Protein: E2F3
Transcription factor E2F3 (E2F-3)

Gene: E2F3
Organism: Homo sapiens
Interactions: 130
UniProt ID: O00716

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

135199

RB
Retinoblastoma-associated protein

9

20

Small-scale

0.968

High

135247

TFDP1
Transcription factor Dp-1

4

20

Small-scale

0.890

High

135248

TFDP2
Transcription factor Dp-2

3

20

High-throughput

0.861

High

135260

TFDP3
Transcription factor Dp family member 3

3

20

High-throughput

0.861

High

135214

RBL1
Retinoblastoma-like protein 1

2

20

Small-scale

0.754

High

135241

E2F1
Transcription factor E2F1

2

14

High-throughput

0.754

High

135222

CCNF
Cyclin-F

2

16

Small-scale

0.620

High

135191

E2F6
Transcription factor E2F6

1

18

High-throughput

0.618

High

135251

E2F2
Transcription factor E2F2

1

14

High-throughput

0.618

High

135255

E2F5
Transcription factor E2F5

1

14

High-throughput

0.618

High

135258

E2F4
Transcription factor E2F4

1

14

High-throughput

0.618

High

135203

MYBB
Myb-related protein B

2

6

Small-scale

0.586

High

135274

CBP
CREB-binding protein

2

11

Small-scale

0.586

High

135208

TFE3
Transcription factor E3

1

3

Small-scale

0.573

High

135201

PARP1
Poly [ADP-ribose] polymerase 1

2

5

Small-scale

0.571

High

135292

HELLS
Lymphoid-specific helicase

1

9

Small-scale

0.569

High

135264

ATAD2
ATPase family AAA domain-containing protein 2

1

3

Small-scale

0.561

High

135303

FZR1
Fizzy-related protein homolog

1

4

Small-scale

0.561

High

135230

HCFC1
Host cell factor 1

1

3

Small-scale

0.552

High

135271

RYBP
RING1 and YY1-binding protein

1

4

Small-scale

0.552

High

135223

BCL6
B-cell lymphoma 6 protein

1

1

Small-scale

0.536

High

135233

RCAN1
Calcipressin-1

1

0

High-throughput

0.518

High

135301

DNM3L
DNA

1

4

Small-scale

0.501

High

135310

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

3

Small-scale

0.501

High

135242

SPIB
Transcription factor Spi-B

1

8

Small-scale

0.481

High

135250

FHL2
Four and a half LIM domains protein 2

1

5

Small-scale

0.481

High

135267

MGAP
MAX gene-associated protein

1

3

Small-scale

0.481

High

135278

TEAD3
Transcriptional enhancer factor TEF-5

1

2

Small-scale

0.481

High

135284

IPKB
cAMP-dependent protein kinase inhibitor beta

1

1

Small-scale

0.481

High

135287

WNK1
Serine/threonine-protein kinase WNK1

1

1

Small-scale

0.481

High

135290

SRA1
Steroid receptor RNA activator 1

1

0

Small-scale

0.480

High

135183

KMT2D
Histone-lysine N-methyltransferase 2D

1

12

Small-scale

0.479

High

135192

MYC
Myc proto-oncogene protein

1

11

High-throughput

0.479

High

135196

P53
Cellular tumor antigen p53

1

3

High-throughput

0.479

High

135205

CCNB1
G2/mitotic-specific cyclin-B1

1

9

Small-scale

0.479

High

135209

USF1
Upstream stimulatory factor 1

1

7

Small-scale

0.479

High

135215

PML
Protein PML

1

6

Small-scale

0.479

High

135216

MCM4
DNA replication licensing factor MCM4

1

3

Small-scale

0.479

High

135238

H31
Histone H3.1

1

3

High-throughput

0.479

High

135239

H33
Histone H3.3

1

3

High-throughput

0.479

High

135245

TIF1B
Transcription intermediary factor 1-beta

1

6

Small-scale

0.479

High

135246

HDAC1
Histone deacetylase 1

1

6

Small-scale

0.479

High

135276

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

10

Small-scale

0.479

High

135277

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

13

Small-scale

0.479

High

135283

PCGF6
Polycomb group RING finger protein 6

1

15

High-throughput

0.479

High

135285

BRD8
Bromodomain-containing protein 8

1

14

Small-scale

0.479

High

135306

PA2G4
Proliferation-associated protein 2G4

1

3

Small-scale

0.479

High

135204

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.458

High

135256

VPS72
Vacuolar protein sorting-associated protein 72 homolog

1

0

Small-scale

0.458

High

135281

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

117505

MYO1C
Unconventional myosin-Ic

1

2

Small-scale

0.445

High

135184

TCRG1
Transcription elongation regulator 1

1

2

Small-scale

0.445

High

135187

AKAP8
A-kinase anchor protein 8

1

2

Small-scale

0.445

High

135188

KDM1A
Lysine-specific histone demethylase 1A

1

6

Small-scale

0.445

High

135189

ZBED4
Zinc finger BED domain-containing protein 4

1

1

Small-scale

0.445

High

135190

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

1

Small-scale

0.445

High

135206

ACADS
Short-chain specific acyl-CoA dehydrogenase, mitochondrial

1

2

Small-scale

0.445

High

135210

RS3
Small ribosomal subunit protein uS3

1

1

Small-scale

0.445

High

135213

SMCA1
Probable global transcription activator SNF2L1

1

5

Small-scale

0.445

High

135218

K1C9
Keratin, type I cytoskeletal 9

1

1

Small-scale

0.445

High

135219

TRI23
E3 ubiquitin-protein ligase TRIM23

1

1

Small-scale

0.445

High

135220

GRP75
Stress-70 protein, mitochondrial

1

1

Small-scale

0.445

High

135224

MATR3
Matrin-3

1

3

Small-scale

0.445

High

135225

MSH2
DNA mismatch repair protein Msh2

1

1

Small-scale

0.445

High

135231

MSH6
DNA mismatch repair protein Msh6

1

1

Small-scale

0.445

High

135232

NUP98
Nuclear pore complex protein Nup98-Nup96

1

2

Small-scale

0.445

High

135240

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

2

Small-scale

0.445

High

135243

CEBPZ
CCAAT/enhancer-binding protein zeta

1

1

Small-scale

0.445

High

135244

DHX9
ATP-dependent RNA helicase A

1

2

Small-scale

0.445

High

135249

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

1

Small-scale

0.445

High

135252

LBR
Delta(14)-sterol reductase LBR

1

1

Small-scale

0.445

High

135253

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

3

Small-scale

0.445

High

135254

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

Small-scale

0.445

High

135259

DDB1
DNA damage-binding protein 1

1

4

Small-scale

0.445

High

135288

DHX33
ATP-dependent RNA helicase DHX33

1

1

Small-scale

0.445

High

135291

TF7L2
Transcription factor 7-like 2

1

7

Small-scale

0.445

High

135297

DIC
Mitochondrial dicarboxylate carrier

1

2

Small-scale

0.445

High

135299

SMBT1
Scm-like with four MBT domains protein 1

1

13

Small-scale

0.445

High

135300

DDX41
Probable ATP-dependent RNA helicase DDX41

1

1

Small-scale

0.445

High

135304

NOTC3
Neurogenic locus notch homolog protein 3

1

1

Small-scale

0.445

High

135228

R144A
E3 ubiquitin-protein ligase RNF144A

1

3

Small-scale

0.439

High

135200

CFAH
Complement factor H

1

1

Small-scale

0.437

High

135211

TNR6
Tumor necrosis factor receptor superfamily member 6

1

1

High-throughput

0.437

High

135266

MIB1
E3 ubiquitin-protein ligase MIB1

1

4

High-throughput

0.437

High

135193

K1C14
Keratin, type I cytoskeletal 14

1

0

Small-scale

0.426

High

135194

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

Small-scale

0.426

High

135195

K2C1
Keratin, type II cytoskeletal 1

1

0

Small-scale

0.426

High

135198

ITB1
Integrin beta-1

1

0

Small-scale

0.426

High

135207

HSP76
Heat shock 70 kDa protein 6

1

0

Small-scale

0.426

High

135237

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

0

Small-scale

0.426

High

135261

INT3
Integrator complex subunit 3

1

0

Small-scale

0.426

High

135263

INT5
Integrator complex subunit 5

1

0

Small-scale

0.426

High

135265

RS27L
Ribosomal protein eS27-like

1

0

Small-scale

0.426

High

135273

NPL4
Nuclear protein localization protein 4 homolog

1

0

Small-scale

0.426

High

135279

CND3
Condensin complex subunit 3

1

0

Small-scale

0.426

High

135295

TECR
Very-long-chain enoyl-CoA reductase

1

0

Small-scale

0.426

High

135302

INT6
Integrator complex subunit 6

1

0

Small-scale

0.426

High

135307

ZN148
Zinc finger protein 148

1

0

Small-scale

0.426

High

135186

MYO1B
Unconventional myosin-Ib

1

2

Small-scale

0.407

High

135197

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

Small-scale

0.407

High

135217

CTNA1
Catenin alpha-1

1

1

Small-scale

0.407

High

135226

GPDM
Glycerol-3-phosphate dehydrogenase, mitochondrial

1

1

Small-scale

0.407

High

135229

RAB13
Ras-related protein Rab-13

1

1

Small-scale

0.407

High

135268

MIRO2
Mitochondrial Rho GTPase 2

1

3

Small-scale

0.407

High

135269

MIRO1
Mitochondrial Rho GTPase 1

1

3

Small-scale

0.407

High

135282

GTPB2
GTP-binding protein 2

1

2

Small-scale

0.407

High

135294

ATD3A
ATPase family AAA domain-containing protein 3A

1

1

Small-scale

0.407

High

135296

DHCR7
7-dehydrocholesterol reductase

1

1

Small-scale

0.407

High

135309

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

1

Small-scale

0.407

High

135311

PCLO
Protein piccolo

1

4

Small-scale

0.407

High

135305

SSRG
Translocon-associated protein subunit gamma

1

0

High-throughput

0.269

Low

135185

MOT4
Monocarboxylate transporter 4

1

0

Small-scale

0.232

Low

135202

PPBI
Intestinal-type alkaline phosphatase

1

0

Small-scale

0.232

Low

135212

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

0

Small-scale

0.232

Low

135221

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

Small-scale

0.232

Low

135227

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

0

Small-scale

0.232

Low

135234

DPOG1
DNA polymerase subunit gamma-1

1

0

Small-scale

0.232

Low

135235

TMM33
Transmembrane protein 33

1

0

Small-scale

0.232

Low

135236

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

0

Small-scale

0.232

Low

135257

ENOX2
Ecto-NOX disulfide-thiol exchanger 2

1

0

Small-scale

0.232

Low

135262

S27A4
Long-chain fatty acid transport protein 4

1

0

Small-scale

0.232

Low

135270

AGRF5
Adhesion G protein-coupled receptor F5

1

0

Small-scale

0.232

Low

135272

DOCK8
Dedicator of cytokinesis protein 8

1

0

Small-scale

0.232

Low

135275

PMM1
Phosphomannomutase 1

1

0

Small-scale

0.232

Low

135280

RT63
Large ribosomal subunit protein mL63

1

0

Small-scale

0.232

Low

135286

RBNS5
Rabenosyn-5

1

0

Small-scale

0.232

Low

135289

GPAT1
Glycerol-3-phosphate acyltransferase 1, mitochondrial

1

0

Small-scale

0.232

Low

135293

PLCE
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

1

0

Small-scale

0.232

Low

135298

SUN2
SUN domain-containing protein 2

1

0

Small-scale

0.232

Low

135308

CCDC9
Coiled-coil domain-containing protein 9

1

0

Small-scale

0.232

Low


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Last updated: 15 Jul 2024