Protein: GRK5
G protein-coupled receptor kinase 5 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK5)

Gene: GRK5
Organism: Homo sapiens
Interactions: 173
UniProt ID: P34947

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004703 - G protein-coupled receptor kinase activity
GO:0005080 - protein kinase C binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

600868

TA2R
Thromboxane A2 receptor

1

20

Small-scale

0.735

High

639684

IKBA
NF-kappa-B inhibitor alpha

1

10

Small-scale

0.692

High

714495

GRK6
G protein-coupled receptor kinase 6

1

16

High-throughput

0.691

High

428938

ADRB2
Beta-2 adrenergic receptor

1

9

Small-scale

0.647

High

435865

OPSD
Rhodopsin

1

14

Small-scale

0.647

High

626733

NK1R
Substance-P receptor

1

11

Small-scale

0.647

High

714481

GRK5
G protein-coupled receptor kinase 5

1

15

Small-scale

0.647

High

714592

CABP1
Calcium-binding protein 1

1

1

Small-scale

0.647

High

324747

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

20

High-throughput

0.618

High

431584

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

437937

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

506529

BCR
Breakpoint cluster region protein

1

4

High-throughput

0.618

High

582089

NUCL
Nucleolin

1

7

High-throughput

0.618

High

668323

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

10

High-throughput

0.618

High

674006

V2R
Vasopressin V2 receptor

1

12

Small-scale

0.618

High

674828

AGTR1
Type-1 angiotensin II receptor

1

13

Small-scale

0.618

High

682138

AKT2
RAC-beta serine/threonine-protein kinase

1

16

High-throughput

0.618

High

714488

V1AR
Vasopressin V1a receptor

1

12

Small-scale

0.618

High

714519

SRSF1
Serine/arginine-rich splicing factor 1

1

12

High-throughput

0.618

High

714529

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

2

High-throughput

0.618

High

714532

KANK1
KN motif and ankyrin repeat domain-containing protein 1

1

4

High-throughput

0.618

High

714537

STK38
Serine/threonine-protein kinase 38

1

15

High-throughput

0.618

High

714538

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

3

High-throughput

0.618

High

714540

DDB1
DNA damage-binding protein 1

1

7

High-throughput

0.618

High

714541

CDC37
Hsp90 co-chaperone Cdc37

1

14

High-throughput

0.618

High

714544

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

4

High-throughput

0.618

High

714545

A16L1
Autophagy-related protein 16-1

1

9

High-throughput

0.618

High

714551

THOC4
THO complex subunit 4

1

7

High-throughput

0.618

High

714552

LIPB1
Liprin-beta-1

1

13

High-throughput

0.618

High

714554

PLPL6
Patatin-like phospholipase domain-containing protein 6

1

20

High-throughput

0.618

High

714567

DCAF5
DDB1- and CUL4-associated factor 5

1

10

High-throughput

0.618

High

714571

SRPK1
SRSF protein kinase 1

1

12

High-throughput

0.618

High

714574

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

2

High-throughput

0.618

High

714580

WDR12
Ribosome biogenesis protein WDR12

1

10

High-throughput

0.618

High

714594

ANFY1
Rabankyrin-5

1

0

High-throughput

0.586

High

165407

SR140
U2 snRNP-associated SURP motif-containing protein

1

7

High-throughput

0.553

High

714482

RECO
Recoverin

1

6

Small-scale

0.553

High

714547

WDR82
WD repeat-containing protein 82

1

9

High-throughput

0.553

High

714550

TARSH
Target of Nesh-SH3

1

2

High-throughput

0.553

High

714562

DDB2
DNA damage-binding protein 2

1

7

High-throughput

0.553

High

714598

AFF4
AF4/FMR2 family member 4

1

2

High-throughput

0.553

High

714605

TBL2
Transducin beta-like protein 2

1

8

High-throughput

0.553

High

282769

SYUG
Gamma-synuclein

1

13

Small-scale

0.501

High

714489

SYUA
Alpha-synuclein

1

13

Small-scale

0.501

High

714517

CAV1
Caveolin-1

1

3

Small-scale

0.501

High

714539

SYUB
Beta-synuclein

1

13

Small-scale

0.501

High

117609

MYO1C
Unconventional myosin-Ic

1

12

High-throughput

0.479

High

121696

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

3

High-throughput

0.479

High

124581

CLIC1
Chloride intracellular channel protein 1

1

1

High-throughput

0.479

High

195355

DHX15
ATP-dependent RNA helicase DHX15

1

4

High-throughput

0.479

High

256731

CAND2
Cullin-associated NEDD8-dissociated protein 2

1

10

High-throughput

0.479

High

302105

AP2A2
AP-2 complex subunit alpha-2

1

4

High-throughput

0.479

High

321495

AP2A1
AP-2 complex subunit alpha-1

1

4

High-throughput

0.479

High

490087

COT1
COUP transcription factor 1

1

13

High-throughput

0.479

High

524808

XRCC5
X-ray repair cross-complementing protein 5

1

3

High-throughput

0.479

High

531051

EF2
Elongation factor 2

1

2

High-throughput

0.479

High

542213

PLAK
Junction plakoglobin

1

4

High-throughput

0.479

High

574605

ARF4
ADP-ribosylation factor 4

1

2

High-throughput

0.479

High

618001

COF1
Cofilin-1

1

2

High-throughput

0.479

High

646669

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

653495

CALR
Calreticulin

1

2

High-throughput

0.479

High

653922

MAP4
Microtubule-associated protein 4

1

19

High-throughput

0.479

High

658633

SMCA1
Probable global transcription activator SNF2L1

1

1

High-throughput

0.479

High

678590

METK2
S-adenosylmethionine synthase isoform type-2

1

1

High-throughput

0.479

High

683165

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

714105

HSP74
Heat shock 70 kDa protein 4

1

12

High-throughput

0.479

High

714483

MYH9
Myosin-9

1

10

High-throughput

0.479

High

714484

MYH10
Myosin-10

1

10

High-throughput

0.479

High

714485

PRS7
26S proteasome regulatory subunit 7

1

7

High-throughput

0.479

High

714486

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.479

High

714490

IF4A3
Eukaryotic initiation factor 4A-III

1

12

High-throughput

0.479

High

714491

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

714492

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

6

High-throughput

0.479

High

714493

MTREX
Exosome RNA helicase MTR4

1

7

High-throughput

0.479

High

714496

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

4

High-throughput

0.479

High

714498

EFTU
Elongation factor Tu, mitochondrial

1

4

High-throughput

0.479

High

714500

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

1

High-throughput

0.479

High

714502

CSN2
COP9 signalosome complex subunit 2

1

3

High-throughput

0.479

High

714504

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

714505

PRS4
26S proteasome regulatory subunit 4

1

7

High-throughput

0.479

High

714506

PRS10
26S proteasome regulatory subunit 10B

1

8

High-throughput

0.479

High

714508

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

714509

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

3

High-throughput

0.479

High

714511

EF1A1
Elongation factor 1-alpha 1

1

2

High-throughput

0.479

High

714512

PRKDC
DNA-dependent protein kinase catalytic subunit

1

12

High-throughput

0.479

High

714513

ARF1
ADP-ribosylation factor 1

1

2

High-throughput

0.479

High

714514

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

8

High-throughput

0.479

High

714515

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

2

High-throughput

0.479

High

714516

OTUD4
OTU domain-containing protein 4

1

4

High-throughput

0.479

High

714518

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

714520

DHX9
ATP-dependent RNA helicase A

1

4

High-throughput

0.479

High

714522

ILF3
Interleukin enhancer-binding factor 3

1

2

High-throughput

0.479

High

714523

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

3

High-throughput

0.479

High

714524

PPIG
Peptidyl-prolyl cis-trans isomerase G

1

1

High-throughput

0.479

High

714525

TCOF
Treacle protein

1

6

High-throughput

0.479

High

714526

MYO9B
Unconventional myosin-IXb

1

9

High-throughput

0.479

High

714527

CUL4A
Cullin-4A

1

7

High-throughput

0.479

High

714528

CUL4B
Cullin-4B

1

7

High-throughput

0.479

High

714530

CKAP5
Cytoskeleton-associated protein 5

1

9

High-throughput

0.479

High

714531

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

14

High-throughput

0.479

High

714534

IMB1
Importin subunit beta-1

1

3

High-throughput

0.479

High

714535

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

7

High-throughput

0.479

High

714536

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

714542

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

3

High-throughput

0.479

High

714543

SPIN3
Spindlin-3

1

2

High-throughput

0.479

High

714546

LARP1
La-related protein 1

1

4

High-throughput

0.479

High

714548

DHX30
ATP-dependent RNA helicase DHX30

1

4

High-throughput

0.479

High

714549

MAEA
E3 ubiquitin-protein transferase MAEA

1

2

High-throughput

0.479

High

714556

SRRM1
Serine/arginine repetitive matrix protein 1

1

3

High-throughput

0.479

High

714557

DOCK4
Dedicator of cytokinesis protein 4

1

2

High-throughput

0.479

High

714558

ABCF1
ATP-binding cassette sub-family F member 1

1

2

High-throughput

0.479

High

714561

MADD
MAP kinase-activating death domain protein

1

2

High-throughput

0.479

High

714565

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

7

High-throughput

0.479

High

714568

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

7

High-throughput

0.479

High

714569

FMNL2
Formin-like protein 2

1

1

High-throughput

0.479

High

714570

RANB9
Ran-binding protein 9

1

8

High-throughput

0.479

High

714573

MMS19
MMS19 nucleotide excision repair protein homolog

1

1

High-throughput

0.479

High

714575

MBB1A
Myb-binding protein 1A

1

1

High-throughput

0.479

High

714577

CSN4
COP9 signalosome complex subunit 4

1

1

High-throughput

0.479

High

714579

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

6

High-throughput

0.479

High

714583

CWC22
Pre-mRNA-splicing factor CWC22 homolog

1

1

High-throughput

0.479

High

714584

DDX21
Nucleolar RNA helicase 2

1

12

High-throughput

0.479

High

714588

TOR4A
Torsin-4A

1

2

High-throughput

0.479

High

714589

KCTD5
BTB/POZ domain-containing protein KCTD5

1

3

High-throughput

0.479

High

714590

BCLF1
Bcl-2-associated transcription factor 1

1

3

High-throughput

0.479

High

714593

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

1

High-throughput

0.479

High

714595

HDAC6
Histone deacetylase 6

1

8

High-throughput

0.479

High

714596

CSN7A
COP9 signalosome complex subunit 7a

1

1

High-throughput

0.479

High

714599

MRT4
mRNA turnover protein 4 homolog

1

1

High-throughput

0.479

High

714600

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

5

High-throughput

0.479

High

714601

SRRM2
Serine/arginine repetitive matrix protein 2

1

3

High-throughput

0.479

High

714602

RUVB1
RuvB-like 1

1

3

High-throughput

0.479

High

714604

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

6

High-throughput

0.479

High

714606

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

4

High-throughput

0.479

High

714607

SPIN1
Spindlin-1

1

2

High-throughput

0.479

High

127729

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.458

High

533649

GYS1
Glycogen [starch] synthase, muscle

1

0

High-throughput

0.458

High

714487

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.458

High

714501

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.458

High

714507

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

High-throughput

0.458

High

714510

SKP1
S-phase kinase-associated protein 1

1

0

High-throughput

0.458

High

714521

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.458

High

714533

BMS1
Ribosome biogenesis protein BMS1 homolog

1

0

High-throughput

0.458

High

714559

AATC2
Putative aspartate aminotransferase, cytoplasmic 2

1

0

High-throughput

0.458

High

714560

TP8L1
Tumor necrosis factor alpha-induced protein 8-like protein 1

1

0

High-throughput

0.458

High

714563

RT27
Small ribosomal subunit protein mS27

1

0

High-throughput

0.458

High

714564

GSLG1
Golgi apparatus protein 1

1

0

High-throughput

0.458

High

714566

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.458

High

714572

SIN3A
Paired amphipathic helix protein Sin3a

1

0

High-throughput

0.458

High

714576

SLD5
DNA replication complex GINS protein SLD5

1

0

High-throughput

0.458

High

714581

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.458

High

714582

PININ
Pinin

1

0

High-throughput

0.458

High

714586

OLA1
Obg-like ATPase 1

1

0

High-throughput

0.458

High

714587

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.458

High

714591

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

High-throughput

0.458

High

714597

DAXX
Death domain-associated protein 6

1

0

High-throughput

0.458

High

714497

ARRB1
Beta-arrestin-1

1

8

Small-scale

0.445

High

119924

AP3B1
AP-3 complex subunit beta-1

1

4

High-throughput

0.437

High

150179

AP3D1
AP-3 complex subunit delta-1

1

5

High-throughput

0.437

High

300466

FRYL
Protein furry homolog-like

1

1

High-throughput

0.437

High

379065

MYCN
N-myc proto-oncogene protein

1

4

High-throughput

0.437

High

567648

UBF1
Nucleolar transcription factor 1

1

5

High-throughput

0.437

High

714494

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.437

High

714499

AP3M2
AP-3 complex subunit mu-2

1

5

High-throughput

0.437

High

714503

LYSC
Lysozyme C

1

1

High-throughput

0.437

High

714555

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

1

High-throughput

0.437

High

714578

RFIP5
Rab11 family-interacting protein 5

1

1

High-throughput

0.437

High

714585

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

11

High-throughput

0.437

High

714603

AP3M1
AP-3 complex subunit mu-1

1

5

High-throughput

0.437

High

135084

NFIB
Nuclear factor 1 B-type

1

0

High-throughput

0.249

Low

518962

PIP
Prolactin-inducible protein

1

0

High-throughput

0.249

Low

714553

S31A7
Spermatogenesis-associated protein 31A7

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024