Protein: GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Adenylate cyclase-stimulating G alpha protein)

Gene: GNAS2, GNAS
Organism: Homo sapiens
Interactions: 207
UniProt ID: P63092

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0005159 - insulin-like growth factor receptor binding
GO:0005525 - GTP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

920928

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

5

20

Small-scale

0.924

High

793179

PI2R
Prostacyclin receptor

4

20

Small-scale

0.878

High

429010

ADRB2
Beta-2 adrenergic receptor

4

9

Small-scale

0.878

High

926649

RIC8B
Synembryn-B

3

13

Small-scale

0.865

High

750005

GNAL
Guanine nucleotide-binding protein G(olf) subunit alpha

3

11

High-throughput

0.861

High

921511

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

3

20

High-throughput

0.861

High

926573

GNA12
Guanine nucleotide-binding protein subunit alpha-12

3

11

High-throughput

0.847

High

926641

GBB4
Guanine nucleotide-binding protein subunit beta-4

3

20

High-throughput

0.847

High

926561

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

2

10

Small-scale

0.768

High

170629

AXIN1
Axin-1

1

20

Small-scale

0.724

High

926661

MAGD2
Melanoma-associated antigen D2

5

2

Small-scale

0.714

High

591206

ACM3
Muscarinic acetylcholine receptor M3

1

12

High-throughput

0.698

High

926646

CLTR2
Cysteinyl leukotriene receptor 2

1

19

High-throughput

0.698

High

926648

RL3R1
Relaxin-3 receptor 1

1

14

High-throughput

0.698

High

503856

HSP7C
Heat shock cognate 71 kDa protein

4

4

High-throughput

0.666

High

825680

MTR1B
Melatonin receptor type 1B

1

18

High-throughput

0.656

High

837674

GBG4

3

20

High-throughput

0.656

High

926564

GBG5

3

20

High-throughput

0.656

High

926578

TROP
Trophinin

3

2

High-throughput

0.656

High

926650

OCAD1
OCIA domain-containing protein 1

3

1

High-throughput

0.656

High

600879

TA2R
Thromboxane A2 receptor

1

19

Small-scale

0.647

High

602211

DRD5
D(1B) dopamine receptor

1

9

Small-scale

0.647

High

674015

V2R
Vasopressin V2 receptor

1

16

Small-scale

0.647

High

782024

RGS2
Regulator of G-protein signaling 2

1

20

Small-scale

0.647

High

620662

CPT2
Carnitine O-palmitoyltransferase 2, mitochondrial

3

0

High-throughput

0.638

High

528938

CFTR
Cystic fibrosis transmembrane conductance regulator

3

5

High-throughput

0.636

High

840930

MAP2
Methionine aminopeptidase 2

3

0

High-throughput

0.628

High

926574

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

3

0

High-throughput

0.628

High

338255

EGFR
Epidermal growth factor receptor

2

8

Small-scale

0.624

High

254161

FZD7
Frizzled-7

1

2

High-throughput

0.621

High

793723

GLP1R
Glucagon-like peptide 1 receptor

1

9

Small-scale

0.621

High

677567

CALCR
Calcitonin receptor

1

9

Small-scale

0.618

High

686282

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

9

Small-scale

0.618

High

714729

CRFR1
Corticotropin-releasing factor receptor 1

1

9

Small-scale

0.618

High

793264

MUC18
Cell surface glycoprotein MUC18

1

2

High-throughput

0.618

High

926639

PKHG2
Pleckstrin homology domain-containing family G member 2

1

8

Small-scale

0.618

High

926640

ECT2
Protein ECT2

1

10

High-throughput

0.618

High

926659

FZR1
Fizzy-related protein homolog

1

6

High-throughput

0.618

High

854168

JAK3
Tyrosine-protein kinase JAK3

2

5

High-throughput

0.611

High

926626

DNJC7
DnaJ homolog subfamily C member 7

2

2

High-throughput

0.611

High

926655

ARMX3
Armadillo repeat-containing X-linked protein 3

2

1

High-throughput

0.611

High

227113

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

374019

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

8

High-throughput

0.584

High

436248

RHOC
Rho-related GTP-binding protein RhoC

2

17

Small-scale

0.584

High

837688

GBG10

2

20

High-throughput

0.584

High

887098

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

2

20

Small-scale

0.584

High

926644

ANLN
Anillin

2

8

High-throughput

0.584

High

926664

SNX13
Sorting nexin-13

1

20

Small-scale

0.579

High

319789

HERC2
E3 ubiquitin-protein ligase HERC2

2

2

High-throughput

0.571

High

887789

CD81
CD81 antigen

2

7

Small-scale

0.571

High

926613

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

2

0

Small-scale

0.559

High

331248

CHK2
Serine/threonine-protein kinase Chk2

1

3

High-throughput

0.541

High

496792

TAU
Microtubule-associated protein tau

1

16

High-throughput

0.536

High

724759

MYH9
Myosin-9

1

3

High-throughput

0.536

High

926589

DREB
Drebrin

1

1

High-throughput

0.536

High

926606

SYNPO
Synaptopodin

1

2

High-throughput

0.536

High

926619

MSD3
Myb/SANT-like DNA-binding domain-containing protein 3

1

0

High-throughput

0.518

High

146619

SOCS2
Suppressor of cytokine signaling 2

1

2

High-throughput

0.515

High

147505

SOCS6
Suppressor of cytokine signaling 6

1

2

High-throughput

0.515

High

926590

FSCN1
Fascin

1

1

High-throughput

0.515

High

926625

TTC1
Tetratricopeptide repeat protein 1

1

6

Small-scale

0.515

High

382383

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

0

Small-scale

0.513

High

876751

NP1L1
Nucleosome assembly protein 1-like 1

1

0

High-throughput

0.513

High

926583

TF2H3
General transcription factor IIH subunit 3

1

0

High-throughput

0.513

High

926623

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

926617

OPTN
Optineurin

1

10

High-throughput

0.501

High

557089

PGFRA
Platelet-derived growth factor receptor alpha

1

6

High-throughput

0.500

High

606402

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.493

High

713488

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.493

High

926662

RUVB1
RuvB-like 1

1

0

High-throughput

0.493

High

926566

NUCB2
Nucleobindin-2

1

7

High-throughput

0.481

High

926572

NUCB1
Nucleobindin-1

1

7

High-throughput

0.481

High

926622

PANX1
Pannexin-1

1

0

Small-scale

0.480

High

119321

LEG9
Galectin-9

1

2

High-throughput

0.479

High

125350

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

High-throughput

0.479

High

155327

NRP1
Neuropilin-1

1

5

High-throughput

0.479

High

167894

NPC1
NPC intracellular cholesterol transporter 1

1

2

High-throughput

0.479

High

169432

BET1
BET1 homolog

1

1

High-throughput

0.479

High

209873

PRC1
Protein regulator of cytokinesis 1

1

2

High-throughput

0.479

High

214203

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.479

High

233353

NUPR1
Nuclear protein 1

1

3

High-throughput

0.479

High

301745

TRI37
E3 ubiquitin-protein ligase TRIM37

1

7

High-throughput

0.479

High

306787

VAMP5
Vesicle-associated membrane protein 5

1

2

High-throughput

0.479

High

346463

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

348605

RASN
GTPase NRas

1

11

High-throughput

0.479

High

350051

RASK
GTPase KRas

1

11

High-throughput

0.479

High

373371

CATA
Catalase

1

1

High-throughput

0.479

High

384622

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

429868

CATL1
Procathepsin L

1

1

High-throughput

0.479

High

487311

ANDR
Androgen receptor

1

9

High-throughput

0.479

High

488664

ARAF
Serine/threonine-protein kinase A-Raf

1

8

High-throughput

0.479

High

501954

BIP
Endoplasmic reticulum chaperone BiP

1

8

High-throughput

0.479

High

525897

IFM1
Interferon-induced transmembrane protein 1

1

5

High-throughput

0.479

High

542856

BRAF
Serine/threonine-protein kinase B-raf

1

11

High-throughput

0.479

High

564471

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

598049

FLNA
Filamin-A

1

2

High-throughput

0.479

High

610339

CBL
E3 ubiquitin-protein ligase CBL

1

4

High-throughput

0.479

High

648714

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.479

High

649082

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

2

High-throughput

0.479

High

650912

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

724426

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

1

Small-scale

0.479

High

726141

BASI
Basigin

1

3

High-throughput

0.479

High

779201

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

808487

YAP1
Transcriptional coactivator YAP1

1

9

High-throughput

0.479

High

849986

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

5

High-throughput

0.479

High

852428

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

892308

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

893881

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

900360

RHOA
Transforming protein RhoA

1

17

High-throughput

0.479

High

904429

1433G
14-3-3 protein gamma

1

1

High-throughput

0.479

High

908323

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

915590

RHOB
Rho-related GTP-binding protein RhoB

1

19

High-throughput

0.479

High

925172

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

926562

GBG1
Guanine nucleotide-binding protein G(T) subunit gamma-T1

1

20

High-throughput

0.479

High

926563

GBG3

1

20

High-throughput

0.479

High

926565

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

926567

RHOG
Rho-related GTP-binding protein RhoG

1

16

High-throughput

0.479

High

926568

VIGLN
Vigilin

1

1

High-throughput

0.479

High

926570

IFM3
Interferon-induced transmembrane protein 3

1

5

High-throughput

0.479

High

926571

KIF23
Kinesin-like protein KIF23

1

15

High-throughput

0.479

High

926575

B2CL1
Bcl-2-like protein 1

1

1

High-throughput

0.479

High

926576

CD47
Leukocyte surface antigen CD47

1

1

Small-scale

0.479

High

926577

TFCP2
Alpha-globin transcription factor CP2

1

7

High-throughput

0.479

High

926579

STK3
Serine/threonine-protein kinase 3

1

5

High-throughput

0.479

High

926580

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

926581

CUL3
Cullin-3

1

2

High-throughput

0.479

High

926582

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

3

High-throughput

0.479

High

926585

TNIP1
TNFAIP3-interacting protein 1

1

10

High-throughput

0.479

High

926586

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

926587

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

926591

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.479

High

926593

DUS6
Dual specificity protein phosphatase 6

1

14

High-throughput

0.479

High

926594

MIDN
Midnolin

1

3

High-throughput

0.479

High

926598

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

926600

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

926601

TM11B
Transmembrane protease serine 11B

1

4

High-throughput

0.479

High

926603

PIM3
Serine/threonine-protein kinase pim-3

1

5

High-throughput

0.479

High

926604

TAXB1
Tax1-binding protein 1

1

5

High-throughput

0.479

High

926605

CMIP
C-Maf-inducing protein

1

2

High-throughput

0.479

High

926608

ARRD4
Arrestin domain-containing protein 4

1

2

High-throughput

0.479

High

926610

TBCK
TBC domain-containing protein kinase-like protein

1

5

High-throughput

0.479

High

926611

HASP
Serine/threonine-protein kinase haspin

1

5

High-throughput

0.479

High

926612

CLC4D
C-type lectin domain family 4 member D

1

4

High-throughput

0.479

High

926614

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

926615

CDKL2
Cyclin-dependent kinase-like 2

1

1

High-throughput

0.479

High

926618

CERS2
Ceramide synthase 2

1

3

High-throughput

0.479

High

926620

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.479

High

926628

FACD2
Fanconi anemia group D2 protein

1

7

High-throughput

0.479

High

926629

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.479

High

926631

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

2

High-throughput

0.479

High

926632

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

2

High-throughput

0.479

High

926633

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

926634

CHM4B
Charged multivesicular body protein 4b

1

6

High-throughput

0.479

High

926635

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

926636

PKHA4
Pleckstrin homology domain-containing family A member 4

1

10

High-throughput

0.479

High

926638

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

926642

NMRL1
NmrA-like family domain-containing protein 1

1

3

High-throughput

0.479

High

926645

TMPS4
Transmembrane protease serine 4

1

4

High-throughput

0.479

High

926647

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

926652

PAK5
Serine/threonine-protein kinase PAK 5

1

12

High-throughput

0.479

High

926653

HDAC6
Histone deacetylase 6

1

6

High-throughput

0.479

High

926654

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

926656

UBQL2
Ubiquilin-2

1

3

High-throughput

0.479

High

926657

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

20

High-throughput

0.479

High

926658

CLC4E
C-type lectin domain family 4 member E

1

4

High-throughput

0.479

High

926660

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

Small-scale

0.479

High

926663

MB212
Protein mab-21-like 2

1

1

High-throughput

0.479

High

148655

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

162607

XPO1
Exportin-1

1

0

High-throughput

0.458

High

236415

RNBP6
Ran-binding protein 6

1

0

High-throughput

0.458

High

294673

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

298396

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

386480

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

726731

FUS
RNA-binding protein FUS

1

0

High-throughput

0.458

High

744391

ETFB
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.458

High

815972

ATPO
ATP synthase subunit O, mitochondrial

1

0

High-throughput

0.458

High

885855

YBEY
Endoribonuclease YbeY

1

0

High-throughput

0.458

High

917080

H4
Histone H4

1

0

High-throughput

0.458

High

926569

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

926599

TF2H5
General transcription factor IIH subunit 5

1

0

High-throughput

0.458

High

926616

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

926627

THIC
Acetyl-CoA acetyltransferase, cytosolic

1

0

High-throughput

0.458

High

926637

ANTR1
Anthrax toxin receptor 1

1

0

Small-scale

0.458

High

926651

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.458

High

239915

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

7

High-throughput

0.445

High

438061

HS90B
Heat shock protein HSP 90-beta

1

3

High-throughput

0.445

High

926584

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

10

High-throughput

0.445

High

926595

PKHA7
Pleckstrin homology domain-containing family A member 7

1

12

High-throughput

0.445

High

926602

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

1

High-throughput

0.445

High

926607

CD177
CD177 antigen

1

4

Small-scale

0.445

High

926621

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

16

High-throughput

0.445

High

926624

ZBT18
Zinc finger and BTB domain-containing protein 18

1

5

High-throughput

0.445

High

926630

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

118268

HAX1
HCLS1-associated protein X-1

1

2

High-throughput

0.437

High

157312

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

4

High-throughput

0.437

High

308598

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.437

High

328797

TOP3B
DNA topoisomerase 3-beta-1

1

3

High-throughput

0.437

High

552459

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

720195

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

926588

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

926592

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

2

High-throughput

0.437

High

926597

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

1

High-throughput

0.437

High

926609

THOC2
THO complex subunit 2

1

2

High-throughput

0.437

High

926643

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

8

High-throughput

0.437

High

329620

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

926596

FBX42
F-box only protein 42

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024