Protein: TLR9
Toll-like receptor 9 (CD antigen CD289)

Gene: TLR9
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q9NR96

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001774 - microglial cell activation
GO:0001932 - regulation of protein phosphorylation
GO:0002224 - toll-like receptor signaling pathway
GO:0002639 - positive regulation of immunoglobulin production

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

986400

BTK
Tyrosine-protein kinase BTK

2

20

Small-scale

0.775

High

835532

GSK3A
Glycogen synthase kinase-3 alpha

1

4

High-throughput

0.691

High

836017

GSK3B
Glycogen synthase kinase-3 beta

1

4

High-throughput

0.691

High

1316133

LRRC3
Leucine-rich repeat-containing protein 3

1

20

High-throughput

0.691

High

1067904

RAGE
Advanced glycosylation end product-specific receptor

1

11

Small-scale

0.665

High

488394

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

0

High-throughput

0.656

High

1306783

MYD88
Myeloid differentiation primary response protein MyD88

3

20

Small-scale

0.650

High

177607

SIGL5
Sialic acid-binding Ig-like lectin 5

1

20

Small-scale

0.618

High

211423

SIGL6
Sialic acid-binding Ig-like lectin 6

1

20

Small-scale

0.618

High

441035

CD14
Monocyte differentiation antigen CD14

1

10

Small-scale

0.618

High

523168

SRC
Proto-oncogene tyrosine-protein kinase Src

1

12

Small-scale

0.618

High

528036

RINI
Ribonuclease inhibitor

1

19

Small-scale

0.618

High

557803

NCK1
SH2/SH3 adapter protein NCK1

1

10

High-throughput

0.618

High

781457

BCL6
B-cell lymphoma 6 protein

1

2

Small-scale

0.618

High

796657

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

848490

IRAK1
Interleukin-1 receptor-associated kinase 1

1

20

Small-scale

0.618

High

983927

KPCZ
Protein kinase C zeta type

1

6

Small-scale

0.618

High

984537

KPCD
Protein kinase C delta type

1

6

Small-scale

0.618

High

1026947

PAK2
Serine/threonine-protein kinase PAK 2

1

2

Small-scale

0.618

High

1217350

VRK3
Serine/threonine-protein kinase VRK3

1

1

High-throughput

0.618

High

1255768

MICA1
[F-actin]-monooxygenase MICAL1

1

1

Small-scale

0.618

High

1344373

TLR8
Toll-like receptor 8

1

18

Small-scale

0.618

High

1344379

TBK1
Serine/threonine-protein kinase TBK1

1

4

Small-scale

0.618

High

1344383

SIGL9
Sialic acid-binding Ig-like lectin 9

1

20

Small-scale

0.618

High

1344372

TLR9
Toll-like receptor 9

1

19

Small-scale

0.590

High

1271568

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

0

Small-scale

0.586

High

152389

ABCD4
Lysosomal cobalamin transporter ABCD4

1

1

High-throughput

0.536

High

161154

CLGN
Calmegin

1

1

High-throughput

0.536

High

502591

BIP
Endoplasmic reticulum chaperone BiP

1

8

High-throughput

0.536

High

1024770

TRAF3
TNF receptor-associated factor 3

1

10

High-throughput

0.536

High

1230862

S11IP
Serine/threonine-protein kinase 11-interacting protein

1

20

High-throughput

0.536

High

1311700

CNPY3
Protein canopy homolog 3

1

7

High-throughput

0.536

High

1327586

TOLIP
Toll-interacting protein

1

3

High-throughput

0.536

High

1328600

UN93B
Protein unc-93 homolog B1

1

7

High-throughput

0.536

High

1333327

DJC18
DnaJ homolog subfamily C member 18

1

1

High-throughput

0.536

High

1344380

KCNG1
Potassium voltage-gated channel subfamily G member 1

1

3

High-throughput

0.536

High

1344386

SNX14
Sorting nexin-14

1

1

High-throughput

0.536

High

745317

RBMX
RNA-binding motif protein, X chromosome

1

3

High-throughput

0.515

High

229574

ADCY3
Adenylate cyclase type 3

1

0

High-throughput

0.513

High

1032816

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

1

0

High-throughput

0.513

High

1132974

CSCL2
CSC1-like protein 2

1

0

High-throughput

0.513

High

1134708

DIK1A
Divergent protein kinase domain 1A

1

0

High-throughput

0.513

High

1243409

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.513

High

1342428

ABCB9
ABC-type oligopeptide transporter ABCB9

1

0

High-throughput

0.513

High

1344377

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

0

High-throughput

0.513

High

1344381

PALD
Paladin

1

0

High-throughput

0.513

High

792252

MTHR
Methylenetetrahydrofolate reductase

1

1

High-throughput

0.489

High

229502

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

2

Small-scale

0.479

High

449819

HMGB1
High mobility group protein B1

1

6

Small-scale

0.479

High

504817

HSP7C
Heat shock cognate 71 kDa protein

1

6

Small-scale

0.479

High

542761

ETS2
Protein C-ets-2

1

3

Small-scale

0.479

High

564194

HSP76
Heat shock 70 kDa protein 6

1

6

Small-scale

0.479

High

584278

ELK1
ETS domain-containing protein Elk-1

1

2

Small-scale

0.479

High

831718

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

Small-scale

0.479

High

845885

RAB13
Ras-related protein Rab-13

1

3

Small-scale

0.479

High

918956

RAB1A
Ras-related protein Rab-1A

1

3

Small-scale

0.479

High

1203454

TRI69
E3 ubiquitin-protein ligase TRIM69

1

3

Small-scale

0.479

High

1272369

RENT1
Regulator of nonsense transcripts 1

1

1

Small-scale

0.479

High

1306323

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

1

Small-scale

0.479

High

1330379

UN45A
Protein unc-45 homolog A

1

5

Small-scale

0.479

High

1344382

CHIP
E3 ubiquitin-protein ligase CHIP

1

4

Small-scale

0.479

High

1344384

TRAF6
TNF receptor-associated factor 6

1

10

Small-scale

0.479

High

1344385

RN115
E3 ubiquitin-protein ligase RNF115

1

4

Small-scale

0.479

High

1344375

RN216
E3 ubiquitin-protein ligase RNF216

1

4

Small-scale

0.464

High

117834

MYO1C
Unconventional myosin-Ic

1

0

Small-scale

0.458

High

131090

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

High-throughput

0.458

High

175234

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

Small-scale

0.458

High

232535

KDM1A
Lysine-specific histone demethylase 1A

1

0

Small-scale

0.458

High

556987

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

Small-scale

0.458

High

599737

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

0

Small-scale

0.458

High

617778

NFYA
Nuclear transcription factor Y subunit alpha

1

0

Small-scale

0.458

High

786153

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

Small-scale

0.458

High

930017

ACTG
Actin, cytoplasmic 2

1

0

Small-scale

0.458

High

942260

GTF2I
General transcription factor II-I

1

0

Small-scale

0.458

High

1085978

IF16
Gamma-interferon-inducible protein 16

1

0

Small-scale

0.458

High

1117451

TPRN
Taperin

1

0

Small-scale

0.458

High

1199428

LYRIC
Protein LYRIC

1

0

Small-scale

0.458

High

1224422

XRN1
5'-3' exoribonuclease 1

1

0

Small-scale

0.458

High

1260218

STYX
Serine/threonine/tyrosine-interacting protein

1

0

High-throughput

0.458

High

1291991

BSCL2
Seipin

1

0

Small-scale

0.458

High

714432

HSP74
Heat shock 70 kDa protein 4

1

8

Small-scale

0.437

High

1233219

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

813179

CAZA2
F-actin-capping protein subunit alpha-2

1

1

High-throughput

0.381

High

857227

CAZA1
F-actin-capping protein subunit alpha-1

1

1

High-throughput

0.381

High

1344378

ARP3B
Actin-related protein 3B

1

2

High-throughput

0.381

High

1216160

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

0

High-throughput

0.365

High

1314368

ELOV1
Very long chain fatty acid elongase 1

1

0

High-throughput

0.365

High

1344376

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.365

High

280829

KRT36
Keratin, type I cuticular Ha6

1

3

High-throughput

0.348

High

943700

KRT85
Keratin, type II cuticular Hb5

1

2

High-throughput

0.348

High

1071412

K1H1
Keratin, type I cuticular Ha1

1

3

High-throughput

0.348

High

1344374

KRT82
Keratin, type II cuticular Hb2

1

2

High-throughput

0.348

High

969066

GCYB1
Guanylate cyclase soluble subunit beta-1

1

0

High-throughput

0.279

Low

132224

PESC
Pescadillo homolog

1

0

Small-scale

0.249

Low

594217

MSH3
DNA mismatch repair protein Msh3

1

0

Small-scale

0.249

Low

887538

ELOF1
Transcription elongation factor 1 homolog

1

0

Small-scale

0.249

Low

1312144

MCMBP
Mini-chromosome maintenance complex-binding protein

1

0

Small-scale

0.249

Low

813774

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.198

Low


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Last updated: 15 Jul 2024