Protein: SYFB
Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS)

Gene: SYFB, FARSB
Organism: Homo sapiens
Interactions: 130
UniProt ID: Q9NSD9

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0003723 - RNA binding
GO:0004826 - phenylalanine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1345537

SYFA
Phenylalanine--tRNA ligase alpha subunit

7

8

Small-scale

0.968

High

331414

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

2

0

High-throughput

0.602

High

664135

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.602

High

1238404

DTX3
Probable E3 ubiquitin-protein ligase DTX3

2

0

High-throughput

0.585

High

228831

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

1343666

ANLN
Anillin

2

1

High-throughput

0.584

High

1345531

ZRAN1
Ubiquitin thioesterase ZRANB1

2

2

High-throughput

0.584

High

370524

ESR1
Estrogen receptor

2

3

High-throughput

0.571

High

508216

FGFR1
Fibroblast growth factor receptor 1

2

2

High-throughput

0.571

High

925657

RAC1
Ras-related C3 botulinum toxin substrate 1

2

3

High-throughput

0.571

High

497657

TAU
Microtubule-associated protein tau

2

1

High-throughput

0.552

High

1069870

PTPRR
Receptor-type tyrosine-protein phosphatase R

2

0

High-throughput

0.547

High

1222596

SLX4
Structure-specific endonuclease subunit SLX4

2

0

High-throughput

0.547

High

1234565

SH2D3
SH2 domain-containing protein 3C

2

0

High-throughput

0.547

High

1291589

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

868763

ATX1
Ataxin-1

1

2

High-throughput

0.515

High

267316

HSBP1
Heat shock factor-binding protein 1

1

0

High-throughput

0.513

High

387594

P53
Cellular tumor antigen p53

1

0

High-throughput

0.513

High

436753

GLI1
Zinc finger protein GLI1

1

0

High-throughput

0.513

High

570653

DCAM
S-adenosylmethionine decarboxylase proenzyme

1

0

High-throughput

0.513

High

585569

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

0

High-throughput

0.513

High

850986

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.513

High

885836

MTPN
Myotrophin

1

0

High-throughput

0.513

High

941966

PITX1
Pituitary homeobox 1

1

0

High-throughput

0.513

High

1161945

FOXR1
Forkhead box protein R1

1

0

High-throughput

0.513

High

1224290

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

0

High-throughput

0.513

High

1260603

BRK1
Protein BRICK1

1

0

High-throughput

0.513

High

1295910

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

0

High-throughput

0.513

High

1345526

CENPM
Centromere protein M

1

0

High-throughput

0.513

High

1345540

MB212
Protein mab-21-like 2

1

0

High-throughput

0.513

High

1345541

SAR1B
Small COPII coat GTPase SAR1B

1

0

High-throughput

0.513

High

890858

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

High-throughput

0.501

High

1345532

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

792022

HD
Huntingtin

1

0

High-throughput

0.493

High

1297554

MAGBA
Melanoma-associated antigen B10

1

1

High-throughput

0.489

High

902771

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

348004

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

374947

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

377725

GCR
Glucocorticoid receptor

1

3

High-throughput

0.479

High

385583

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

436531

RHOC
Rho-related GTP-binding protein RhoC

1

4

High-throughput

0.479

High

504822

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

545644

RAC2
Ras-related C3 botulinum toxin substrate 2

1

3

High-throughput

0.479

High

570109

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

780173

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

900956

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

909192

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

916009

RHOB
Rho-related GTP-binding protein RhoB

1

4

High-throughput

0.479

High

1029924

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

1036122

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1064761

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1146875

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

1171898

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

1183573

RHOU
Rho-related GTP-binding protein RhoU

1

5

High-throughput

0.479

High

1231346

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.479

High

1269235

RND1
Rho-related GTP-binding protein Rho6

1

5

High-throughput

0.479

High

1307006

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

1316763

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

1331398

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

1345536

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

1345539

ARI1
E3 ubiquitin-protein ligase ARIH1

1

2

High-throughput

0.479

High

1073646

SF3B4
Splicing factor 3B subunit 4

1

0

High-throughput

0.460

High

1345534

MSRA
Mitochondrial peptide methionine sulfoxide reductase

1

0

Small-scale

0.460

High

119535

LEG9
Galectin-9

1

0

High-throughput

0.458

High

295300

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

303498

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

530758

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

532622

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

547237

EZRI
Ezrin

1

0

High-throughput

0.458

High

719180

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

749885

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

829068

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

832732

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

836023

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.458

High

875352

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

932403

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

963909

SET
Protein SET

1

0

High-throughput

0.458

High

997225

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

0

High-throughput

0.458

High

1108736

ANR55
Ankyrin repeat domain-containing protein 55

1

0

High-throughput

0.458

High

1139125

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

1163878

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1200691

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1201706

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

1220402

SKA3
Spindle and kinetochore-associated protein 3

1

0

Small-scale

0.458

High

1221766

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1241429

MTMRE
Myotubularin-related protein 14

1

0

High-throughput

0.458

High

1267182

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1315510

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

1326970

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

0

High-throughput

0.458

High

1327587

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1330030

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

0

Small-scale

0.458

High

1345527

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

1345528

EHD3
EH domain-containing protein 3

1

0

High-throughput

0.458

High

1345542

MTCH2
Mitochondrial carrier homolog 2

1

0

High-throughput

0.458

High

331094

PAK4
Serine/threonine-protein kinase PAK 4

1

1

High-throughput

0.445

High

402523

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

660720

GRN
Progranulin

1

1

High-throughput

0.445

High

1130636

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

244993

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.437

High

553831

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

652367

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

1080388

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

1165990

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1269720

ESR2
Estrogen receptor beta

1

3

High-throughput

0.437

High

1296746

RHOV
Rho-related GTP-binding protein RhoV

1

4

High-throughput

0.437

High

1317627

RHBT2
Rho-related BTB domain-containing protein 2

1

3

High-throughput

0.437

High

786435

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.426

High

882596

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.426

High

1298068

CEP63
Centrosomal protein of 63 kDa

1

0

High-throughput

0.426

High

831721

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.373

High

1302296

GPX7
Glutathione peroxidase 7

2

0

High-throughput

0.328

High

581869

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.313

High

361933

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

0

High-throughput

0.279

Low

363315

FINC
Fibronectin

1

0

High-throughput

0.279

Low

571223

EGLN
Endoglin

1

0

High-throughput

0.279

Low

620580

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

0

High-throughput

0.279

Low

872922

ARSF
Arylsulfatase F

1

0

High-throughput

0.279

Low

1286155

ZBTB9
Zinc finger and BTB domain-containing protein 9

1

0

High-throughput

0.279

Low

1314395

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.279

Low

1345530

GHRL
Appetite-regulating hormone

1

0

High-throughput

0.279

Low

353308

CD4
T-cell surface glycoprotein CD4

1

0

Small-scale

0.249

Low

441781

CFAH
Complement factor H

1

0

Small-scale

0.249

Low

721559

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

824426

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

1252219

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

1327118

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

1345529

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.249

Low

1345533

TEKT2
Tektin-2

1

0

High-throughput

0.249

Low

1345535

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

1345538

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024