Protein: AKT2
RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC protein kinase beta) (RAC-PK-beta)

Gene: AKT2
Organism: Homo sapiens
Interactions: 125
UniProt ID: P31751

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005769 - early endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

682191

SH3R1
E3 ubiquitin-protein ligase SH3RF1

3

9

Small-scale

0.878

High

682217

DP13A
DCC-interacting protein 13-alpha

3

7

Small-scale

0.874

High

682166

CDK3
Cyclin-dependent kinase 3

3

8

High-throughput

0.861

High

474936

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

14

High-throughput

0.811

High

681681

AKT1
RAC-alpha serine/threonine-protein kinase

2

17

High-throughput

0.802

High

682200

SNX27
Sorting nexin-27

2

20

High-throughput

0.793

High

235479

VINEX
Vinexin

2

10

High-throughput

0.783

High

682143

CDN1A
Cyclin-dependent kinase inhibitor 1

1

8

Small-scale

0.747

High

682182

PKHO1
Pleckstrin homology domain-containing family O member 1

1

2

Small-scale

0.747

High

682199

CLIP3
CAP-Gly domain-containing linker protein 3

1

8

Small-scale

0.747

High

167482

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

Small-scale

0.724

High

326466

SNAI1
Zinc finger protein SNAI1

1

3

Small-scale

0.724

High

682203

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

16

Small-scale

0.724

High

682150

GSK3B
Glycogen synthase kinase-3 beta

1

20

Small-scale

0.692

High

682206

RGAP1
Rac GTPase-activating protein 1

1

1

High-throughput

0.691

High

682218

AKT3
RAC-gamma serine/threonine-protein kinase

1

17

High-throughput

0.691

High

682156

TCL1A
T-cell leukemia/lymphoma protein 1A

3

7

Small-scale

0.677

High

437928

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.665

High

621338

FSHR
Follicle-stimulating hormone receptor

1

5

Small-scale

0.665

High

682169

KPCZ
Protein kinase C zeta type

1

17

Small-scale

0.665

High

682149

MAPK2
MAP kinase-activated protein kinase 2

1

15

Small-scale

0.647

High

682184

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

12

High-throughput

0.647

High

682207

SIK2
Serine/threonine-protein kinase SIK2

1

13

Small-scale

0.647

High

122153

PSMD9
26S proteasome non-ATPase regulatory subunit 9

3

0

High-throughput

0.638

High

622765

COT2
COUP transcription factor 2

2

14

High-throughput

0.628

High

682204

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

2

7

High-throughput

0.628

High

298951

SRBS2
Sorbin and SH3 domain-containing protein 2

1

10

High-throughput

0.621

High

682170

TISB
mRNA decay activator protein ZFP36L1

2

3

Small-scale

0.619

High

182096

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

20

Small-scale

0.618

High

226638

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

232792

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

19

Small-scale

0.618

High

338005

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

349916

RASK
GTPase KRas

1

13

High-throughput

0.618

High

431573

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

433609

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

564425

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

590134

CCNA2
Cyclin-A2

1

3

Small-scale

0.618

High

682138

GRK5
G protein-coupled receptor kinase 5

1

16

High-throughput

0.618

High

682145

CCNF
Cyclin-F

1

9

High-throughput

0.618

High

682148

MK08
Mitogen-activated protein kinase 8

1

20

Small-scale

0.618

High

682157

DJB13
DnaJ homolog subfamily B member 13

1

13

High-throughput

0.618

High

682159

RAB2A
Ras-related protein Rab-2A

1

3

High-throughput

0.618

High

682161

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

4

Small-scale

0.618

High

682172

SRSF5
Serine/arginine-rich splicing factor 5

1

11

High-throughput

0.618

High

682173

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

14

Small-scale

0.618

High

682177

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.618

High

682179

CDC37
Hsp90 co-chaperone Cdc37

1

18

Small-scale

0.618

High

682190

PHLP2
PH domain leucine-rich repeat-containing protein phosphatase 2

1

16

Small-scale

0.618

High

682202

TRIB3
Tribbles homolog 3

1

16

Small-scale

0.618

High

682210

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

682211

WDR26
WD repeat-containing protein 26

1

9

Small-scale

0.618

High

682213

SEC12
Guanine nucleotide-exchange factor SEC12

1

11

High-throughput

0.618

High

682168

REL
Proto-oncogene c-Rel

2

12

High-throughput

0.606

High

682214

PICK1
PRKCA-binding protein

2

5

High-throughput

0.606

High

682164

PRKDC
DNA-dependent protein kinase catalytic subunit

2

19

Small-scale

0.602

High

682176

PDK1
[Pyruvate dehydrogenase

2

6

Small-scale

0.602

High

369067

ESR1
Estrogen receptor

1

20

Small-scale

0.598

High

682155

MTCP1
Protein p13 MTCP-1

2

7

Small-scale

0.586

High

456507

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

6

Small-scale

0.578

High

682144

VHL
von Hippel-Lindau disease tumor suppressor

1

6

Small-scale

0.561

High

682189

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.553

High

682153

TTC3
E3 ubiquitin-protein ligase TTC3

1

8

Small-scale

0.543

High

682146

CASP3
Caspase-3

1

5

Small-scale

0.536

High

682152

BIEA
Biliverdin reductase A

1

3

Small-scale

0.536

High

119706

AP4M1
AP-4 complex subunit mu-1

1

5

High-throughput

0.536

High

131639

USP9Y
Ubiquitin carboxyl-terminal hydrolase 9Y

1

9

High-throughput

0.536

High

206867

KCNQ3
Potassium voltage-gated channel subfamily KQT member 3

1

5

High-throughput

0.536

High

434350

TPM2
Tropomyosin beta chain

1

7

High-throughput

0.536

High

682188

XAF1
XIAP-associated factor 1

1

1

High-throughput

0.536

High

682208

ABCG8
ATP-binding cassette sub-family G member 8

1

0

High-throughput

0.518

High

682215

PLPL3
1-acylglycerol-3-phosphate O-acyltransferase PNPLA3

1

0

High-throughput

0.518

High

212600

AP1G1
AP-1 complex subunit gamma-1

1

5

High-throughput

0.515

High

443355

VIME
Vimentin

1

12

Small-scale

0.515

High

682175

SETB1
Histone-lysine N-methyltransferase SETDB1

1

4

Small-scale

0.515

High

682187

Q6FHY5
MEOX2 protein

1

6

High-throughput

0.515

High

682171

LMAN2
Vesicular integral-membrane protein VIP36

1

0

High-throughput

0.513

High

682201

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.513

High

682216

NSE4A
Non-structural maintenance of chromosomes element 4 homolog A

1

0

High-throughput

0.513

High

231379

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

1

3

Small-scale

0.501

High

394195

A4
Amyloid-beta precursor protein

1

11

High-throughput

0.501

High

682139

CTNB1
Catenin beta-1

1

6

Small-scale

0.501

High

682163

H31
Histone H3.1

1

13

Small-scale

0.501

High

682165

XIAP
E3 ubiquitin-protein ligase XIAP

1

2

Small-scale

0.501

High

682197

FUBP2
Far upstream element-binding protein 2

1

8

Small-scale

0.501

High

682219

MYO5A
Unconventional myosin-Va

1

5

Small-scale

0.501

High

682158

DEST
Destrin

1

3

High-throughput

0.489

High

682195

FAT3
Protocadherin Fat 3

1

2

High-throughput

0.489

High

329027

TCL1B
T-cell leukemia/lymphoma protein 1B

1

7

Small-scale

0.481

High

361322

APOA1
Apolipoprotein A-I

1

1

High-throughput

0.481

High

682151

MEOX2
Homeobox protein MOX-2

1

6

High-throughput

0.481

High

682186

STEA4
Metalloreductase STEAP4

1

2

High-throughput

0.481

High

420807

H2B1J
Histone H2B type 1-J

1

20

High-throughput

0.479

High

505776

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

4

High-throughput

0.479

High

506891

LAMP1
Lysosome-associated membrane glycoprotein 1

1

4

High-throughput

0.479

High

521225

SKI
Ski oncogene

1

1

Small-scale

0.479

High

552039

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

566939

CXA1
Gap junction alpha-1 protein

1

6

High-throughput

0.479

High

617927

H2B1O
Histone H2B type 1-O

1

20

High-throughput

0.479

High

650467

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

10

High-throughput

0.479

High

682136

ARRB2
Beta-arrestin-2

1

5

Small-scale

0.479

High

682137

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.479

High

682140

RFA3
Replication protein A 14 kDa subunit

1

9

High-throughput

0.479

High

682160

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

682162

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

13

Small-scale

0.479

High

682167

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

3

Small-scale

0.479

High

682174

CUL1
Cullin-1

1

5

Small-scale

0.479

High

682181

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.479

High

682194

H2B3B
Histone H2B type 3-B

1

20

High-throughput

0.479

High

682205

EGLN1
Egl nine homolog 1

1

2

Small-scale

0.479

High

682193

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

14

High-throughput

0.470

High

376430

APOB
Apolipoprotein B-100

1

0

High-throughput

0.460

High

682141

SPR2A
Small proline-rich protein 2A

1

0

High-throughput

0.460

High

682147

NAMPT
Nicotinamide phosphoribosyltransferase

1

0

High-throughput

0.460

High

682178

TMED2
Transmembrane emp24 domain-containing protein 2

1

0

High-throughput

0.460

High

682212

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

0

High-throughput

0.460

High

682142

COIL
Coilin

1

0

High-throughput

0.458

High

496408

TAU
Microtubule-associated protein tau

1

17

High-throughput

0.445

High

682196

AP2C
Transcription factor AP-2 gamma

1

0

High-throughput

0.438

High

682183

YIF1B
Protein YIF1B

1

1

High-throughput

0.437

High

682185

OTUD1
OTU domain-containing protein 1

1

4

Small-scale

0.437

High

682192

TMM17
Transmembrane protein 17

1

1

High-throughput

0.437

High

682180

CCL14
C-C motif chemokine 14

1

0

High-throughput

0.251

Low

682209

OFUT1
GDP-fucose protein O-fucosyltransferase 1

1

0

High-throughput

0.251

Low

682154

CMC4
Cx9C motif-containing protein 4

1

0

Small-scale

0.249

Low

682198

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024