Protein: MPIP3
M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C)

Gene: MPIP3, CDC25C
Organism: Homo sapiens
Interactions: 148
UniProt ID: P30307

Gene Ontology (top 5):
GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0004721 - phosphoprotein phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

154138

CHK1
Serine/threonine-protein kinase Chk1

17

3

Small-scale

0.988

High

331223

CHK2
Serine/threonine-protein kinase Chk2

13

4

Small-scale

0.981

High

673554

PLK1
Serine/threonine-protein kinase PLK1

7

3

Small-scale

0.974

High

414769

CDK1
Cyclin-dependent kinase 1

5

18

Small-scale

0.924

High

647834

MARK3
MAP/microtubule affinity-regulating kinase 3

4

3

Small-scale

0.904

High

625160

CDK2
Cyclin-dependent kinase 2

3

18

Small-scale

0.845

High

673626

PLK3
Serine/threonine-protein kinase PLK3

2

4

Small-scale

0.843

High

658805

MK01
Mitogen-activated protein kinase 1

2

5

Small-scale

0.806

High

673586

MK14
Mitogen-activated protein kinase 14

2

12

Small-scale

0.789

High

673552

MK09
Mitogen-activated protein kinase 9

2

11

Small-scale

0.768

High

673545

1433B
14-3-3 protein beta/alpha

15

20

Small-scale

0.762

High

673571

1433F
14-3-3 protein eta

10

20

Small-scale

0.756

High

673559

1433G
14-3-3 protein gamma

9

20

Small-scale

0.754

High

673560

1433E
14-3-3 protein epsilon

9

9

Small-scale

0.752

High

646657

1433T
14-3-3 protein theta

6

20

Small-scale

0.733

High

673562

1433Z
14-3-3 protein zeta/delta

6

20

Small-scale

0.730

High

647479

MK03
Mitogen-activated protein kinase 3

1

5

Small-scale

0.724

High

673619

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

2

Small-scale

0.724

High

673642

SUFU
Suppressor of fused homolog

5

2

High-throughput

0.718

High

673585

PKN1
Serine/threonine-protein kinase N1

1

0

Small-scale

0.708

High

673577

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

3

1

Small-scale

0.667

High

337997

EGFR
Epidermal growth factor receptor

3

3

High-throughput

0.664

High

673566

CSK21
Casein kinase II subunit alpha

1

9

Small-scale

0.647

High

673567

CDK5
Cyclin-dependent kinase 5

1

18

Small-scale

0.647

High

673603

BRSK2
Serine/threonine-protein kinase BRSK2

1

2

Small-scale

0.647

High

673578

FHL1
Four and a half LIM domains protein 1

2

5

Small-scale

0.631

High

673587

CDC37
Hsp90 co-chaperone Cdc37

3

0

Small-scale

0.628

High

230845

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

1

High-throughput

0.618

High

586582

CSK22
Casein kinase II subunit alpha'

1

12

High-throughput

0.618

High

673364

MPIP1
M-phase inducer phosphatase 1

1

3

Small-scale

0.618

High

673544

MPIP3
M-phase inducer phosphatase 3

1

3

High-throughput

0.618

High

517082

PCNA
Proliferating cell nuclear antigen

2

0

Small-scale

0.605

High

666004

SHC1
SHC-transforming protein 1

2

0

High-throughput

0.602

High

673546

1433S
14-3-3 protein sigma

2

20

Small-scale

0.584

High

624549

CCNE1
G1/S-specific cyclin-E1

1

11

Small-scale

0.561

High

673581

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

2

0

Small-scale

0.559

High

166538

DCLK1
Serine/threonine-protein kinase DCLK1

1

2

High-throughput

0.553

High

673584

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

3

High-throughput

0.541

High

673604

LMTK2
Serine/threonine-protein kinase LMTK2

1

2

High-throughput

0.541

High

117604

MYO1C
Unconventional myosin-Ic

1

1

High-throughput

0.536

High

214513

MYO1B
Unconventional myosin-Ib

1

1

High-throughput

0.536

High

303831

CCNB2
G2/mitotic-specific cyclin-B2

1

8

High-throughput

0.536

High

673613

RPGR
X-linked retinitis pigmentosa GTPase regulator

1

1

High-throughput

0.536

High

535805

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.513

High

673555

S12A2
Solute carrier family 12 member 2

1

0

High-throughput

0.513

High

673565

TPM4
Tropomyosin alpha-4 chain

1

0

High-throughput

0.513

High

673643

LZTS1
Leucine zipper putative tumor suppressor 1

1

0

Small-scale

0.513

High

673553

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

0

Small-scale

0.505

High

538482

CCNB1
G2/mitotic-specific cyclin-B1

1

9

Small-scale

0.501

High

673583

IMB1
Importin subunit beta-1

1

1

Small-scale

0.501

High

601820

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

3

High-throughput

0.494

High

673569

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

1

High-throughput

0.494

High

673588

ANR39
Ankyrin repeat domain-containing protein 39

1

1

High-throughput

0.489

High

673549

BRCA1
Breast cancer type 1 susceptibility protein

1

0

Small-scale

0.480

High

673605

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

Small-scale

0.480

High

196404

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

1

High-throughput

0.479

High

216455

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

1

High-throughput

0.479

High

237171

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.479

High

253320

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

1

High-throughput

0.479

High

264274

GGYF1
GRB10-interacting GYF protein 1

1

2

High-throughput

0.479

High

264681

VP26A
Vacuolar protein sorting-associated protein 26A

1

1

High-throughput

0.479

High

316234

NADK
NAD kinase

1

1

High-throughput

0.479

High

319728

HERC2
E3 ubiquitin-protein ligase HERC2

1

1

High-throughput

0.479

High

320818

HS74L
Heat shock 70 kDa protein 4L

1

1

High-throughput

0.479

High

431567

HS90A
Heat shock protein HSP 90-alpha

1

1

Small-scale

0.479

High

499560

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

598431

NF1
Neurofibromin

1

3

High-throughput

0.479

High

638230

RBTN2
Rhombotin-2

1

4

Small-scale

0.479

High

638480

RBTN1
Rhombotin-1

1

4

Small-scale

0.479

High

673547

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

673548

HSP74
Heat shock 70 kDa protein 4

1

1

Small-scale

0.479

High

673550

CCNF
Cyclin-F

1

12

High-throughput

0.479

High

673551

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

673556

HDAC4
Histone deacetylase 4

1

2

High-throughput

0.479

High

673563

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

1

High-throughput

0.479

High

673572

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

3

High-throughput

0.479

High

673575

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

1

High-throughput

0.479

High

673576

ILK
Integrin-linked protein kinase

1

1

High-throughput

0.479

High

673579

FHL3
Four and a half LIM domains protein 3

1

5

Small-scale

0.479

High

673580

FHL2
Four and a half LIM domains protein 2

1

5

Small-scale

0.479

High

673582

ZN638
Zinc finger protein 638

1

1

High-throughput

0.479

High

673589

NU188
Nucleoporin NUP188

1

1

High-throughput

0.479

High

673590

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

1

High-throughput

0.479

High

673591

SPD2A
SH3 and PX domain-containing protein 2A

1

2

High-throughput

0.479

High

673592

DEN4C
DENN domain-containing protein 4C

1

3

High-throughput

0.479

High

673593

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

1

High-throughput

0.479

High

673594

PKHA7
Pleckstrin homology domain-containing family A member 7

1

5

High-throughput

0.479

High

673596

U17L2
Ubiquitin carboxyl-terminal hydrolase 17

1

2

Small-scale

0.479

High

673597

GGYF2
GRB10-interacting GYF protein 2

1

4

High-throughput

0.479

High

673599

PHLB2
Pleckstrin homology-like domain family B member 2

1

3

High-throughput

0.479

High

673600

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

2

High-throughput

0.479

High

673601

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

1

Small-scale

0.479

High

673602

KSR1
Kinase suppressor of Ras 1

1

4

High-throughput

0.479

High

673607

NAV1
Neuron navigator 1

1

1

High-throughput

0.479

High

673609

LMO3
LIM domain only protein 3

1

4

Small-scale

0.479

High

673610

DEN1A
DENN domain-containing protein 1A

1

3

High-throughput

0.479

High

673612

SRS12
Serine/arginine-rich splicing factor 12

1

1

High-throughput

0.479

High

673617

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

2

High-throughput

0.479

High

673618

TESK2
Dual specificity testis-specific protein kinase 2

1

1

High-throughput

0.479

High

673620

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

High-throughput

0.479

High

673623

RTKN
Rhotekin

1

1

High-throughput

0.479

High

673627

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

673630

KI13B
Kinesin-like protein KIF13B

1

3

High-throughput

0.479

High

673636

LIMA1
LIM domain and actin-binding protein 1

1

1

High-throughput

0.479

High

673637

NGAP
Ras GTPase-activating protein nGAP

1

3

High-throughput

0.479

High

673639

ZBT21
Zinc finger and BTB domain-containing protein 21

1

1

High-throughput

0.479

High

673640

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.479

High

673644

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

673645

STA13
StAR-related lipid transfer protein 13

1

2

High-throughput

0.479

High

597974

FLNA
Filamin-A

1

0

Small-scale

0.458

High

643814

SYVC
Valine--tRNA ligase

1

0

High-throughput

0.458

High

672003

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

0

High-throughput

0.458

High

673557

CTBP2
C-terminal-binding protein 2

1

0

High-throughput

0.458

High

673558

S10AA
Protein S100-A10

1

0

High-throughput

0.458

High

673561

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

0

High-throughput

0.458

High

673564

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.458

High

673568

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

673570

LGUL
Lactoylglutathione lyase

1

0

High-throughput

0.458

High

673574

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

0

High-throughput

0.458

High

673606

NUP93
Nuclear pore complex protein Nup93

1

0

High-throughput

0.458

High

673608

FAD1
FAD synthase

1

0

High-throughput

0.458

High

673615

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

High-throughput

0.458

High

673621

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.458

High

673624

OSBL6
Oxysterol-binding protein-related protein 6

1

0

High-throughput

0.458

High

673625

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

673628

GRPE1
GrpE protein homolog 1, mitochondrial

1

0

High-throughput

0.458

High

673631

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

0

High-throughput

0.458

High

673632

TBCC1
TBCC domain-containing protein 1

1

0

High-throughput

0.458

High

673647

P2R3B
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

1

0

High-throughput

0.458

High

216906

KIF1C
Kinesin-like protein KIF1C

1

3

High-throughput

0.437

High

673595

PHLB3
Pleckstrin homology-like domain family B member 3

1

2

High-throughput

0.437

High

673598

SYDE1
Rho GTPase-activating protein SYDE1

1

4

High-throughput

0.437

High

673611

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

2

High-throughput

0.437

High

673616

APLD1
Apolipoprotein L domain-containing protein 1

1

1

High-throughput

0.437

High

673629

TANC2
Protein TANC2

1

1

High-throughput

0.437

High

673634

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

1

High-throughput

0.437

High

673635

CING
Cingulin

1

1

High-throughput

0.437

High

673638

PNMA2
Paraneoplastic antigen Ma2

1

1

High-throughput

0.437

High

673646

KCTD3
BTB/POZ domain-containing protein KCTD3

1

3

High-throughput

0.437

High

173438

RER1
Protein RER1

1

0

High-throughput

0.279

Low

673622

SWET1
Sugar transporter SWEET1

1

0

High-throughput

0.279

Low

673641

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.279

Low

673614

CDS1
Phosphatidate cytidylyltransferase 1

1

0

Small-scale

0.261

Low

154590

TPP1
Tripeptidyl-peptidase 1

1

0

High-throughput

0.249

Low

215431

SCO2
Protein SCO2 homolog, mitochondrial

1

0

High-throughput

0.249

Low

673633

HPBP1
Hsp70-binding protein 1

1

0

High-throughput

0.249

Low

673573

F27E3
Protein FAM27E3

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024