Protein: APOE
Apolipoprotein E (Apo-E)

Gene: APOE
Organism: Homo sapiens
Interactions: 146
UniProt ID: P02649

Gene Ontology (top 5):
GO:0000302 - response to reactive oxygen species
GO:0001540 - amyloid-beta binding
GO:0001937 - negative regulation of endothelial cell proliferation
GO:0002021 - response to dietary excess
GO:0005102 - signaling receptor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

361417

APOE
Apolipoprotein E

2

3

Small-scale

0.783

High

361424

A4
Amyloid-beta precursor protein

6

4

Small-scale

0.723

High

361435

TAU
Microtubule-associated protein tau

5

2

Small-scale

0.714

High

361455

SYUA
Alpha-synuclein

3

1

Small-scale

0.691

High

361480

LRP1
Prolow-density lipoprotein receptor-related protein 1

3

7

Small-scale

0.684

High

361485

LRP8
Low-density lipoprotein receptor-related protein 8

3

7

Small-scale

0.674

High

361428

MMP3
Stromelysin-1

3

2

High-throughput

0.667

High

361482

MMRN1
Multimerin-1

3

1

High-throughput

0.667

High

361519

ACE2
Angiotensin-converting enzyme 2

3

0

Small-scale

0.659

High

361442

VDAC1
Voltage-dependent anion-selective channel protein 1

3

1

High-throughput

0.657

High

361441

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

3

0

High-throughput

0.638

High

351033

LDLR
Low-density lipoprotein receptor

2

7

Small-scale

0.635

High

361431

MMP10
Stromelysin-2

2

2

High-throughput

0.628

High

361540

VDAC3
Voltage-dependent anion-selective channel protein 3

2

1

High-throughput

0.628

High

361419

CO9
Complement component C9 [Cleaved into: Complement component C9a; Complement component C9b]

2

8

High-throughput

0.621

High

344394

A2MG
Alpha-2-macroglobulin

2

0

Small-scale

0.613

High

361525

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.602

High

361463

CD81
CD81 antigen

2

1

Small-scale

0.601

High

361508

SORL
Sortilin-related receptor

2

7

Small-scale

0.595

High

341173

HPT
Haptoglobin

1

1

Small-scale

0.589

High

361489

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.565

High

361492

PDCD4
Programmed cell death protein 4

1

0

High-throughput

0.565

High

361515

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

0

High-throughput

0.565

High

361429

CFAH
Complement factor H

1

0

Small-scale

0.564

High

361453

RL4
Large ribosomal subunit protein uL4

2

0

High-throughput

0.561

High

361471

ACTG
Actin, cytoplasmic 2

2

0

High-throughput

0.561

High

361458

F10A1
Hsc70-interacting protein

1

0

High-throughput

0.557

High

253827

TMCC2
Transmembrane and coiled-coil domains protein 2

1

0

Small-scale

0.549

High

157403

IFIT3
Interferon-induced protein with tetratricopeptide repeats 3

1

1

High-throughput

0.541

High

361434

CP2C8
Cytochrome P450 2C8

1

1

High-throughput

0.541

High

361543

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

2

High-throughput

0.541

High

198345

KLK10
Kallikrein-10

1

2

High-throughput

0.536

High

361418

APOC2
Apolipoprotein C-II

1

1

High-throughput

0.536

High

361420

ALBU
Albumin

1

2

High-throughput

0.536

High

361546

NPTN
Neuroplastin

1

1

High-throughput

0.536

High

361423

S100B
Protein S100-B

1

0

High-throughput

0.518

High

361457

PSN1
Presenilin-1

1

0

High-throughput

0.518

High

361511

LOXL4
Lysyl oxidase homolog 4

1

0

High-throughput

0.518

High

361537

CLCF1
Cardiotrophin-like cytokine factor 1

1

1

Small-scale

0.515

High

361432

LEG1
Galectin-1

1

3

High-throughput

0.515

High

361436

MTAP2
Microtubule-associated protein 2

1

2

High-throughput

0.515

High

361439

ZNF24
Zinc finger protein 24

1

2

High-throughput

0.515

High

361459

RBM5
RNA-binding protein 5

1

1

High-throughput

0.515

High

361479

APLP2
Amyloid beta precursor like protein 2

1

4

High-throughput

0.515

High

361491

FX4L6
Forkhead box protein D4-like 6

1

1

High-throughput

0.515

High

361501

Q8IUW6
CLSTN3 protein

1

1

High-throughput

0.515

High

361507

SCRB1
Scavenger receptor class B member 1

1

1

High-throughput

0.515

High

361547

EMIL1
EMILIN-1

1

3

High-throughput

0.515

High

361447

CEAM8
Carcinoembryonic antigen-related cell adhesion molecule 8

1

0

High-throughput

0.513

High

361449

IFNA8
Interferon alpha-8

1

0

High-throughput

0.513

High

361490

MICB
MHC class I polypeptide-related sequence B

1

0

High-throughput

0.513

High

361512

FIMP
Fertilization-influencing membrane protein

1

0

High-throughput

0.513

High

361518

TMM59
Transmembrane protein 59

1

0

High-throughput

0.513

High

361522

CSTL1
Cystatin-like 1

1

0

High-throughput

0.513

High

361445

NOS3
Nitric oxide synthase 3

1

0

High-throughput

0.504

High

361422

LCAT
Phosphatidylcholine-sterol acyltransferase

1

2

Small-scale

0.501

High

361427

HS90A
Heat shock protein HSP 90-alpha

1

1

Small-scale

0.501

High

361446

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

Small-scale

0.501

High

361474

VLDLR
Very low-density lipoprotein receptor

1

7

Small-scale

0.501

High

361475

LRP2
Low-density lipoprotein receptor-related protein 2

1

7

Small-scale

0.501

High

361535

TREM2
Triggering receptor expressed on myeloid cells 2

1

1

Small-scale

0.501

High

263898

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.493

High

361421

MT2
Metallothionein-2

1

0

High-throughput

0.493

High

361444

CNTF
Ciliary neurotrophic factor

1

0

High-throughput

0.493

High

361484

BACD2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

1

0

High-throughput

0.493

High

361497

RN111
E3 ubiquitin-protein ligase Arkadia

1

0

High-throughput

0.493

High

361500

SPA2L
Spermatogenesis-associated protein 2-like protein

1

0

High-throughput

0.493

High

361506

UBA3
NEDD8-activating enzyme E1 catalytic subunit

1

0

High-throughput

0.493

High

361520

LDH6B
L-lactate dehydrogenase A-like 6B

1

0

High-throughput

0.493

High

361523

CSTP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1

1

0

High-throughput

0.493

High

361524

DCR1B
5' exonuclease Apollo

1

0

High-throughput

0.493

High

361526

VPP4
V-type proton ATPase 116 kDa subunit a 4

1

0

High-throughput

0.493

High

361530

RASF1
Ras association domain-containing protein 1

1

0

High-throughput

0.493

High

361532

CT141
Uncharacterized protein C20orf141

1

0

High-throughput

0.493

High

361539

KAD3
GTP:AMP phosphotransferase AK3, mitochondrial

1

0

High-throughput

0.493

High

361544

MSRB2
Methionine-R-sulfoxide reductase B2, mitochondrial

1

0

High-throughput

0.493

High

361503

CA2D3
Voltage-dependent calcium channel subunit alpha-2/delta-3

1

1

High-throughput

0.489

High

307495

EPN2
Epsin-2

1

1

High-throughput

0.481

High

361443

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

1

High-throughput

0.481

High

361450

CP2CI
Cytochrome P450 2C18

1

1

High-throughput

0.481

High

361454

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.481

High

361461

FOXG1
Forkhead box protein G1

1

3

High-throughput

0.481

High

361478

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

5

High-throughput

0.481

High

361483

IFIT5
Interferon-induced protein with tetratricopeptide repeats 5

1

1

High-throughput

0.481

High

361513

ZN558
Zinc finger protein 558

1

1

High-throughput

0.481

High

361514

PRAM
PML-RARA-regulated adapter molecule 1

1

1

High-throughput

0.481

High

361426

NFM
Neurofilament medium polypeptide

1

0

Small-scale

0.480

High

361473

CSK21
Casein kinase II subunit alpha

1

0

Small-scale

0.480

High

119067

LEG9
Galectin-9

1

3

Small-scale

0.479

High

260437

PITX3
Pituitary homeobox 3

1

1

Small-scale

0.479

High

361425

TPM3
Tropomyosin alpha-3 chain

1

1

High-throughput

0.479

High

361433

TPM1
Tropomyosin alpha-1 chain

1

1

High-throughput

0.479

High

361438

ITAM
Integrin alpha-M

1

1

Small-scale

0.479

High

361460

PLTP
Phospholipid transfer protein

1

2

Small-scale

0.479

High

361481

FOXO1
Forkhead box protein O1

1

2

High-throughput

0.479

High

361498

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

361516

CSTN3
Calsyntenin-3

1

1

Small-scale

0.479

High

361502

Q8IY40
GRIK2 protein

1

1

High-throughput

0.470

High

361448

PRDX2
Peroxiredoxin-2

1

0

High-throughput

0.460

High

361462

FXYD7
FXYD domain-containing ion transport regulator 7

1

0

High-throughput

0.460

High

361487

RHEB
GTP-binding protein Rheb

1

0

High-throughput

0.460

High

361488

ELAV1
ELAV-like protein 1

1

0

High-throughput

0.460

High

361494

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

0

High-throughput

0.460

High

361509

HTRA1
Serine protease HTRA1

1

0

High-throughput

0.460

High

361528

ANKH
Mineralization regulator ANKH

1

0

High-throughput

0.460

High

361529

M1IP1
Mid1-interacting protein 1

1

0

High-throughput

0.460

High

361541

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.460

High

129634

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.458

High

361437

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

361451

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

361452

ACHA7
Neuronal acetylcholine receptor subunit alpha-7

1

0

Small-scale

0.458

High

361456

YAP1
Transcriptional coactivator YAP1

1

0

High-throughput

0.458

High

361464

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.458

High

361465

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.458

High

361466

RS14
Small ribosomal subunit protein uS11

1

0

High-throughput

0.458

High

361467

RS26
Small ribosomal subunit protein eS26

1

0

High-throughput

0.458

High

361468

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.458

High

361469

RL8
Large ribosomal subunit protein uL2

1

0

High-throughput

0.458

High

361470

1433Z
14-3-3 protein zeta/delta

1

0

High-throughput

0.458

High

361476

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.458

High

361477

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.458

High

361486

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.458

High

361505

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

361527

SENP2
Sentrin-specific protease 2

1

0

Small-scale

0.458

High

361536

RRBP1
Ribosome-binding protein 1

1

0

High-throughput

0.458

High

361538

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

277873

PIAS1
E3 SUMO-protein ligase PIAS1

1

2

High-throughput

0.457

High

278204

PIAS2
E3 SUMO-protein ligase PIAS2

1

2

High-throughput

0.457

High

361499

HIPK1
Homeodomain-interacting protein kinase 1

1

3

High-throughput

0.457

High

361548

PIAS3
E3 SUMO-protein ligase PIAS3

1

2

High-throughput

0.457

High

361440

VCAM1
Vascular cell adhesion protein 1

1

2

High-throughput

0.445

High

361495

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.445

High

361542

PKHA6
Pleckstrin homology domain-containing family A member 6

1

1

High-throughput

0.439

High

361430

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.438

High

361472

UBC9
SUMO-conjugating enzyme UBC9

1

0

High-throughput

0.438

High

361493

PLAG1
Zinc finger protein PLAG1

1

0

High-throughput

0.438

High

361531

TOPRS
E3 ubiquitin-protein ligase Topors

1

0

High-throughput

0.438

High

361545

ZN451
E3 SUMO-protein ligase ZNF451

1

0

High-throughput

0.438

High

361510

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.282

High

361521

RNF32
RING finger protein 32

1

0

High-throughput

0.282

High

361496

TTC33
Tetratricopeptide repeat protein 33

1

0

High-throughput

0.268

Low

361534

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

0

High-throughput

0.268

Low

361504

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

0

High-throughput

0.251

Low

361517

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.251

Low

361533

FXL12
F-box/LRR-repeat protein 12

1

0

High-throughput

0.251

Low


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Last updated: 15 Jul 2024