Protein: LRP1
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]

Gene: LRP1
Organism: Homo sapiens
Interactions: 165
UniProt ID: Q07954

Gene Ontology (top 5):
GO:0001523 - retinoid metabolic process
GO:0001540 - amyloid-beta binding
GO:0002265 - astrocyte activation involved in immune response
GO:0003723 - RNA binding
GO:0005041 - low-density lipoprotein particle receptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

674653

AMRP
Alpha-2-macroglobulin receptor-associated protein

6

10

Small-scale

0.951

High

434641

TSP1
Thrombospondin-1

3

12

Small-scale

0.845

High

992733

LOXL2
Lysyl oxidase homolog 2

2

3

High-throughput

0.811

High

341549

TPA
Tissue-type plasminogen activator

2

11

Small-scale

0.696

High

992692

PCSK5
Proprotein convertase subtilisin/kexin type 5

1

13

High-throughput

0.691

High

338326

EGFR
Epidermal growth factor receptor

4

20

High-throughput

0.685

High

361480

APOE
Apolipoprotein E

3

7

Small-scale

0.684

High

120900

APBB1
Amyloid beta precursor protein binding family B member 1

3

1

Small-scale

0.669

High

992686

ZFP41
Zinc finger protein 41 homolog

3

20

High-throughput

0.667

High

420668

LIPL
Lipoprotein lipase

3

7

Small-scale

0.655

High

394598

A4
Amyloid-beta precursor protein

3

12

Small-scale

0.650

High

341272

FA9
Coagulation factor IX

1

10

Small-scale

0.647

High

310049

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

2

6

High-throughput

0.628

High

381175

TBB4A
Tubulin beta-4A chain

2

5

High-throughput

0.628

High

502014

BIP
Endoplasmic reticulum chaperone BiP

2

4

High-throughput

0.628

High

518326

ADT3
ADP/ATP translocase 3

2

4

High-throughput

0.628

High

919367

RL23
Large ribosomal subunit protein uL14

2

1

High-throughput

0.628

High

933769

TBB4B
Tubulin beta-4B chain

2

5

High-throughput

0.628

High

972093

GCNT1
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

2

1

High-throughput

0.628

High

992658

FOXF2
Forkhead box protein F2

2

7

High-throughput

0.628

High

992662

TBB3
Tubulin beta-3 chain

2

5

High-throughput

0.628

High

992665

TBB2A
Tubulin beta-2A chain

2

5

High-throughput

0.628

High

992673

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

2

4

High-throughput

0.628

High

992674

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

2

1

High-throughput

0.628

High

992678

SAMD1
Sterile alpha motif domain-containing protein 1

2

1

High-throughput

0.628

High

992680

TBA1A
Tubulin alpha-1A chain

2

4

High-throughput

0.628

High

992697

LCOR
Ligand-dependent corepressor

2

2

High-throughput

0.628

High

992704

SCMC3
Mitochondrial adenyl nucleotide antiporter SLC25A23

2

4

High-throughput

0.628

High

992707

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

2

6

High-throughput

0.628

High

992714

PAPD1
Poly(A) RNA polymerase, mitochondrial

2

1

High-throughput

0.628

High

992718

SENP1
Sentrin-specific protease 1

2

2

High-throughput

0.628

High

992722

NOCT
Nocturnin

2

1

High-throughput

0.628

High

666087

SHC1
SHC-transforming protein 1

2

9

Small-scale

0.624

High

235021

CUBN
Cubilin

1

11

Small-scale

0.618

High

992726

NOTC3
Neurogenic locus notch homolog protein 3

1

17

Small-scale

0.618

High

992729

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

2

20

Small-scale

0.609

High

942331

DLG4
Disks large homolog 4

2

9

Small-scale

0.606

High

602396

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

2

0

High-throughput

0.602

High

829258

SYHM
Histidine--tRNA ligase, mitochondrial

2

0

High-throughput

0.602

High

992659

NPRL3
GATOR1 complex protein NPRL3

2

0

High-throughput

0.602

High

992687

HASP
Serine/threonine-protein kinase haspin

2

0

High-throughput

0.602

High

992723

INT6
Integrator complex subunit 6

2

0

High-throughput

0.602

High

992731

MTO1
Protein MTO1 homolog, mitochondrial

2

0

High-throughput

0.602

High

397103

PAI1
Plasminogen activator inhibitor 1

1

0

Small-scale

0.586

High

296551

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

2

1

High-throughput

0.574

High

933414

TBA4A
Tubulin alpha-4A chain

2

5

High-throughput

0.574

High

992670

TBB8
Tubulin beta-8 chain

2

5

High-throughput

0.574

High

992672

KMCP1
Kidney mitochondrial carrier protein 1

2

4

High-throughput

0.574

High

992709

MTG2
Mitochondrial ribosome-associated GTPase 2

2

5

High-throughput

0.574

High

269141

DAB1
Disabled homolog 1

2

20

Small-scale

0.568

High

985943

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

3

Small-scale

0.561

High

992679

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.553

High

882905

RBM11
Splicing regulator RBM11

1

2

High-throughput

0.541

High

677569

CALCR
Calcitonin receptor

1

0

Small-scale

0.537

High

976205

UPAR
Urokinase plasminogen activator surface receptor

1

0

Small-scale

0.537

High

119345

LEG9
Galectin-9

1

10

High-throughput

0.536

High

153116

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

2

High-throughput

0.536

High

237589

DIAP1
Protein diaphanous homolog 1

1

1

High-throughput

0.536

High

271556

ERAL1
GTPase Era, mitochondrial

1

1

High-throughput

0.536

High

386603

P53
Cellular tumor antigen p53

1

1

High-throughput

0.536

High

397353

ADT2
ADP/ATP translocase 2

1

3

High-throughput

0.536

High

992657

FOXF1
Forkhead box protein F1

1

7

High-throughput

0.536

High

992666

MELK
Maternal embryonic leucine zipper kinase

1

1

High-throughput

0.536

High

992695

RB39B
Ras-related protein Rab-39B

1

8

High-throughput

0.536

High

992701

FOXB1
Forkhead box protein B1

1

7

High-throughput

0.536

High

992702

TBA1C
Tubulin alpha-1C chain

1

5

High-throughput

0.536

High

992705

TBB2B
Tubulin beta-2B chain

1

5

High-throughput

0.536

High

992708

SMOC1
SPARC-related modular calcium-binding protein 1

1

2

High-throughput

0.536

High

992717

RTEL1
Regulator of telomere elongation helicase 1

1

1

High-throughput

0.536

High

992712

FBX6
F-box only protein 6

2

7

High-throughput

0.533

High

152739

ITBP1
Integrin beta-1-binding protein 1

1

2

Small-scale

0.527

High

158182

GIPC1
PDZ domain-containing protein GIPC1

1

3

Small-scale

0.527

High

253555

CAPON
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

1

20

Small-scale

0.527

High

883908

SYJ2B
Synaptojanin-2-binding protein

1

17

Small-scale

0.527

High

992661

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

20

Small-scale

0.527

High

992734

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.515

High

380770

S100B
Protein S100-B

1

1

High-throughput

0.515

High

796553

KSYK
Tyrosine-protein kinase SYK

1

17

High-throughput

0.515

High

992728

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

High-throughput

0.515

High

344488

A2MG
Alpha-2-macroglobulin

1

1

Small-scale

0.514

High

513570

PYC
Pyruvate carboxylase, mitochondrial

1

0

High-throughput

0.513

High

921537

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.513

High

992655

TROP
Trophinin

1

0

High-throughput

0.513

High

992688

PTCD2
Pentatricopeptide repeat-containing protein 2, mitochondrial

1

0

High-throughput

0.513

High

992689

GLMP
Glycosylated lysosomal membrane protein

1

0

High-throughput

0.513

High

992706

S26A6
Solute carrier family 26 member 6

1

0

High-throughput

0.513

High

992710

PGES2
Prostaglandin E synthase 2

1

0

High-throughput

0.513

High

992727

DD19B
ATP-dependent RNA helicase DDX19B

1

0

High-throughput

0.513

High

992732

TCAF1
TRPM8 channel-associated factor 1

1

0

High-throughput

0.513

High

132306

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

4

High-throughput

0.508

High

521346

SKIL
Ski-like protein

1

1

High-throughput

0.508

High

992681

PCLI1
PTB-containing, cubilin and LRP1-interacting protein

1

1

Small-scale

0.504

High

350964

PDGFB
Platelet-derived growth factor subunit B

1

2

Small-scale

0.501

High

431777

HS90A
Heat shock protein HSP 90-alpha

1

1

Small-scale

0.501

High

500781

CLUS
Clusterin

1

3

Small-scale

0.501

High

505126

LIPC
Hepatic triacylglycerol lipase

1

7

Small-scale

0.501

High

522937

SRC
Proto-oncogene tyrosine-protein kinase Src

1

3

Small-scale

0.501

High

957171

DAB2
Disabled homolog 2

1

20

Small-scale

0.501

High

992667

SNX17
Sorting nexin-17

1

4

Small-scale

0.501

High

992694

KAT5
Histone acetyltransferase KAT5

1

3

Small-scale

0.501

High

992664

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.493

High

992720

VPS29
Vacuolar protein sorting-associated protein 29

1

0

High-throughput

0.493

High

506299

MBL2
Mannose-binding protein C

1

1

Small-scale

0.489

High

992668

FCN2
Ficolin-2

1

6

Small-scale

0.489

High

305302

NXPH4
Neurexophilin-4

1

1

High-throughput

0.489

High

958872

HXA4
Homeobox protein Hox-A4

1

1

High-throughput

0.489

High

986503

GFPT1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1

1

1

High-throughput

0.489

High

992683

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.489

High

992685

AN36B
Ankyrin repeat domain-containing protein 36B

1

11

High-throughput

0.489

High

162021

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

1

Small-scale

0.481

High

442096

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

Small-scale

0.481

High

992682

ANS1B
Ankyrin repeat and sterile alpha motif domain-containing protein 1B

1

9

Small-scale

0.481

High

992700

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

1

12

Small-scale

0.481

High

336813

FA8
Coagulation factor VIII

1

0

Small-scale

0.480

High

205309

TGON2
Trans-Golgi network integral membrane protein 2

1

8

High-throughput

0.479

High

227264

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

319176

BRD1
Bromodomain-containing protein 1

1

3

High-throughput

0.479

High

362465

C1QA
Complement C1q subcomponent subunit A

1

1

Small-scale

0.479

High

449695

HMGB1
High mobility group protein B1

1

1

High-throughput

0.479

High

566374

KPCA
Protein kinase C alpha type

1

1

Small-scale

0.479

High

591825

RAB4A
Ras-related protein Rab-4A

1

12

High-throughput

0.479

High

653568

CALR
Calreticulin

1

4

Small-scale

0.479

High

654281

CALX
Calnexin

1

4

Small-scale

0.479

High

838518

MMP14
Matrix metalloproteinase-14

1

2

Small-scale

0.479

High

904485

1433G
14-3-3 protein gamma

1

2

High-throughput

0.479

High

914028

RB11A
Ras-related protein Rab-11A

1

6

High-throughput

0.479

High

940819

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.479

High

984565

CALD1
Caldesmon

1

1

High-throughput

0.479

High

992656

NMDE1
Glutamate receptor ionotropic, NMDA 2A

1

5

Small-scale

0.479

High

992663

CUL3
Cullin-3

1

11

High-throughput

0.479

High

992677

APOA5
Apolipoprotein A-V

1

7

Small-scale

0.479

High

992693

CSN5
COP9 signalosome complex subunit 5

1

2

Small-scale

0.479

High

992696

CHFR
E3 ubiquitin-protein ligase CHFR

1

1

Small-scale

0.479

High

992698

ZDH15
Palmitoyltransferase ZDHHC15

1

1

Small-scale

0.479

High

992699

RANB9
Ran-binding protein 9

1

4

Small-scale

0.479

High

992711

WDR76
WD repeat-containing protein 76

1

3

High-throughput

0.479

High

992721

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

992724

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.479

High

992735

DUS10
Dual specificity protein phosphatase 10

1

2

High-throughput

0.479

High

992669

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

Small-scale

0.460

High

992675

C2D1A
Coiled-coil and C2 domain-containing protein 1A

1

0

Small-scale

0.460

High

992713

RIC8B
Synembryn-B

1

0

Small-scale

0.460

High

503960

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

351491

NGF
Beta-nerve growth factor

1

3

Small-scale

0.457

High

595714

NTF3
Neurotrophin-3

1

3

Small-scale

0.457

High

618261

BDNF
Brain-derived neurotrophic factor

1

3

Small-scale

0.457

High

710105

NTF4
Neurotrophin-4

1

3

Small-scale

0.457

High

992719

GULP1
PTB domain-containing engulfment adapter protein 1

1

20

Small-scale

0.457

High

887824

CD81
CD81 antigen

1

3

High-throughput

0.445

High

992691

DDX12
Putative ATP-dependent RNA helicase DDX12

1

1

High-throughput

0.445

High

992730

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

992715

SCN3A
Sodium channel protein type 3 subunit alpha

1

4

Small-scale

0.439

High

992725

APC10
Anaphase-promoting complex subunit 10

1

3

Small-scale

0.439

High

301783

TRI37
E3 ubiquitin-protein ligase TRIM37

1

7

High-throughput

0.437

High

600959

MK
Midkine

1

5

Small-scale

0.437

High

992660

PDIA2
Protein disulfide-isomerase A2

1

6

Small-scale

0.437

High

992716

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

4

High-throughput

0.437

High

135608

NDKM
Nucleoside diphosphate kinase, mitochondrial

2

0

High-throughput

0.328

High

276707

GATB
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial

2

0

High-throughput

0.328

High

992671

ERFE
Erythroferrone

2

0

High-throughput

0.328

High

992676

KCD18
BTB/POZ domain-containing protein KCTD18

2

0

High-throughput

0.328

High

992703

CQ080
Mitochondrial nucleoid-associated protein 1

2

0

High-throughput

0.328

High

902267

NPC2
NPC intracellular cholesterol transporter 2

1

0

High-throughput

0.279

Low

992684

TRM44
Probable tRNA

1

0

High-throughput

0.279

Low

992690

ALG3
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

1

0

Small-scale

0.264

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024