Protein: HAPR1
HUWE1-associated protein modifying stress responses 1 (Telomere attrition and p53 response 1 protein)

Gene: HAPR1, HAPSTR1
Organism: Homo sapiens
Interactions: 191
UniProt ID: Q14CZ0

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0031625 - ubiquitin protein ligase binding
GO:0080135 - regulation of cellular response to stress
GO:1901797 - negative regulation of signal transduction by p53 class mediator

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1062166

HUWE1
E3 ubiquitin-protein ligase HUWE1

5

0

Small-scale

0.687

High

1062188

INT12
Integrator complex subunit 12

2

0

High-throughput

0.580

High

870648

SYYC
Tyrosine--tRNA ligase, cytoplasmic

2

0

Small-scale

0.559

High

1062187

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

0

High-throughput

0.559

High

1062146

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.505

High

121762

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

1

High-throughput

0.479

High

122016

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

1

High-throughput

0.479

High

124210

TAF4
Transcription initiation factor TFIID subunit 4

1

1

High-throughput

0.479

High

127271

IPO5
Importin-5

1

3

High-throughput

0.479

High

128182

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

2

High-throughput

0.479

High

162753

XPO1
Exportin-1

1

3

High-throughput

0.479

High

174898

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.479

High

231303

GANP
Germinal-center associated nuclear protein

1

2

Small-scale

0.479

High

238681

IMA7
Importin subunit alpha-7

1

1

High-throughput

0.479

High

254590

CLAP2
CLIP-associating protein 2

1

1

High-throughput

0.479

High

296027

MTA2
Metastasis-associated protein MTA2

1

1

High-throughput

0.479

High

300146

PRP6
Pre-mRNA-processing factor 6

1

2

High-throughput

0.479

High

403227

LA
Lupus La protein

1

1

High-throughput

0.479

High

415332

ATPB
ATP synthase subunit beta, mitochondrial

1

1

Small-scale

0.479

High

474813

POTEI
POTE ankyrin domain family member I

1

2

High-throughput

0.479

High

474880

POTEJ
POTE ankyrin domain family member J

1

2

High-throughput

0.479

High

573265

TCPA
T-complex protein 1 subunit alpha

1

3

High-throughput

0.479

High

672126

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

2

High-throughput

0.479

High

708445

MCM4
DNA replication licensing factor MCM4

1

1

High-throughput

0.479

High

708912

MCM7
DNA replication licensing factor MCM7

1

1

High-throughput

0.479

High

714228

HSP74
Heat shock 70 kDa protein 4

1

2

High-throughput

0.479

High

770837

TCPZ
T-complex protein 1 subunit zeta

1

3

High-throughput

0.479

High

842872

TCPQ
T-complex protein 1 subunit theta

1

5

High-throughput

0.479

High

853291

IMA1
Importin subunit alpha-1

1

1

High-throughput

0.479

High

874510

XPO2
Exportin-2

1

4

High-throughput

0.479

High

906831

PRS4
26S proteasome regulatory subunit 4

1

1

High-throughput

0.479

High

907031

PRS8
26S proteasome regulatory subunit 8

1

1

High-throughput

0.479

High

943234

TCPB
T-complex protein 1 subunit beta

1

4

High-throughput

0.479

High

966701

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

1

Small-scale

0.479

High

1047733

CKAP5
Cytoskeleton-associated protein 5

1

5

High-throughput

0.479

High

1057928

RRP5
Protein RRP5 homolog

1

2

Small-scale

0.479

High

1060748

IMB1
Importin subunit beta-1

1

3

High-throughput

0.479

High

1062156

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

1

High-throughput

0.479

High

1062158

RIF1
Telomere-associated protein RIF1

1

1

High-throughput

0.479

High

1062160

LARP1
La-related protein 1

1

1

High-throughput

0.479

High

1062165

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

1

High-throughput

0.479

High

1062167

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

3

High-throughput

0.479

High

1062169

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

2

High-throughput

0.479

High

1062175

IPO4
Importin-4

1

4

High-throughput

0.479

High

1062178

AUTS2
Autism susceptibility gene 2 protein

1

1

Small-scale

0.479

High

1062180

HS105
Heat shock protein 105 kDa

1

2

High-throughput

0.479

High

1062181

GCN1
Stalled ribosome sensor GCN1

1

5

High-throughput

0.479

High

1062184

FUBP2
Far upstream element-binding protein 2

1

2

High-throughput

0.479

High

1062186

TNPO1
Transportin-1

1

5

High-throughput

0.479

High

1062191

TCPH
T-complex protein 1 subunit eta

1

4

High-throughput

0.479

High

1062196

NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

1

1

High-throughput

0.479

High

1062199

WDR26
WD repeat-containing protein 26

1

1

High-throughput

0.479

High

1062200

XPO5
Exportin-5

1

2

High-throughput

0.479

High

1062203

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

2

High-throughput

0.479

High

1062206

RERE
Arginine-glutamic acid dipeptide repeats protein

1

1

Small-scale

0.479

High

1062215

BSN
Protein bassoon

1

2

High-throughput

0.479

High

1062217

SRRM2
Serine/arginine repetitive matrix protein 2

1

2

High-throughput

0.479

High

154804

TCRG1
Transcription elongation regulator 1

1

0

High-throughput

0.458

High

165482

SR140
U2 snRNP-associated SURP motif-containing protein

1

0

High-throughput

0.458

High

201336

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.458

High

202172

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

0

High-throughput

0.458

High

231099

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

Small-scale

0.458

High

282903

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

0

High-throughput

0.458

High

311544

SMC2
Structural maintenance of chromosomes protein 2

1

0

High-throughput

0.458

High

417724

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

434479

FUMH
Fumarate hydratase, mitochondrial

1

0

High-throughput

0.458

High

455459

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

518871

TPR
Nucleoprotein TPR

1

0

High-throughput

0.458

High

523764

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

531315

MT1G
Metallothionein-1G

1

0

Small-scale

0.458

High

533301

PLST
Plastin-3

1

0

High-throughput

0.458

High

548708

VAV
Proto-oncogene vav

1

0

Small-scale

0.458

High

641781

U2AF2
Splicing factor U2AF 65 kDa subunit

1

0

High-throughput

0.458

High

670030

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

681450

DNJA1
DnaJ homolog subfamily A member 1

1

0

High-throughput

0.458

High

713975

HS71L
Heat shock 70 kDa protein 1-like

1

0

High-throughput

0.458

High

724079

K1C9
Keratin, type I cytoskeletal 9

1

0

High-throughput

0.458

High

725955

ADDA
Alpha-adducin

1

0

High-throughput

0.458

High

789790

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

803542

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.458

High

825828

NASP
Nuclear autoantigenic sperm protein

1

0

High-throughput

0.458

High

832985

YLPM1
YLP motif-containing protein 1

1

0

Small-scale

0.458

High

880112

SYMC
Methionine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

888366

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.458

High

902417

RL37
Large ribosomal subunit protein eL37

1

0

Small-scale

0.458

High

920969

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

0

Small-scale

0.458

High

932164

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

942162

GTF2I
General transcription factor II-I

1

0

High-throughput

0.458

High

943836

RAE1L
mRNA export factor RAE1

1

0

Small-scale

0.458

High

958032

RBM10
RNA-binding protein 10

1

0

High-throughput

0.458

High

965190

CAP1
Adenylyl cyclase-associated protein 1

1

0

High-throughput

0.458

High

966546

OTUD4
OTU domain-containing protein 4

1

0

High-throughput

0.458

High

987974

RING1
E3 ubiquitin-protein ligase RING1

1

0

Small-scale

0.458

High

1018794

SF3A3
Splicing factor 3A subunit 3

1

0

High-throughput

0.458

High

1035171

ROCK1
Rho-associated protein kinase 1

1

0

High-throughput

0.458

High

1036404

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

0

Small-scale

0.458

High

1037800

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

0

High-throughput

0.458

High

1039216

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.458

High

1043356

CUL4B
Cullin-4B

1

0

High-throughput

0.458

High

1051279

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.458

High

1055116

HLTF
Helicase-like transcription factor

1

0

Small-scale

0.458

High

1062148

SF3B4
Splicing factor 3B subunit 4

1

0

High-throughput

0.458

High

1062149

SF3A2
Splicing factor 3A subunit 2

1

0

High-throughput

0.458

High

1062150

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.458

High

1062151

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

0

High-throughput

0.458

High

1062152

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.458

High

1062153

DREB
Drebrin

1

0

High-throughput

0.458

High

1062155

PDCD4
Programmed cell death protein 4

1

0

High-throughput

0.458

High

1062157

UBAP2
Ubiquitin-associated protein 2

1

0

Small-scale

0.458

High

1062161

F111B
Serine protease FAM111B

1

0

Small-scale

0.458

High

1062163

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.458

High

1062174

PUM2
Pumilio homolog 2

1

0

Small-scale

0.458

High

1062179

RT27
Small ribosomal subunit protein mS27

1

0

High-throughput

0.458

High

1062183

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

0

Small-scale

0.458

High

1062189

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

High-throughput

0.458

High

1062192

MBB1A
Myb-binding protein 1A

1

0

High-throughput

0.458

High

1062195

NADAP
Kanadaptin

1

0

High-throughput

0.458

High

1062197

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.458

High

1062198

REN3B
Regulator of nonsense transcripts 3B

1

0

High-throughput

0.458

High

1062202

MIC19
MICOS complex subunit MIC19

1

0

Small-scale

0.458

High

1062204

CAMP3
Calmodulin-regulated spectrin-associated protein 3

1

0

High-throughput

0.458

High

1062205

ANFY1
Rabankyrin-5

1

0

High-throughput

0.458

High

1062207

SAE2
SUMO-activating enzyme subunit 2

1

0

Small-scale

0.458

High

1062211

C8AP2
CASP8-associated protein 2

1

0

High-throughput

0.458

High

1062212

AKP8L
A-kinase anchor protein 8-like

1

0

Small-scale

0.458

High

1062213

MAGD2
Melanoma-associated antigen D2

1

0

High-throughput

0.458

High

1062214

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

High-throughput

0.458

High

1062221

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

0

High-throughput

0.458

High

1062223

YTHD2
YTH domain-containing family protein 2

1

0

Small-scale

0.458

High

1062224

SP16H
FACT complex subunit SPT16

1

0

Small-scale

0.458

High

178167

IPO8
Importin-8

1

4

High-throughput

0.437

High

312272

IPO7
Importin-7

1

5

High-throughput

0.437

High

571717

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

1

Small-scale

0.437

High

636927

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

Small-scale

0.437

High

727257

NU214
Nuclear pore complex protein Nup214

1

3

Small-scale

0.437

High

820926

PRC2A
Protein PRRC2A

1

2

High-throughput

0.437

High

821217

TCPE
T-complex protein 1 subunit epsilon

1

4

High-throughput

0.437

High

826667

TCPG
T-complex protein 1 subunit gamma

1

4

High-throughput

0.437

High

834602

NU153
Nuclear pore complex protein Nup153

1

3

Small-scale

0.437

High

843201

TCPD
T-complex protein 1 subunit delta

1

3

High-throughput

0.437

High

857981

NUP98
Nuclear pore complex protein Nup98-Nup96

1

2

Small-scale

0.437

High

1062164

NUP54
Nucleoporin p54

1

3

Small-scale

0.437

High

1062168

PRSR1
Proline and serine-rich protein 1

1

1

High-throughput

0.437

High

1062173

NIN
Ninein

1

1

High-throughput

0.437

High

1062222

PRC2C
Protein PRRC2C

1

3

High-throughput

0.437

High

1062170

FAM9B
Protein FAM9B

3

0

High-throughput

0.352

High

1062162

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

2

0

Small-scale

0.305

High

118315

HAX1
HCLS1-associated protein X-1

1

0

Small-scale

0.249

Low

197307

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.249

Low

240738

USO1
General vesicular transport factor p115

1

0

High-throughput

0.249

Low

273105

SURF6
Surfeit locus protein 6

1

0

Small-scale

0.249

Low

300754

GLSK
Glutaminase kidney isoform, mitochondrial

1

0

Small-scale

0.249

Low

301292

MTCL2
Microtubule cross-linking factor 2

1

0

High-throughput

0.249

Low

307814

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

1

0

High-throughput

0.249

Low

314329

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

Small-scale

0.249

Low

489743

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.249

Low

556620

CBR1
Carbonyl reductase [NADPH] 1

1

0

Small-scale

0.249

Low

609012

ADRO
NADPH:adrenodoxin oxidoreductase, mitochondrial

1

0

Small-scale

0.249

Low

657609

ITPI2
Protein ITPRID2

1

0

High-throughput

0.249

Low

666909

TKT
Transketolase

1

0

Small-scale

0.249

Low

682502

PUR9
Bifunctional purine biosynthesis protein ATIC

1

0

High-throughput

0.249

Low

726206

BASI
Basigin

1

0

High-throughput

0.249

Low

735945

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

Small-scale

0.249

Low

778149

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

836644

GUAA
GMP synthase [glutamine-hydrolyzing]

1

0

Small-scale

0.249

Low

844526

RAB5C
Ras-related protein Rab-5C

1

0

Small-scale

0.249

Low

846472

BLK
Tyrosine-protein kinase Blk

1

0

High-throughput

0.249

Low

994749

GOGA3
Golgin subfamily A member 3

1

0

High-throughput

0.249

Low

1014012

AP1B1
AP-1 complex subunit beta-1

1

0

High-throughput

0.249

Low

1062147

ACAP2
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

1

0

High-throughput

0.249

Low

1062154

PCKGM
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

1

0

Small-scale

0.249

Low

1062159

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.249

Low

1062171

NUP93
Nuclear pore complex protein Nup93

1

0

Small-scale

0.249

Low

1062172

LRC47
Leucine-rich repeat-containing protein 47

1

0

High-throughput

0.249

Low

1062176

PDC6I
Programmed cell death 6-interacting protein

1

0

High-throughput

0.249

Low

1062177

ATX2L
Ataxin-2-like protein

1

0

High-throughput

0.249

Low

1062182

SORL
Sortilin-related receptor

1

0

High-throughput

0.249

Low

1062185

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

1

0

Small-scale

0.249

Low

1062190

METH
Methionine synthase

1

0

High-throughput

0.249

Low

1062193

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.249

Low

1062194

NUP85
Nuclear pore complex protein Nup85

1

0

Small-scale

0.249

Low

1062201

ARGL1
Arginine and glutamate-rich protein 1

1

0

Small-scale

0.249

Low

1062208

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.249

Low

1062209

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.249

Low

1062210

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.249

Low

1062216

SATB2
DNA-binding protein SATB2

1

0

Small-scale

0.249

Low

1062218

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

0

High-throughput

0.249

Low

1062219

RT02
Small ribosomal subunit protein uS2m

1

0

Small-scale

0.249

Low

1062220

TLN1
Talin-1

1

0

High-throughput

0.249

Low

1062225

NS1BP
Influenza virus NS1A-binding protein

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024