Protein: LAS1L
Ribosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog)

Gene: LAS1L
Organism: Homo sapiens
Interactions: 173
UniProt ID: Q9Y4W2

Gene Ontology (top 5):
GO:0000460 - maturation of 5.8S rRNA
GO:0000470 - maturation of LSU-rRNA
GO:0003723 - RNA binding
GO:0004519 - endonuclease activity
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1132188

NOL9
Polynucleotide 5'-hydroxyl-kinase NOL9

3

2

Small-scale

0.847

High

1224552

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

5

2

Small-scale

0.713

High

1313455

WDR18
WD repeat-containing protein 18

5

3

Small-scale

0.709

High

1331219

SENP3
Sentrin-specific protease 3

5

1

Small-scale

0.706

High

271461

NPM3
Nucleoplasmin-3

3

1

High-throughput

0.675

High

348348

MYC
Myc proto-oncogene protein

4

0

High-throughput

0.648

High

127410

IPO5
Importin-5

3

0

Small-scale

0.638

High

418831

NPM
Nucleophosmin

2

1

High-throughput

0.628

High

603815

FBRL
rRNA 2'-O-methyltransferase fibrillarin

3

0

High-throughput

0.616

High

1086058

IF16
Gamma-interferon-inducible protein 16

2

3

High-throughput

0.611

High

1153992

IFIX
Pyrin and HIN domain-containing protein 1

2

3

High-throughput

0.611

High

316210

CBX6
Chromobox protein homolog 6

2

0

High-throughput

0.602

High

1042926

CUL3
Cullin-3

2

0

High-throughput

0.585

High

456040

PARP1
Poly [ADP-ribose] polymerase 1

2

1

High-throughput

0.584

High

902823

SUMO2
Small ubiquitin-related modifier 2

2

0

High-throughput

0.577

High

370807

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

916995

RS6
Small ribosomal subunit protein eS6

2

0

High-throughput

0.559

High

1347956

TEX10
Testis-expressed protein 10

2

0

Small-scale

0.559

High

157097

AIM2
Interferon-inducible protein AIM2

1

3

High-throughput

0.536

High

781864

MNDA
Myeloid cell nuclear differentiation antigen

1

3

High-throughput

0.536

High

863809

LIMK1
LIM domain kinase 1

1

1

High-throughput

0.536

High

929743

RACK1
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.536

High

943045

SRPK2
SRSF protein kinase 2

1

2

High-throughput

0.536

High

1202215

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

1302116

SRPK1
SRSF protein kinase 1

1

2

High-throughput

0.536

High

1312110

RBM42
RNA-binding protein 42

1

1

High-throughput

0.536

High

1147688

FTM
Protein fantom

1

1

High-throughput

0.515

High

283636

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.513

High

390640

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.513

High

391281

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.513

High

448023

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

585596

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

0

High-throughput

0.513

High

587084

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

595488

LMNB1
Lamin-B1

1

0

High-throughput

0.513

High

649852

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

763144

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.513

High

806238

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

818655

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.513

High

828954

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

831094

CTCF
Transcriptional repressor CTCF

1

0

High-throughput

0.513

High

899092

PSME3
Proteasome activator complex subunit 3

1

0

High-throughput

0.513

High

908240

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

1048396

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.513

High

1054033

CAPR1
Caprin-1

1

0

High-throughput

0.513

High

1199471

LYRIC
Protein LYRIC

1

0

High-throughput

0.513

High

1253705

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.513

High

1263595

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.513

High

1303892

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

1316242

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

1328451

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

0

High-throughput

0.513

High

1355313

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

1357495

MAGD2
Melanoma-associated antigen D2

1

0

High-throughput

0.513

High

1377144

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.513

High

1377788

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

0

High-throughput

0.513

High

1302962

PNKP
Bifunctional polynucleotide phosphatase/kinase

1

0

High-throughput

0.493

High

1355748

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

821827

NEST
Nestin

1

1

High-throughput

0.489

High

854220

JAK3
Tyrosine-protein kinase JAK3

1

1

High-throughput

0.489

High

1357647

SRPK3
SRSF protein kinase 3

1

2

High-throughput

0.489

High

1270024

ESR2
Estrogen receptor beta

1

2

High-throughput

0.484

High

163520

XPO1
Exportin-1

1

1

High-throughput

0.479

High

179904

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.479

High

323364

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.479

High

542089

ETS1
Protein C-ets-1

1

1

High-throughput

0.479

High

554154

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

685140

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

718361

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.479

High

781249

ETV3
ETS translocation variant 3

1

1

High-throughput

0.479

High

826383

CDK8
Cyclin-dependent kinase 8

1

1

High-throughput

0.479

High

945000

RED1
Double-stranded RNA-specific editase 1

1

2

High-throughput

0.479

High

1018772

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.479

High

1020017

ILF3
Interleukin enhancer-binding factor 3

1

2

High-throughput

0.479

High

1026603

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

1059964

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.479

High

1064292

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

1236595

SIR6
NAD-dependent protein deacylase sirtuin-6

1

1

High-throughput

0.479

High

1244597

NUP43
Nucleoporin Nup43

1

2

High-throughput

0.479

High

1282736

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

1

High-throughput

0.479

High

1288408

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

1

High-throughput

0.479

High

1304213

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

1305156

DNJC7
DnaJ homolog subfamily C member 7

1

1

High-throughput

0.479

High

1313231

DDX23
Probable ATP-dependent RNA helicase DDX23

1

1

High-throughput

0.479

High

1327560

XRN2
5'-3' exoribonuclease 2

1

2

High-throughput

0.479

High

1331268

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

1

High-throughput

0.479

High

1344556

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

1377902

RBM8A
RNA-binding protein 8A

1

1

High-throughput

0.479

High

147580

SOCS6
Suppressor of cytokine signaling 6

1

1

High-throughput

0.470

High

123126

MEN1
Menin

1

0

High-throughput

0.458

High

133749

NOP56
Nucleolar protein 56

1

0

High-throughput

0.458

High

149465

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

182969

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

245131

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

298924

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

345589

FOS
Protein c-Fos

1

0

High-throughput

0.458

High

476629

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.458

High

570225

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

652712

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

653048

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

669103

PML
Protein PML

1

0

High-throughput

0.458

High

721877

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

750558

COIL
Coilin

1

0

High-throughput

0.458

High

824581

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

828433

CENPA
Histone H3-like centromeric protein A

1

0

High-throughput

0.458

High

841366

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.458

High

877979

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

918201

H4
Histone H4

1

0

High-throughput

0.458

High

918791

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

920411

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

922491

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

1054707

RBM39
RNA-binding protein 39

1

0

High-throughput

0.458

High

1057037

MDC1
Mediator of DNA damage checkpoint protein 1

1

0

High-throughput

0.458

High

1156438

ZN746
Zinc finger protein 746

1

0

High-throughput

0.458

High

1220324

DHX40
Probable ATP-dependent RNA helicase DHX40

1

0

High-throughput

0.458

High

1221872

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1235728

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.458

High

1251097

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.458

High

1256513

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1281887

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1286510

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1294179

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1299501

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

1305993

BARD1
BRCA1-associated RING domain protein 1

1

0

High-throughput

0.458

High

1316950

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

0

High-throughput

0.458

High

1326474

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

1327172

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1332818

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1333836

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

1343851

ANLN
Anillin

1

0

High-throughput

0.458

High

1345590

SLX9
Ribosome biogenesis protein SLX9 homolog

1

0

Small-scale

0.458

High

1347481

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

1348932

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1350144

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

1377736

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

903643

WDR5
WD repeat-containing protein 5

1

1

Small-scale

0.445

High

229168

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.437

High

385789

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

822700

LHX1
LIM/homeobox protein Lhx1

1

1

High-throughput

0.437

High

1313560

CP250
Centrosome-associated protein CEP250

1

1

High-throughput

0.437

High

1331730

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

275483

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.426

High

990408

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

Small-scale

0.426

High

1057747

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

1356724

AGO1
Protein argonaute-1

1

0

High-throughput

0.426

High

780385

CCNF
Cyclin-F

2

0

High-throughput

0.313

High

375151

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

0

High-throughput

0.305

High

1130772

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

0

High-throughput

0.288

High

156729

TR13B
Tumor necrosis factor receptor superfamily member 13B

1

0

High-throughput

0.279

Low

428521

TBB5
Tubulin beta chain

1

0

High-throughput

0.279

Low

472810

H2AB1
Histone H2A-Bbd type 1

1

0

High-throughput

0.279

Low

473176

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.279

Low

515313

KPSH1
Serine/threonine-protein kinase H1

1

0

High-throughput

0.279

Low

1160313

PKN3
Serine/threonine-protein kinase N3

1

0

High-throughput

0.279

Low

1302898

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.279

Low

1315418

KLF16
Krueppel-like factor 16

1

0

High-throughput

0.279

Low

1345646

NRBP2
Nuclear receptor-binding protein 2

1

0

High-throughput

0.279

Low

1377901

NGN3
Neurogenin-3

1

0

High-throughput

0.279

Low

1257296

MOT10
Monocarboxylate transporter 10

1

0

High-throughput

0.269

Low

118503

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.249

Low

119581

LEG9
Galectin-9

1

0

High-throughput

0.249

Low

256179

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

846549

BLK
Tyrosine-protein kinase Blk

1

0

High-throughput

0.249

Low

909392

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

1053706

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1061711

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

1077372

T22D1
TSC22 domain family protein 1

1

0

High-throughput

0.249

Low

1172428

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1189108

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1231382

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

1300889

PASK
PAS domain-containing serine/threonine-protein kinase

1

0

High-throughput

0.249

Low

1347003

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

Small-scale

0.249

Low

1357031

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

1299813

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.232

Low

1316320

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024