Protein: TLR4
Toll-like receptor 4 (hToll) (CD antigen CD284)

Gene: TLR4
Organism: Homo sapiens
Interactions: 84
UniProt ID: O00206

Gene Ontology (top 5):
GO:0001530 - lipopolysaccharide binding
GO:0001540 - amyloid-beta binding
GO:0001726 - ruffle
GO:0001875 - lipopolysaccharide immune receptor activity
GO:0001891 - phagocytic cup

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

120191

LY96
Lymphocyte antigen 96

19

2

Small-scale

0.987

High

120109

TLR4
Toll-like receptor 4

5

18

Small-scale

0.901

High

120139

KSYK
Tyrosine-protein kinase SYK

3

20

Small-scale

0.827

High

120128

MBL2
Mannose-binding protein C

2

13

Small-scale

0.819

High

120179

IRAK4
Interleukin-1 receptor-associated kinase 4

2

20

Small-scale

0.789

High

120129

SRC
Proto-oncogene tyrosine-protein kinase Src

2

12

Small-scale

0.776

High

120156

SIGIR
Single Ig IL-1-related receptor

2

18

Small-scale

0.776

High

120142

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

12

3

Small-scale

0.761

High

120173

MYD88
Myeloid differentiation primary response protein MyD88

15

19

Small-scale

0.761

High

120137

SFTPD
Pulmonary surfactant-associated protein D

2

8

Small-scale

0.754

High

120140

IRAK1
Interleukin-1 receptor-associated kinase 1

2

20

Small-scale

0.754

High

120160

TCAM2
TIR domain-containing adapter molecule 2

8

8

Small-scale

0.747

High

120161

TCAM1
TIR domain-containing adapter molecule 1

4

8

Small-scale

0.683

High

120112

SIGL5
Sialic acid-binding Ig-like lectin 5

1

20

Small-scale

0.681

High

120114

SIGL6
Sialic acid-binding Ig-like lectin 6

1

20

Small-scale

0.681

High

120187

SIGL9
Sialic acid-binding Ig-like lectin 9

1

20

Small-scale

0.681

High

120118

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.665

High

120154

TLR1
Toll-like receptor 1

1

18

Small-scale

0.665

High

120149

BTK
Tyrosine-protein kinase BTK

1

19

Small-scale

0.656

High

120134

PGS1
Biglycan

1

20

Small-scale

0.647

High

120171

SIG11
Sialic acid-binding Ig-like lectin 11

1

20

Small-scale

0.647

High

120185

SIGL7
Sialic acid-binding Ig-like lectin 7

1

20

Small-scale

0.647

High

120186

TLR6
Toll-like receptor 6

1

18

Small-scale

0.646

High

120175

TOLIP
Toll-interacting protein

2

3

Small-scale

0.634

High

120113

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

20

Small-scale

0.618

High

120116

TLR5
Toll-like receptor 5

1

19

Small-scale

0.618

High

120117

LY86
Lymphocyte antigen 86

1

4

Small-scale

0.618

High

120123

PGS2
Decorin

1

20

Small-scale

0.618

High

120124

CD14
Monocyte differentiation antigen CD14

1

10

Small-scale

0.618

High

120148

KPCZ
Protein kinase C zeta type

1

11

Small-scale

0.618

High

120158

TRIL
TLR4 interactor with leucine rich repeats

1

20

Small-scale

0.618

High

120176

TREM1
Triggering receptor expressed on myeloid cells 1

1

1

Small-scale

0.618

High

120180

TBK1
Serine/threonine-protein kinase TBK1

1

6

Small-scale

0.618

High

120151

TRAF3
TNF receptor-associated factor 3

2

14

Small-scale

0.611

High

120164

SFTA1
Pulmonary surfactant-associated protein A1

1

11

Small-scale

0.595

High

120177

NOX4
NADPH oxidase 4

2

1

Small-scale

0.591

High

120174

CNPY3
Protein canopy homolog 3

2

14

Small-scale

0.584

High

120189

TRAF6
TNF receptor-associated factor 6

2

14

Small-scale

0.584

High

120125

HMGB1
High mobility group protein B1

2

6

Small-scale

0.571

High

120163

SFPA2
Pulmonary surfactant-associated protein A2

1

12

Small-scale

0.553

High

120178

RN216
E3 ubiquitin-protein ligase RNF216

2

5

Small-scale

0.548

High

120188

TMED7
Transmembrane emp24 domain-containing protein 7

2

1

Small-scale

0.544

High

120131

CD36
Platelet glycoprotein 4

1

1

Small-scale

0.536

High

120165

S11IP
Serine/threonine-protein kinase 11-interacting protein

1

20

High-throughput

0.536

High

120182

UBQL1
Ubiquilin-1

1

1

Small-scale

0.508

High

120110

FCN1
Ficolin-1

1

4

Small-scale

0.501

High

120119

FIBG
Fibrinogen gamma chain

1

4

Small-scale

0.501

High

120120

FINC
Fibronectin

1

7

Small-scale

0.501

High

120135

TENA
Tenascin

1

8

Small-scale

0.501

High

120166

TENR
Tenascin-R

1

6

Small-scale

0.501

High

120184

TENN
Tenascin-N

1

6

Small-scale

0.501

High

120145

SMAD3
Mothers against decapentaplegic homolog 3

1

1

High-throughput

0.481

High

120111

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

3

Small-scale

0.479

High

120122

P53
Cellular tumor antigen p53

1

6

Small-scale

0.479

High

120127

HSP7C
Heat shock cognate 71 kDa protein

1

7

Small-scale

0.479

High

120130

ENPL
Endoplasmin

1

4

Small-scale

0.479

High

120132

SPI1
Transcription factor PU.1

1

6

Small-scale

0.479

High

120141

PAR2
Proteinase-activated receptor 2

1

1

Small-scale

0.479

High

120144

RAB1A
Ras-related protein Rab-1A

1

2

Small-scale

0.479

High

120146

IRF8
Interferon regulatory factor 8

1

14

Small-scale

0.479

High

120147

CAV1
Caveolin-1

1

1

Small-scale

0.479

High

120150

HSP7E
Heat shock 70 kDa protein 14

1

8

Small-scale

0.479

High

120152

CUL4A
Cullin-4A

1

1

High-throughput

0.479

High

120153

IRF4
Interferon regulatory factor 4

1

14

Small-scale

0.479

High

120157

BCAP
Phosphoinositide 3-kinase adapter protein 1

1

1

Small-scale

0.479

High

120159

TRI69
E3 ubiquitin-protein ligase TRIM69

1

6

Small-scale

0.479

High

120168

PAQR1
Adiponectin receptor protein 1

1

5

Small-scale

0.479

High

120169

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

2

Small-scale

0.479

High

120170

TRI44
Tripartite motif-containing protein 44

1

4

Small-scale

0.479

High

120172

NEUR1
Sialidase-1

1

3

Small-scale

0.479

High

120183

CHIP
E3 ubiquitin-protein ligase CHIP

1

7

Small-scale

0.479

High

120190

RN115
E3 ubiquitin-protein ligase RNF115

1

5

Small-scale

0.479

High

120181

SRTD1
SERTA domain-containing protein 1

1

0

High-throughput

0.460

High

120115

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

Small-scale

0.458

High

120138

TNFL9
Tumor necrosis factor ligand superfamily member 9

1

0

Small-scale

0.458

High

120143

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

0

Small-scale

0.458

High

120155

ELAV1
ELAV-like protein 1

1

0

Small-scale

0.458

High

120126

CH60
60 kDa heat shock protein, mitochondrial

1

5

Small-scale

0.445

High

120121

FETUA
Alpha-2-HS-glycoprotein

1

2

Small-scale

0.437

High

120136

HSP74
Heat shock 70 kDa protein 4

1

9

Small-scale

0.437

High

120167

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

1

Small-scale

0.437

High

120133

MAL
Myelin and lymphocyte protein

1

0

Small-scale

0.249

Low

120162

MFN1
Mitofusin-1

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024