Protein: DEST
Destrin (Actin-depolymerizing factor) (ADF)

Gene: DEST, DSTN
Organism: Homo sapiens
Interactions: 87
UniProt ID: P60981

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0008154 - actin polymerization or depolymerization
GO:0015629 - actin cytoskeleton
GO:0030042 - actin filament depolymerization
GO:0030043 - actin filament fragmentation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

891649

ACTB
Actin, cytoplasmic 1

8

20

High-throughput

0.974

High

894652

ACTG
Actin, cytoplasmic 2

5

20

High-throughput

0.934

High

894691

COF2
Cofilin-2

3

10

High-throughput

0.839

High

618039

COF1
Cofilin-1

1

10

High-throughput

0.691

High

528869

CFTR
Cystic fibrosis transmembrane conductance regulator

4

4

High-throughput

0.691

High

894672

TAXB1
Tax1-binding protein 1

3

14

High-throughput

0.675

High

894667

Q549N0
Cofilin-2

1

10

High-throughput

0.665

High

411658

LCK
Tyrosine-protein kinase Lck

1

2

High-throughput

0.618

High

894651

ACTA
Actin, aortic smooth muscle

1

20

High-throughput

0.618

High

894665

Q1KLZ0
Actin, cytoplasmic 1

1

20

High-throughput

0.594

High

227025

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

346375

MYC
Myc proto-oncogene protein

2

5

High-throughput

0.584

High

261098

SH3L1
Adapter SH3BGRL

2

3

High-throughput

0.571

High

244195

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.553

High

117648

MYO1C
Unconventional myosin-Ic

1

9

High-throughput

0.536

High

313787

SVIL
Supervillin

1

1

High-throughput

0.536

High

336440

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

496692

TAU
Microtubule-associated protein tau

1

8

High-throughput

0.536

High

571105

EGLN
Endoglin

1

1

High-throughput

0.536

High

724739

MYH9
Myosin-9

1

4

High-throughput

0.536

High

862015

DAPK1
Death-associated protein kinase 1

1

5

High-throughput

0.536

High

894649

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

4

High-throughput

0.536

High

894658

SCRB2
Lysosome membrane protein 2

1

2

High-throughput

0.536

High

894675

MY18A
Unconventional myosin-XVIIIa

1

8

High-throughput

0.536

High

171382

SMAD9
Mothers against decapentaplegic homolog 9

1

1

High-throughput

0.508

High

894673

SSH1
Protein phosphatase Slingshot homolog 1

1

5

Small-scale

0.501

High

682158

AKT2
RAC-beta serine/threonine-protein kinase

1

3

High-throughput

0.489

High

301709

TRI37
E3 ubiquitin-protein ligase TRIM37

1

9

High-throughput

0.479

High

303069

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

369285

ESR1
Estrogen receptor

1

4

High-throughput

0.479

High

397878

ISG15
Ubiquitin-like protein ISG15

1

3

Small-scale

0.479

High

418094

NPM
Nucleophosmin

1

1

High-throughput

0.479

High

503793

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

590761

BTF3
Transcription factor BTF3

1

2

High-throughput

0.479

High

625282

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.479

High

832288

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

894656

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.479

High

894657

CUL3
Cullin-3

1

3

High-throughput

0.479

High

894659

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

5

High-throughput

0.479

High

894666

SMU1
WD40 repeat-containing protein SMU1

1

3

High-throughput

0.479

High

894670

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

894674

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

894679

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

894681

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

894682

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.479

High

894683

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

894684

ANLN
Anillin

1

3

High-throughput

0.479

High

894685

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

894689

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

894690

TNIK
TRAF2 and NCK-interacting protein kinase

1

3

High-throughput

0.479

High

894671

Q7KZS0
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.470

High

380946

SHBG
Sex hormone-binding globulin

1

0

Small-scale

0.460

High

674305

PURA2
Adenylosuccinate synthetase isozyme 2

1

0

High-throughput

0.458

High

726121

BASI
Basigin

1

0

High-throughput

0.458

High

894663

FSCN1
Fascin

1

0

High-throughput

0.458

High

894669

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

894692

DTX4
E3 ubiquitin-protein ligase DTX4

1

0

Small-scale

0.458

High

267976

EED
Polycomb protein EED

1

8

High-throughput

0.437

High

329566

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

379186

MYCN
N-myc proto-oncogene protein

1

5

High-throughput

0.437

High

841602

CDK9
Cyclin-dependent kinase 9

1

5

High-throughput

0.437

High

877664

FOXA1
Hepatocyte nuclear factor 3-alpha

1

1

High-throughput

0.437

High

894650

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

894654

UBE3A
Ubiquitin-protein ligase E3A

1

2

High-throughput

0.437

High

894660

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.437

High

894661

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.437

High

894662

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

894668

VIR
Protein virilizer homolog

1

1

High-throughput

0.437

High

894677

ESR2
Estrogen receptor beta

1

4

High-throughput

0.437

High

894686

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

2

High-throughput

0.437

High

894688

RRBP1
Ribosome-binding protein 1

1

7

High-throughput

0.437

High

894693

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

894655

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.426

High

894687

SPHK1
Sphingosine kinase 1

1

0

Small-scale

0.426

High

401738

JUN
Transcription factor Jun

1

4

High-throughput

0.407

High

894680

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

5

High-throughput

0.407

High

279109

ATP5H
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.269

Low

771860

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.251

Low

239546

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.249

Low

351737

SOMA
Somatotropin

1

0

High-throughput

0.249

Low

750201

COIL
Coilin

1

0

High-throughput

0.249

Low

881607

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.249

Low

894653

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.249

Low

894664

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

894676

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.249

Low

894678

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.249

Low

894694

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024