Protein: SPHK1
Sphingosine kinase 1 (SK 1) (SPK 1) (EC 2.7.1.91) (Acetyltransferase SPHK1) (EC 2.3.1.-)

Gene: SPHK1
Organism: Homo sapiens
Interactions: 86
UniProt ID: Q9NYA1

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001568 - blood vessel development
GO:0001727 - lipid kinase activity
GO:0003677 - DNA binding
GO:0005516 - calmodulin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1190759

DCXR
L-xylulose reductase

4

1

Small-scale

0.691

High

1020960

TRAF2
TNF receptor-associated factor 2

3

1

Small-scale

0.664

High

1343341

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

3

0

High-throughput

0.638

High

1348332

TRAF6
TNF receptor-associated factor 6

2

1

Small-scale

0.601

High

826555

DHYS
Deoxyhypusine synthase

2

0

High-throughput

0.585

High

176293

PPM1G
Protein phosphatase 1G

2

3

Small-scale

0.571

High

1036147

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

Small-scale

0.561

High

1299558

KLHL5
Kelch-like protein 5

1

1

Small-scale

0.549

High

530814

RARG
Retinoic acid receptor gamma

1

2

High-throughput

0.541

High

932898

EF1A1
Elongation factor 1-alpha 1

1

0

Small-scale

0.537

High

1146252

MAP1S
Microtubule-associated protein 1S

1

1

High-throughput

0.536

High

1192576

CTU1
Cytoplasmic tRNA 2-thiolation protein 1

1

1

High-throughput

0.536

High

1305055

TTC1
Tetratricopeptide repeat protein 1

1

1

High-throughput

0.536

High

1313247

TCAB1
Telomerase Cajal body protein 1

1

4

High-throughput

0.536

High

1348326

KLHL8
Kelch-like protein 8

1

1

High-throughput

0.536

High

1348330

MAN1
Inner nuclear membrane protein Man1

1

2

High-throughput

0.536

High

795580

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

0

High-throughput

0.513

High

953182

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.513

High

1103453

CTU2
Cytoplasmic tRNA 2-thiolation protein 2

1

0

High-throughput

0.513

High

1114247

TBB8
Tubulin beta-8 chain

1

0

High-throughput

0.513

High

1161344

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

1

0

High-throughput

0.513

High

1242015

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.513

High

1292497

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

0

High-throughput

0.513

High

1314141

AFG2B
ATPase family gene 2 protein homolog B

1

0

High-throughput

0.513

High

1334063

QTRT2
Queuine tRNA-ribosyltransferase accessory subunit 2

1

0

High-throughput

0.513

High

1345338

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.513

High

1348329

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.513

High

1101841

SPKAP
A-kinase anchor protein SPHKAP

1

0

Small-scale

0.506

High

1050820

FHL2
Four and a half LIM domains protein 2

1

5

Small-scale

0.506

High

412378

FYN
Tyrosine-protein kinase Fyn

1

4

Small-scale

0.501

High

999149

EP300
Histone acetyltransferase p300

1

2

Small-scale

0.501

High

527845

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.493

High

1348331

SHLB1
Endophilin-B1

1

0

High-throughput

0.493

High

1253253

RDH11
Retinol dehydrogenase 11

1

2

High-throughput

0.489

High

1301666

KS6C1
Ribosomal protein S6 kinase delta-1

1

1

Small-scale

0.479

High

1054216

BECN1
Beclin-1

1

0

Small-scale

0.458

High

1058627

MBTP1
Membrane-bound transcription factor site-1 protease

1

1

Small-scale

0.457

High

117841

MYO1C
Unconventional myosin-Ic

1

3

Small-scale

0.445

High

124260

TAF4
Transcription initiation factor TFIID subunit 4

1

1

Small-scale

0.445

High

149362

CTRO
Citron Rho-interacting kinase

1

1

Small-scale

0.445

High

214684

MYO1B
Unconventional myosin-Ib

1

3

Small-scale

0.445

High

254519

ROCK2
Rho-associated protein kinase 2

1

1

Small-scale

0.445

High

297420

MYO1D
Unconventional myosin-Id

1

3

Small-scale

0.445

High

378588

OAT
Ornithine aminotransferase, mitochondrial

1

1

Small-scale

0.445

High

597780

CSRP1
Cysteine and glycine-rich protein 1

1

1

Small-scale

0.445

High

610077

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

1

Small-scale

0.445

High

827628

EFTU
Elongation factor Tu, mitochondrial

1

1

Small-scale

0.445

High

832169

PSB2
Proteasome subunit beta type-2

1

1

Small-scale

0.445

High

892071

ACTB
Actin, cytoplasmic 1

1

1

Small-scale

0.445

High

924903

GRB2
Growth factor receptor-bound protein 2

1

5

Small-scale

0.445

High

930025

ACTG
Actin, cytoplasmic 2

1

1

Small-scale

0.445

High

958249

RBM3
RNA-binding protein 3

1

1

Small-scale

0.445

High

1085080

DREB
Drebrin

1

1

Small-scale

0.445

High

1132927

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

1

8

Small-scale

0.445

High

1158586

L2GL2
LLGL scribble cell polarity complex component 2

1

1

Small-scale

0.445

High

1192246

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

Small-scale

0.445

High

1307019

ANM1
Protein arginine N-methyltransferase 1

1

1

Small-scale

0.445

High

1309707

AIF1L
Allograft inflammatory factor 1-like

1

2

Small-scale

0.445

High

169140

ARPC3
Actin-related protein 2/3 complex subunit 3

1

0

Small-scale

0.426

High

240645

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

0

Small-scale

0.426

High

313892

SVIL
Supervillin

1

0

Small-scale

0.426

High

323227

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

Small-scale

0.426

High

324081

BAG2
BAG family molecular chaperone regulator 2

1

0

Small-scale

0.426

High

504864

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.426

High

638025

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.426

High

656650

PSB6
Proteasome subunit beta type-6

1

0

Small-scale

0.426

High

725043

MYH9
Myosin-9

1

0

Small-scale

0.426

High

823289

MRP
MARCKS-related protein

1

0

Small-scale

0.426

High

847226

GALK1
Galactokinase

1

0

Small-scale

0.426

High

894687

DEST
Destrin

1

0

Small-scale

0.426

High

927886

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

0

Small-scale

0.426

High

1024106

ACACA
Acetyl-CoA carboxylase 1

1

0

Small-scale

0.426

High

1029334

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

Small-scale

0.426

High

1036947

SQSTM
Sequestosome-1

1

0

Small-scale

0.426

High

1070420

RAB35
Ras-related protein Rab-35

1

0

Small-scale

0.426

High

1087885

PCKGM
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

1

0

Small-scale

0.426

High

1131416

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

Small-scale

0.426

High

1250777

PSMA8
Proteasome subunit alpha-type 8

1

0

Small-scale

0.426

High

1308637

ARP5L
Actin-related protein 2/3 complex subunit 5-like protein

1

0

Small-scale

0.426

High

1348327

ARMX3
Armadillo repeat-containing X-linked protein 3

1

0

Small-scale

0.426

High

1348328

DPP2
Dipeptidyl peptidase 2

1

0

Small-scale

0.426

High

1149575

ANR40
Ankyrin repeat domain-containing protein 40

1

0

High-throughput

0.279

Low

431287

CATB
Cathepsin B

1

0

Small-scale

0.261

Low

131797

LAD1
Ladinin-1

1

0

Small-scale

0.232

Low

1059041

LTBP1
Latent-transforming growth factor beta-binding protein 1

1

0

Small-scale

0.232

Low

1348325

TMOD3
Tropomodulin-3

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024