Protein: COX2
Cytochrome c oxidase subunit 2 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide II)

Gene: COX2, MT-CO2
Organism: Homo sapiens
Interactions: 144
UniProt ID: P00403

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0004129 - cytochrome-c oxidase activity
GO:0005507 - copper ion binding
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

335769

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

3

1

High-throughput

0.847

High

335642

COX1
Cytochrome c oxidase subunit 1

1

1

Small-scale

0.618

High

324973

AIFM1
Apoptosis-inducing factor 1, mitochondrial

3

0

High-throughput

0.616

High

335881

COA3
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial

3

0

Small-scale

0.606

High

335764

COX6C
Cytochrome c oxidase subunit 6C

1

0

High-throughput

0.586

High

335826

COA6
Cytochrome c oxidase assembly factor 6 homolog

1

0

Small-scale

0.586

High

226193

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

335755

EGFR
Epidermal growth factor receptor

2

0

Small-scale

0.582

High

335759

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

335876

NLGN3
Neuroligin-3

1

0

Small-scale

0.568

High

335871

SFXN1
Sideroflexin-1

2

0

High-throughput

0.559

High

335775

VDAC1
Voltage-dependent anion-selective channel protein 1

1

1

High-throughput

0.536

High

335756

MYC
Myc proto-oncogene protein

2

3

High-throughput

0.533

High

335767

RALB
Ras-related protein Ral-B

2

2

High-throughput

0.521

High

335801

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.518

High

335768

CX6A1
Cytochrome c oxidase subunit 6A1, mitochondrial

1

0

High-throughput

0.513

High

335772

COX7C
Cytochrome c oxidase subunit 7C, mitochondrial

1

0

High-throughput

0.513

High

335777

CX7A1
Cytochrome c oxidase subunit 7A1, mitochondrial

1

0

High-throughput

0.513

High

335788

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.513

High

335813

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.513

High

335795

NRAM2
Natural resistance-associated macrophage protein 2

1

0

Small-scale

0.506

High

335860

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

3

High-throughput

0.494

High

335804

HTRA4
Serine protease HTRA4

1

1

High-throughput

0.489

High

335798

RIDA
2-iminobutanoate/2-iminopropanoate deaminase

1

1

High-throughput

0.481

High

215410

SCO2
Protein SCO2 homolog, mitochondrial

1

2

Small-scale

0.479

High

335780

STOM
Stomatin

1

5

High-throughput

0.479

High

335786

PHB1
Prohibitin 1

1

4

High-throughput

0.479

High

335789

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.479

High

335807

MPPA
Mitochondrial-processing peptidase subunit alpha

1

3

High-throughput

0.479

High

335817

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

335819

SURF1
Surfeit locus protein 1

1

1

High-throughput

0.479

High

335838

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.479

High

335841

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.479

High

335843

MCU
Calcium uniporter protein, mitochondrial

1

1

High-throughput

0.479

High

335844

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

335847

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

335851

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

335852

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

1

Small-scale

0.479

High

335863

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

335864

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

1

High-throughput

0.479

High

335869

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

1

High-throughput

0.479

High

335874

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

1

High-throughput

0.479

High

335877

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

224252

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.460

High

335790

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.460

High

117327

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.458

High

274467

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

0

High-throughput

0.458

High

327329

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

335757

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

335760

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

335766

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.458

High

335773

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

0

High-throughput

0.458

High

335781

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

335784

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.458

High

335791

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

335806

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

335808

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.458

High

335811

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

335815

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

335818

PDK1
[Pyruvate dehydrogenase

1

0

Small-scale

0.458

High

335827

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

Small-scale

0.458

High

335830

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

0

High-throughput

0.458

High

335834

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

335839

NELFD
Negative elongation factor C/D

1

0

High-throughput

0.458

High

335846

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.458

High

335848

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.458

High

335850

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

335854

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

335855

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

335857

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

335861

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

335873

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

335875

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

335878

COX16
Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial

1

0

Small-scale

0.458

High

316767

KLF8
Krueppel-like factor 8

1

1

High-throughput

0.457

High

335858

KLF16
Krueppel-like factor 16

1

1

High-throughput

0.457

High

335765

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

335776

USF1
Upstream stimulatory factor 1

1

3

High-throughput

0.445

High

335799

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

335880

ITM2B
Integral membrane protein 2B

1

2

High-throughput

0.445

High

182067

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

1

Small-scale

0.437

High

196252

PJA2
E3 ubiquitin-protein ligase Praja-2

1

1

Small-scale

0.437

High

301512

TRI37
E3 ubiquitin-protein ligase TRIM37

1

1

High-throughput

0.437

High

335761

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.437

High

335794

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

335805

VIGLN
Vigilin

1

1

High-throughput

0.437

High

335822

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.437

High

335823

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

1

High-throughput

0.437

High

335833

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

335859

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.437

High

335862

RHBT2
Rho-related BTB domain-containing protein 2

1

1

High-throughput

0.437

High

335866

Q9H4D1
Protein kinase

1

1

High-throughput

0.437

High

335883

TRAF6
TNF receptor-associated factor 6

1

1

High-throughput

0.437

High

335770

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

335810

CUL3
Cullin-3

1

0

High-throughput

0.426

High

335840

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.426

High

335865

S38A1
Sodium-coupled neutral amino acid symporter 1

1

0

High-throughput

0.426

High

335763

ELNE
Neutrophil elastase

1

1

Small-scale

0.417

High

335845

HTRA1
Serine protease HTRA1

1

1

Small-scale

0.417

High

335774

TFEB
Transcription factor EB

1

1

High-throughput

0.407

High

335783

RXRB
Retinoic acid receptor RXR-beta

1

2

High-throughput

0.407

High

335793

HD
Huntingtin

1

1

High-throughput

0.407

High

335800

RHOA
Transforming protein RhoA

2

0

High-throughput

0.298

High

335758

FINC
Fibronectin

1

0

High-throughput

0.279

Low

335785

CNR2
Cannabinoid receptor 2

1

0

Small-scale

0.279

Low

335849

FAF2
FAS-associated factor 2

1

0

High-throughput

0.279

Low

335853

GORS1
Golgi reassembly-stacking protein 1

1

0

High-throughput

0.279

Low

335872

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

0

High-throughput

0.279

Low

335821

HSPB2
Heat shock protein beta-2

1

0

High-throughput

0.265

Low

335779

PSA1
Proteasome subunit alpha type-1

1

0

High-throughput

0.251

Low

335796

DNLI4
DNA ligase 4

1

0

High-throughput

0.251

Low

335870

ECT2
Protein ECT2

1

0

High-throughput

0.251

Low

119063

LEG9
Galectin-9

1

0

High-throughput

0.249

Low

209571

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.249

Low

243766

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

335771

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

335778

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.249

Low

335782

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

335787

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

335792

BCL6
B-cell lymphoma 6 protein

1

0

High-throughput

0.249

Low

335797

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

High-throughput

0.249

Low

335802

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

335803

RED1
Double-stranded RNA-specific editase 1

1

0

High-throughput

0.249

Low

335809

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

335812

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.249

Low

335814

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

335816

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

335820

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

335824

MIDN
Midnolin

1

0

High-throughput

0.249

Low

335825

TM41B
Transmembrane protein 41B

1

0

High-throughput

0.249

Low

335828

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

335829

ZN746
Zinc finger protein 746

1

0

High-throughput

0.249

Low

335831

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.249

Low

335832

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

335835

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

335836

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

0

High-throughput

0.249

Low

335837

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.249

Low

335856

DUS23
Dual specificity protein phosphatase 23

1

0

High-throughput

0.249

Low

335867

ANTR1
Anthrax toxin receptor 1

1

0

Small-scale

0.249

Low

335868

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.249

Low

335879

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

335882

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

335762

JUN
Transcription factor Jun

1

0

High-throughput

0.232

Low

335842

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024