Protein: PRDX6
Peroxiredoxin-6 (EC 1.11.1.27) (1-Cys peroxiredoxin) (1-Cys PRX) (24 kDa protein) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.4) (Antioxidant protein 2) (Glutathione-dependent peroxiredoxin) (Liver 2D page spot 40) (Lysophosphatidylcholine acyltransferase 5) (LPC acyltransferase 5) (LPCAT-5) (Lyso-PC acyltransferase 5) (EC 2.3.1.23) (Non-selenium glutathione peroxidase) (NSGPx) (Red blood cells page spot 12)

Gene: PRDX6
Organism: Homo sapiens
Interactions: 180
UniProt ID: P30041

Gene Ontology (top 5):
GO:0004602 - glutathione peroxidase activity
GO:0004623 - phospholipase A2 activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

670664

PRDX6
Peroxiredoxin-6

3

14

Small-scale

0.829

High

528615

CFTR
Cystic fibrosis transmembrane conductance regulator

3

4

High-throughput

0.662

High

496383

TAU
Microtubule-associated protein tau

3

7

High-throughput

0.650

High

226611

PRKN
E3 ubiquitin-protein ligase parkin

3

14

Small-scale

0.640

High

329403

AGR2
Anterior gradient protein 2 homolog

2

5

Small-scale

0.601

High

517077

PCNA
Proliferating cell nuclear antigen

2

2

Small-scale

0.596

High

322228

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

1

High-throughput

0.584

High

346021

MYC
Myc proto-oncogene protein

2

9

High-throughput

0.584

High

503505

HSP7C
Heat shock cognate 71 kDa protein

2

3

Small-scale

0.584

High

625148

CDK2
Cyclin-dependent kinase 2

2

9

High-throughput

0.584

High

670674

YAP1
Transcriptional coactivator YAP1

2

10

High-throughput

0.584

High

670746

CASPA
Caspase-10

1

1

Small-scale

0.582

High

670676

PSMD8
26S proteasome non-ATPase regulatory subunit 8

2

0

High-throughput

0.580

High

670708

CASP8
Caspase-8

1

1

Small-scale

0.573

High

548865

NDKA
Nucleoside diphosphate kinase A

2

3

High-throughput

0.571

High

581464

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.571

High

670679

TERF1
Telomeric repeat-binding factor 1

1

4

High-throughput

0.568

High

670688

1433E
14-3-3 protein epsilon

1

1

Small-scale

0.561

High

652754

APEX1
DNA repair nuclease/redox regulator APEX1

2

0

Small-scale

0.559

High

452638

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

7

High-throughput

0.554

High

601139

VDAC1
Voltage-dependent anion-selective channel protein 1

1

1

High-throughput

0.554

High

670725

COX15
Heme A synthase COX15

1

3

High-throughput

0.554

High

587796

NCF2
Neutrophil cytosol factor 2

1

2

Small-scale

0.552

High

670732

STH
Saitohin

1

0

Small-scale

0.549

High

128458

DNM1L
Dynamin-1-like protein

1

3

High-throughput

0.536

High

201231

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

3

High-throughput

0.536

High

336378

SODC
Superoxide dismutase [Cu-Zn]

1

3

High-throughput

0.536

High

362857

FINC
Fibronectin

1

4

High-throughput

0.536

High

555311

H2AX
Histone H2AX

1

4

High-throughput

0.536

High

670668

SOAT1
Sterol O-acyltransferase 1

1

1

High-throughput

0.536

High

670693

KPCZ
Protein kinase C zeta type

1

4

High-throughput

0.536

High

670702

CUL1
Cullin-1

1

18

High-throughput

0.536

High

670712

MYLK
Myosin light chain kinase, smooth muscle

1

2

High-throughput

0.536

High

670730

CDKL3
Cyclin-dependent kinase-like 3

1

12

High-throughput

0.536

High

670738

PPTC7
Protein phosphatase PTC7 homolog

1

1

High-throughput

0.536

High

670739

RIN3
Ras and Rab interactor 3

1

3

High-throughput

0.536

High

670741

NEK7
Serine/threonine-protein kinase Nek7

1

8

High-throughput

0.536

High

670747

SGK3
Serine/threonine-protein kinase Sgk3

1

5

High-throughput

0.536

High

670753

PARK7
Parkinson disease protein 7

1

4

High-throughput

0.536

High

670754

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

6

High-throughput

0.536

High

670768

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.518

High

359687

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.513

High

670740

PHOP1
Phosphoethanolamine/phosphocholine phosphatase

1

0

High-throughput

0.513

High

670758

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.513

High

670772

RCAN3
Calcipressin-3

1

0

High-throughput

0.513

High

448295

GSTP1
Glutathione S-transferase P

1

2

Small-scale

0.501

High

658802

MK01
Mitogen-activated protein kinase 1

1

5

Small-scale

0.501

High

670685

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.501

High

670731

SFTA1
Pulmonary surfactant-associated protein A1

1

2

Small-scale

0.501

High

670778

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

9

Small-scale

0.501

High

670766

ARFG3
ADP-ribosylation factor GTPase-activating protein 3

1

0

High-throughput

0.493

High

670729

MYLK4
Myosin light chain kinase family member 4

1

1

High-throughput

0.489

High

487909

RARA
Retinoic acid receptor alpha

1

12

High-throughput

0.481

High

611378

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

13

High-throughput

0.481

High

670669

GPX4
Phospholipid hydroperoxide glutathione peroxidase GPX4

1

1

High-throughput

0.481

High

670692

PPARD
Peroxisome proliferator-activated receptor delta

1

7

High-throughput

0.481

High

670707

HNF4G
Hepatocyte nuclear factor 4-gamma

1

11

High-throughput

0.481

High

670723

PAXI1
PAX-interacting protein 1

1

2

High-throughput

0.481

High

119190

LEG9
Galectin-9

1

6

High-throughput

0.479

High

148428

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.479

High

241983

PAGE4
P antigen family member 4

1

1

High-throughput

0.479

High

243987

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

294417

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

298190

UFL1
E3 UFM1-protein ligase 1

1

4

High-throughput

0.479

High

326459

SNAI1
Zinc finger protein SNAI1

1

2

High-throughput

0.479

High

351949

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

3

High-throughput

0.479

High

369049

ESR1
Estrogen receptor

1

16

High-throughput

0.479

High

373744

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

379047

MYCN
N-myc proto-oncogene protein

1

9

High-throughput

0.479

High

381813

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

4

High-throughput

0.479

High

386164

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

393058

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

High-throughput

0.479

High

397803

ISG15
Ubiquitin-like protein ISG15

1

11

Small-scale

0.479

High

417968

NPM
Nucleophosmin

1

1

High-throughput

0.479

High

450735

F16P1
Fructose-1,6-bisphosphatase 1

1

2

High-throughput

0.479

High

455125

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

475376

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

10

Small-scale

0.479

High

521747

CADH1
Cadherin-1

1

1

High-throughput

0.479

High

530447

ITA4
Integrin alpha-4

1

5

High-throughput

0.479

High

547451

FOLR1
Folate receptor alpha

1

2

High-throughput

0.479

High

552019

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

562517

IL7RA
Interleukin-7 receptor subunit alpha

1

2

High-throughput

0.479

High

569248

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

591746

RAB4A
Ras-related protein Rab-4A

1

4

High-throughput

0.479

High

650445

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

670665

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

670666

PHB1
Prohibitin 1

1

3

High-throughput

0.479

High

670670

MDHM
Malate dehydrogenase, mitochondrial

1

5

High-throughput

0.479

High

670671

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

670672

BCL6
B-cell lymphoma 6 protein

1

2

High-throughput

0.479

High

670675

SOX2
Transcription factor SOX-2

1

8

High-throughput

0.479

High

670678

CDK7
Cyclin-dependent kinase 7

1

9

High-throughput

0.479

High

670680

CTBP2
C-terminal-binding protein 2

1

4

High-throughput

0.479

High

670684

UBC12
NEDD8-conjugating enzyme Ubc12

1

5

High-throughput

0.479

High

670686

WDR5
WD repeat-containing protein 5

1

7

High-throughput

0.479

High

670687

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

670689

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.479

High

670690

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.479

High

670691

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

13

High-throughput

0.479

High

670694

FOXO1
Forkhead box protein O1

1

4

High-throughput

0.479

High

670695

TFCP2
Alpha-globin transcription factor CP2

1

2

High-throughput

0.479

High

670697

DUS4
Dual specificity protein phosphatase 4

1

3

High-throughput

0.479

High

670698

RFA4
Replication protein A 30 kDa subunit

1

5

High-throughput

0.479

High

670699

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.479

High

670701

BIRC3
Baculoviral IAP repeat-containing protein 3

1

10

High-throughput

0.479

High

670703

CUL3
Cullin-3

1

18

High-throughput

0.479

High

670704

CUL4A
Cullin-4A

1

18

High-throughput

0.479

High

670705

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

1

High-throughput

0.479

High

670706

TRI14
Tripartite motif-containing protein 14

1

4

High-throughput

0.479

High

670709

CUL7
Cullin-7

1

3

High-throughput

0.479

High

670710

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

670711

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

670714

EZH2
Histone-lysine N-methyltransferase EZH2

1

5

High-throughput

0.479

High

670715

E2F4
Transcription factor E2F4

1

1

High-throughput

0.479

High

670716

EMC4
ER membrane protein complex subunit 4

1

1

High-throughput

0.479

High

670717

TET5C
Terminal nucleotidyltransferase 5C

1

1

High-throughput

0.479

High

670718

VIR
Protein virilizer homolog

1

3

High-throughput

0.479

High

670719

PRP8
Pre-mRNA-processing-splicing factor 8

1

4

High-throughput

0.479

High

670720

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

670722

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.479

High

670726

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

7

High-throughput

0.479

High

670727

ZN598
E3 ubiquitin-protein ligase ZNF598

1

4

High-throughput

0.479

High

670728

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

670735

EMC1
ER membrane protein complex subunit 1

1

2

High-throughput

0.479

High

670736

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

670737

RN149
E3 ubiquitin-protein ligase RNF149

1

6

High-throughput

0.479

High

670742

NUDC2
NudC domain-containing protein 2

1

1

High-throughput

0.479

High

670743

ASB12
Ankyrin repeat and SOCS box protein 12

1

4

High-throughput

0.479

High

670744

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

9

High-throughput

0.479

High

670745

ESR2
Estrogen receptor beta

1

16

High-throughput

0.479

High

670748

CHM4C
Charged multivesicular body protein 4c

1

5

High-throughput

0.479

High

670750

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.479

High

670752

CIC
Protein capicua homolog

1

8

High-throughput

0.479

High

670755

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.479

High

670756

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

6

High-throughput

0.479

High

670757

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

670759

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

High-throughput

0.479

High

670761

WWTR1
WW domain-containing transcription regulator protein 1

1

8

High-throughput

0.479

High

670764

Q9H4D1
Protein kinase

1

5

High-throughput

0.479

High

670765

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.479

High

670767

PIHD1
PIH1 domain-containing protein 1

1

4

High-throughput

0.479

High

670769

HDAC6
Histone deacetylase 6

1

8

High-throughput

0.479

High

670770

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

670771

DS13B
Dual specificity protein phosphatase 13B

1

3

High-throughput

0.479

High

670773

HDAC5
Histone deacetylase 5

1

8

High-throughput

0.479

High

670774

RUVB1
RuvB-like 1

1

2

High-throughput

0.479

High

670776

TRAF6
TNF receptor-associated factor 6

1

7

Small-scale

0.479

High

670777

ASB3
Ankyrin repeat and SOCS box protein 3

1

5

High-throughput

0.479

High

586096

A1AG2
Alpha-1-acid glycoprotein 2

1

0

High-throughput

0.460

High

117355

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.458

High

231848

MARH6
E3 ubiquitin-protein ligase MARCHF6

1

0

High-throughput

0.458

High

314238

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

Small-scale

0.458

High

456808

FURIN
Furin

1

0

High-throughput

0.458

High

670713

MSMO1
Methylsterol monooxygenase 1

1

0

High-throughput

0.458

High

173846

MK13
Mitogen-activated protein kinase 13

1

10

Small-scale

0.445

High

230582

KATIP
Katanin-interacting protein

1

1

High-throughput

0.445

High

401480

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

670673

RAD52
DNA repair protein RAD52 homolog

1

2

Small-scale

0.445

High

670681

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

2

High-throughput

0.445

High

670682

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

5

High-throughput

0.445

High

670683

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.445

High

670700

CTBP1
C-terminal-binding protein 1

1

4

High-throughput

0.445

High

670734

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.445

High

670749

OTUB1
Ubiquitin thioesterase OTUB1

1

2

High-throughput

0.445

High

670751

CEP63
Centrosomal protein of 63 kDa

1

6

High-throughput

0.445

High

670762

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

20

High-throughput

0.445

High

670763

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

20

High-throughput

0.445

High

416358

S10A9
Protein S100-A9

1

0

Small-scale

0.438

High

225540

PCDH7
Protocadherin-7

1

2

High-throughput

0.437

High

384337

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

670667

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

670677

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.437

High

670696

ZBT17
Zinc finger and BTB domain-containing protein 17

1

1

Small-scale

0.437

High

670724

ASXL2
Putative Polycomb group protein ASXL2

1

10

High-throughput

0.437

High

670733

ASXL1
Polycomb group protein ASXL1

1

9

High-throughput

0.437

High

670760

ASXL3
Putative Polycomb group protein ASXL3

1

10

High-throughput

0.437

High

670775

AAR2
Protein AAR2 homolog

1

4

High-throughput

0.437

High

397642

IPSP
Plasma serine protease inhibitor

1

0

Small-scale

0.426

High

670721

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

2

High-throughput

0.407

High


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024