Protein: BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2)

Gene: BIG2, ARFGEF2
Organism: Homo sapiens
Interactions: 119
UniProt ID: Q9Y6D5

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001881 - receptor recycling
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005794 - Golgi apparatus
GO:0005802 - trans-Golgi network

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1378202

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

5

9

Small-scale

0.924

High

1255553

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

3

1

High-throughput

0.667

High

1357947

LAMP3
Lysosome-associated membrane glycoprotein 3

3

7

High-throughput

0.667

High

498386

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

3

Small-scale

0.636

High

1303446

MYCBP
c-Myc-binding protein

3

1

Small-scale

0.623

High

776215

ARL1
ADP-ribosylation factor-like protein 1

1

20

High-throughput

0.618

High

1310274

CAB45
45 kDa calcium-binding protein

2

3

High-throughput

0.611

High

1204242

F131B
Protein FAM131B

2

0

High-throughput

0.602

High

206238

TGON2
Trans-Golgi network integral membrane protein 2

2

3

High-throughput

0.584

High

592089

RAB4A
Ras-related protein Rab-4A

2

16

High-throughput

0.584

High

409811

GLPB
Glycophorin-B

2

1

High-throughput

0.574

High

623019

EDNRB
Endothelin receptor type B

2

7

High-throughput

0.574

High

1237341

SIGL1
SIGLEC family-like protein 1

2

3

High-throughput

0.574

High

1343112

TMM9B
Transmembrane protein 9B

2

6

High-throughput

0.574

High

1030777

SLAF1
Signaling lymphocytic activation molecule

2

8

High-throughput

0.558

High

1318481

CD244
Natural killer cell receptor 2B4

2

6

High-throughput

0.558

High

1331764

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.553

High

1283819

PLPL2
Patatin-like phospholipase domain-containing protein 2

1

2

Small-scale

0.552

High

354625

HLAB
HLA class I histocompatibility antigen, B alpha chain

2

6

High-throughput

0.552

High

172309

GP182
G-protein coupled receptor 182

1

16

High-throughput

0.536

High

196909

CYB5B
Cytochrome b5 type B

1

2

High-throughput

0.536

High

207678

AKA10
A-kinase anchor protein 10, mitochondrial

1

2

High-throughput

0.536

High

274313

STK16
Serine/threonine-protein kinase 16

1

3

High-throughput

0.536

High

445143

K1C16
Keratin, type I cytoskeletal 16

1

4

High-throughput

0.536

High

488431

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

6

High-throughput

0.536

High

595579

GRAH
Granzyme H

1

3

High-throughput

0.536

High

599035

FPR1
fMet-Leu-Phe receptor

1

10

High-throughput

0.536

High

639671

TNR5
Tumor necrosis factor receptor superfamily member 5

1

8

High-throughput

0.536

High

726495

BASI
Basigin

1

8

High-throughput

0.536

High

864338

ITA8
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

1

2

High-throughput

0.536

High

1205256

K2C73
Keratin, type II cytoskeletal 73

1

1

High-throughput

0.536

High

1232106

LRC25
Leucine-rich repeat-containing protein 25

1

2

High-throughput

0.536

High

1233082

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

3

High-throughput

0.536

High

1287790

ORAI1
Calcium release-activated calcium channel protein 1

1

1

High-throughput

0.536

High

1299285

OPALI
Opalin

1

2

High-throughput

0.536

High

1318633

DPY30
Protein dpy-30 homolog

1

1

High-throughput

0.536

High

1328371

F234A
Protein FAM234A

1

2

High-throughput

0.536

High

1347750

OCAD1
OCIA domain-containing protein 1

1

1

High-throughput

0.536

High

1349823

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

6

High-throughput

0.536

High

1355546

CLC2D
C-type lectin domain family 2 member D

1

5

High-throughput

0.536

High

1356187

HSPB8
Heat shock protein beta-8

1

1

High-throughput

0.536

High

1357549

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

2

High-throughput

0.536

High

1377078

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

5

High-throughput

0.536

High

1377955

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

4

High-throughput

0.536

High

533891

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

3

Small-scale

0.527

High

584514

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

8

Small-scale

0.515

High

198767

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

0

High-throughput

0.513

High

400140

ICAM1
Intercellular adhesion molecule 1

1

0

High-throughput

0.513

High

874208

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

High-throughput

0.513

High

913380

PRS10
26S proteasome regulatory subunit 10B

1

0

High-throughput

0.513

High

1027843

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

High-throughput

0.513

High

1035367

MADCA
Mucosal addressin cell adhesion molecule 1

1

0

High-throughput

0.513

High

1284493

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

0

High-throughput

0.513

High

1356223

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.513

High

263888

PR40A
Pre-mRNA-processing factor 40 homolog A

1

2

High-throughput

0.508

High

1053741

PDE3A
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

1

3

Small-scale

0.500

High

131987

UPK2
Uroplakin-2

1

3

High-throughput

0.489

High

971844

HEN2
Helix-loop-helix protein 2

1

3

High-throughput

0.489

High

1020154

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

7

High-throughput

0.489

High

1031126

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

16

High-throughput

0.489

High

1082780

RM23
Large ribosomal subunit protein uL23m

1

1

High-throughput

0.489

High

1083622

SGCA
Alpha-sarcoglycan

1

1

High-throughput

0.489

High

1150815

VASN
Vasorin

1

2

High-throughput

0.489

High

1254698

HUMMR
Protein MGARP

1

3

High-throughput

0.489

High

1265980

CLC2B
C-type lectin domain family 2 member B

1

7

High-throughput

0.489

High

1297048

ANM6
Protein arginine N-methyltransferase 6

1

5

High-throughput

0.489

High

1312843

TBB6
Tubulin beta-6 chain

1

1

High-throughput

0.489

High

1357811

KCNH4
Potassium voltage-gated channel subfamily H member 4

1

3

High-throughput

0.489

High

1378170

NPTN
Neuroplastin

1

10

High-throughput

0.489

High

1357750

EXOC7
Exocyst complex component 7

1

0

Small-scale

0.484

High

132648

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

3

High-throughput

0.479

High

178894

STX7
Syntaxin-7

1

2

High-throughput

0.479

High

213083

STX6
Syntaxin-6

1

6

High-throughput

0.479

High

305700

ZFPL1
Zinc finger protein-like 1

1

3

High-throughput

0.479

High

349038

RASN
GTPase NRas

1

20

High-throughput

0.479

High

349770

RASH
GTPase HRas

1

12

High-throughput

0.479

High

527918

LAMP2
Lysosome-associated membrane glycoprotein 2

1

7

High-throughput

0.479

High

533178

HLAE
HLA class I histocompatibility antigen, alpha chain E

1

6

High-throughput

0.479

High

545730

RAC2
Ras-related C3 botulinum toxin substrate 2

1

11

High-throughput

0.479

High

636535

DNJB2
DnaJ homolog subfamily B member 2

1

1

High-throughput

0.479

High

679417

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

3

Small-scale

0.479

High

717470

CTNB1
Catenin beta-1

1

3

Small-scale

0.479

High

738153

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

2

Small-scale

0.479

High

845393

RAB7A
Ras-related protein Rab-7a

1

19

High-throughput

0.479

High

845834

RAB9A
Ras-related protein Rab-9A

1

20

High-throughput

0.479

High

875495

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.479

High

914498

RB11A
Ras-related protein Rab-11A

1

7

High-throughput

0.479

High

945914

NUCB2
Nucleobindin-2

1

1

Small-scale

0.479

High

1042955

CUL3
Cullin-3

1

4

High-throughput

0.479

High

1070486

RAB35
Ras-related protein Rab-35

1

12

High-throughput

0.479

High

1152234

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.479

High

1163933

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

1264901

RFFL
E3 ubiquitin-protein ligase rififylin

1

1

Small-scale

0.479

High

1335428

RHOF
Rho-related GTP-binding protein RhoF

1

17

High-throughput

0.479

High

1348630

ELOV5
Very long chain fatty acid elongase 5

1

3

High-throughput

0.479

High

1355043

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

170577

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

1

0

High-throughput

0.458

High

697578

HPPD
4-hydroxyphenylpyruvate dioxygenase

1

0

Small-scale

0.458

High

931962

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.458

High

1261356

TM171
Transmembrane protein 171

1

0

High-throughput

0.458

High

1290428

DTBP1
Dysbindin

1

0

High-throughput

0.458

High

1348808

ERAP1
Endoplasmic reticulum aminopeptidase 1

1

0

Small-scale

0.458

High

500924

CLUS
Clusterin

1

0

High-throughput

0.438

High

554185

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

645869

FKBP2
Peptidyl-prolyl cis-trans isomerase FKBP2

1

1

Small-scale

0.437

High

652743

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

721913

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

749999

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.437

High

1166898

LRC31
Leucine-rich repeat-containing protein 31

1

1

High-throughput

0.437

High

1172480

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

1331016

RHOJ
Rho-related GTP-binding protein RhoJ

1

17

High-throughput

0.437

High

1335587

SACA1
Sperm acrosome membrane-associated protein 1

1

2

High-throughput

0.437

High

771264

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

0

High-throughput

0.328

High

1291900

MRAP2
Melanocortin-2 receptor accessory protein 2

2

0

High-throughput

0.328

High

1295513

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

118508

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.279

Low

1039979

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.279

Low

1067960

PDCD1
Programmed cell death protein 1

1

0

High-throughput

0.279

Low

1357317

CLC4A
C-type lectin domain family 4 member A

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024