Protein: ACACA
Acetyl-CoA carboxylase 1 (ACC1) (EC 6.4.1.2) (Acetyl-Coenzyme A carboxylase alpha) (ACC-alpha)

Gene: ACACA
Organism: Homo sapiens
Interactions: 230
UniProt ID: Q13085

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0001894 - tissue homeostasis
GO:0003989 - acetyl-CoA carboxylase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1024005

ACACA
Acetyl-CoA carboxylase 1

2

14

Small-scale

0.811

High

749438

BRCA1
Breast cancer type 1 susceptibility protein

8

6

Small-scale

0.751

High

136012

ACACB
Acetyl-CoA carboxylase 2

1

16

High-throughput

0.691

High

626643

ARBK1
Beta-adrenergic receptor kinase 1

2

8

High-throughput

0.628

High

1024016

KS6A1
Ribosomal protein S6 kinase alpha-1

2

8

High-throughput

0.628

High

1024006

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

2

6

Small-scale

0.619

High

398251

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

16

High-throughput

0.618

High

398351

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

18

High-throughput

0.618

High

513571

PYC
Pyruvate carboxylase, mitochondrial

1

17

High-throughput

0.618

High

1024075

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

15

High-throughput

0.618

High

1024098

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

18

High-throughput

0.618

High

346668

MYC
Myc proto-oncogene protein

4

6

High-throughput

0.613

High

822006

KC1A
Casein kinase I isoform alpha

2

9

High-throughput

0.611

High

1024009

ILK
Integrin-linked protein kinase

2

3

High-throughput

0.611

High

1024096

EGLN3
Prolyl hydroxylase EGLN3

2

1

High-throughput

0.611

High

669554

OAS2
2'-5'-oligoadenylate synthase 2

2

0

High-throughput

0.602

High

227322

PRKN
E3 ubiquitin-protein ligase parkin

2

15

High-throughput

0.584

High

322551

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

2

High-throughput

0.584

High

779332

CCNF
Cyclin-F

2

5

High-throughput

0.584

High

1024109

ZRAN1
Ubiquitin thioesterase ZRANB1

2

6

High-throughput

0.584

High

498263

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

4

High-throughput

0.571

High

1024107

PD1L1
Programmed cell death 1 ligand 1

2

0

Small-scale

0.559

High

509864

PSG1
Pregnancy-specific beta-1-glycoprotein 1

2

1

High-throughput

0.558

High

496944

TAU
Microtubule-associated protein tau

2

3

Small-scale

0.552

High

1024071

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

16

Small-scale

0.546

High

131568

STK25
Serine/threonine-protein kinase 25

1

13

High-throughput

0.536

High

200110

DAPK3
Death-associated protein kinase 3

1

4

High-throughput

0.536

High

315929

NPTXR
Neuronal pentraxin receptor

1

1

High-throughput

0.536

High

320520

OXSR1
Serine/threonine-protein kinase OSR1

1

14

High-throughput

0.536

High

456278

IFIT1
Interferon-induced protein with tetratricopeptide repeats 1

1

4

High-throughput

0.536

High

549890

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

2

High-throughput

0.536

High

830341

KC1E
Casein kinase I isoform epsilon

1

8

High-throughput

0.536

High

960436

CDK17
Cyclin-dependent kinase 17

1

7

High-throughput

0.536

High

1024007

STK3
Serine/threonine-protein kinase 3

1

10

High-throughput

0.536

High

1024041

PXK
PX domain-containing protein kinase-like protein

1

11

High-throughput

0.536

High

1024049

PAF1
RNA polymerase II-associated factor 1 homolog

1

4

High-throughput

0.536

High

1024062

THRSP
Thyroid hormone-inducible hepatic protein

1

4

High-throughput

0.536

High

1024084

RIOK2
Serine/threonine-protein kinase RIO2

1

4

High-throughput

0.536

High

1024100

M1IP1
Mid1-interacting protein 1

1

4

High-throughput

0.536

High

1024108

KS6B2
Ribosomal protein S6 kinase beta-2

1

11

High-throughput

0.536

High

1024119

KC1G3
Casein kinase I isoform gamma-3

1

10

High-throughput

0.536

High

1024074

SGCZ
Zeta-sarcoglycan

2

1

High-throughput

0.533

High

1024083

SH3G3
Endophilin-A3

2

1

High-throughput

0.521

High

127641

EF2K
Eukaryotic elongation factor 2 kinase

1

0

High-throughput

0.513

High

827184

ARRB1
Beta-arrestin-1

1

0

High-throughput

0.513

High

224577

AK1BA
Aldo-keto reductase family 1 member B10

1

0

Small-scale

0.512

High

868464

ATX1
Ataxin-1

1

2

High-throughput

0.508

High

871005

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

3

Small-scale

0.501

High

1024077

TRIB3
Tribbles homolog 3

1

8

Small-scale

0.501

High

1024078

TRIB1
Tribbles homolog 1

1

11

Small-scale

0.501

High

1024092

SIK2
Serine/threonine-protein kinase SIK2

1

6

Small-scale

0.501

High

1024116

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

1

Small-scale

0.501

High

305761

ELP1
Elongator complex protein 1

1

0

Small-scale

0.493

High

805655

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.493

High

995353

LG3BP
Galectin-3-binding protein

1

3

High-throughput

0.489

High

958667

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

5

High-throughput

0.484

High

119355

LEG9
Galectin-9

1

6

High-throughput

0.479

High

129287

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

7

High-throughput

0.479

High

147517

SOCS6
Suppressor of cytokine signaling 6

1

6

High-throughput

0.479

High

150967

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

2

High-throughput

0.479

High

160543

AURKA
Aurora kinase A

1

5

High-throughput

0.479

High

165845

KDM6B
Lysine-specific demethylase 6B

1

1

Small-scale

0.479

High

165975

PER2
Period circadian protein homolog 2

1

4

Small-scale

0.479

High

176440

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

1

High-throughput

0.479

High

258439

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.479

High

268060

EED
Polycomb protein EED

1

13

High-throughput

0.479

High

296905

LTN1
E3 ubiquitin-protein ligase listerin

1

3

High-throughput

0.479

High

338355

EGFR
Epidermal growth factor receptor

1

7

High-throughput

0.479

High

384752

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.479

High

386641

P53
Cellular tumor antigen p53

1

5

Small-scale

0.479

High

418224

NPM
Nucleophosmin

1

1

Small-scale

0.479

High

420831

H2B1J
Histone H2B type 1-J

1

1

High-throughput

0.479

High

475692

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

11

Small-scale

0.479

High

503999

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

529058

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.479

High

574662

ARF4
ADP-ribosylation factor 4

1

11

High-throughput

0.479

High

601234

VDAC1
Voltage-dependent anion-selective channel protein 1

1

1

High-throughput

0.479

High

610380

CBL
E3 ubiquitin-protein ligase CBL

1

6

High-throughput

0.479

High

617532

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

646854

1433T
14-3-3 protein theta

1

7

High-throughput

0.479

High

651084

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

666093

SHC1
SHC-transforming protein 1

1

7

High-throughput

0.479

High

668640

PML
Protein PML

1

11

High-throughput

0.479

High

684676

STIP1
Stress-induced-phosphoprotein 1

1

5

High-throughput

0.479

High

717770

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.479

High

726785

FUS
RNA-binding protein FUS

1

1

High-throughput

0.479

High

788028

AF9
Protein AF-9

1

1

Small-scale

0.479

High

808566

YAP1
Transcriptional coactivator YAP1

1

11

High-throughput

0.479

High

835351

GSK3A
Glycogen synthase kinase-3 alpha

1

6

High-throughput

0.479

High

835711

GSK3B
Glycogen synthase kinase-3 beta

1

8

High-throughput

0.479

High

841696

CDK9
Cyclin-dependent kinase 9

1

5

High-throughput

0.479

High

868163

ATX3
Ataxin-3

1

2

High-throughput

0.479

High

871371

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

6

High-throughput

0.479

High

874877

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.479

High

880705

HDAC4
Histone deacetylase 4

1

14

High-throughput

0.479

High

890640

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

7

Small-scale

0.479

High

896431

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

2

Small-scale

0.479

High

908463

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

921237

RBX1
E3 ubiquitin-protein ligase RBX1

1

6

High-throughput

0.479

High

921544

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

11

High-throughput

0.479

High

930825

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

5

Small-scale

0.479

High

961084

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

974482

ENL
Protein ENL

1

3

Small-scale

0.479

High

997698

RBBP4
Histone-binding protein RBBP4

1

13

High-throughput

0.479

High

998632

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

1022483

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

2

High-throughput

0.479

High

1024010

HDAC1
Histone deacetylase 1

1

14

High-throughput

0.479

High

1024011

CUL3
Cullin-3

1

2

High-throughput

0.479

High

1024012

GRB7
Growth factor receptor-bound protein 7

1

8

Small-scale

0.479

High

1024015

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

1024017

RBBP7
Histone-binding protein RBBP7

1

16

High-throughput

0.479

High

1024020

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1024022

LARP7
La-related protein 7

1

3

High-throughput

0.479

High

1024023

DCAF6
DDB1- and CUL4-associated factor 6

1

16

High-throughput

0.479

High

1024026

DCA12
DDB1- and CUL4-associated factor 12

1

1

High-throughput

0.479

High

1024029

DCA15
DDB1- and CUL4-associated factor 15

1

4

High-throughput

0.479

High

1024030

A16L1
Autophagy-related protein 16-1

1

12

High-throughput

0.479

High

1024031

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

1024033

ZN746
Zinc finger protein 746

1

4

High-throughput

0.479

High

1024034

CDC73
Parafibromin

1

1

High-throughput

0.479

High

1024039

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

1024043

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

1024046

SLX4
Structure-specific endonuclease subunit SLX4

1

5

High-throughput

0.479

High

1024047

WDTC1
WD and tetratricopeptide repeats protein 1

1

18

High-throughput

0.479

High

1024052

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

1024053

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

1024054

COP1
E3 ubiquitin-protein ligase COP1

1

20

High-throughput

0.479

High

1024060

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

1024061

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

1024064

FBX32
F-box only protein 32

1

2

High-throughput

0.479

High

1024066

PF21A
PHD finger protein 21A

1

7

High-throughput

0.479

High

1024068

OPTN
Optineurin

1

4

High-throughput

0.479

High

1024069

AP2M1
AP-2 complex subunit mu

1

2

High-throughput

0.479

High

1024070

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

12

High-throughput

0.479

High

1024072

BICD1
Protein bicaudal D homolog 1

1

1

High-throughput

0.479

High

1024079

RUFY1
RUN and FYVE domain-containing protein 1

1

4

High-throughput

0.479

High

1024082

NECD
Necdin

1

3

High-throughput

0.479

High

1024087

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

8

High-throughput

0.479

High

1024090

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

6

High-throughput

0.479

High

1024091

SPRTN
DNA-dependent metalloprotease SPRTN

1

3

High-throughput

0.479

High

1024093

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.479

High

1024102

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

16

High-throughput

0.479

High

1024103

FBX6
F-box only protein 6

1

2

High-throughput

0.479

High

1024111

DCTN4
Dynactin subunit 4

1

2

High-throughput

0.479

High

1024114

FBW1A
F-box/WD repeat-containing protein 1A

1

16

High-throughput

0.479

High

1024118

SAR1B
Small COPII coat GTPase SAR1B

1

20

High-throughput

0.479

High

123580

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.458

High

130495

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

594899

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.458

High

1024013

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

0

Small-scale

0.458

High

1024014

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

1024027

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

1024067

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

1024059

TRIB2
Tribbles homolog 2

1

8

Small-scale

0.457

High

306148

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

6

High-throughput

0.445

High

587551

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

10

High-throughput

0.445

High

1023034

STK4
Serine/threonine-protein kinase 4

1

11

High-throughput

0.445

High

1024025

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

1024028

CP135
Centrosomal protein of 135 kDa

1

1

High-throughput

0.445

High

1024113

PPM1H
Protein phosphatase 1H

1

1

Small-scale

0.445

High

232134

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.437

High

282891

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

11

High-throughput

0.437

High

328830

TOP3B
DNA topoisomerase 3-beta-1

1

1

Small-scale

0.437

High

329692

AGR2
Anterior gradient protein 2 homolog

1

4

High-throughput

0.437

High

351367

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

1

High-throughput

0.437

High

353411

PIGR
Polymeric immunoglobulin receptor

1

4

Small-scale

0.437

High

552611

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

555440

H2AX
Histone H2AX

1

2

High-throughput

0.437

High

720349

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

734614

TRI23
E3 ubiquitin-protein ligase TRIM23

1

16

High-throughput

0.437

High

787155

RHG25
Rho GTPase-activating protein 25

1

2

High-throughput

0.437

High

823949

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.437

High

830738

ARL4D
ADP-ribosylation factor-like protein 4D

1

18

High-throughput

0.437

High

903185

WDR5
WD repeat-containing protein 5

1

12

High-throughput

0.437

High

928589

DYLT1
Dynein light chain Tctex-type 1

1

3

High-throughput

0.437

High

946642

SSBP2
Single-stranded DNA-binding protein 2

1

2

Small-scale

0.437

High

950605

ARF5
ADP-ribosylation factor 5

1

11

High-throughput

0.437

High

1024008

TIF1B
Transcription intermediary factor 1-beta

1

13

High-throughput

0.437

High

1024021

ANR55
Ankyrin repeat domain-containing protein 55

1

4

High-throughput

0.437

High

1024024

DCA10
DDB1- and CUL4-associated factor 10

1

13

High-throughput

0.437

High

1024035

CTR9
RNA polymerase-associated protein CTR9 homolog

1

2

High-throughput

0.437

High

1024036

LRC31
Leucine-rich repeat-containing protein 31

1

2

High-throughput

0.437

High

1024037

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

1024038

UBP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

1

8

Small-scale

0.437

High

1024040

DET1
DET1 homolog

1

4

High-throughput

0.437

High

1024042

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

3

High-throughput

0.437

High

1024044

HOOK3
Protein Hook homolog 3

1

8

High-throughput

0.437

High

1024048

SIR6
NAD-dependent protein deacylase sirtuin-6

1

16

High-throughput

0.437

High

1024050

ARL10
ADP-ribosylation factor-like protein 10

1

18

High-throughput

0.437

High

1024051

KDF1
Keratinocyte differentiation factor 1

1

1

High-throughput

0.437

High

1024055

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

1

High-throughput

0.437

High

1024056

DCAF4
DDB1- and CUL4-associated factor 4

1

3

High-throughput

0.437

High

1024073

ARL5B
ADP-ribosylation factor-like protein 5B

1

19

High-throughput

0.437

High

1024080

RING2
E3 ubiquitin-protein ligase RING2

1

10

High-throughput

0.437

High

1024081

TBX5
T-box transcription factor TBX5

1

2

High-throughput

0.437

High

1024088

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

1

High-throughput

0.437

High

1024095

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.437

High

1024099

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

2

High-throughput

0.437

High

1024101

SAR1A
Small COPII coat GTPase SAR1A

1

20

High-throughput

0.437

High

1024104

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

3

High-throughput

0.437

High

1024105

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.437

High

1024110

HOOK1
Protein Hook homolog 1

1

8

High-throughput

0.437

High

1024112

RCOR1
REST corepressor 1

1

4

High-throughput

0.437

High

1024115

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

1024117

ARL5A
ADP-ribosylation factor-like protein 5A

1

20

High-throughput

0.437

High

1024076

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

1024097

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

1024106

SPHK1
Sphingosine kinase 1

1

0

Small-scale

0.426

High

997506

Q08AT0
SGCZ protein

1

1

High-throughput

0.407

High

1024089

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

1024085

FND11
Fibronectin type III domain-containing protein 11

2

0

High-throughput

0.318

High

361628

APOC1
Apolipoprotein C-I

2

0

High-throughput

0.316

High

1024063

FGF14
Fibroblast growth factor 14

2

0

High-throughput

0.316

High

393780

SCG1
Secretogranin-1

1

0

High-throughput

0.282

High

363116

FINC
Fibronectin

1

0

High-throughput

0.279

Low

991102

PIGF
Phosphatidylinositol-glycan biosynthesis class F protein

1

0

High-throughput

0.279

Low

1024019

ODAPH
Odontogenesis associated phosphoprotein

1

0

High-throughput

0.279

Low

1024045

CCD71
Coiled-coil domain-containing protein 71

1

0

High-throughput

0.279

Low

1024057

CKAP2
Cytoskeleton-associated protein 2

1

0

High-throughput

0.279

Low

1024032

RHBD2
Rhomboid domain-containing protein 2

1

0

High-throughput

0.268

Low

537204

CX7A2
Cytochrome c oxidase subunit 7A2, mitochondrial

1

0

High-throughput

0.249

Low

856317

EFNA3
Ephrin-A3

1

0

High-throughput

0.249

Low

872015

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

0

High-throughput

0.249

Low

1024018

CAH9
Carbonic anhydrase 9

1

0

Small-scale

0.249

Low

1024058

LIPH
Lipase member H

1

0

High-throughput

0.249

Low

1024065

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

1024086

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.249

Low

1024094

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

1

0

High-throughput

0.249

Low

517230

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024