Protein: C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial (EC 6.3.4.3) (Formyltetrahydrofolate synthetase)

Gene: C1TM, MTHFD1L
Organism: Homo sapiens
Interactions: 149
UniProt ID: Q6UB35

Gene Ontology (top 5):
GO:0001843 - neural tube closure
GO:0004329 - formate-tetrahydrofolate ligase activity
GO:0004477 - methenyltetrahydrofolate cyclohydrolase activity
GO:0004488 - methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

325239

AIFM1
Apoptosis-inducing factor 1, mitochondrial

3

2

High-throughput

0.643

High

1041854

CUL3
Cullin-3

2

3

High-throughput

0.611

High

789849

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

2

0

High-throughput

0.585

High

347105

MYC
Myc proto-oncogene protein

3

3

High-throughput

0.585

High

1086623

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

High-throughput

0.584

High

369850

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

1164731

MTMR7
Myotubularin-related protein 7

2

0

High-throughput

0.559

High

121498

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

1

High-throughput

0.536

High

724882

MYH9
Myosin-9

1

1

High-throughput

0.536

High

801209

KI67
Proliferation marker protein Ki-67

1

2

High-throughput

0.536

High

864867

MK10
Mitogen-activated protein kinase 10

1

2

High-throughput

0.536

High

907976

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.536

High

1164685

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.536

High

1164732

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

258728

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

0

High-throughput

0.513

High

418381

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

813554

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

1050225

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.513

High

1156315

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

1

0

High-throughput

0.513

High

1159891

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

0

High-throughput

0.513

High

1164676

TPC6B
Trafficking protein particle complex subunit 6B

1

0

High-throughput

0.513

High

1164684

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.513

High

1164688

MARC2
Mitochondrial amidoxime reducing component 2

1

0

High-throughput

0.513

High

1164692

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

1164693

SYMM
Methionine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

1164702

5NT3A
Cytosolic 5'-nucleotidase 3A

1

0

High-throughput

0.513

High

1164703

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.513

High

1164727

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

1164729

ANGE1
Protein angel homolog 1

1

0

High-throughput

0.513

High

160050

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

1

Small-scale

0.501

High

830284

CASP4
Caspase-4

1

0

High-throughput

0.493

High

1164675

UBP50
Ubiquitin carboxyl-terminal hydrolase 50

1

0

High-throughput

0.493

High

1164736

MAGD1
Melanoma-associated antigen D1

1

0

High-throughput

0.493

High

831900

CEBPD
CCAAT/enhancer-binding protein delta

1

5

High-throughput

0.489

High

125530

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

5

High-throughput

0.479

High

227812

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

262857

CISY
Citrate synthase, mitochondrial

1

1

High-throughput

0.479

High

294947

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

298598

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

302546

CE152
Centrosomal protein of 152 kDa

1

2

High-throughput

0.479

High

317983

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

3

High-throughput

0.479

High

326691

SNAI1
Zinc finger protein SNAI1

1

2

High-throughput

0.479

High

385031

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

429074

ADRB2
Beta-2 adrenergic receptor

1

1

High-throughput

0.479

High

440582

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

486556

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

499849

CH60
60 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.479

High

504269

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

572645

VGFR1
Vascular endothelial growth factor receptor 1

1

3

High-throughput

0.479

High

609364

FGFR3
Fibroblast growth factor receptor 3

1

5

High-throughput

0.479

High

729300

VGFR3
Vascular endothelial growth factor receptor 3

1

3

High-throughput

0.479

High

738229

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

3

High-throughput

0.479

High

777606

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

779622

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

793000

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

3

High-throughput

0.479

High

799263

EFTS
Elongation factor Ts, mitochondrial

1

1

High-throughput

0.479

High

803145

IF2M
Translation initiation factor IF-2, mitochondrial

1

3

High-throughput

0.479

High

827959

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

1

High-throughput

0.479

High

841783

CDK9
Cyclin-dependent kinase 9

1

2

High-throughput

0.479

High

908713

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

921615

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

2

High-throughput

0.479

High

951092

RHOG
Rho-related GTP-binding protein RhoG

1

1

High-throughput

0.479

High

990130

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1020466

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

6

High-throughput

0.479

High

1022125

NFX1
Transcriptional repressor NF-X1

1

2

High-throughput

0.479

High

1033494

ILK
Integrin-linked protein kinase

1

1

High-throughput

0.479

High

1035837

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1056054

NBR1
Next to BRCA1 gene 1 protein

1

1

High-throughput

0.479

High

1064420

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1066285

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

1067992

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

1101127

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1128161

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

1152868

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

1164678

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.479

High

1164680

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

1164681

COP1
E3 ubiquitin-protein ligase COP1

1

3

High-throughput

0.479

High

1164683

ASB12
Ankyrin repeat and SOCS box protein 12

1

3

High-throughput

0.479

High

1164686

FBX32
F-box only protein 32

1

1

High-throughput

0.479

High

1164687

FAKD4
FAST kinase domain-containing protein 4

1

1

High-throughput

0.479

High

1164689

OPTN
Optineurin

1

2

High-throughput

0.479

High

1164696

ANM1
Protein arginine N-methyltransferase 1

1

4

High-throughput

0.479

High

1164698

TR61B
tRNA

1

1

High-throughput

0.479

High

1164700

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

1164705

TXNIP
Thioredoxin-interacting protein

1

1

Small-scale

0.479

High

1164707

Q9H4D1
Protein kinase

1

4

High-throughput

0.479

High

1164709

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1164710

MET17
Ribosome assembly protein METTL17, mitochondrial

1

1

High-throughput

0.479

High

1164711

NEK6
Serine/threonine-protein kinase Nek6

1

2

High-throughput

0.479

High

1164713

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

1164714

ANLN
Anillin

1

2

High-throughput

0.479

High

1164716

TMPS4
Transmembrane protease serine 4

1

1

High-throughput

0.479

High

1164717

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

1164723

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

1164726

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1164728

HOOK1
Protein Hook homolog 1

1

3

High-throughput

0.479

High

1164725

WRP73
WD repeat-containing protein WRAP73

1

2

High-throughput

0.470

High

119423

LEG9
Galectin-9

1

0

High-throughput

0.458

High

525540

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

532556

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

648802

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

739997

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.458

High

920230

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

1017934

GRSF1
G-rich sequence factor 1

1

0

High-throughput

0.458

High

1062831

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

0

High-throughput

0.458

High

1072764

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.458

High

1077302

T22D1
TSC22 domain family protein 1

1

0

High-throughput

0.458

High

1148639

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1164691

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

1164694

SNX27
Sorting nexin-27

1

0

High-throughput

0.458

High

1164697

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

1164699

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

1164704

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

1164719

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

1164721

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1164722

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

883546

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

4

High-throughput

0.445

High

1062237

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

1

Small-scale

0.445

High

1164706

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

4

High-throughput

0.445

High

1164737

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

1

High-throughput

0.445

High

489112

H14
Histone H1.4

1

1

High-throughput

0.437

High

552993

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

651494

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

720743

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

824123

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

1029546

TIF1B
Transcription intermediary factor 1-beta

1

5

High-throughput

0.437

High

1080048

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

1102994

SMU1
WD40 repeat-containing protein SMU1

1

3

High-throughput

0.437

High

1108697

ANR55
Ankyrin repeat domain-containing protein 55

1

5

High-throughput

0.437

High

1164674

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1164677

HOOK3
Protein Hook homolog 3

1

3

High-throughput

0.437

High

1164679

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.437

High

1164682

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.437

High

1164701

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.437

High

1164708

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

1164715

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.437

High

1164718

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.437

High

1164724

HECW2
E3 ubiquitin-protein ligase HECW2

1

5

High-throughput

0.437

High

1164730

TRI33
E3 ubiquitin-protein ligase TRIM33

1

5

High-throughput

0.437

High

1164733

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

402166

JUN
Transcription factor Jun

1

3

High-throughput

0.407

High

1062162

HAPR1
HUWE1-associated protein modifying stress responses 1

2

0

Small-scale

0.305

High

261838

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

0

High-throughput

0.279

Low

1164690

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

1164695

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.249

Low

1164712

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

0

High-throughput

0.249

Low

1164720

DJC28
DnaJ homolog subfamily C member 28

1

0

High-throughput

0.249

Low

1164734

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

1164735

PHLA3
Pleckstrin homology-like domain family A member 3

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024