Protein: MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha)

Gene: MCCA, MCCC1
Organism: Homo sapiens
Interactions: 161
UniProt ID: Q96RQ3

Gene Ontology (top 5):
GO:0002169 - 3-methylcrotonyl-CoA carboxylase complex, mitochondrial
GO:0004075 - biotin carboxylase activity
GO:0004485 - methylcrotonoyl-CoA carboxylase activity
GO:0004658 - propionyl-CoA carboxylase activity
GO:0004847 - urea carboxylase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1301283

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

3

18

High-throughput

0.847

High

398394

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

2

18

High-throughput

0.789

High

270936

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

3

2

High-throughput

0.667

High

1022583

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

3

2

High-throughput

0.667

High

1301275

SCOT2
Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial

3

0

High-throughput

0.638

High

258767

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

1

High-throughput

0.628

High

827535

EFTU
Elongation factor Tu, mitochondrial

2

5

High-throughput

0.628

High

1156325

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

2

2

High-throughput

0.628

High

1301292

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

2

2

High-throughput

0.628

High

398291

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

16

High-throughput

0.618

High

513621

PYC
Pyruvate carboxylase, mitochondrial

1

16

High-throughput

0.618

High

1024075

ACACA
Acetyl-CoA carboxylase 1

1

15

High-throughput

0.618

High

612048

HEMH
Ferrochelatase, mitochondrial

2

0

High-throughput

0.602

High

1287311

FXRD1
FAD-dependent oxidoreductase domain-containing protein 1

2

0

High-throughput

0.602

High

1301274

TMM70
Transmembrane protein 70, mitochondrial

2

0

High-throughput

0.602

High

387342

P53
Cellular tumor antigen p53

2

5

Small-scale

0.584

High

779952

CCNF
Cyclin-F

2

5

High-throughput

0.584

High

1294799

MET2A
tRNA N(3)-methylcytidine methyltransferase METTL2A

2

1

High-throughput

0.574

High

992518

SOS2
Son of sevenless homolog 2

2

1

High-throughput

0.571

High

272379

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

1

High-throughput

0.536

High

336892

OTC
Ornithine transcarbamylase, mitochondrial

1

4

High-throughput

0.536

High

456293

IFIT1
Interferon-induced protein with tetratricopeptide repeats 1

1

4

High-throughput

0.536

High

610904

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

2

High-throughput

0.536

High

782859

PLPL4
Patatin-like phospholipase domain-containing protein 4

1

1

High-throughput

0.536

High

790269

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

1

High-throughput

0.536

High

815420

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

2

High-throughput

0.536

High

885894

YBEY
Endoribonuclease YbeY

1

2

High-throughput

0.536

High

1030116

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

1

High-throughput

0.536

High

1043527

CUL4B
Cullin-4B

1

2

High-throughput

0.536

High

1157959

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

1

High-throughput

0.536

High

1233871

CBR4
3-oxoacyl-[acyl-carrier-protein] reductase

1

2

High-throughput

0.536

High

1266236

DHB8
(3R)-3-hydroxyacyl-CoA dehydrogenase

1

2

High-throughput

0.536

High

1288529

ARHGQ
Rho guanine nucleotide exchange factor 26

1

1

High-throughput

0.536

High

1289677

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

2

High-throughput

0.536

High

1301267

PFD5
Prefoldin subunit 5

1

1

High-throughput

0.536

High

1301271

NPS3B
Protein NipSnap homolog 3B

1

2

High-throughput

0.536

High

1301276

LDH6B
L-lactate dehydrogenase A-like 6B

1

2

High-throughput

0.536

High

1301281

MTG2
Mitochondrial ribosome-associated GTPase 2

1

5

High-throughput

0.536

High

1301294

NPS3A
Protein NipSnap homolog 3A

1

2

High-throughput

0.536

High

1301296

MRM2
rRNA methyltransferase 2, mitochondrial

1

1

High-throughput

0.536

High

1301300

AGO2
Protein argonaute-2

1

1

High-throughput

0.536

High

1301302

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

1301303

RT02
Small ribosomal subunit protein uS2m

1

3

High-throughput

0.536

High

347651

MYC
Myc proto-oncogene protein

2

6

High-throughput

0.533

High

816825

IREB2
Iron-responsive element-binding protein 2

1

1

High-throughput

0.515

High

915481

ACTA
Actin, aortic smooth muscle

1

0

High-throughput

0.513

High

1082719

RM23
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.513

High

1160885

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

1204132

NUD13
NAD(P)H pyrophosphatase NUDT13, mitochondrial

1

0

High-throughput

0.513

High

1234807

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

1

0

High-throughput

0.513

High

1301273

MYL10
Myosin regulatory light chain 10

1

0

High-throughput

0.513

High

1301278

COMD5
COMM domain-containing protein 5

1

0

High-throughput

0.513

High

1301286

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

0

High-throughput

0.513

High

1301293

DIC
Mitochondrial dicarboxylate carrier

1

0

High-throughput

0.513

High

305025

DUS14
Dual specificity protein phosphatase 14

1

3

High-throughput

0.489

High

949092

HTRA3
Serine protease HTRA3

1

1

High-throughput

0.489

High

1237147

PAF1
RNA polymerase II-associated factor 1 homolog

1

4

High-throughput

0.489

High

1285820

TRI43
Tripartite motif-containing protein 43

1

2

High-throughput

0.489

High

1289859

RT24
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.489

High

1301270

LSMD1
N-alpha-acetyltransferase 38, NatC auxiliary subunit

1

1

High-throughput

0.489

High

1301272

HDHD3
Haloacid dehalogenase-like hydrolase domain-containing protein 3

1

1

High-throughput

0.489

High

119488

LEG9
Galectin-9

1

6

High-throughput

0.479

High

151148

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

2

High-throughput

0.479

High

1038646

HDAC1
Histone deacetylase 1

1

12

High-throughput

0.479

High

166006

PER2
Period circadian protein homolog 2

1

4

Small-scale

0.479

High

228431

PRKN
E3 ubiquitin-protein ligase parkin

1

13

High-throughput

0.479

High

267439

ECI2
Enoyl-CoA delta isomerase 2

1

2

High-throughput

0.479

High

323025

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

385377

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

388670

HSPB1
Heat shock protein beta-1

1

2

Small-scale

0.479

High

476238

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

9

Small-scale

0.479

High

504611

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

529600

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.479

High

572433

LEG3
Galectin-3

1

6

Small-scale

0.479

High

574734

ARF4
ADP-ribosylation factor 4

1

11

High-throughput

0.479

High

594261

MX1
Interferon-induced GTP-binding protein Mx1

1

1

High-throughput

0.479

High

647207

1433T
14-3-3 protein theta

1

5

High-throughput

0.479

High

652018

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

890808

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

7

Small-scale

0.479

High

916786

RS6
Small ribosomal subunit protein eS6

1

3

High-throughput

0.479

High

921400

RBX1
E3 ubiquitin-protein ligase RBX1

1

6

High-throughput

0.479

High

950543

ARF1
ADP-ribosylation factor 1

1

11

High-throughput

0.479

High

1044077

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.479

High

1075531

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

1

Small-scale

0.479

High

1116473

LARP7
La-related protein 7

1

3

High-throughput

0.479

High

1132567

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

2

High-throughput

0.479

High

1146156

DCA15
DDB1- and CUL4-associated factor 15

1

4

High-throughput

0.479

High

1156379

ZN746
Zinc finger protein 746

1

4

High-throughput

0.479

High

1190067

MAVS
Mitochondrial antiviral-signaling protein

1

6

Small-scale

0.479

High

1192176

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

10

High-throughput

0.479

High

1200594

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

1221664

SMC5
Structural maintenance of chromosomes protein 5

1

8

High-throughput

0.479

High

1222531

SLX4
Structure-specific endonuclease subunit SLX4

1

5

High-throughput

0.479

High

1239720

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

1285336

PF21A
PHD finger protein 21A

1

6

High-throughput

0.479

High

1301266

RUFY1
RUN and FYVE domain-containing protein 1

1

4

High-throughput

0.479

High

1301269

NECD
Necdin

1

3

High-throughput

0.479

High

1301279

RN208
RING finger protein 208

1

5

Small-scale

0.479

High

1301287

ARL8B
ADP-ribosylation factor-like protein 8B

1

7

High-throughput

0.479

High

1301295

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1301298

DCTN4
Dynactin subunit 4

1

2

High-throughput

0.479

High

1301304

TRAF6
TNF receptor-associated factor 6

1

2

Small-scale

0.479

High

1301306

SAR1B
Small COPII coat GTPase SAR1B

1

20

High-throughput

0.479

High

847209

GALK1
Galactokinase

1

0

Small-scale

0.458

High

879542

BID
BH3-interacting domain death agonist

1

0

Small-scale

0.458

High

913702

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.458

High

1262379

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

0

High-throughput

0.458

High

1264590

CHC10
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

1

0

High-throughput

0.458

High

1301285

SALL1
Sal-like protein 1

1

0

High-throughput

0.458

High

1301290

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1301301

LHX6
LIM/homeobox protein Lhx6

1

0

High-throughput

0.458

High

798981

GATA4
Transcription factor GATA-4

1

1

High-throughput

0.457

High

587685

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

10

High-throughput

0.445

High

958753

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

5

High-throughput

0.445

High

1023096

STK4
Serine/threonine-protein kinase 4

1

10

High-throughput

0.445

High

1199524

TLK2
Serine/threonine-protein kinase tousled-like 2

1

7

High-throughput

0.445

High

1301307

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

16

High-throughput

0.445

High

225665

PCDH7
Protocadherin-7

1

2

High-throughput

0.437

High

232445

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.437

High

329904

AGR2
Anterior gradient protein 2 homolog

1

4

High-throughput

0.437

High

353459

PIGR
Polymeric immunoglobulin receptor

1

4

Small-scale

0.437

High

553491

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

721218

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

734737

TRI23
E3 ubiquitin-protein ligase TRIM23

1

16

High-throughput

0.437

High

824298

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.437

High

830778

ARL4D
ADP-ribosylation factor-like protein 4D

1

18

High-throughput

0.437

High

917782

H4
Histone H4

1

6

High-throughput

0.437

High

928668

DYLT1
Dynein light chain Tctex-type 1

1

3

High-throughput

0.437

High

946660

SSBP2
Single-stranded DNA-binding protein 2

1

2

Small-scale

0.437

High

950686

ARF5
ADP-ribosylation factor 5

1

11

High-throughput

0.437

High

1002061

ARL16
ADP-ribosylation factor-like protein 16

1

20

High-throughput

0.437

High

1101572

ISX
Intestine-specific homeobox

1

3

High-throughput

0.437

High

1159421

FBX42
F-box only protein 42

1

3

High-throughput

0.437

High

1171333

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

1173997

UBP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

1

8

Small-scale

0.437

High

1185079

DET1
DET1 homolog

1

4

High-throughput

0.437

High

1200320

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

3

High-throughput

0.437

High

1202444

HOOK3
Protein Hook homolog 3

1

8

High-throughput

0.437

High

1237775

ARL10
ADP-ribosylation factor-like protein 10

1

18

High-throughput

0.437

High

1270392

HDAC2
Histone deacetylase 2

1

12

High-throughput

0.437

High

1296034

ARL5B
ADP-ribosylation factor-like protein 5B

1

19

High-throughput

0.437

High

1298850

NP1L5
Nucleosome assembly protein 1-like 5

1

1

High-throughput

0.437

High

1301268

RING2
E3 ubiquitin-protein ligase RING2

1

9

High-throughput

0.437

High

1301277

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

1

High-throughput

0.437

High

1301280

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.437

High

1301282

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

1301284

SAR1A
Small COPII coat GTPase SAR1A

1

20

High-throughput

0.437

High

1301288

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

3

High-throughput

0.437

High

1301291

VSX1
Visual system homeobox 1

1

3

High-throughput

0.437

High

1301297

HOOK1
Protein Hook homolog 1

1

8

High-throughput

0.437

High

1301299

RCOR1
REST corepressor 1

1

4

High-throughput

0.437

High

1301305

ARL5A
ADP-ribosylation factor-like protein 5A

1

20

High-throughput

0.437

High

1062260

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

0

Small-scale

0.426

High

1288188

CMBL
Carboxymethylenebutenolidase homolog

1

0

High-throughput

0.426

High

1301289

TRM1
tRNA

1

0

High-throughput

0.426

High

1245356

NPB
Neuropeptide B

2

0

High-throughput

0.328

High

1197760

DSG4
Desmoglein-4

1

0

High-throughput

0.279

Low

1200459

FA83A
Protein FAM83A

1

0

High-throughput

0.279

Low

1237290

STPG3
Protein STPG3

1

0

High-throughput

0.279

Low

1032567

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.249

Low

240150

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024