Protein: RIPK3
Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3)

Gene: RIPK3
Organism: Homo sapiens
Interactions: 134
UniProt ID: Q9Y572

Gene Ontology (top 5):
GO:0001914 - regulation of T cell mediated cytotoxicity
GO:0002819 - regulation of adaptive immune response
GO:0003713 - transcription coactivator activity
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1038346

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

25

20

Small-scale

0.992

High

1239429

MLKL
Mixed lineage kinase domain-like protein

9

18

Small-scale

0.963

High

1026669

FADD
FAS-associated death domain protein

7

18

Small-scale

0.949

High

1377937

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

4

17

Small-scale

0.906

High

1059405

CASP8
Caspase-8

5

7

Small-scale

0.902

High

1328503

ZBP1
Z-DNA-binding protein 1

4

3

Small-scale

0.878

High

872734

EPHA4
Ephrin type-A receptor 4

3

15

High-throughput

0.861

High

1083067

CDC37
Hsp90 co-chaperone Cdc37

2

5

High-throughput

0.776

High

972616

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

15

High-throughput

0.665

High

1035071

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

15

High-throughput

0.665

High

943047

SRPK2
SRSF protein kinase 2

1

1

High-throughput

0.647

High

161477

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

7

High-throughput

0.618

High

229175

PRKN
E3 ubiquitin-protein ligase parkin

1

9

Small-scale

0.618

High

432396

HS90A
Heat shock protein HSP 90-alpha

1

17

High-throughput

0.618

High

438651

HS90B
Heat shock protein HSP 90-beta

1

17

High-throughput

0.618

High

453732

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.618

High

475256

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

6

High-throughput

0.618

High

580706

ML12A
Myosin regulatory light chain 12A

1

14

High-throughput

0.618

High

681664

DNJA1
DnaJ homolog subfamily A member 1

1

14

High-throughput

0.618

High

683038

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

1

High-throughput

0.618

High

862139

DAPK1
Death-associated protein kinase 1

1

10

High-throughput

0.618

High

930066

ACTG
Actin, cytoplasmic 2

1

4

High-throughput

0.618

High

1045574

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

4

High-throughput

0.618

High

1069994

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

2

High-throughput

0.618

High

1167447

MPRIP
Myosin phosphatase Rho-interacting protein

1

5

High-throughput

0.618

High

1216112

TCAM1
TIR domain-containing adapter molecule 1

1

4

Small-scale

0.618

High

1349609

RAI14
Ankycorbin

1

8

High-throughput

0.618

High

563850

ZSC20
Zinc finger and SCAN domain-containing protein 20

1

0

Small-scale

0.614

High

1036246

BIRC3
Baculoviral IAP repeat-containing protein 3

1

17

Small-scale

0.589

High

1036381

BIRC2
Baculoviral IAP repeat-containing protein 2

1

20

Small-scale

0.589

High

1069833

NONO
Non-POU domain-containing octamer-binding protein

1

0

High-throughput

0.586

High

352732

TNFA
Tumor necrosis factor

2

4

Small-scale

0.584

High

1291031

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

2

Small-scale

0.578

High

1354580

DAXX
Death domain-associated protein 6

1

2

Small-scale

0.578

High

1052817

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

8

Small-scale

0.561

High

1377873

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.561

High

398314

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

5

High-throughput

0.536

High

1128141

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

2

High-throughput

0.536

High

1293839

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

1

Small-scale

0.536

High

1346942

RNF12
E3 ubiquitin-protein ligase RLIM

1

5

High-throughput

0.536

High

1377938

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

1

4

High-throughput

0.536

High

957806

XIAP
E3 ubiquitin-protein ligase XIAP

1

20

Small-scale

0.527

High

1210867

RFX6
DNA-binding protein RFX6

1

0

High-throughput

0.518

High

239229

CTND1
Catenin delta-1

1

1

High-throughput

0.515

High

685142

STIP1
Stress-induced-phosphoprotein 1

1

9

High-throughput

0.515

High

1296280

LRAT2
Protein LRATD2

1

0

High-throughput

0.513

High

1345994

T11L1
T-complex protein 11-like protein 1

1

0

High-throughput

0.513

High

484874

AMY1B
Alpha-amylase 1B

2

1

High-throughput

0.504

High

237000

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

2

Small-scale

0.501

High

559309

H15
Histone H1.5

1

3

Small-scale

0.501

High

979602

GLGB
1,4-alpha-glucan-branching enzyme

1

1

Small-scale

0.501

High

1232792

TXND3
Thioredoxin domain-containing protein 3

1

4

Small-scale

0.501

High

1255016

HELQ
Helicase POLQ-like

1

2

Small-scale

0.501

High

1290430

HBAP1
HSPB1-associated protein 1

1

5

Small-scale

0.501

High

1333278

TLE6
Transducin-like enhancer protein 6

1

5

Small-scale

0.501

High

417547

PYGL
Glycogen phosphorylase, liver form

1

0

High-throughput

0.493

High

1311820

INP5K
Inositol polyphosphate 5-phosphatase K

1

0

High-throughput

0.493

High

1377579

UTP11
Probable U3 small nucleolar RNA-associated protein 11

1

0

Small-scale

0.480

High

117874

MYO1C
Unconventional myosin-Ic

1

7

High-throughput

0.479

High

134265

DDX3X
ATP-dependent RNA helicase DDX3X

1

1

High-throughput

0.479

High

211699

ACTN4
Alpha-actinin-4

1

1

High-throughput

0.479

High

214699

MYO1B
Unconventional myosin-Ib

1

9

High-throughput

0.479

High

297434

MYO1D
Unconventional myosin-Id

1

7

High-throughput

0.479

High

325475

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.479

High

381334

TBB4A
Tubulin beta-4A chain

1

20

High-throughput

0.479

High

397555

ADT2
ADP/ATP translocase 2

1

10

High-throughput

0.479

High

419087

TPM3
Tropomyosin alpha-3 chain

1

2

High-throughput

0.479

High

428522

TBB5
Tubulin beta chain

1

20

High-throughput

0.479

High

431082

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

2

High-throughput

0.479

High

443902

VIME
Vimentin

1

2

High-throughput

0.479

High

451334

TPM1
Tropomyosin alpha-1 chain

1

1

High-throughput

0.479

High

502720

BIP
Endoplasmic reticulum chaperone BiP

1

16

High-throughput

0.479

High

505013

HSP7C
Heat shock cognate 71 kDa protein

1

12

High-throughput

0.479

High

538712

MYL6B
Myosin light chain 6B

1

12

High-throughput

0.479

High

571645

DDX5
Probable ATP-dependent RNA helicase DDX5

1

1

High-throughput

0.479

High

598393

FLNA
Filamin-A

1

2

High-throughput

0.479

High

653415

PYR1
Multifunctional protein CAD

1

3

High-throughput

0.479

High

669501

EF1D
Elongation factor 1-delta

1

2

High-throughput

0.479

High

714103

HS71L
Heat shock 70 kDa protein 1-like

1

12

High-throughput

0.479

High

725275

MYH10
Myosin-10

1

2

High-throughput

0.479

High

738149

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

3

High-throughput

0.479

High

751899

GRP75
Stress-70 protein, mitochondrial

1

18

High-throughput

0.479

High

778346

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

5

High-throughput

0.479

High

788953

RS27
Small ribosomal subunit protein eS27

1

5

High-throughput

0.479

High

809497

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

3

High-throughput

0.479

High

821476

TCPE
T-complex protein 1 subunit epsilon

1

3

High-throughput

0.479

High

891634

MYL6
Myosin light polypeptide 6

1

12

High-throughput

0.479

High

906646

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

3

High-throughput

0.479

High

910206

1433E
14-3-3 protein epsilon

1

7

High-throughput

0.479

High

919574

RL23
Large ribosomal subunit protein uL14

1

1

High-throughput

0.479

High

921086

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

2

High-throughput

0.479

High

921794

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

2

High-throughput

0.479

High

943559

TCPB
T-complex protein 1 subunit beta

1

6

High-throughput

0.479

High

944494

PRKDC
DNA-dependent protein kinase catalytic subunit

1

3

High-throughput

0.479

High

946336

BASP1
Brain acid soluble protein 1

1

3

High-throughput

0.479

High

959348

S25A3
Solute carrier family 25 member 3

1

12

High-throughput

0.479

High

961035

CLH1
Clathrin heavy chain 1

1

3

High-throughput

0.479

High

963460

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

4

High-throughput

0.479

High

984471

EF1A2
Elongation factor 1-alpha 2

1

2

High-throughput

0.479

High

989422

PRDX1
Peroxiredoxin-1

1

4

High-throughput

0.479

High

1021002

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.479

High

1030064

TIF1B
Transcription intermediary factor 1-beta

1

2

Small-scale

0.479

High

1148989

CYTSA
Cytospin-A

1

6

High-throughput

0.479

High

1302001

NEB2
Neurabin-2

1

4

High-throughput

0.479

High

1306760

TCPH
T-complex protein 1 subunit eta

1

3

High-throughput

0.479

High

1309713

AIF1L
Allograft inflammatory factor 1-like

1

13

High-throughput

0.479

High

1313700

TBB2B
Tubulin beta-2B chain

1

20

High-throughput

0.479

High

1317003

TRI34
E3 ubiquitin-protein ligase TRIM34

1

6

Small-scale

0.479

High

1326497

SKI8
Superkiller complex protein 8

1

1

High-throughput

0.479

High

1334931

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

2

High-throughput

0.479

High

1346668

ATD3A
ATPase family AAA domain-containing protein 3A

1

13

High-throughput

0.479

High

1357271

MYO6
Unconventional myosin-VI

1

4

High-throughput

0.479

High

1357874

Q9UQC1
Heat shock protein 72

1

15

High-throughput

0.479

High

1376988

RUVB2
RuvB-like 2

1

2

High-throughput

0.479

High

1377048

RUVB1
RuvB-like 1

1

2

High-throughput

0.479

High

1377808

TRRAP
Transformation/transcription domain-associated protein

1

3

High-throughput

0.479

High

1377939

SCIN
Scinderin

1

5

High-throughput

0.479

High

313677

TIAF1
Putative TGFB1-induced anti-apoptotic factor 1

1

0

High-throughput

0.458

High

444815

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

0

High-throughput

0.458

High

813884

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

857261

CAZA1
F-actin-capping protein subunit alpha-1

1

0

High-throughput

0.458

High

990411

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1085108

DREB
Drebrin

1

0

High-throughput

0.458

High

1287950

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.458

High

1354050

GBG12

1

0

High-throughput

0.458

High

1355291

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.458

High

1357069

COR1C
Coronin-1C

1

0

High-throughput

0.458

High

584511

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

10

Small-scale

0.437

High

1114400

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

4

High-throughput

0.437

High

792870

EAA3
Excitatory amino acid transporter 3

1

0

High-throughput

0.279

Low

1355927

GGT7
Glutathione hydrolase 7

1

0

High-throughput

0.279

Low

1022384

IL24
Interleukin-24

1

0

Small-scale

0.261

Low

1102568

TMM44
Transmembrane protein 44

1

0

Small-scale

0.261

Low


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Last updated: 15 Jul 2024