Protein: COF2
Cofilin-2 (Cofilin, muscle isoform)

Gene: COF2, CFL2
Organism: Homo sapiens
Interactions: 90
UniProt ID: Q9Y281

Gene Ontology (top 5):
GO:0005615 - extracellular space
GO:0005737 - cytoplasm
GO:0007519 - skeletal muscle tissue development
GO:0015629 - actin cytoskeleton
GO:0016363 - nuclear matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

892124

ACTB
Actin, cytoplasmic 1

8

20

High-throughput

0.975

High

930059

ACTG
Actin, cytoplasmic 2

7

20

High-throughput

0.973

High

618199

COF1
Cofilin-1

5

10

High-throughput

0.920

High

894691

DEST
Destrin

3

10

High-throughput

0.839

High

813856

CAPZB
F-actin-capping protein subunit beta

1

4

High-throughput

0.691

High

1085104

DREB
Drebrin

1

2

High-throughput

0.691

High

932464

ACTC
Actin, alpha cardiac muscle 1

1

20

High-throughput

0.665

High

1377081

COF2
Cofilin-2

1

10

High-throughput

0.621

High

895325

RAB2A
Ras-related protein Rab-2A

2

1

High-throughput

0.606

High

1318707

TRIM7
E3 ubiquitin-protein ligase TRIM7

2

1

High-throughput

0.606

High

1346260

POTE1
Protection of telomeres protein 1

3

3

High-throughput

0.597

High

1343814

ANLN
Anillin

2

3

High-throughput

0.584

High

941592

RNF4
E3 ubiquitin-protein ligase RNF4

2

0

High-throughput

0.580

High

1079188

STK11
Serine/threonine-protein kinase STK11

1

4

High-throughput

0.541

High

117865

MYO1C
Unconventional myosin-Ic

1

9

High-throughput

0.536

High

497833

TAU
Microtubule-associated protein tau

1

8

High-throughput

0.536

High

598382

FLNA
Filamin-A

1

2

High-throughput

0.536

High

725077

MYH9
Myosin-9

1

4

High-throughput

0.536

High

809488

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

5

High-throughput

0.536

High

813214

CAZA2
F-actin-capping protein subunit alpha-2

1

5

High-throughput

0.536

High

862133

DAPK1
Death-associated protein kinase 1

1

5

High-throughput

0.536

High

906640

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

4

High-throughput

0.536

High

1052352

SRC8
Src substrate cortactin

1

3

High-throughput

0.536

High

1232645

SYNPO
Synaptopodin

1

4

High-throughput

0.536

High

1255919

TBCK
TBC domain-containing protein kinase-like protein

1

3

High-throughput

0.536

High

1268120

MY18A
Unconventional myosin-XVIIIa

1

8

High-throughput

0.536

High

1293081

MYO19
Unconventional myosin-XIX

1

7

High-throughput

0.536

High

1355283

LIMA1
LIM domain and actin-binding protein 1

1

4

High-throughput

0.536

High

648937

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.515

High

1271981

KLK6
Kallikrein-6

1

2

High-throughput

0.515

High

1336012

MOV10
Helicase MOV-10

1

0

High-throughput

0.513

High

1355740

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.513

High

1377083

MB212
Protein mab-21-like 2

1

0

High-throughput

0.513

High

1051714

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.493

High

1343655

PRDM7
Histone-lysine N-methyltransferase PRDM7

1

1

High-throughput

0.489

High

768490

CAP2
Adenylyl cyclase-associated protein 2

1

9

High-throughput

0.481

High

930461

UBC9
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.481

High

839867

CSRP3
Cysteine and glycine-rich protein 3

1

0

Small-scale

0.480

High

149440

CTRO
Citron Rho-interacting kinase

1

6

High-throughput

0.479

High

200150

DAPK3
Death-associated protein kinase 3

1

7

High-throughput

0.479

High

210380

PRC1
Protein regulator of cytokinesis 1

1

5

High-throughput

0.479

High

229094

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

233696

NUPR1
Nuclear protein 1

1

2

High-throughput

0.479

High

303543

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

870936

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.479

High

887985

CD81
CD81 antigen

1

1

High-throughput

0.479

High

894598

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.479

High

1043317

CUL4A
Cullin-4A

1

3

High-throughput

0.479

High

1044286

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.479

High

1172321

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

1221851

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

1267275

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

1269260

RND1
Rho-related GTP-binding protein Rho6

1

5

High-throughput

0.479

High

1281802

IGSF8
Immunoglobulin superfamily member 8

1

1

High-throughput

0.479

High

1306406

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

1

High-throughput

0.479

High

1330565

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.479

High

1331660

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.479

High

1333821

ECT2
Protein ECT2

1

4

High-throughput

0.479

High

1335401

RHOF
Rho-related GTP-binding protein RhoF

1

2

High-throughput

0.479

High

1354903

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1377082

ARI1
E3 ubiquitin-protein ligase ARIH1

1

6

High-throughput

0.479

High

1183321

Q7KZS0
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.470

High

1307227

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

1349901

LUZP4
Leucine zipper protein 4

1

0

Small-scale

0.458

High

924964

GRB2
Growth factor receptor-bound protein 2

1

6

High-throughput

0.445

High

1081264

NF2L2
Nuclear factor erythroid 2-related factor 2

1

3

High-throughput

0.445

High

1233271

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.445

High

1304802

ZBT18
Zinc finger and BTB domain-containing protein 18

1

3

High-throughput

0.445

High

309175

KI20A
Kinesin-like protein KIF20A

1

8

High-throughput

0.437

High

562591

IL7RA
Interleukin-7 receptor subunit alpha

1

1

High-throughput

0.437

High

708804

MCM5
DNA replication licensing factor MCM5

1

3

High-throughput

0.437

High

737529

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.437

High

903617

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.437

High

970078

KIF23
Kinesin-like protein KIF23

1

4

High-throughput

0.437

High

1066898

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.437

High

1080494

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

1116633

LARP7
La-related protein 7

1

1

High-throughput

0.437

High

1119520

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

2

High-throughput

0.437

High

1184392

MEPCE
7SK snRNA methylphosphate capping enzyme

1

1

High-throughput

0.437

High

1317640

RHBT2
Rho-related BTB domain-containing protein 2

1

5

High-throughput

0.437

High

1334447

NANOG
Homeobox protein NANOG

1

1

High-throughput

0.437

High

787333

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

High-throughput

0.426

High

718335

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.407

High

1173342

NEK10
Serine/threonine-protein kinase Nek10

1

5

High-throughput

0.407

High

771483

PSB10
Proteasome subunit beta type-10

1

0

High-throughput

0.279

Low

1314472

HIRP3
HIRA-interacting protein 3

1

0

High-throughput

0.279

Low

1354042

COMD3
COMM domain-containing protein 3

1

0

High-throughput

0.279

Low

995607

ECHP
Peroxisomal bifunctional enzyme

1

0

High-throughput

0.268

Low

1284276

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024