3

High-throughput

0.470

High

146574

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.470

High

146587

ADT3
ADP/ATP translocase 3

1

3

High-throughput

0.470

High

146621

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

11

High-throughput

0.470

High

146633

SHRM1
Protein Shroom1

1

3

High-throughput

0.470

High

146643

KCD12
BTB/POZ domain-containing protein KCTD12

1

7

High-throughput

0.470

High

146648

GCP60
Golgi resident protein GCP60

1

1

High-throughput

0.470

High

146649

RTN4
Reticulon-4

1

9

High-throughput

0.470

High

146651

DIC
Mitochondrial dicarboxylate carrier

1

9

High-throughput

0.470

High

146652

NWD2
NACHT and WD repeat domain-containing protein 2

1

5

High-throughput

0.470

High

146656

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

1

High-throughput

0.470

High

146573

H2AY
Core histone macro-H2A.1

1

3

Small-scale

0.437

High

146595

CCNC
Cyclin-C

1

8

Small-scale

0.437

High

146654

XCT
Cystine/glutamate transporter

1

5

Small-scale

0.437

High

146606

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.269

Low

146616

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

0

High-throughput

0.269

Low

146620

SPT4H
Transcription elongation factor SPT4

1

0

High-throughput

0.269

Low

146639

UBAC2
Ubiquitin-associated domain-containing protein 2

1

0

High-throughput

0.269

Low

146614

CTBP2
C-terminal-binding protein 2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024