Protein: TOPK
Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase)

Gene: TOPK, PBK
Organism: Homo sapiens
Interactions: 97
UniProt ID: Q96KB5

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0001933 - negative regulation of protein phosphorylation
GO:0004674 - protein serine/threonine kinase activity
GO:0004708 - MAP kinase kinase activity
GO:0004713 - protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

415026

CDK1
Cyclin-dependent kinase 1

2

4

Small-scale

0.818

High

301226

RHBT3
Rho-related BTB domain-containing protein 3

2

6

High-throughput

0.811

High

1257178

ZN526
Zinc finger protein 526

2

0

High-throughput

0.742

High

1290736

MCRS1
Microspherule protein 1

2

0

High-throughput

0.742

High

1256938

DOK4
Docking protein 4

3

0

High-throughput

0.720

High

238431

JAK2
Tyrosine-protein kinase JAK2

1

5

High-throughput

0.691

High

258150

DNJB6
DnaJ homolog subfamily B member 6

1

4

High-throughput

0.691

High

885821

MTPN
Myotrophin

1

2

High-throughput

0.691

High

523110

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

Small-scale

0.687

High

1148054

MSL1
Male-specific lethal 1 homolog

4

0

High-throughput

0.670

High

119484

LEG9
Galectin-9

3

2

High-throughput

0.667

High

1107980

LEG9B
Galectin-9B

3

2

High-throughput

0.667

High

1296018

ZBT26
Zinc finger and BTB domain-containing protein 26

2

1

High-throughput

0.665

High

488779

ARAF
Serine/threonine-protein kinase A-Raf

1

20

Small-scale

0.656

High

387309

P53
Cellular tumor antigen p53

3

0

Small-scale

0.647

High

476214

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

6

High-throughput

0.647

High

1296015

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

16

Small-scale

0.647

High

833501

RBM25
RNA-binding protein 25

1

1

High-throughput

0.618

High

1296020

CABP2
Calcium-binding protein 2

1

12

High-throughput

0.618

High

228376

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.618

High

586921

CSK22
Casein kinase II subunit alpha'

1

11

High-throughput

0.618

High

779931

CCNF
Cyclin-F

1

2

High-throughput

0.618

High

538589

CCNB1
G2/mitotic-specific cyclin-B1

1

0

Small-scale

0.614

High

1234601

ARRD1
Arrestin domain-containing protein 1

3

1

High-throughput

0.609

High

1216194

TF2LY
Homeobox protein TGIF2LY

2

0

High-throughput

0.602

High

1261480

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.602

High

1294602

ZN414
Zinc finger protein 414

2

0

High-throughput

0.602

High

374707

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

19

Small-scale

0.590

High

1290119

CHFR
E3 ubiquitin-protein ligase CHFR

1

0

Small-scale

0.586

High

1235604

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.578

High

1130456

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

20

High-throughput

0.575

High

301969

TRI37
E3 ubiquitin-protein ligase TRIM37

2

6

High-throughput

0.561

High

1252402

LNX1
E3 ubiquitin-protein ligase LNX

2

1

Small-scale

0.554

High

1171272

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.553

High

1021550

DLG1
Disks large homolog 1

1

0

Small-scale

0.549

High

210205

PRC1
Protein regulator of cytokinesis 1

1

0

Small-scale

0.537

High

890801

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.537

High

867246

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

1

High-throughput

0.536

High

985247

HME1
Homeobox protein engrailed-1

1

1

High-throughput

0.536

High

1296016

KAT8
Histone acetyltransferase KAT8

1

1

High-throughput

0.536

High

1028194

GPS2
G protein pathway suppressor 2

1

0

High-throughput

0.518

High

555601

H2AX
Histone H2AX

1

0

Small-scale

0.513

High

579728

XRCC1
DNA repair protein XRCC1

1

0

High-throughput

0.513

High

1148735

VIR
Protein virilizer homolog

1

0

High-throughput

0.513

High

1240933

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

1271338

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.513

High

1272209

XPF
DNA repair endonuclease XPF

1

0

High-throughput

0.513

High

1296021

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.513

High

875230

TERA
Transitional endoplasmic reticulum ATPase

1

2

Small-scale

0.501

High

906080

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

3

Small-scale

0.501

High

263787

PR40A
Pre-mRNA-processing factor 40 homolog A

1

4

High-throughput

0.489

High

537547

AK1A1
Aldo-keto reductase family 1 member A1

1

1

High-throughput

0.489

High

1284763

EFMT3
EEF1A lysine methyltransferase 3

1

2

High-throughput

0.489

High

1296019

E41L5
Band 4.1-like protein 5

1

3

High-throughput

0.489

High

1296030

NTNG1
Netrin-G1

1

1

High-throughput

0.489

High

1296031

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

1

High-throughput

0.489

High

1296032

WIF1
Wnt inhibitory factor 1

1

2

High-throughput

0.489

High

362098

MBP
Myelin basic protein

1

0

Small-scale

0.480

High

1296029

NSF1C
NSFL1 cofactor p47

1

0

Small-scale

0.480

High

295137

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

908973

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

1022854

STRN3
Striatin-3

1

2

High-throughput

0.479

High

1064606

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

1296025

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1296028

TTF2
Transcription termination factor 2

1

2

High-throughput

0.479

High

154045

TERT
Telomerase reverse transcriptase

1

0

Small-scale

0.460

High

1128898

GASP1
G-protein coupled receptor-associated sorting protein 1

1

0

High-throughput

0.460

High

651977

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

1188722

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1296023

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

361904

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

0

High-throughput

0.328

High

1190915

TAFA3
Chemokine-like protein TAFA-3

2

0

High-throughput

0.328

High

1224061

TRM2A
tRNA

2

0

High-throughput

0.328

High

1296024

CE126
Centrosomal protein of 126 kDa

1

0

High-throughput

0.282

High

341228

HPT
Haptoglobin

1

0

High-throughput

0.279

Low

655196

IL1R2
Interleukin-1 receptor type 2

1

0

High-throughput

0.279

Low

879420

FCGRN
IgG receptor FcRn large subunit p51

1

0

High-throughput

0.279

Low

1129278

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

0

High-throughput

0.279

Low

1131951

TMM69
Transmembrane protein 69

1

0

High-throughput

0.279

Low

1134931

SYT6
Synaptotagmin-6

1

0

High-throughput

0.279

Low

1233752

MESH1
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

1

0

High-throughput

0.279

Low

1238288

F133A
Protein FAM133A

1

0

High-throughput

0.279

Low

1244821

BBS1
Bardet-Biedl syndrome 1 protein

1

0

High-throughput

0.279

Low

1287917

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.279

Low

1296017

PAAT
ATPase PAAT

1

0

High-throughput

0.279

Low

1296022

FGOP2
FGFR1 oncogene partner 2

1

0

High-throughput

0.279

Low

1296026

PGAP2
Post-GPI attachment to proteins factor 2

1

0

High-throughput

0.279

Low

1296033

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.279

Low

1296027

ATS5
A disintegrin and metalloproteinase with thrombospondin motifs 5

1

0

High-throughput

0.269

Low

1287641

DDT4L
DNA damage-inducible transcript 4-like protein

1

0

High-throughput

0.268

Low

1205512

PTOV1
Prostate tumor-overexpressed gene 1 protein

1

0

Small-scale

0.261

Low

205842

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

391107

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

721180

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1284596

VOPP1
WW domain binding protein VOPP1

1

0

High-throughput

0.238

Low

354117

IGHA1
Immunoglobulin heavy constant alpha 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024