Protein: ACON
Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase)

Gene: ACON, ACO2
Organism: Homo sapiens
Interactions: 149
UniProt ID: Q99798

Gene Ontology (top 5):
GO:0001889 - liver development
GO:0003994 - aconitate hydratase activity
GO:0005506 - iron ion binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1086747

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

3

0

Small-scale

0.613

High

228483

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

431032

SYEP
Bifunctional glutamate/proline--tRNA ligase

2

0

High-throughput

0.559

High

874159

PSMD4
26S proteasome non-ATPase regulatory subunit 4

2

0

Small-scale

0.559

High

1064070

TNIP1
TNFAIP3-interacting protein 1

2

0

High-throughput

0.559

High

581838

VCAM1
Vascular cell adhesion protein 1

2

1

High-throughput

0.549

High

497500

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.536

High

1218930

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.530

High

336586

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

395575

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

894355

CDC42
Cell division control protein 42 homolog

1

2

High-throughput

0.501

High

1306479

TCIM
Transcriptional and immune response regulator

1

0

High-throughput

0.493

High

387382

P53
Cellular tumor antigen p53

1

0

High-throughput

0.479

High

153767

ANM5
Protein arginine N-methyltransferase 5

1

2

High-throughput

0.479

High

211234

BUB3
Mitotic checkpoint protein BUB3

1

1

High-throughput

0.479

High

262931

CISY
Citrate synthase, mitochondrial

1

2

High-throughput

0.479

High

428386

TBB5
Tubulin beta chain

1

1

High-throughput

0.479

High

440689

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

3

High-throughput

0.479

High

500045

CH60
60 kDa heat shock protein, mitochondrial

1

4

High-throughput

0.479

High

502472

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.479

High

504641

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

516664

PABP1
Polyadenylate-binding protein 1

1

2

High-throughput

0.479

High

596237

NEBU
Nebulin

1

1

High-throughput

0.479

High

616484

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

618158

COF1
Cofilin-1

1

1

High-throughput

0.479

High

631225

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

637036

ATPA
ATP synthase subunit alpha, mitochondrial

1

3

High-throughput

0.479

High

655453

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

3

High-throughput

0.479

High

674970

PUR8
Adenylosuccinate lyase

1

1

High-throughput

0.479

High

682953

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

1

High-throughput

0.479

High

685756

PRDX2
Peroxiredoxin-2

1

2

High-throughput

0.479

High

713591

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

1

High-throughput

0.479

High

717305

CTNB1
Catenin beta-1

1

3

High-throughput

0.479

High

751796

GRP75
Stress-70 protein, mitochondrial

1

11

High-throughput

0.479

High

757733

IF4A3
Eukaryotic initiation factor 4A-III

1

2

High-throughput

0.479

High

777694

MDHM
Malate dehydrogenase, mitochondrial

1

3

High-throughput

0.479

High

806983

RS9
Small ribosomal subunit protein uS4

1

1

High-throughput

0.479

High

822503

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

1

High-throughput

0.479

High

874574

XPO2
Exportin-2

1

1

High-throughput

0.479

High

893136

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

906576

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

1

High-throughput

0.479

High

907734

RS15A
Small ribosomal subunit protein uS8

1

2

High-throughput

0.479

High

910542

RS14
Small ribosomal subunit protein uS11

1

2

High-throughput

0.479

High

916335

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

919491

RL23
Large ribosomal subunit protein uL14

1

1

High-throughput

0.479

High

921037

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

1

High-throughput

0.479

High

922335

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.479

High

924127

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

3

High-throughput

0.479

High

929631

RACK1
Small ribosomal subunit protein RACK1

1

1

High-throughput

0.479

High

929983

ACTG
Actin, cytoplasmic 2

1

2

High-throughput

0.479

High

959287

S25A3
Solute carrier family 25 member 3

1

1

High-throughput

0.479

High

963403

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

2

High-throughput

0.479

High

965555

HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

1

1

High-throughput

0.479

High

989375

PRDX1
Peroxiredoxin-1

1

2

High-throughput

0.479

High

1020531

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

5

High-throughput

0.479

High

1032146

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

1

High-throughput

0.479

High

1146777

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

1192185

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

1267737

HS105
Heat shock protein 105 kDa

1

5

High-throughput

0.479

High

1273209

TNPO1
Transportin-1

1

1

High-throughput

0.479

High

1288761

ASB9
Ankyrin repeat and SOCS box protein 9

1

2

High-throughput

0.479

High

1306484

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1306485

NFU1
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial

1

4

High-throughput

0.479

High

1306488

RUVB2
RuvB-like 2

1

4

High-throughput

0.479

High

1306489

RUVB1
RuvB-like 1

1

4

High-throughput

0.479

High

1306490

FND3A
Fibronectin type-III domain-containing protein 3A

1

1

High-throughput

0.479

High

117442

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.458

High

323990

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.458

High

360332

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

378566

OAT
Ornithine aminotransferase, mitochondrial

1

0

High-throughput

0.458

High

417762

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

523965

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

541411

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

550921

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

573439

TCPA
T-complex protein 1 subunit alpha

1

0

High-throughput

0.458

High

653353

PYR1
Multifunctional protein CAD

1

0

High-throughput

0.458

High

670854

PRDX5
Peroxiredoxin-5, mitochondrial

1

0

High-throughput

0.458

High

671321

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.458

High

678388

GDIA
Rab GDP dissociation inhibitor alpha

1

0

High-throughput

0.458

High

799333

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

806136

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.458

High

807220

RS5
Small ribosomal subunit protein uS7

1

0

High-throughput

0.458

High

813707

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

828011

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

839078

EMD
Emerin

1

0

High-throughput

0.458

High

875255

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

881008

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.458

High

891591

MYL6
Myosin light polypeptide 6

1

0

High-throughput

0.458

High

909008

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

910915

RS18
Small ribosomal subunit protein uS13

1

0

High-throughput

0.458

High

911229

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

911488

RS11
Small ribosomal subunit protein uS17

1

0

High-throughput

0.458

High

915058

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

High-throughput

0.458

High

920306

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

920686

RS26
Small ribosomal subunit protein eS26

1

0

High-throughput

0.458

High

921949

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.458

High

923173

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.458

High

1036007

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1066584

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1068053

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1071982

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.458

High

1088609

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

1222215

YAF2
YY1-associated factor 2

1

0

High-throughput

0.458

High

1244674

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1306478

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

1306480

OLA1
Obg-like ATPase 1

1

0

High-throughput

0.458

High

1306482

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.458

High

473558

ATX1L
Ataxin-1-like

1

1

High-throughput

0.439

High

153943

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

2

High-throughput

0.437

High

195529

DHX15
ATP-dependent RNA helicase DHX15

1

1

High-throughput

0.437

High

211650

ACTN4
Alpha-actinin-4

1

2

High-throughput

0.437

High

329915

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

385416

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

564660

RHOQ
Rho-related GTP-binding protein RhoQ

1

2

High-throughput

0.437

High

652066

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

902735

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.437

High

935166

H31
Histone H3.1

1

1

High-throughput

0.437

High

1037365

TBB3
Tubulin beta-3 chain

1

1

High-throughput

0.437

High

1046149

DX39B
Spliceosome RNA helicase DDX39B

1

3

High-throughput

0.437

High

1054537

RBM39
RNA-binding protein 39

1

2

High-throughput

0.437

High

1171408

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1231319

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.437

High

1306477

Q9H4D1
Protein kinase

1

2

High-throughput

0.437

High

883619

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.407

High

1306483

C5AR2
C5a anaphylatoxin chemotactic receptor 2

1

0

High-throughput

0.282

High

338898

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.279

Low

1255584

NEK7
Serine/threonine-protein kinase Nek7

1

0

High-throughput

0.279

Low

1306476

KDM4C
Lysine-specific demethylase 4C

1

0

High-throughput

0.279

Low

347705

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

530732

ITA4
Integrin alpha-4

1

0

High-throughput

0.249

Low

553535

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

654699

CALX
Calnexin

1

0

High-throughput

0.249

Low

721261

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

781432

BCL6
B-cell lymphoma 6 protein

1

0

High-throughput

0.249

Low

786100

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.249

Low

824310

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

903464

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

1080274

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

1139115

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.249

Low

1146440

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

1

0

High-throughput

0.249

Low

1271346

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.249

Low

1306473

ERP44
Endoplasmic reticulum resident protein 44

1

0

High-throughput

0.249

Low

1306474

API5
Apoptosis inhibitor 5

1

0

High-throughput

0.249

Low

1306481

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low

1306486

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

High-throughput

0.249

Low

1306487

SRRM2
Serine/arginine repetitive matrix protein 2

1

0

High-throughput

0.249

Low

1306491

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.249

Low

776382

MLH1
DNA mismatch repair protein Mlh1

1

0

Small-scale

0.238

Low

1306475

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024