Protein: T2FA
General transcription factor IIF subunit 1 (General transcription factor IIF 74 kDa subunit) (Transcription initiation factor IIF subunit alpha) (TFIIF-alpha) (Transcription initiation factor RAP74)

Gene: T2FA, GTF2F1
Organism: Homo sapiens
Interactions: 159
UniProt ID: P35269

Gene Ontology (top 5):
GO:0001091 - RNA polymerase II general transcription initiation factor binding
GO:0001096 - TFIIF-class transcription factor complex binding
GO:0003677 - DNA binding
GO:0003723 - RNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

534072

T2FB
General transcription factor IIF subunit 2

8

2

Small-scale

0.967

High

624792

RPB1
DNA-directed RNA polymerase II subunit RPB1

7

1

Small-scale

0.963

High

722659

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

3

4

Small-scale

0.882

High

676823

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

1

High-throughput

0.789

High

600091

TAF1
Transcription initiation factor TFIID subunit 1

5

1

Small-scale

0.721

High

722597

TF2B
Transcription initiation factor IIB

4

2

Small-scale

0.696

High

663999

T2EA
General transcription factor IIE subunit 1

4

1

Small-scale

0.694

High

589797

TBP
TATA-box-binding protein

4

0

Small-scale

0.671

High

572874

PRS6A
26S proteasome regulatory subunit 6A

3

1

High-throughput

0.667

High

722585

PSME3
Proteasome activator complex subunit 3

3

0

High-throughput

0.638

High

722639

DCC1
Sister chromatid cohesion protein DCC1

3

0

High-throughput

0.638

High

346084

MYC
Myc proto-oncogene protein

2

1

Small-scale

0.629

High

722584

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

2

1

High-throughput

0.628

High

722588

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

1

High-throughput

0.628

High

455152

PARP1
Poly [ADP-ribose] polymerase 1

2

3

Small-scale

0.624

High

487182

ANDR
Androgen receptor

2

5

Small-scale

0.624

High

722632

STAC3
SH3 and cysteine-rich domain-containing protein 3

2

1

High-throughput

0.611

High

722583

PRPS1
Ribose-phosphate pyrophosphokinase 1

3

1

High-throughput

0.609

High

664046

T2EB
Transcription initiation factor IIE subunit beta

2

1

Small-scale

0.602

High

722571

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

2

0

High-throughput

0.602

High

722612

PHF19
PHD finger protein 19

2

0

High-throughput

0.602

High

722613

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

2

0

High-throughput

0.602

High

722621

PCD20
Protocadherin-20

2

0

High-throughput

0.602

High

722651

SPNXA
Sperm protein associated with the nucleus on the X chromosome A

2

0

High-throughput

0.602

High

722626

TF2H4
General transcription factor IIH subunit 4

2

0

Small-scale

0.592

High

722601

MED21
Mediator of RNA polymerase II transcription subunit 21

2

0

Small-scale

0.585

High

722631

EAF1
ELL-associated factor 1

2

0

High-throughput

0.585

High

612964

TCEA1
Transcription elongation factor A protein 1

2

1

Small-scale

0.585

High

244024

BRD4
Bromodomain-containing protein 4

2

2

High-throughput

0.584

High

697719

TF2H1
General transcription factor IIH subunit 1

2

1

Small-scale

0.584

High

722572

CDK8
Cyclin-dependent kinase 8

2

2

Small-scale

0.584

High

722578

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

2

1

Small-scale

0.584

High

722599

HNRPU
Heterogeneous nuclear ribonucleoprotein U

2

2

Small-scale

0.584

High

722575

CDK9
Cyclin-dependent kinase 9

2

0

Small-scale

0.577

High

369092

ESR1
Estrogen receptor

2

5

High-throughput

0.571

High

722607

KPCD1
Serine/threonine-protein kinase D1

2

1

High-throughput

0.571

High

515561

SRF
Serum response factor

2

0

Small-scale

0.569

High

317415

YETS4
YEATS domain-containing protein 4

1

1

Small-scale

0.561

High

528670

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.541

High

722580

DAPK1
Death-associated protein kinase 1

1

4

High-throughput

0.536

High

117613

MYO1C
Unconventional myosin-Ic

1

1

High-throughput

0.536

High

181394

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

1

High-throughput

0.536

High

583404

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

Small-scale

0.536

High

583659

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

High-throughput

0.536

High

722581

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

1

High-throughput

0.536

High

722598

CDK16
Cyclin-dependent kinase 16

1

2

High-throughput

0.536

High

722603

NOG2
Nucleolar GTP-binding protein 2

1

2

High-throughput

0.536

High

722605

TF2H3
General transcription factor IIH subunit 3

1

1

High-throughput

0.536

High

722608

TAF11
Transcription initiation factor TFIID subunit 11

1

0

Small-scale

0.527

High

536743

TRI27
Zinc finger protein RFP

1

0

High-throughput

0.518

High

597365

PTN
Pleiotrophin

1

0

High-throughput

0.518

High

323616

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

380747

S100B
Protein S100-B

1

0

High-throughput

0.513

High

453184

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.513

High

574260

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

722596

SERF2
Small EDRK-rich factor 2

1

0

High-throughput

0.513

High

722600

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

722602

THOC5
THO complex subunit 5 homolog

1

0

High-throughput

0.513

High

722611

LBH
Protein LBH

1

0

High-throughput

0.513

High

722625

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.513

High

722628

KCD12
BTB/POZ domain-containing protein KCTD12

1

0

High-throughput

0.513

High

722634

KIF2C
Kinesin-like protein KIF2C

1

0

High-throughput

0.513

High

722636

TCAL7
Transcription elongation factor A protein-like 7

1

0

High-throughput

0.513

High

722637

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.513

High

722645

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.513

High

722648

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.513

High

722649

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.513

High

722650

PRD11
PR domain-containing protein 11

1

0

High-throughput

0.513

High

722662

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.513

High

295599

RMP
Unconventional prefoldin RPB5 interactor 1

1

0

Small-scale

0.512

High

236704

CCNT1
Cyclin-T1

1

1

Small-scale

0.501

High

345353

FOS
Protein c-Fos

1

1

Small-scale

0.501

High

649048

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

3

Small-scale

0.501

High

722565

AHR
Aryl hydrocarbon receptor

1

4

Small-scale

0.501

High

559582

H12
Histone H1.2

1

0

High-throughput

0.493

High

515811

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

1

High-throughput

0.489

High

722660

WIF1
Wnt inhibitory factor 1

1

1

High-throughput

0.489

High

239437

MAGC1
Melanoma-associated antigen C1

1

0

Small-scale

0.486

High

337372

ABL1
Tyrosine-protein kinase ABL1

1

0

Small-scale

0.480

High

401519

JUN
Transcription factor Jun

1

0

Small-scale

0.480

High

722564

MSX2
Homeobox protein MSX-2

1

0

Small-scale

0.480

High

722579

TF2AA
Transcription initiation factor IIA subunit 1

1

0

Small-scale

0.480

High

722594

CSK21
Casein kinase II subunit alpha

1

0

Small-scale

0.480

High

179563

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

2

High-throughput

0.479

High

239308

CC14B
Dual specificity protein phosphatase CDC14B

1

3

High-throughput

0.479

High

325644

LATS1
Serine/threonine-protein kinase LATS1

1

2

High-throughput

0.479

High

384381

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

552075

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

568565

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

2

High-throughput

0.479

High

624403

CCNC
Cyclin-C

1

1

Small-scale

0.479

High

650505

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

718548

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

719814

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

722069

RFC2
Replication factor C subunit 2

1

1

High-throughput

0.479

High

722570

ATRX
Transcriptional regulator ATRX

1

3

Small-scale

0.479

High

722573

CENPA
Histone H3-like centromeric protein A

1

2

High-throughput

0.479

High

722586

WDR5
WD repeat-containing protein 5

1

5

High-throughput

0.479

High

722587

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

722590

H2B1C
Histone H2B type 1-C/E/F/G/I

1

2

High-throughput

0.479

High

722595

H31
Histone H3.1

1

2

High-throughput

0.479

High

722617

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

722620

SLX4
Structure-specific endonuclease subunit SLX4

1

2

High-throughput

0.479

High

722627

KAT6A
Histone acetyltransferase KAT6A

1

3

High-throughput

0.479

High

722629

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

4

High-throughput

0.479

High

722630

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

722642

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

2

High-throughput

0.479

High

722644

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

1

High-throughput

0.479

High

722655

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

722641

B2L13
Bcl-2-like protein 13

1

0

Small-scale

0.460

High

133349

NOP56
Nucleolar protein 56

1

0

High-throughput

0.458

High

162444

XPO1
Exportin-1

1

0

High-throughput

0.458

High

386208

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

501005

IRF1
Interferon regulatory factor 1

1

0

Small-scale

0.458

High

574132

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

1

0

Small-scale

0.458

High

584560

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

0

High-throughput

0.458

High

652763

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

722566

PRS7
26S proteasome regulatory subunit 7

1

0

Small-scale

0.458

High

722568

COIL
Coilin

1

0

High-throughput

0.458

High

722576

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.458

High

722577

IMA1
Importin subunit alpha-1

1

0

High-throughput

0.458

High

722582

ANM2
Protein arginine N-methyltransferase 2

1

0

High-throughput

0.458

High

722589

RL23A
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

722591

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

722592

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

722604

TF2H2
General transcription factor IIH subunit 2

1

0

High-throughput

0.458

High

722606

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

722615

TF2H5
General transcription factor IIH subunit 5

1

0

High-throughput

0.458

High

722616

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

722618

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

722622

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

722624

PLPR1
Phospholipid phosphatase-related protein type 1

1

0

High-throughput

0.458

High

722633

TBX5
T-box transcription factor TBX5

1

0

High-throughput

0.458

High

722638

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

High-throughput

0.458

High

722643

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

722652

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

722656

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.458

High

722657

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

722567

BRCA1
Breast cancer type 1 susceptibility protein

1

2

Small-scale

0.445

High

722569

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

3

High-throughput

0.445

High

722593

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.437

High

722614

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

722647

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

722574

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

722640

C1QT2
Complement C1q tumor necrosis factor-related protein 2

3

0

High-throughput

0.347

High

224902

ZNRD2
Protein ZNRD2

2

0

High-throughput

0.328

High

722635

FEZ1
Fasciculation and elongation protein zeta-1

1

0

High-throughput

0.282

High

361832

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

0

High-throughput

0.279

Low

679690

FGF9
Fibroblast growth factor 9

1

0

High-throughput

0.279

Low

722610

P5CR3
Pyrroline-5-carboxylate reductase 3

1

0

High-throughput

0.279

Low

722619

CCD71
Coiled-coil domain-containing protein 71

1

0

High-throughput

0.279

Low

722646

CAD23
Cadherin-23

1

0

High-throughput

0.279

Low

722653

PEN2
Gamma-secretase subunit PEN-2

1

0

High-throughput

0.279

Low

722654

GRHPR
Glyoxylate reductase/hydroxypyruvate reductase

1

0

High-throughput

0.279

Low

722658

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.279

Low

722661

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.279

Low

168239

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

0

High-throughput

0.249

Low

441709

CFAH
Complement factor H

1

0

Small-scale

0.249

Low

722609

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.249

Low

722623

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024