Protein: DCLK1
Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1)

Gene: DCLK1
Organism: Homo sapiens
Interactions: 124
UniProt ID: O15075

Gene Ontology (top 5):
GO:0001764 - neuron migration
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

166521

DCX
Neuronal migration protein doublecortin

4

6

High-throughput

0.903

High

166535

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

7

High-throughput

0.691

High

166555

ACK1
Activated CDC42 kinase 1

1

18

High-throughput

0.691

High

166565

DGUOK
Deoxyguanosine kinase, mitochondrial

3

3

High-throughput

0.667

High

166519

DCLK1
Serine/threonine-protein kinase DCLK1

1

17

Small-scale

0.647

High

166536

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

9

High-throughput

0.618

High

166564

DDB1
DNA damage-binding protein 1

1

4

High-throughput

0.618

High

166597

FEM1C
Protein fem-1 homolog C

1

4

High-throughput

0.618

High

166610

FEM1A
Protein fem-1 homolog A

1

4

High-throughput

0.618

High

166631

G3BP2
Ras GTPase-activating protein-binding protein 2

1

3

High-throughput

0.618

High

166522

KIF1C
Kinesin-like protein KIF1C

1

4

High-throughput

0.618

High

166523

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

14

High-throughput

0.618

High

166537

MPIP2
M-phase inducer phosphatase 2

1

2

High-throughput

0.618

High

166544

AFAD
Afadin

1

16

High-throughput

0.618

High

166553

CDK16
Cyclin-dependent kinase 16

1

6

High-throughput

0.618

High

166557

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

13

High-throughput

0.618

High

166559

MELK
Maternal embryonic leucine zipper kinase

1

13

High-throughput

0.618

High

166570

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

10

High-throughput

0.618

High

166581

PHLB2
Pleckstrin homology-like domain family B member 2

1

9

High-throughput

0.618

High

166583

KSR1
Kinase suppressor of Ras 1

1

12

High-throughput

0.618

High

166603

TESK2
Dual specificity testis-specific protein kinase 2

1

4

High-throughput

0.618

High

166612

PKHA4
Pleckstrin homology domain-containing family A member 4

1

19

High-throughput

0.618

High

166613

PKHA5
Pleckstrin homology domain-containing family A member 5

1

18

High-throughput

0.618

High

166614

TRI36
E3 ubiquitin-protein ligase TRIM36

1

19

High-throughput

0.618

High

166615

KI13B
Kinesin-like protein KIF13B

1

3

High-throughput

0.618

High

166634

GAB2
GRB2-associated-binding protein 2

1

10

High-throughput

0.618

High

118114

HAX1
HCLS1-associated protein X-1

3

3

High-throughput

0.609

High

166567

BOREA
Borealin

3

1

High-throughput

0.609

High

166618

KTU
Protein kintoun

3

3

High-throughput

0.609

High

166624

NUFP1
FMR1-interacting protein NUFIP1

3

2

High-throughput

0.609

High

166621

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.586

High

166558

DCTN1
Dynactin subunit 1

2

10

High-throughput

0.584

High

166529

ESR1
Estrogen receptor

2

11

High-throughput

0.571

High

166568

EFHC2
EF-hand domain-containing family member C2

2

16

High-throughput

0.553

High

166626

CDC23
Cell division cycle protein 23 homolog

2

6

High-throughput

0.553

High

166538

MPIP3
M-phase inducer phosphatase 3

1

2

High-throughput

0.553

High

166560

ZN638
Zinc finger protein 638

1

4

High-throughput

0.553

High

166569

CE170
Centrosomal protein of 170 kDa

1

5

High-throughput

0.553

High

166573

AN34A
Ankyrin repeat domain-containing protein 34A

1

8

High-throughput

0.553

High

166574

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.553

High

166577

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.553

High

166585

RPTOR
Regulatory-associated protein of mTOR

1

8

High-throughput

0.553

High

166593

SRS12
Serine/arginine-rich splicing factor 12

1

3

High-throughput

0.553

High

166628

ZBT21
Zinc finger and BTB domain-containing protein 21

1

1

High-throughput

0.553

High

166630

PPM1H
Protein phosphatase 1H

1

13

High-throughput

0.553

High

166632

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

13

High-throughput

0.553

High

166531

TAU
Microtubule-associated protein tau

1

19

High-throughput

0.536

High

166540

MCM7
DNA replication licensing factor MCM7

1

5

High-throughput

0.536

High

166542

MCM2
DNA replication licensing factor MCM2

1

6

High-throughput

0.536

High

166543

GPM6A
Neuronal membrane glycoprotein M6-a

1

3

High-throughput

0.536

High

166547

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

15

High-throughput

0.536

High

166549

1433E
14-3-3 protein epsilon

1

12

High-throughput

0.536

High

166550

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

166554

1433F
14-3-3 protein eta

1

20

High-throughput

0.536

High

166561

TRIP6
Thyroid receptor-interacting protein 6

1

4

High-throughput

0.536

High

166604

NEB2
Neurabin-2

1

20

High-throughput

0.536

High

166629

NEB1
Neurabin-1

1

20

High-throughput

0.536

High

166528

MYC
Myc proto-oncogene protein

2

7

High-throughput

0.533

High

166611

RTKN
Rhotekin

1

0

High-throughput

0.517

High

166552

LRP2
Low-density lipoprotein receptor-related protein 2

1

0

High-throughput

0.513

High

166530

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.501

High

166534

1433T
14-3-3 protein theta

1

20

High-throughput

0.489

High

166539

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.489

High

166546

1433G
14-3-3 protein gamma

1

20

High-throughput

0.489

High

166551

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

1

High-throughput

0.489

High

166591

FBLI1
Filamin-binding LIM protein 1

1

4

High-throughput

0.489

High

166596

DCAF5
DDB1- and CUL4-associated factor 5

1

8

High-throughput

0.489

High

166606

IMP2L
Mitochondrial inner membrane protease subunit 2

1

2

High-throughput

0.489

High

166520

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

2

High-throughput

0.479

High

166525

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

8

High-throughput

0.479

High

166532

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.479

High

166533

NF1
Neurofibromin

1

17

High-throughput

0.479

High

166541

SYUA
Alpha-synuclein

1

4

Small-scale

0.479

High

166545

HDAC4
Histone deacetylase 4

1

13

High-throughput

0.479

High

166548

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

166572

DEN4C
DENN domain-containing protein 4C

1

3

High-throughput

0.479

High

166586

NAV1
Neuron navigator 1

1

2

High-throughput

0.479

High

166592

DEP1B
DEP domain-containing protein 1B

1

8

High-throughput

0.479

High

166601

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

17

High-throughput

0.479

High

166607

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

2

High-throughput

0.479

High

166617

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

1

High-throughput

0.479

High

166622

CING
Cingulin

1

3

High-throughput

0.479

High

166623

LIMA1
LIM domain and actin-binding protein 1

1

3

High-throughput

0.479

High

166627

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

4

High-throughput

0.479

High

166639

KCTD3
BTB/POZ domain-containing protein KCTD3

1

3

High-throughput

0.479

High

166598

KLH15
Kelch-like protein 15

1

5

Small-scale

0.470

High

166527

NADK
NAD kinase

1

0

High-throughput

0.458

High

166636

ITM2B
Integral membrane protein 2B

1

11

High-throughput

0.445

High

166616

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

166526

GGYF1
GRB10-interacting GYF protein 1

1

5

High-throughput

0.437

High

166556

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

6

High-throughput

0.437

High

166562

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

6

High-throughput

0.437

High

166563

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.437

High

166566

TBC25
TBC1 domain family member 25

1

1

High-throughput

0.437

High

166571

SPD2A
SH3 and PX domain-containing protein 2A

1

6

High-throughput

0.437

High

166575

LARP1
La-related protein 1

1

1

High-throughput

0.437

High

166576

GGYF2
GRB10-interacting GYF protein 2

1

7

High-throughput

0.437

High

166578

CE128
Centrosomal protein of 128 kDa

1

5

High-throughput

0.437

High

166579

SYDE1
Rho GTPase-activating protein SYDE1

1

10

High-throughput

0.437

High

166580

MYCPP
C-myc promoter-binding protein

1

3

High-throughput

0.437

High

166582

LCA5
Lebercilin

1

4

High-throughput

0.437

High

166587

F110B
Protein FAM110B

1

3

High-throughput

0.437

High

166588

DEN1A
DENN domain-containing protein 1A

1

3

High-throughput

0.437

High

166589

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

7

High-throughput

0.437

High

166590

HDAC7
Histone deacetylase 7

1

13

High-throughput

0.437

High

166594

ARHG2
Rho guanine nucleotide exchange factor 2

1

13

Small-scale

0.437

High

166602

CIC
Protein capicua homolog

1

8

High-throughput

0.437

High

166608

F110A
Protein FAM110A

1

3

High-throughput

0.437

High

166625

NGAP
Ras GTPase-activating protein nGAP

1

17

High-throughput

0.437

High

166633

MARE3
Microtubule-associated protein RP/EB family member 3

1

3

High-throughput

0.437

High

166637

CBY1
Protein chibby homolog 1

1

2

High-throughput

0.437

High

166638

STA13
StAR-related lipid transfer protein 13

1

6

High-throughput

0.437

High

166599

CEP63
Centrosomal protein of 63 kDa

1

5

High-throughput

0.407

High

166605

CK5P2
CDK5 regulatory subunit-associated protein 2

1

8

High-throughput

0.407

High

161180

VP26C
Vacuolar protein sorting-associated protein 26C

1

0

High-throughput

0.282

High

166635

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

0

High-throughput

0.279

Low

166524

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.249

Low

166584

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.249

Low

166595

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.249

Low

166600

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.249

Low

166609

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.249

Low

166619

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low

166620

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024