Protein: LIMK2
LIM domain kinase 2 (LIMK-2) (EC 2.7.11.1)

Gene: LIMK2
Organism: Homo sapiens
Interactions: 82
UniProt ID: P53671

Gene Ontology (top 5):
GO:0001934 - positive regulation of protein phosphorylation
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

863756

LIMK1
LIM domain kinase 1

3

18

Small-scale

0.853

High

863822

ROCK1
Rho-associated protein kinase 1

2

8

Small-scale

0.812

High

863821

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

10

High-throughput

0.811

High

618027

COF1
Cofilin-1

2

2

Small-scale

0.768

High

515385

CDK4
Cyclin-dependent kinase 4

1

4

High-throughput

0.691

High

804182

NOTC1
Neurogenic locus notch homolog protein 1

1

8

High-throughput

0.691

High

858599

PPP5
Serine/threonine-protein phosphatase 5

1

1

High-throughput

0.691

High

863819

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

10

High-throughput

0.691

High

863826

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

9

High-throughput

0.691

High

863835

ST32C
Serine/threonine-protein kinase 32C

1

8

High-throughput

0.691

High

863855

RPKL1
Ribosomal protein S6 kinase-like 1

1

9

High-throughput

0.691

High

863829

CDC37
Hsp90 co-chaperone Cdc37

3

12

High-throughput

0.662

High

863846

HIPK3
Homeodomain-interacting protein kinase 3

1

20

High-throughput

0.656

High

863820

U119A
Protein unc-119 homolog A

3

1

High-throughput

0.656

High

863813

LIMK2
LIM domain kinase 2

1

17

Small-scale

0.647

High

438023

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.621

High

118714

AIP
AH receptor-interacting protein

1

9

High-throughput

0.618

High

683917

1433S
14-3-3 protein sigma

1

16

High-throughput

0.618

High

863816

1433E
14-3-3 protein epsilon

1

3

High-throughput

0.618

High

863847

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

431684

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.611

High

474964

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

1

High-throughput

0.611

High

863838

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

2

1

High-throughput

0.611

High

863851

TRI35
E3 ubiquitin-protein ligase TRIM35

2

1

High-throughput

0.611

High

863844

TTC1
Tetratricopeptide repeat protein 1

3

7

High-throughput

0.609

High

863840

PP14B
Protein phosphatase 1 regulatory subunit 14B

2

0

High-throughput

0.595

High

598447

NF1
Neurofibromin

1

11

Small-scale

0.573

High

863814

VMAT1
Chromaffin granule amine transporter

2

2

High-throughput

0.558

High

863837

PARD3
Partitioning defective 3 homolog

1

20

Small-scale

0.553

High

164838

SC16A
Protein transport protein Sec16A

1

4

High-throughput

0.536

High

243344

DNJA2
DnaJ homolog subfamily A member 2

1

5

High-throughput

0.536

High

304087

UBR5
E3 ubiquitin-protein ligase UBR5

1

6

High-throughput

0.536

High

393117

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

High-throughput

0.536

High

503744

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.536

High

538167

ENPL
Endoplasmin

1

20

High-throughput

0.536

High

636285

DNJB1
DnaJ homolog subfamily B member 1

1

5

High-throughput

0.536

High

653210

PYR1
Multifunctional protein CAD

1

3

High-throughput

0.536

High

681380

DNJA1
DnaJ homolog subfamily A member 1

1

5

High-throughput

0.536

High

838738

EMD
Emerin

1

2

High-throughput

0.536

High

858212

TXTP
Tricarboxylate transport protein, mitochondrial

1

3

High-throughput

0.536

High

863817

TBA4A
Tubulin alpha-4A chain

1

9

High-throughput

0.536

High

863823

SQSTM
Sequestosome-1

1

2

High-throughput

0.536

High

863833

ECM29
Proteasome adapter and scaffold protein ECM29

1

7

High-throughput

0.536

High

863834

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

1

High-throughput

0.536

High

863839

GCN1
Stalled ribosome sensor GCN1

1

6

High-throughput

0.536

High

863842

MMS19
MMS19 nucleotide excision repair protein homolog

1

1

High-throughput

0.536

High

863843

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

1

High-throughput

0.536

High

863828

KS6A1
Ribosomal protein S6 kinase alpha-1

1

7

Small-scale

0.527

High

130809

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

High-throughput

0.513

High

201660

MSI1H
RNA-binding protein Musashi homolog 1

1

0

High-throughput

0.513

High

359792

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.513

High

388330

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.513

High

451870

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.513

High

531092

EF2
Elongation factor 2

1

0

High-throughput

0.513

High

863852

RUVB2
RuvB-like 2

1

0

High-throughput

0.513

High

362071

MBP
Myelin basic protein

1

1

Small-scale

0.501

High

863818

H11
Histone H1.1

1

3

Small-scale

0.501

High

863854

FBX7
F-box only protein 7

1

5

High-throughput

0.501

High

171963

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.489

High

216201

CALU
Calumenin

1

6

High-throughput

0.489

High

778085

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

5

High-throughput

0.489

High

839554

SERPH
Serpin H1

1

1

High-throughput

0.489

High

863825

RCN2
Reticulocalbin-2

1

6

High-throughput

0.489

High

863827

RCN1
Reticulocalbin-1

1

5

High-throughput

0.489

High

863836

SFPA2
Pulmonary surfactant-associated protein A2

1

3

High-throughput

0.489

High

863841

ATPMK
ATP synthase membrane subunit K, mitochondrial

1

1

High-throughput

0.489

High

863848

GHC1
Mitochondrial glutamate carrier 1

1

3

High-throughput

0.489

High

863850

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

2

High-throughput

0.489

High

863824

CUL3
Cullin-3

1

1

High-throughput

0.479

High

863849

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

863845

CECR2
Chromatin remodeling regulator CECR2

1

0

High-throughput

0.458

High

863830

H90B4
Putative heat shock protein HSP 90-beta 4

1

20

High-throughput

0.445

High

863831

HS904
Putative heat shock protein HSP 90-alpha A4

1

20

High-throughput

0.445

High

118246

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.279

Low

179160

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

270851

PGRP1
Peptidoglycan recognition protein 1

1

0

High-throughput

0.279

Low

323657

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

838558

PPOX
Protoporphyrinogen oxidase

1

0

High-throughput

0.279

Low

863832

NU188
Nucleoporin NUP188

1

0

High-throughput

0.279

Low

863853

HIG1A
HIG1 domain family member 1A, mitochondrial

1

0

High-throughput

0.279

Low

863815

ATP5E
ATP synthase subunit epsilon, mitochondrial

1

0

High-throughput

0.269

Low


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Last updated: 15 Jul 2024