Protein: IRF4
Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (Multiple myeloma oncogene 1) (NF-EM5)

Gene: IRF4
Organism: Homo sapiens
Interactions: 113
UniProt ID: Q15306

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000786 - nucleosome
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

786484

STAT6
Signal transducer and activator of transcription 6

3

20

Small-scale

0.875

High

1071036

IRF4
Interferon regulatory factor 4

3

15

Small-scale

0.827

High

1059000

STAT4
Signal transducer and activator of transcription 4

2

20

Small-scale

0.789

High

781371

BCL6
B-cell lymphoma 6 protein

4

5

Small-scale

0.702

High

1071038

BATF
Basic leucine zipper transcriptional factor ATF-like

1

2

High-throughput

0.698

High

587581

NFKB1
Nuclear factor NF-kappa-B p105 subunit

3

20

Small-scale

0.657

High

572566

SPI1
Transcription factor PU.1

3

10

Small-scale

0.650

High

971733

IRF8
Interferon regulatory factor 8

1

15

Small-scale

0.618

High

998733

EP300
Histone acetyltransferase p300

1

18

High-throughput

0.618

High

978762

TF65
Transcription factor p65

2

20

Small-scale

0.601

High

1035237

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

2

20

Small-scale

0.601

High

1071068

MYD88
Myeloid differentiation primary response protein MyD88

2

20

Small-scale

0.601

High

1071083

TRAF6
TNF receptor-associated factor 6

2

20

Small-scale

0.601

High

848374

IRAK1
Interleukin-1 receptor-associated kinase 1

1

2

High-throughput

0.586

High

1071050

TLK2
Serine/threonine-protein kinase tousled-like 2

1

3

High-throughput

0.586

High

201799

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

2

1

Small-scale

0.584

High

353005

IL1B
Interleukin-1 beta

2

2

Small-scale

0.584

High

397980

ISG15
Ubiquitin-like protein ISG15

2

10

Small-scale

0.584

High

569759

CEBPB
CCAAT/enhancer-binding protein beta

2

3

Small-scale

0.584

High

702490

C2TA
MHC class II transactivator

2

7

Small-scale

0.584

High

981584

REL
Proto-oncogene c-Rel

2

20

Small-scale

0.584

High

1071046

SEN54
tRNA-splicing endonuclease subunit Sen54

2

0

High-throughput

0.580

High

305771

ELP1
Elongator complex protein 1

1

0

High-throughput

0.561

High

1024342

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

2

Small-scale

0.561

High

198800

HXC11
Homeobox protein Hox-C11

1

7

High-throughput

0.541

High

1020669

TRAF2
TNF receptor-associated factor 2

1

20

High-throughput

0.541

High

1071063

HXB13
Homeobox protein Hox-B13

1

9

High-throughput

0.541

High

1071084

ETV7
Transcription factor ETV7

1

10

High-throughput

0.541

High

417472

FCER2
Low affinity immunoglobulin epsilon Fc receptor

2

1

Small-scale

0.533

High

972510

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

3

Small-scale

0.529

High

1071062

PROX1
Prospero homeobox protein 1

1

0

High-throughput

0.518

High

901873

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

5

Small-scale

0.515

High

1071047

PEG10
Retrotransposon-derived protein PEG10

1

0

High-throughput

0.513

High

1071051

CARM1
Histone-arginine methyltransferase CARM1

1

0

High-throughput

0.513

High

1071066

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.513

High

120153

TLR4
Toll-like receptor 4

1

14

Small-scale

0.479

High

130158

ELL2
RNA polymerase II elongation factor ELL2

1

1

Small-scale

0.479

High

146226

ARI1A
AT-rich interactive domain-containing protein 1A

1

8

High-throughput

0.479

High

152651

KMT2D
Histone-lysine N-methyltransferase 2D

1

7

High-throughput

0.479

High

164228

ZN609
Zinc finger protein 609

1

5

High-throughput

0.479

High

183119

KDM6A
Lysine-specific demethylase 6A

1

4

High-throughput

0.479

High

265652

E2F6
Transcription factor E2F6

1

1

High-throughput

0.479

High

271767

PRDM1
PR domain zinc finger protein 1

1

1

Small-scale

0.479

High

272569

OFD1
Centriole and centriolar satellite protein OFD1

1

4

High-throughput

0.479

High

317971

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

20

Small-scale

0.479

High

346843

MYC
Myc proto-oncogene protein

1

4

Small-scale

0.479

High

396856

IL4
Interleukin-4

1

3

Small-scale

0.479

High

435101

SP1
Transcription factor Sp1

1

2

Small-scale

0.479

High

473516

ATX1L
Ataxin-1-like

1

1

High-throughput

0.479

High

610411

CBL
E3 ubiquitin-protein ligase CBL

1

6

Small-scale

0.479

High

713390

CD68
Macrosialin

1

2

Small-scale

0.479

High

837765

MNX1
Motor neuron and pancreas homeobox protein 1

1

6

High-throughput

0.479

High

846780

SMCA2
Probable global transcription activator SNF2L2

1

4

High-throughput

0.479

High

858105

NKX25
Homeobox protein Nkx-2.5

1

4

High-throughput

0.479

High

867206

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

1

Small-scale

0.479

High

868500

ATX1
Ataxin-1

1

1

High-throughput

0.479

High

960179

CDK6
Cyclin-dependent kinase 6

1

2

Small-scale

0.479

High

964487

RELB
Transcription factor RelB

1

20

Small-scale

0.479

High

966977

SATB1
DNA-binding protein SATB1

1

2

High-throughput

0.479

High

980611

TLE1
Transducin-like enhancer protein 1

1

3

High-throughput

0.479

High

981257

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

993428

TLE5
TLE family member 5

1

2

High-throughput

0.479

High

1018225

NFIA
Nuclear factor 1 A-type

1

3

High-throughput

0.479

High

1052399

FLOT2
Flotillin-2

1

6

High-throughput

0.479

High

1071037

SSXT
Protein SSXT

1

5

High-throughput

0.479

High

1071039

BCL7A
B-cell CLL/lymphoma 7 protein family member A

1

2

High-throughput

0.479

High

1071042

ARID2
AT-rich interactive domain-containing protein 2

1

6

High-throughput

0.479

High

1071043

NIPBL
Nipped-B-like protein

1

4

High-throughput

0.479

High

1071044

BCOR
BCL-6 corepressor

1

5

High-throughput

0.479

High

1071045

PAXI1
PAX-interacting protein 1

1

2

High-throughput

0.479

High

1071049

PB1
Protein polybromo-1

1

4

High-throughput

0.479

High

1071052

ABC3F
DNA dC->dU-editing enzyme APOBEC-3F

1

2

Small-scale

0.479

High

1071053

FOXP4
Forkhead box protein P4

1

8

High-throughput

0.479

High

1071055

KMT2C
Histone-lysine N-methyltransferase 2C

1

7

High-throughput

0.479

High

1071056

ZMIZ2
Zinc finger MIZ domain-containing protein 2

1

4

High-throughput

0.479

High

1071057

ARI1B
AT-rich interactive domain-containing protein 1B

1

11

High-throughput

0.479

High

1071058

KDM2B
Lysine-specific demethylase 2B

1

1

High-throughput

0.479

High

1071060

DPF1
Zinc finger protein neuro-d4

1

8

High-throughput

0.479

High

1071061

REQU
Zinc finger protein ubi-d4

1

8

High-throughput

0.479

High

1071065

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

3

High-throughput

0.479

High

1071067

CIC
Protein capicua homolog

1

6

High-throughput

0.479

High

1071070

PCGF1
Polycomb group RING finger protein 1

1

8

High-throughput

0.479

High

1071072

SSBP3
Single-stranded DNA-binding protein 3

1

1

High-throughput

0.479

High

1071076

BRD7
Bromodomain-containing protein 7

1

16

High-throughput

0.479

High

1071078

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

2

High-throughput

0.479

High

1071079

TCF20
Transcription factor 20

1

6

High-throughput

0.479

High

1071080

ZN608
Zinc finger protein 608

1

3

High-throughput

0.479

High

1071081

PRR12
Proline-rich protein 12

1

5

High-throughput

0.479

High

1071082

SATB2
DNA-binding protein SATB2

1

2

High-throughput

0.479

High

1071085

NCOR2
Nuclear receptor corepressor 2

1

6

High-throughput

0.479

High

1071086

NCOA3
Nuclear receptor coactivator 3

1

3

High-throughput

0.479

High

1071040

PRC2B
Protein PRRC2B

1

7

High-throughput

0.470

High

136170

SCD
Stearoyl-CoA desaturase

1

0

Small-scale

0.458

High

515709

CD20
B-lymphocyte antigen CD20

1

0

Small-scale

0.458

High

624431

CCNC
Cyclin-C

1

0

Small-scale

0.458

High

654355

CALX
Calnexin

1

0

Small-scale

0.458

High

1055227

ERG1
Squalene monooxygenase

1

0

Small-scale

0.458

High

1059583

MEF2D
Myocyte-specific enhancer factor 2D

1

0

High-throughput

0.458

High

1071048

LDB1
LIM domain-binding protein 1

1

0

High-throughput

0.458

High

1071054

STAG2
Cohesin subunit SA-2

1

0

Small-scale

0.458

High

1071069

PYGO2
Pygopus homolog 2

1

0

High-throughput

0.458

High

1071077

PIM2
Serine/threonine-protein kinase pim-2

1

0

Small-scale

0.458

High

968035

SPIB
Transcription factor Spi-B

1

10

High-throughput

0.457

High

1071073

DEFI6
Differentially expressed in FDCP 6 homolog

1

3

Small-scale

0.457

High

1071064

CUL5
Cullin-5

1

1

High-throughput

0.445

High

667337

IL12A
Interleukin-12 subunit alpha

1

7

Small-scale

0.437

High

1071041

OTUD1
OTU domain-containing protein 1

1

2

Small-scale

0.437

High

508541

TOP1
DNA topoisomerase 1

1

3

Small-scale

0.408

High

1071071

Q9BU62
BAT2L protein

1

1

High-throughput

0.407

High

1071059

GIPC2
PDZ domain-containing protein GIPC2

2

0

High-throughput

0.316

High

1071074

YTDC2
3'-5' RNA helicase YTHDC2

1

0

High-throughput

0.306

High

1071075

FBRS
Probable fibrosin-1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024