Protein: HPRT
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8)

Gene: HPRT, HPRT1
Organism: Homo sapiens
Interactions: 116
UniProt ID: P00492

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0000287 - magnesium ion binding
GO:0001913 - T cell mediated cytotoxicity
GO:0001975 - response to amphetamine
GO:0004422 - hypoxanthine phosphoribosyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

337131

PRDC1
Phosphoribosyltransferase domain-containing protein 1

9

5

High-throughput

0.978

High

337042

HPRT
Hypoxanthine-guanine phosphoribosyltransferase

5

5

Small-scale

0.918

High

337111

NTAQ1
Protein N-terminal glutamine amidohydrolase

6

1

High-throughput

0.740

High

132702

SDCB1
Syntenin-1

4

0

High-throughput

0.668

High

337090

CUL3
Cullin-3

2

1

High-throughput

0.611

High

337110

EF2KT
Protein-lysine N-methyltransferase EEF2KMT

2

1

High-throughput

0.606

High

337134

SPG21
Maspardin

2

1

High-throughput

0.606

High

337126

ISCU
Iron-sulfur cluster assembly enzyme ISCU

2

0

High-throughput

0.601

High

337094

GNMT
Glycine N-methyltransferase

2

0

High-throughput

0.580

High

337097

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

2

High-throughput

0.571

High

226197

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

337069

CCNF
Cyclin-F

2

0

High-throughput

0.559

High

337078

CASP9
Caspase-9

2

0

High-throughput

0.547

High

337052

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.536

High

337108

CUL5
Cullin-5

1

1

High-throughput

0.536

High

337115

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.536

High

337124

SHRPN
Sharpin

1

1

High-throughput

0.536

High

337075

FXR1
RNA-binding protein FXR1

1

0

High-throughput

0.518

High

337101

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

1

High-throughput

0.515

High

128389

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

201161

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

337055

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.513

High

337066

GLRX1
Glutaredoxin-1

1

0

High-throughput

0.513

High

337086

KPCZ
Protein kinase C zeta type

1

0

High-throughput

0.513

High

337120

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.513

High

337142

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.513

High

245865

HUS1
Checkpoint protein HUS1

1

0

High-throughput

0.493

High

337060

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.493

High

337070

HD
Huntingtin

1

0

High-throughput

0.493

High

337085

TIE2
Angiopoietin-1 receptor

1

0

High-throughput

0.479

High

119064

LEG9
Galectin-9

1

1

High-throughput

0.479

High

337043

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

337049

RHOC
Rho-related GTP-binding protein RhoC

1

2

High-throughput

0.479

High

337056

RAC2
Ras-related C3 botulinum toxin substrate 2

1

1

High-throughput

0.479

High

337058

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

337065

FUS
RNA-binding protein FUS

1

2

High-throughput

0.479

High

337071

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

337079

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

3

High-throughput

0.479

High

337083

RHOB
Rho-related GTP-binding protein RhoB

1

2

High-throughput

0.479

High

337084

EWS
RNA-binding protein EWS

1

2

High-throughput

0.479

High

337091

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

2

High-throughput

0.479

High

337099

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

337105

RIN3
Ras and Rab interactor 3

1

1

High-throughput

0.479

High

337121

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

337123

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

3

High-throughput

0.479

High

337141

TRAF6
TNF receptor-associated factor 6

1

1

High-throughput

0.479

High

176523

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.460

High

294244

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

302756

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

322047

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

326366

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

337044

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

337046

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

337048

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

337050

ANXA5
Annexin A5

1

0

High-throughput

0.458

High

337053

EPB41
Protein 4.1

1

0

High-throughput

0.458

High

337062

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

337064

BASI
Basigin

1

0

High-throughput

0.458

High

337067

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

337068

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

337074

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

337076

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

337077

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

337080

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

337081

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.458

High

337082

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

337087

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

337089

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

337093

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

337095

CUL7
Cullin-7

1

0

High-throughput

0.458

High

337096

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.458

High

337098

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

337106

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

337112

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

337114

RUFY1
RUN and FYVE domain-containing protein 1

1

0

High-throughput

0.458

High

337116

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

337117

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

337119

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

337127

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

337128

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

337129

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

337130

SIAS
Sialic acid synthase

1

0

High-throughput

0.458

High

337132

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

337133

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

337135

TRM7
tRNA

1

0

High-throughput

0.458

High

337136

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

337137

HERC5
E3 ISG15--protein ligase HERC5

1

0

Small-scale

0.458

High

337138

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.458

High

337140

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

305881

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

3

High-throughput

0.445

High

337059

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

1

High-throughput

0.445

High

337125

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

3

High-throughput

0.445

High

337045

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

337100

ASXL2
Putative Polycomb group protein ASXL2

1

2

High-throughput

0.437

High

337102

ASXL1
Polycomb group protein ASXL1

1

2

High-throughput

0.437

High

337122

ASXL3
Putative Polycomb group protein ASXL3

1

2

High-throughput

0.437

High

337054

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

337109

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

337047

JUN
Transcription factor Jun

1

1

High-throughput

0.407

High

337073

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.373

High

337103

EFCB3
EF-hand calcium-binding domain-containing protein 3

2

0

High-throughput

0.316

High

337104

SR1IP
Protein SREK1IP1

2

0

High-throughput

0.316

High

337051

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

337118

ELOV1
Very long chain fatty acid elongase 1

1

0

High-throughput

0.279

Low

239471

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.269

Low

329208

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

337057

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

337061

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

337063

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

337072

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

337088

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.249

Low

337092

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

337107

TNR14
Tumor necrosis factor receptor superfamily member 14

1

0

High-throughput

0.249

Low

337113

LMTK3
Serine/threonine-protein kinase LMTK3

1

0

High-throughput

0.249

Low

337139

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024